Clinical trials: sponsored by CHU de Reims
Periodontitis, Gingivitis
Intraoral Scanners as Periodontal and Dental Pathologies Diagnosis Tools
Periodontal diseases and dental pathologies are highly prevalent oral diseases. Thirty-three to fifty percent of adult population presented at least one untreated caries and more than 50% of French population are affected by…
- Conditions
- Periodontitis, Gingivitis, Dental Caries, Diagnosis
- Trial name
- Odonto3D (NCT06006429)
- Testing
- Numerical dental impression by intraoral scanner
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Alcohol Use Disorder
Social Cognition in Severe Alcohol Use Disorder
With 41,000 deaths per year, alcohol consumption is the second leading cause of preventable mortality in France. Nearly 3.4% of adults engage in excessive and chronic alcohol use, meeting criteria for Severe Alcohol Use Disorder…
- Trial name
- COSMO (NCT07464613)
- Testing
- Analysis of social functioning and social cognition processes
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Bipolar Disorder, Major Depressive Disorder
Functional Magnetic Resonance Imaging Study of Inhibitory Control in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder and unipolar depressive disorder are two chronic mood disorders associated with a significant social impact, even during euthymic phases.
- Trial name
- COLIBRI (NCT07503275)
- Testing
- Analysis of inhibitory control
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Bipolar Disorder and Major Depressive Disorder
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their…
- Trial name
- COMET (NCT06740331)
- Testing
- Analysis of social cognition, memory functioning, and executive functioning processes
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Chronic Obstructive Pulmonary Disease, Asthma
A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine
Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Bronchiectasis, Cystic Fibrosis
- Trial name
- PALMIRE (NCT07274631)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Elderly Persons
Biological MArkers of FRAilty in Elderly Subjects
Epidemiological data from Europe have shown that around 30% of subjects aged over 65 years of age are pre-frail, and 15% are frail.
- Trial name
- MAFRA (NCT02816580)
- Testing
- Blood collection
- Where
- France
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Alcohol Use Disorder
Social Cognition and Executive Functions in Alcohol Use Disorders - Transverse Study
Over the past few years, researchers and clinicians have stressed the major role of executive and social cognition impairments in the development and the maintenance of Alcohol Use Disorders (AUD).
- Trial name
- COSEFEX-T (NCT04647422)
- Testing
- Analysis of executive functioning and of social cognition processes
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Bipolar Disorder
fMRI of Flight of Ideas in Bipolar Disorder
Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. The observations of the patient's speech and language behaviour due to flight of ideas or loss of goal…
- Trial name
- i-TCP (NCT02794129)
- Testing
- Functional Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Lupus Nephritis
Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN)?
Introduction and background : Glomerulonephritis and auto-immune diseases are often associated. Lupus nephritis (LN) is one of the major clinical manifestations of systemic lupus erythematosus (SLE) which have a severe impact on…
- Trial name
- GOODLUPUS (NCT03664908)
- Testing
- Detection of circulating anti-GBM antibodies (using chemiluminescence method and indirect immunofluorescence (IIF) method).
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Hidradenitis Suppurativa
Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients
The objective is to investigate ex vivo the inflammatory response in hidradenitis suppurativa (HS) (activation of an inflammasome, role of pro-inflammatory cytokines) in the skin of patients treated surgically for this disease.
- Trial name
- NCT02833909
- Testing
- surgery
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Preterm Children
Preterm Birth and Social Cognition
The study aims at investigating social cognition outcomes of children born prematurely. Social cognition can be briefly defined as a process which underlines people's social and emotional behaviors.
- Trial name
- TERM-COG (NCT03007095)
- Testing
- Evaluation of the children's social cognitive development
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Alzheimer Disease
Amyloid Beta-peptide 1-40 and Alzheimer's Disease
The combined measurement of Ab42 and tau protein (total and phosphorylated) in the spinal fluid has been shown to be promising in the diagnosis of Alzheimer's disease (AD), and has justified its inclusion new diagnostic criteria.
- Trial name
- ADAB40 (NCT02770482)
- Testing
- spinal fluid collection
- Where
- France
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Binge Drinking
Risk Factors Associated With Binge Drinking Behaviors Among College Students
The purpose of this study is to specify the psychological, cognitive, neuro-functional and genetic profile associated with binge drinker behaviors among young adults.
- Trial name
- AlcoolPredict (NCT02794311)
- Testing
- Alcoolpredict
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Alzheimer Disease
Erythrocyte Complement Receptor 1 and Alzheimer Disease
Main objective: investigate whether a functional polymorphism of CR1 (length, number of binding sites in C4b C3b, erythrocyte density, rate of soluble CR1 ...) so determined genetic or acquired, is a susceptibility factor for the…
- Trial name
- NCT01565434
- Testing
- CR1 impact
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Pregnancy
Pregnancy Denial and Attachment
Described in the 1970's, pregnancy denial occurs as the un-consciousness of being pregnant for several months or throughout the entire period. Body transformations are most of the time not clearly noticeable.
- Trial name
- Denial-attach (NCT02867579)
- Testing
- evaluation of the child quality attachment ("Strange situation")
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Validation of Raman Spectroscopy Usefulness in Systemic Sclerosis
Skin Fibrosis Analysis by Raman Spectroscopy in Systemic Sclerosis
Systemic sclerosis (SSc) is a rare connective tissue disease characterized by a high clinical heterogeneity with unpredictable evolution that could engage functional and life-threatening prognosis.
- Trial name
- RAMSES (NCT04996082)
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Parental Anxiety Following Premature Birth
Impact of Preterm Birth on Symptoms of Anxiety and Depression in Parents, and on the Precursors of Cognition, Including Social Cognition in Their Child
In 2018, the World Health Organization (WHO) counted no less than 15 million preterm births each year worldwide, or more than one in ten children.
- Trial name
- PréDANPa (NCT05734768)
- Testing
- State-Trait Anxiety Inventory - Y ou STAI-Y
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Obstructive Sleep Apnea Syndrome
Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome
The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration.
- Trial name
- IRM SAOS (NCT05147649)
- Testing
- functional magnetic resonance imaging
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Alzheimer Disease
Ability to Drive of Early Stage Alzheimer Disease
The main objectives of this study are: To evaluate the driving capacities in a population of elderly subjects with early stage Alzheimer Disease (AD) in a real-life situation.
- Trial name
- DRIVE COG (NCT01566071)
- Testing
- Assessment of drive abilities
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Pediatric Epilepsy
Social Cognition in Pediatric Epilepsy
The purpose of this study is to investigate the development of social cognition skills in pediatric epilepsy compared to healthy children.
- Trial name
- TOMEPI (NCT04253379)
- Testing
- Neuropsychological evaluation , Evaluation of theory of mind, Evaluation of executive functions, Evaluation of verbal skills
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- CHU de Reims