Clinical trials: sponsored by Centre Hospitalier St Anne
Mental Health
Study of Individual Neurocognitive Changes Associated With the Training of the Working Memory.
8 participants including 2 pilots. The 2 pilot participants will each execute an MRI acquisition session in order to adjust the experimental paradigm
- Trial name
- SAMPLEX (NCT07851051)
- Where
- France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Depression, Bipolar Disorder
Neuro-computational Study of Thymic Fluctuations in Mood Disorders
Depression and bipolar disorder are frequent, debilitating conditions. Both are thought to be primarily caused by an impaired regulation of mood, which is why they are sometimes referred to as "mood disorders".
- Conditions
- Depression, Bipolar Disorder, Recurrent Depression, Mood Disorders
- Trial name
- MOODELING (NCT07033923)
- Testing
- Brain magnetic resonance imaging (MRI) with structural (anatomical) and functional sequences (optional), Computerized cognitive tests, Daily longitudinal monitoring by mobile MOODELING application
- Where
- 2 sites in France
- Volunteers
- 588 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Alzheimer Disease
Impact of Microglial Activation on Synaptic Density in Alzheimer's Disease
This study aims to analyse, in vivo, the interplay between microglial activation and tau pathology in Alzheimer's disease (AD) using [18F]-DPA-714 and [18F]-Ro948 tracers by Position Emission Tomography (PET), and their…
- Trial name
- GliSyn (NCT05911178)
- Testing
- [11C]-UCB-J, [18F]-DPA-714, [18F]-RO-948
- Where
- 3 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Typical Development, Typically Developing Children Ages 3 to 6
Assessment of Language Comprehension and Learning in Children Attending Child Psychiatry Services (TICOALA-SOINS)
Language is central to children's cognitive, emotional, and social development, and language difficulties are a frequent reason for consultation in child psychiatry, often co-occurring with psychiatric disorders.
- Conditions
- Typical Development, Typically Developing Children Ages 3 to 6, Typical Preschoolers Who Can Not Zipper, Children
- Trial name
- TICOALA-SOINS (NCT07283458)
- Testing
- TICOALA
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Epilepsy, Anxiety
Phenotypic Exploration During Sensory Stimulation in an Acoustic Chamber
An observational behavioural and neurophysiological study of the effects of controlled sensory stimulation (such as music, for example) on brain function
- Conditions
- Epilepsy, Anxiety, Depression Anxiety Disorder
- Trial name
- EMO-INTRA (NCT07544563)
- Where
- France
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Stroke, Upper Extremity Paresis
Sensory Mechanisms of Manual Dexterity Recovery After Stroke: a Prospective Cohort Study of Prediction and Cerebral Correlates
In the proposed research, we will assess motor and sensory functions of the hand using clinical tests and a tool designed to measure manual dexterity combined with vibrotactile stimulation.
- Conditions
- Stroke, Upper Extremity Paresis, Manual Dexterity, Sensory Integration Dysfunction
- Trial name
- HapticS 2 (NCT07340736)
- Testing
- Haptic stimulation device, Brain MRI
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Neurologic Disorders, Schizophrenia
Characterization of High-Level Cognitive Impairments in Patients With Neuropsychiatric Disorders
Neuropsychiatric disorders are extremely common, severe, and disabling conditions. In the field of psychiatry, they notably include schizophrenia, mood disorders (depressive and bipolar disorders), autism spectrum or…
- Conditions
- Neurologic Disorders, Schizophrenia, Bipolar Disorder (BD), Depressive Disorder
- Trial name
- COGPSY (NCT07295652)
- Testing
- Cognitive assessment, Brain MRI (optional), Electroencephalography (optional)
- Where
- 3 sites in France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Role of the Noradrenergic System in the Regulation of Learning Dynamics, No Disease or Condition is Being Studied
Role of the Noradrenergic System in the Regulation of Learning Dynamics: Evaluation of the Effect of a Low-dose Selective Noradrenaline Reuptake Inhibitor (NOISYXETINE)
Administration of low-dose selective noradrenaline reuptake inhibitor (sNRI) (e.g. atomoxetine) to healthy subjects is a validated model of increasing cortical noradrenaline levels which, combined with computational modelling of…
- Trial name
- NOISYXETINE (NCT07239791)
- Testing
- Atomoxetine
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Mental Health
Implications of Myelin in Executive Control in Adolescence and Early Adulthood
The Myelex study is a fundamental research study that aims to better understand how the brain functions and develops. The objective of this study is to better understand the role of myelin, a sheath that surrounds nerve fibers…
- Trial name
- MYELEX (NCT06868966)
- Where
- France
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
FTD, AD
Metabolic Characterization of Alzheimer's Disease and Frontotemporal Dementia by 23Na-MRI and FDG-PET
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common forms of neurodegenerative dementia. However, their differential and timely diagnosis can be challenging for clinicians, therefore often closing the…
- Conditions
- FTD, AD, Healthy Controls
- Trial name
- MetaAD_FTD (NCT07100470)
- Testing
- Sodium MRI
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Major Depressive Disorder (MDD), Bipolar Disorder Depression
Cognitive Effects Associated With Hippocampal Neurogenesis Induced by ECT in the Treatment of Depression
Electroconvulsive therapy (ECT) is the treatment of choice for drug-resistant depression (30% of patients), or when there is a short-term risk to the patient's life.
- Trial name
- CONHECT (NCT06661616)
- Where
- France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
No Condition
Domain-general and Domain-specific Contributions to the Development of Numerical Cognition
Exploring the non-symbolic and symbolic arithmetic competencies in two groups of children (5-, and 7-year-olds). Additionally, we explored the relationship with domain-general factors such as inhibition and attention.
- Trial name
- CFDDCN (NCT06658392)
- Testing
- cognitive tasks
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
First Episode Psychosis (FEP)
Self-administered COgnitive Personalized Training in Early Psychosis
The overall objective of SCOPe is to improve early intervention in psychosis by providing an innovative eHealth tool that will enable personalized cognitive training, adapted to the individual's cognitive abilities.
- Trial name
- SCOPe (NCT06634446)
- Testing
- a mobile application for cognitive training, video games
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Depressive Disorder
Study of the Neural Circuits Underlying the Negative Emotional Bias of Depressive Disorders and Their Response to Ketamine
Major depressive disorder is the leading cause of disability worldwide, affecting up to 300 million people each year, and one in five people will experience depression at least once in their lives.
- Trial name
- EMOKET (NCT06630065)
- Testing
- fMRI with emotional task and pupillometry, Behavioral task with emotional facial expressions, Biological investigation
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Patients With Cognitive Disturbances
Hippocampal Sclerosis and Amnesia Not Due to Alzheimer's Disease
Hippocampal Sclerosis (HS) leads to anterograde amnesia mimicking early Alzheimer's disease (AD) (so called HSA-nonAD). Recent studies showed that (a) the deficit of episodic memory as well as the level of hippocampal atrophy in…
- Trial name
- ShaTau7 (NCT02576821)
- Testing
- Neurological examinations, Neuropsychological examinations, Clinical examinations
- Where
- France
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Healthy
NEUROR: Exploring the Neural Basis of Reasoning
Decades of research have long established that people's reasoning can be biased by their intuitions and deviate from logical norms.
- Trial name
- NEUROR (NCT04849208)
- Testing
- Presentation of fast and slow trials
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Cerebral Vascular Accident
Evaluation of the Benefit of the Training of the Manual Dexterity Post Stroke.
Stroke is the second leading cause of death and disability in France: more than half of stroke survivors have a disabling motor deficit, affecting mainly the upper limb.
- Trial name
- DEXTRAIN (NCT03934073)
- Testing
- DEXTRAIN, CONVENTIONNELLE, CONTROLE
- Where
- France
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Discrimination, Racial
Family Experiences After International Adoption
The purpose of this study is to determine the types of experiences faced by families in France who have adopted a child internationally.
- Trial name
- VF-ADIN (NCT03646838)
- Where
- 4 sites in France
- Volunteers
- 991 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Healthy Subjects
Cognitive Biases Under Ketamine
Characterise cognitive biases resulting from low dose ketamine infusion, used as a pharmacological model of psychosis. Our assumption is that low dose ketamine results in reasoning biases by impairing the way uncertainty is…
- Trial name
- KETABI (NCT02235012)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Neurosciences, MRI
OPTIMIZATION of ADVANCED MR SEQUENCES
This monocentric methodological study aims at optimizing advanced MR sequences for image quality (reduced artefacts, signal to noise ratio, acquisition time, stability of quantitative measurements) on a new MR unit dedicated to…
- Conditions
- Neurosciences, MRI, Brain Tumor, Mental Disorders
- Trial name
- OPT-IRM (NCT05618990)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne