Clinical trials: sponsored by Kaiser Permanente
Colon Cancer
Study of Colorectal Cancer Screening Options
The investigators propose to evaluate Guardant Health's commercially available colorectal cancer screening assay(Guardant SHIELD) in individuals who are not up to date with CRC screening.
- Trial name
- NCT05987709
- Testing
- GuardantSHIELD Blood Test
- Where
- United States
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Suicide, Attempted, Suicide, Fatal
Implementation of Suicide Risk Models in Health Systems
The goal of this clinical trial is to evaluate a suicide risk model in patients receiving behavioral health care treatment. The main question it aims to answer is: Does the implementation of the suicide risk model reduce suicide…
- Trial name
- NCT06060535
- Testing
- Suicide Attempt Risk Model Care Pathway
- Where
- 3 sites in United States
- Volunteers
- 394,000 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
COVID-19 Testing
COVID-19 Antibody and Reinfection Study
The goal of this study is to establish a cohort of Kaiser Permanente Colorado (KPCO) members who have and have not had COVID-19 infection for serial antibody testing and PCR testing to: 1.
- Trial name
- NCT05365750
- Where
- United States
- Volunteers
- 4,235 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Hereditary Cancer Syndrome
Cancer Health Assessments Reaching Many
The CHARM (Cancer Health Assessment Reaching Many) study will assess the utility of clinical exome sequencing and how it affects care in diverse populations.
- Trial name
- CHARM (NCT03426878)
- Testing
- Modified genetic counseling, Traditional genetic counseling
- Where
- 2 sites in United States
- Volunteers
- 967 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Obesity
Motivational Wellness Coaching to Reduce Childhood Obesity in Families and Kids
Primary care settings lack interventions to address the childhood obesity epidemic that are feasible and sustainable without requiring significant resources.
- Trial name
- WC4K (NCT05143697)
- Testing
- Wellness Coaching for Families and Kids
- Where
- United States
- Volunteers
- 6,600 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Mental Health
Novel Methods for Implementing Measurement-Based Care for Youth in Low-resource Environments
This study will visit 4 community mental health clinics in Washington state and work with clinic staff to find out if staff are regularly evaluating clinical outcomes using questionnaires (which is also called measurement-based…
- Trial name
- NIMBLE (NCT05644756)
- Testing
- IMPACT Methods to Identify and Prioritize Determinants (Challenge I), Challenge and Match strategies to Prioritized Determinants (Challenge II)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Cardiovascular Diseases, Influenza
Kaiser Permanente VACCination Improvement With Nudge-based CardiovAscular Targeted Engagement
In randomized clinical trials and observational studies, influenza vaccination is effective in reducing influenza-related illness and hospitalizations and potentially cardiovascular (CV) events and mortality in select…
- Conditions
- Cardiovascular Diseases, Influenza, Behavior, Social
- Trial name
- KP-VACCINATE (NCT06571747)
- Testing
- Cardiovascular-Focused Nudge Communication
- Where
- 2 sites in United States
- Volunteers
- 3,668,428 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Diet, Healthy, Overweight and Obesity
Food Prescriptions to Promote Affordable Diets
This is an Randomized controlled trial (RCT) to assess the impact of meal planning and affordable grocery delivery on weight loss, dietary quality and health on members of multigenerational Latino households.
- Trial name
- FoodRx (NCT05309395)
- Testing
- FoodRx
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Distress, Cancer
POEM (Practice Of Embracing Each Moment) STUDY
A cancer diagnosis is extremely stressful, emotionally challenging, and often life-altering for both patients and their loved ones.
- Conditions
- Distress, Cancer, Chemotherapy Effect
- Trial name
- POEM (NCT03078608)
- Testing
- Mindfulness meditation program (administered via mobile app), Progressive muscle relaxation (via mobile app)
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Prostate Cancer, Prostate Cancer Stage I
Randomized Trial of HIFU vs. Cryo for Prostate Cancer
HIFU has been FDA approved and is widely utilized across the United States and Europe for the treatment of prostate cancer. Despite this, HIFU has not been offered within SCPMG until now due to growing patient demand.
- Conditions
- Prostate Cancer, Prostate Cancer Stage I, Prostate Cancer Stage II, High Intensity Focused Ultrasound
- Trial name
- KPFT (NCT06929065)
- Testing
- HIFU vs Cryoablation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Influenza, Pneumonia
Flublok v. Standard Dose Vaccine Effectiveness Among Kaiser Permanente Northern California Adults 18-64 Years
The overall objective of this study is to describe the effectiveness of Flublok Quadrivalent vaccine compared to standard dose inactivated influenza vaccine (SD-IIV) in adults 18 through 64 years of age.
- Conditions
- Influenza, Pneumonia, Lower Respiratory Tract Infection, Acute Myocardial Infarction
- Trial name
- NCT03694392
- Testing
- Flublok Quadrivalent, Standard Dose Inactivated Influenza Vaccine (SD-IIV)
- Where
- United States
- Volunteers
- 2,776,278 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Heart Attack, Stroke
CV Wizard: Does a Clinical Decision Support Tool Improve CVD Risk Factor Control in Safety Net Clinics?
This project aims to reduce disparities in cardiovascular disease (CVD) risk factor control and in rates of heart attacks and strokes among the low-income, racially / ethnically diverse Americans who receive primary care at…
- Conditions
- Heart Attack, Stroke, Cardiovascular Diseases
- Trial name
- CV_WIZARD (NCT03001713)
- Testing
- CV WIZARD
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Chest Infection, Pulmonary Edema - Acute
Grasshopper: a Novel Clinical Dashboard for Radiologists
Does a radiology clinical dashboard increase radiologist use of specific reporting language for chest X-rays (CXRs) and thereby decrease rates of unnecessary Emergency Department (ED) prescriptions and follow-up imaging?
- Trial name
- Grasshopper (NCT06785246)
- Testing
- Grasshopper dashboard
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Alcohol, Drinking, Alcohol Use Disorder
Sustaining Patient-centered Alcohol-related Care
Alcohol use is the third greatest cause of disability and death for US adults. Care for unhealthy alcohol use is lacking in most primary care settings.
- Trial name
- SPARC (NCT02675777)
- Testing
- Quality Improvement Intervention
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Cannabis-Related Disorder, Cannabis Abuse
Implementing Screening for Cannabis and Other Drug Use Disorders in Primary Care: Impact on Diagnosis and Treatment
Our proposed evaluation study is designed to evaluate the impact of a recently completed stepped wedge cluster randomized trial, conducted at Kaiser Permanente Washington (KPWA), of an intervention to improve care and management…
- Conditions
- Cannabis-Related Disorder, Cannabis Abuse, Drug Abuse, Drug Use Disorders
- Trial name
- NCT06249542
- Testing
- Care Delivery Improvement Intervention
- Volunteers
- 363,936 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Child Behavior Disorders
Safer Use of Antipsychotics in Youth
This study tests the effectiveness of an intervention treatment algorithm vs. usual care control in a practical clinical trial. Control arm providers will receive a standard medication alert in the electronic medical record (EMR)…
- Trial name
- SUAY (NCT03448575)
- Testing
- Control - Provider Medication Alert Only, Intervention - Alert + CAP Review AND Enhanced BH Access
- Where
- 4 sites in United States
- Volunteers
- 733 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
COVID-19
Engaging Staff to Improve COVID-19 Vaccination Response at Long-Term Care Facilities
The ENSPIRE study is a cluster-randomized comparative effectiveness trial being conducted within long-term care and residential facilities that will test a communication and engagement strategy for increasing COVID-19 booster…
- Trial name
- ENSPIRE (NCT05449418)
- Testing
- Full Intervention, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 988 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Depression, Anxiety
Collaborative Care for Treatment of Depression and Anxiety
The goal of this project is to evaluate the effectiveness of a collaborative care model for primary care patients at Kaiser Permanente Colorado (KPCO) with depression and/or anxiety.
- Trial name
- NCT06556589
- Testing
- Collaborative Care
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Sedentary Lifestyle
Healthy Aging Resources to Thrive (HART)
Healthy Aging Resources to Thrive (HART) uses a rigorous two-stage randomized control design, adapted and refined based on pilot studies, to test a novel intervention to reduce sitting time in older adults.
- Trial name
- HART (NCT03739762)
- Testing
- i-STAND, Healthy Living control
- Where
- United States
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Hypersomnia, Narcolepsy
Feasibility Study of At-Home EEG Monitoring for Hypersomnia
The central hypothesis is that home EEG monitoring (Dream 3 wearable) can be feasibly utilized for data capture of continuous sleep and wake measurements for the diagnostic evaluation and treatment monitoring of hypersomnia.
- Trial name
- NCT05627388
- Testing
- Dreem 3 System At-Home Monitoring
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kaiser Permanente