Clinical trials: sponsored by McMaster University
Endometriosis (Diagnosis), Endometriosis
Combining Ultrasound and Biomarkers to Diagnose Superficial Endometriosis
Endometriosis is a benign gynecological disease characterized by uterine-like cells growing outside the uterus, leading to pain, infertility, and inflammation.
- Trial name
- SPGENDO (NCT05523284)
- Testing
- SonoPODography
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Fibromyalgia
Neurophysiology of Fibromyalgia
Fibromyalgia is a syndrome associated with fatigue and chronic pain, leading to significant physical limitations and impaired quality of life.
- Trial name
- NCT06006130
- Testing
- Active Controlled Pulse Parameter Transcranial Magnetic Stimulation (cTMS)
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Low Back Pain, Chronic Pain
Aging, Mobility and Chronic Low Back Pain
Chronic low back pain (CLBP) is very common in older adults and is one of the most common reasons for disability and poor quality of life.
- Trial name
- "Chronic pain" (NCT05167877)
- Testing
- No intervention will be given to the participants
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Domestic Violence, Child Maltreatment
RISE With Residents
Prevention of child maltreatment (CM) remains a public health priority in Canada; approximately one-third of Canadians report exposure to at least one form of CM.
- Conditions
- Domestic Violence, Child Maltreatment, Pediatric ALL, Psychiatry
- Trial name
- RISE Residents (NCT05490121)
- Testing
- Violence, Evidence, Guidance, Action Project (VEGA) Education Intervention
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- McMaster University
Domestic Violence, Veterans Family
RISE With Veteran Service Providers
Veterans and their families are more likely to experience forms of family violence like intimate-partner violence and child maltreatment.
- Conditions
- Domestic Violence, Veterans Family, Veterans, Child Maltreatment
- Trial name
- RISE Vet (NCT05490004)
- Testing
- Violence, Evidence, Guidance, Action Project (VEGA) Education Intervention
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Child Behavior Problem
Family STEPS: Family Check-Up+
Interventions that promote safe, stable, and nurturing relationships between caregivers and children are key to improving healthy family relationships, reducing child socioemotional and behaviour problems, and preventing child…
- Trial name
- FamilySTEPS (NCT07433361)
- Testing
- Family Check Up
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cerebrovascular Function, Cognition
Ketone Dose and Cerebral Blood Flow Study
Ketone bodies are produced by the liver during periods of food scarcity or severe carbohydrate restriction. Blood ketones are an alternative fuel source used by the brain, heart, and skeletal muscle during periods of fasting.
- Trial name
- kCBF (NCT06032156)
- Testing
- Low Dose β-OHB, High Dose β-OHB
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Low Back Pain
Back to Living Well: Implementation of a Community-based Program for Low Back Pain
Low back pain (LBP) is usually a long-term condition with episodes of improvement, remission, and recurrence. There is evidence that long term exercise combined with education and self-management is effective at reducing the…
- Trial name
- NCT05929846
- Testing
- Back to Living Well Program
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- McMaster University
Dementia Prevention
Dementia Prevention Internet-Based Intervention: Randomized Controlled Trial and Knowledge Translation
In this proposal, the investigators plan to study the effectiveness of a web-based intervention on dementia prevention knowledge, intentions, and behaviour change related to dementia risk.
- Trial name
- NCT06911047
- Testing
- Education Intervention, Education Control
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
COVID-19 Infection
A Trial of a Next Generation COVID-19 Vaccine Delivered by Inhaled Aerosol
The goal of this clinical trial is to study the safety of a new inhaled vaccine to prevent COVID infection and learn about the immune responses that are made in the lungs and the blood after vaccination.
- Trial name
- AeroVax (NCT06381739)
- Testing
- ChAd-triCoV/Mac, Control
- Where
- 2 sites in Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- McMaster University
Education of Primary Care Clinicians, Palliative Care
All Providers Better Communication Skills Program' (ABCs)
High quality, person-centered communication for those living with serious illness benefits patients, families and clinicians. Evidence shows that clinicians rarely engage patients in these, sometimes challenging, discussions.
- Conditions
- Education of Primary Care Clinicians, Palliative Care, Communication
- Trial name
- NCT06606470
- Testing
- All providers Better Communication Skills program' (ABCs) interprofessional provider education
- Where
- 2 sites in Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- McMaster University
Concussion, Brain
Development of a Concussion Management Platform for Children and Youth
This multi-centred, randomized controlled trial will evaluate the effectiveness of a pilot tested mobile device Application built to guide youth in recovery from concussion.
- Trial name
- Back2PlayApp (NCT05471791)
- Testing
- Back2Play App
- Where
- 2 sites in Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- McMaster University
Firefighters
PeerOnCall: Implementing and Evaluating App-Based Peer Support in Canadian Fire Services
The goal of this clinical trial is to test how best to implement a mobile peer support app called PeerOnCall in Canadian fire services. The main questions it aims to answer are: 1.
- Trial name
- NCT07199387
- Testing
- App Users (Structured Implementation), App Users (Standard Implementation)
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- McMaster University
Covid19, Corona Virus Infection
Functional Recovery of Hospitalised Patients With COVID-19: The COREG Extension Study
Older adults and those with chronic underlying health conditions are the most susceptible to COVID-19 and its complications. Although there has been a rapid response to studying the effects of COVID-19 in the acute stages, little…
- Conditions
- Covid19, Corona Virus Infection, Mobility Limitation, Frailty
- Trial name
- NCT04602260
- Where
- Canada
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- McMaster University
Psychological Stress
Intermittent Fasting Interventions on Brain Health in Women
Adults experience high psychological stress due to many factors such as school, workplace, or personal life. Adult women are known to experience higher stress levels than men.
- Trial name
- NCT05628727
- Testing
- Time Restricted Feeding, 5:2 Fasting
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- McMaster University
Alcohol Use Disorder, Alcohol Drinking
Using Neuroeconomics to Characterize State-Based Increases and Decreases in Alcohol Value
This study uses techniques from an area of research known as neuroeconomics, which integrates concepts and methods from psychology, neuroscience, and economics to better understand how people make decisions and how these…
- Trial name
- NCT04067765
- Testing
- Cue Exposure
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Cough (CC), Asthma
The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
The inhalation of adenosine 5'-triphosphate (ATP) to evoke cough (ATP cough challenge) is becoming increasingly used as a tool to measure cough hypersensitivity in patients with chronic cough.
- Trial name
- NCT07085975
- Testing
- Adenosine 5'-triphosphate
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Aging
Virtual GERAS DANCE Feasibility RCT
GERAS DANcing for Cognition and Exercise (DANCE) is a therapeutic mind-body program for older adults (aged 60+) developed with rehabilitation and geriatric medicine expertise at the GERAS Centre for Aging Research at Hamilton…
- Trial name
- NCT05202522
- Testing
- Virtual GERAS DANCE
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- McMaster University
Menstrual Cycle, Resistance Exercise
Menstrual Cycle Phase Based Training
The primary purpose of this study is to employ state-of-the-art methods to fill current knowledge gaps on the effects of the menstrual cycle on resistance exercise training adaptations.
- Trial name
- MCPBT (NCT05936424)
- Testing
- Unilateral Resistance Exercise Leg, Non-Exercise Control Leg
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Glucose Tolerance Impaired
Dose Response Relationship Between Fat Ingestion and Metabolism
The goal of this clinical trial is to compare features of metabolism in healthy, young adults after they consume four meals of differing fat quantity.
- Trial name
- AFDR (NCT05906342)
- Testing
- 20% fat meal, 40% fat meal, 60% fat meal
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University