Clinical trials: sponsored by McMaster University
Covid-19, Asthma
COVID-19 Related Lung Ventilation and Perfusion Injury
Little is currently known about the immediate and long-term effect of COVID-19 on lung ventilation (delivery of air to the lungs) and lung perfusion (delivery of blood to the lungs).
- Conditions
- Covid-19, Asthma, Healthy
- Trial name
- NCT04549636
- Testing
- V/Q SPECT-CT, St. George's Respiratory Questionnaire (SGRQ), mMRC (Modified Medical Research Council) Dyspnea Scale
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- McMaster University
Depression, Anxiety
Evaluate the Usefulness of Mental Health e-Learning
In this proposal, the investigators plan to study the impact of In this proposal, we plan to study the impact of e-learning on mental health literacy and stigma related to anxiety and depression.
- Trial name
- NCT06393322
- Testing
- Depression e-Learning A, Depression e-Learning B, Anxiety e-Learning A
- Where
- Canada
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- McMaster University
COVID-19, SARS-CoV2 Infection
Phase 1 Trial of ChAd68 and Ad5 Adenovirus COVID-19 Vaccines Delivered by Aerosol
This is a phase 1 study in healthy volunteers who have received at least three doses of an mRNA COVID-19 vaccine, to evaluate the safety and immune responses that develop in the blood and lungs following the administration by…
- Trial name
- NCT05094609
- Testing
- Ad5-triCoV/Mac, ChAd-triCoV/Mac
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
High Altitude Hypoxia, Exercise
Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral…
- Trial name
- NCT07063732
- Testing
- Ketone Monoester (KME)
- Where
- 2 sites in United States, Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mental Health Issue, Mental Stress
Evaluating Implementation and Impact of PeerOnCall, a Mobile Health Approach to Peer Support for Canadian Public Safety Personnel
A prospective cohort study design will be implemented across four sectors and multiple organizations sites to evaluate implementation and impact of the apps.
- Conditions
- Mental Health Issue, Mental Stress, Post Traumatic Stress Disorder
- Trial name
- NCT05429619
- Testing
- PeerOnCall
- Where
- 3 sites in Canada
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity, Risk Factors
Motivational Interviewing to Promote Healthy Behaviours in Young Adults
The overall goals of this project are to evaluate the feasibility of web-based nurse-led motivational interviewing and educational interventions to promote healthy behaviours for obesity prevention and maintenance of healthy…
- Trial name
- Motivate (NCT05264740)
- Testing
- Motivational interviewing, Educational materials
- Where
- Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Cough (CC)
Investigating the Role of ATP Production by Airway Epithelium in Patients With Refractory and Unexplained Chronic Cough (RCC/UCC).
Chronic cough is a common troublesome symptom which has a global prevalence of approximately 10%, but with wide variations across continents.
- Trial name
- APEC (NCT06600646)
- Testing
- Bronchoscopy
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Diabetes, Gestational
A Culturally-tailored Personalized Nutrition Intervention in South Asian Women at Risk of Gestational Diabetes
This trial will assess the impact of a culturally tailored, personalized nutrition intervention on glycemic response to an oral glucose load (as measured by the area-under-the curve glucose) in high-risk pregnancies of South…
- Trial name
- DESI-GDM (NCT03607799)
- Testing
- Dietary Intervention, Control
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cerebrovascular Function, Cerebral Blood Flow
Mechanistic Effect of Ketones on Cerebral Blood Flow
Oral supplements containing exogenous ketones have recently become available and represent a novel tool for increasing plasma ketone bodies without the need for dietary restriction.
- Trial name
- MEKC (NCT06217159)
- Testing
- Poikilocapnia, Normocapnia
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- McMaster University
Surgical Skill Training
Remote Video-Delivered Suturing Education with Smartphones
Medical students were randomized to receive live video- or recorded video-delivered feedback on suturing skills. A non-randomized control group received in-person feedback.
- Trial name
- REVISE (NCT06857266)
- Testing
- Live Video-delivered Feedback, In-Person Feedback, Recorded Video-delivered feedback
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McMaster University
Oncology
Remote Education Strategies Training Oncology Residents for End-of-Life Discussions
Difficult conversations are common in oncology practice and patient-centered communication is essential to care for individuals with cancer.
- Trial name
- RESTORED (NCT05810987)
- Testing
- RESTORE, Medical Interaction and Coaching
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- McMaster University
Menstrual Cycle, Resistance Exercise
Menstrual Cycle Phase and Oral Contraceptive Pill (OCP) Use on Muscle Protein Synthesis
Skeletal muscle size and function is regulated by various factors, including hormones. While we understand the role of male sex hormones (testosterone), we aren't sure how female sex hormones (estrogen and progesterone) influence…
- Conditions
- Menstrual Cycle, Resistance Exercise, Muscle Protein Synthesis, OCP
- Trial name
- NCT05347667
- Testing
- Unilateral Resistance Exercise Leg, Control Leg
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Child Behavior Problem, Parenting
Promoting Healthy Families: A Canadian Evaluation
Interventions that promote safe, stable, and nurturing relationships between caregivers and children are key to improving healthy family relationships, reducing child socioemotional and behaviour problems, and preventing child…
- Trial name
- PHF (NCT04702191)
- Testing
- Triple P, Circle of Security Parenting
- Where
- Canada
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- McMaster University
Diabetes Mellitus, Type 1
Healthy Outcomes for Muscle with Exercise in T1D
Over 300,000 people in Canada suffer from Type 1 Diabetes (T1D), a chronic condition whose incidence rate has been increasing in Canada every year by 5.1% (higher than the global average).
- Trial name
- HOME T1D (NCT05740514)
- Testing
- Exercise, De-training
- Where
- Canada
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- McMaster University
Opioid Use, Pain, Postoperative
Timing of TAP Blocks in Bariatric Surgery
This clinical trial aims to determine the optimal timing for administering a Transversus Abdominis Plane (TAP) block in bariatric surgery, specifically investigating whether initiating TAP blocks at the beginning of surgery is…
- Trial name
- NCT06270147
- Testing
- Bupivacaine-epinephrine
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
Inflammatory Bowel Diseases
AIRE-2 Device for Study of Breath Analysis in IBD
The goal of this Prospective single-blinded intervention feasibility study is the utilization of the AIRE-2 device and FoodMarble app to elucidate the interplay among diet, symptoms, and microbial fermentable features in IBD…
- Trial name
- AIRE-2 (NCT06541938)
- Testing
- low FODMAP diet, Lactose Sachet, Fructose Sachet
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Skeletal Muscle Protein Synthesis
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome
Generally, resistance exercise increases muscle mass and strength, and fatigue resistance. How resistance exercise achieves these adaptations remains understudied, but what is known is that skeletal muscle translates the physical…
- Trial name
- NCT04263714
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Influenza
Adjuvanted Inactivated Vaccine Versus Inactivated Influenza Vaccine in Hutterite Children
This study is a randomized controlled trial (RCT) comparing adjuvanted influenza vaccine (AV) to unadjuvanted inactivated influenza vaccine (IIV). Children in Hutterite colonies in Alberta and Saskatchewan will receive AV or IIV.
- Trial name
- NCT02871206
- Testing
- Fluad, Fluzone
- Where
- Canada
- Volunteers
- 3,425 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cholangiocarcinoma, Liver Fluke-Related Cholangiocarcinoma
Evaluating a Community-Based Behaviour Change Communication Model to Prevent Cholangiocarcinoma in Khon Kaen, Thailand
Liver cancer, specifically cholangiocarcinoma (CCA), is very common in different areas in Thailand. Many factors make this cancer more common, such as liver fluke infection, older age, eating raw fish, family history of cancer…
- Conditions
- Cholangiocarcinoma, Liver Fluke-Related Cholangiocarcinoma, Opisthorchiasis
- Trial name
- eCHEC (NCT05321992)
- Testing
- eCHEC program
- Where
- Thailand
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- McMaster University
Quality of Life
Effects of Genetic Variation on the Efficacy of Aerobic Exercise
This study investigates whether, after six weeks of exercise, a genetic variant (Val66Met) in the gene that makes a molecule (BDNF) important for brain health and function, influences the beneficial effects of a further session…
- Trial name
- NCT03670186
- Testing
- High-Intensity Interval Training (HIIT)
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McMaster University