Clinical trials: sponsored by Milton S. Hershey Medical Center
Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients
Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients
This is a pilot feasibility study examining the use of immersive virtual reality (VR) in adult intensive care unit (ICU) patients.
- Conditions
- Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety Acute
- Trial name
- NCT07649876
- Testing
- Virtual reality (VR) therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Dependence
Use of Nicotine Pouches Among Daily Smokers
The purpose of this clinical trial is to understand the health effects of a new oral nicotine pouch, and also to understand if this product can help reduce traditional cigarette smoking. The main aims are: 1.
- Trial name
- NCT06043362
- Testing
- 0 mg nicotine pouch, 3 mg nicotine pouch, 6 mg nicotine pouch
- Where
- 2 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Advance Care Planning, American Indian or Alaska Native
Using a Conversation Game to Engage Native American Washoe Tribe Members in Advance Care Planning: Preparation for a Clinical Trial
The goal of this study is to learn if a culturally adapted version of the Hello game, an advance care planning (ACP) conversation tool, is feasible and acceptable for use with members of the Washoe Tribe.
- Conditions
- Advance Care Planning, American Indian or Alaska Native, Gamification
- Trial name
- NCT07439393
- Testing
- Aim 1: Talking Circles, Aim 2: Play Modified Hello Game
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pediatric Obesity, Pediatric Overweight
BasketballRx: Game Changing Health
The goal of this study is to learn if BasketballRx, a basketball and health program, works well for children and teens who are overweight or have obesity.
- Conditions
- Pediatric Obesity, Pediatric Overweight, Anxiety, Depression Disorders
- Trial name
- NCT07778433
- Testing
- BasketballRx
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Postural Tachycardia Syndrome
fMRI in Postural Tachycardia Syndrome
Postural tachycardia syndrome (POTS) is one of the most common forms of chronic orthostatic intolerance in the United States. This is a disabling disorder characterized by an excessive increase in heart rate upon standing that is…
- Trial name
- POTS (NCT04137757)
- Testing
- Lower Body Negative Pressure
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Aging
Angiotensin-(1-7) Cardiovascular Effects in Aging
Aging is an independent risk factor for developing hypertension and cardiovascular disease; however, the mechanisms underlying age-related cardiovascular disease remain poorly understood.
- Trial name
- NCT05301192
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Concussion, Mild
Predicting Concussion Outcomes With Salivary miRNA
The purpose of this study is to identify changes in salivary ribosomal nucleic acid (RNA) expression that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.
- Trial name
- NCT02901821
- Testing
- salivary RNA collection
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Advance Care Planning, Advance Directives
Project Talk Trial: Engaging Underserved Communities in End-of-life Conversations
Compared to the general population, individuals from underserved communities are more likely to receive low quality end-of-life care and unwanted, costly and burdensome treatments due in part to a lack of advance care planning…
- Conditions
- Advance Care Planning, Advance Directives, Terminal Illness, Chronic Illness
- Trial name
- NCT04612738
- Testing
- Hello (serious game), The Conversation Project (CP) Starter Kit, Table Topics (general conversation game)
- Where
- 79 sites in United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Asthma
Severe Asthma Research Program
The mission of the SARP is to improve the understanding of severe asthma through integrated study of its clinical and biological features and to evaluate their changes over time.
- Trial name
- SARP (NCT01606826)
- Where
- 8 sites in United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Child Abuse
iLookOut for Child Abuse: Micro-learning to Improve Knowledge Retention
This proposed randomized controlled trial will examine whether gamified micro-learning is a feasible and effective way to promote long-term learning about child abuse and its reporting.
- Trial name
- NCT04324619
- Testing
- Online interactive learning activities
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Knowledge, Attitudes
iLookOut Micro-learning to Improve Knowledge Retention
This project investigates whether a multi-faceted strategy involving iLookOut's evidence-based Core Training plus an innovative follow-up Micro-Learning can promote knowledge retention and change behavior among early childhood…
- Conditions
- Knowledge, Attitudes, Practice
- Trial name
- NCT06273618
- Testing
- Micro-Learning
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Physical Inactivity, Walking
Daily Goal Setting to Increase Everyday Physical Activity and Promote Cognitive Health in Midlife
The purpose of this study is to determine whether interaction with an adaptive Fitbit-based goal setting application can increase levels of everyday light intensity physical activity in middle-aged adults.
- Conditions
- Physical Inactivity, Walking, Cognitive Health, Self-regulation
- Trial name
- NCT05826379
- Testing
- Adaptive Daily Goal Setting, Interim Goal Prompt
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Venous Distension Reflex, Blood Pressure
Autonomic Control of the Circulation and VDR
The study objective of this project is to examine the mechanisms of the venous distension reflex (VDR) in humans. We hypothesize that COX blockade with ketorolac tromethamine, an intravenous NSAID, will attenuate the muscle…
- Trial name
- VDR (NCT03513770)
- Testing
- Wrist-to-elbow (W-E) occlusion, ketorolac tromethamine, saline control
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Blood Pressure
The Venous Distension Reflex and Orthostatic Hypertension
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).
- Trial name
- OH (NCT03496792)
- Testing
- Tilt + external pressure, Tilt + no external pressure., Limb occlusion + negative pressure
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Digital Assessment of Speech and Fine Motor Control in ALS
This is a single-session, case-control study that incorporates digital tools for assessing speech and motor function in motor neuron disease.
- Conditions
- Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy
- Trial name
- NCT06315673
- Testing
- Digital Speech and Handwriting Assessment
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Amyotrophic Lateral Sclerosis
Remote Speech and Swallowing Assessment in ALS
The investigators propose a longitudinal home study of ALS patients to measure the severity of speech and swallowing (bulbar) impairment via a smartphone-based, remote speech and swallow assessment (rSSA).
- Trial name
- NCT04889898
- Testing
- Digital recording of speech and swallow sounds using the Beiwe Digital Health App on a personal smartphone, Modified Barium Swallow Study (MBSS), Speech Intelligibility Test (SIT)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Burn Out, Nurses
Mitigating Burnout in Nursing and Associated Healthcare Staff
Workplace stress for healthcare workers is at an all-time high and the COVID-19 Pandemic magnified and amplified the impact of stress and burnout on health care workers, especially for frontline staff such as nurses.
- Trial name
- NCT07018609
- Testing
- Zen Den Experience, Music Therapy Experience
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Musculoskeletal Injury, Anterior Cruciate Ligament Injuries
Micro-Doppler Radar: A Gold Standard Comparison
The purpose of this study is to see if the study team can use micro-Doppler signal (MDS) technology to determine if someone has had an anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT05521126
- Where
- 2 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Fractures, Bone, Serious Fall-related Injuries
Working to Increase Stability Through Exercise
The investigators propose a 36-month multi-center randomized effectiveness trial to compare the impact of an Enhanced Usual Care (Control) intervention, with Exercise Coaching (Exercise), on Serious Fall-Related Injuries (SFI) in…
- Trial name
- WISE (NCT02714257)
- Testing
- Enhanced Usual Care plus Exercise Coaching
- Where
- United States
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Cancer Education, Health Equity
BINGO: Bridging Knowledge, Increasing Awareness
The U.S. population is becoming more diverse, but minority groups are still significantly underrepresented in cancer clinical trials. This disparity limits our understanding of how treatments work across different populations.
- Trial name
- NCT06504407
- Testing
- Bingo Educational Game
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center