Clinical trials: sponsored by The Hospital for Sick Children
Maternal Nutrition, Child Nutrition
Climate-Responsive Nutrition, WASH, and Heat Counselling for Maternal and Child Health in Sindh, Pakistan
The goal of this trial is to evaluate whether a climate- and gender-responsive integrated package of nutrition, hygiene (WASH), and heat-adaptation counselling can improve maternal and child health and nutrition outcomes among…
- Trial name
- IGNIT3 (NCT07819994)
- Testing
- Training of Lady Health Workers (LHWs), Training of Healthcare Providers (HCPs) at Facilities
- Where
- Pakistan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Protein Absorption and Amino Acid Availability
MA of Tryptophan in Cornmeal in Healthy Adults>60y
The world's population will reach 12 billion by this century's end. As the human population increases, the world faces the continuous challenge of optimizing a limited food supply.
- Trial name
- NCT07272668
- Testing
- Tryptophan
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy
Tryptophan Metabolism in Healthy Young Adults
Tryptophan is an essential amino acid needed for growth and bodily functions. It is used to make serotonin which is needed for the brain to develop and function properly.
- Trial name
- NCT06551545
- Testing
- Tryptophan intake
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Intubation Performance Using AI Versus Conventional Videolaryngoscope in a Mannikin
AI-assisted Endotracheal Intubation
This study evaluates artificial intelligence (AI)-assisted videolaryngoscopy for endotracheal intubation in a simulated pediatric airway environment.
- Trial name
- NCT07508826
- Testing
- AI-assisted videolaryngoscopy, Conventional Intubation
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Malnutrition, Child, Nutrition Poor
Implementation of P-INPAC
The framework for Pediatric Integrated Nutrition Pathway for Acute Care (P-INPAC) was developed by the Canadian Malnutrition Task Force (CMTF); however, it has not been implemented in a research setting.
- Trial name
- P-INPAC (NCT06645639)
- Testing
- Pediatric Integrated Nutrition Pathway for Acute Care Pathway (P-INPAC)
- Where
- 3 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Hypertension, Pulmonary
Inflammatory Biomarkers of Pediatric Pulmonary Hypertension
To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared…
- Trial name
- NCT03581695
- Testing
- Blood test
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Genetic Disease, Inherited Disease
Adaptive Optics Retinal Imaging in Inherited and Acquired Retinal Disorders
This is a Prospective Observational study. The aim of the study is to understand the underlying photoreceptor, retinal pigment epithelium or retinal vascular aberrations in inherited and acquired retinal disorders.
- Trial name
- NCT05386134
- Testing
- Adaptive Optics Retinal Camera
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Anesthesia Ergonomics, Anesthesia Airway Management
Effect of Anesthesia Equipment Position on Anesthesiologists' Performance
The purpose of this study is to determine if the position of the anesthesia machine affects the ability of anesthesiologists to manage a crisis situation and perform critical tasks.
- Conditions
- Anesthesia Ergonomics, Anesthesia Airway Management, Simulation in Training Center
- Trial name
- NCT07518849
- Testing
- Simualted laryngospasm crisis
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis (CF)
MRI Assessment of Lung Airways in Cystic Fibrosis: Evaluate MRI's Ability to Detect Changes in Airway Structure .
This study is being done to determine whether MRI can produce high quality lung and airway images in healthy and CF patients and if MRI can be used to evaluate size and shape of the airways with computer assistance.
- Trial name
- UTE Airway MR (NCT07454681)
- Testing
- Advanced ultrashort echo time (UTE) MRI - Ultrashort echo time (UTE) imaging is a technique that can quickly capture the fast-decaying 1H lung signal., Multiple Breath Wash out (MBW)
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis, Asthma
Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease
Aim of this study is to evaluate image quality and reproducibility of Xenon-129 and Inert fluorinated (19F) gas Magnetic Resonance Imaging (MRI) and to evaluate changes in lung structure and function in participants with cystic…
- Trial name
- NCT02740868
- Testing
- Xenon-129 and Perfluoropropane (19F), Magnetic Resonance Imaging, Lung Clearance Index
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Group 1: Healthy Controls, Group 2: Stable CF
Assessment of CFTR-Modulator Treatment in Cystic Fibrosis Lung Disease Using Novel Structural and Functional MRI
This is a prospective, longitudinal observational study conducted at The Hospital for Sick Children (SickKids). The purpose of this study is to evaluate the ability of MRI to detect changes in lung structure and function in CF…
- Conditions
- Group 1: Healthy Controls, Group 2: Stable CF, Group 3: CF Participants Anticipated to Receive CFTR-modulator Therapy, Group 4: 4-8 yo CF Participants Starting Triple Combination Modulator Therapy
- Trial name
- NCT04391322
- Where
- Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Non-anemic Iron Deficiency
Iron Treatment for Young Children With Non-anemic Iron Deficiency
The pre-school years are critical years for children to acquire early learning skills such as language, fine motor and social skills; this is termed early child development.
- Trial name
- OptEC (NCT01481766)
- Testing
- Ferrous Sulfate, Dietary counseling
- Where
- 2 sites in Canada
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy Volunteers
Development of Hardware and Software for Pulmonary Magnetic Resonance Imaging Using Inhaled Tracer Gases
This is a single centre study. The overarching hypothesis of this study is that MRI with inhaled tracer gases can provide high quality images of lung function to complement conventional 1H MRI.
- Trial name
- NCT04726618
- Testing
- Hyperpolarized 129-xenon gas and Perfluoropropane gas
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy
Hyperpolarized Xenon-129 Lung and/or Brain Magnetic Resonance Imaging: Healthy Adult Volunteer Pilot Study
In this pilot study, MRI of the lungs and/or brain of healthy adult volunteers will be performed at 3Tesla to assess image quality using a prototype chest coil and pulse sequence following inhalation of hyperpolarized 129Xe…
- Trial name
- NCT02195206
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Lung Transplant Rejection
HP 129Xe MRI for Evaluation of CLAD in Lung Transplant Recipients
To evaluate the feasibility of hyperpolarized 129Xe MRI in lung transplant recipients and assess structural and functional pulmonary changes using hyperpolarized 129Xe MRI
- Trial name
- NCT05550662
- Testing
- 129Xenon
- Where
- 2 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Bronchopulmonary Dysplasia
MRI of Lung Structure and Function in Preterm Children
The MRI tools developed by the investigators are well positioned for assessing regional changes in lung structure and function in preterm children with bronchopulmonary dysplasia (BPD), in which airway limitation similar to…
- Trial name
- NCT03475264
- Testing
- Lung MRI
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Informed Consent Process
Comparing AI Role-Play and Peer Role-Play for Informed Consent Training in Endoscopy: A Randomized Control Trial
The goal of this randomized controlled trial is to find out whether AI-based role play is effective in teaching healthcare trainees how to obtain informed consent from patients for endoscopic procedures.
- Trial name
- NCT07069504
- Testing
- AI-based role play, Peer role play
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy
Metabolic Availability of Lysine From Barley in Young Adult Men
Protein is the key determinant of growth and bodily functions. The quality of food proteins depend on their amino acid content and the amount of amino acids used by the body to make proteins.
- Trial name
- NCT03907020
- Testing
- Barley
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy
Glutathione (GSH) Synthesis in Healthy School-aged Children and Healthy Young and Old Adults
To measure the fractional and absolute synthesis rates of GSH, an antioxidant that protects cells from damage, in the erythrocytes of healthy school-aged children, young adults and old adults in response to graded intakes of…
- Trial name
- NCT02971046
- Testing
- varying protein intakes
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy Aging
The Tryptophan Requirement in Healthy Adults
The aging population is growing rapidly. For the first time ever, Canadian seniors outnumbered young adults in 2016. Aging is associated with many physical and metabolic deteriorations including the loss of muscle mass and…
- Trial name
- NCT06283706
- Testing
- Tryptophan
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children