Clinical trials: sponsored by UMC Utrecht
Recurrent Miscarriages
Maternal Embryo Interaction in Recurrent Miscarriages
Background of the study: The etiology of recurrent miscarriage (RM, defined as three or more consecutive miscarriages without any proven maternal or fetal cause), remains undiagnosed in more than 50% of cases.
- Trial name
- MEER (NCT03156491)
- Where
- Netherlands
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
FSH Assay
Spiking-and-Recovery Experiment DOREMI Study
The purpose of this study is to test the validity of our in-house chemiluminescence assay for measurement of folliclestimulating hormone (FSH) serum levels before and during exogenous recombinant FSH (rFSH) administration.
- Trial name
- NCT02622347
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Breast Cancer Risk
The Effects of Equivalent Weight Loss With or Without Exercise Training on Breast Cancer Risk (SHAPE-2)
Physical inactivity and overweight are two accepted risk factors for breast cancer. However, because of their correlation it is not clear which is most relevant to risk.
- Trial name
- SHAPE-2 (NCT01511276)
- Testing
- Diet, Mainly exercise induced weight loss
- Where
- 2 sites in Netherlands
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Appetite Regulation
Brain Activity and Hormonal Changes During Food Administration
The amount and kind of food which is ingested influences the regulation of meal size. Neural signals from the gastrointestinal tract travel via the vagus nerve to the brainstem and thalamus, which projects to the rest of the…
- Trial name
- NCT01644539
- Testing
- Water with guar gum - Non Caloric, Chocolate milk - Oral Caloric, Chocolate milk - Intra Gastric Caloric
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Postpartum Hemorrhage
Active Management of the Third Stage of Labour: Uterine Tonus Assessment by Midwife vs. Patient Self-administration
To determine whether there is a difference in effectiveness of routine uterine tonus assessment (every 15 minutes, for 2 hours) when performed by a midwife or self-administered by a patient on the incidence of postpartum…
- Trial name
- UTAMP (NCT02223806)
- Testing
- Uterine Tonus Assessment by Midwife, Patient self-assessment of uterine tonus
- Where
- Ghana
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Hallucinations, No Hallucinations
Understanding Hallucinations (Part I)
Psychotic symptoms (hallucinations and delusions) are present in several psychiatric and neurological disorders as well as in the general population.
- Trial name
- UH-1 (NCT01907568)
- Where
- 4 sites in Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Atrial Fibrillation
Improving DEtection of Atrial fibriLlation in Primary Care With the MyDiagnostick
Atrial fibrillation (AF) is the most common arrhythmia and a common cause of stroke. AF can be asymptomatic and remain undiagnosed.
- Trial name
- IDEAL-MD (NCT02270151)
- Testing
- MyDiagnostick
- Where
- Netherlands
- Volunteers
- 16,000 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Atrial Fibrillation
Screening for Silent Atrial Fibrillation During Influenza Vaccination
Silent atrial fibrillation is an important cause of unnecessary strokes. If diagnosed and treated in time with anticoagulants, many disabling strokes can be prevented.
- Trial name
- NCT02006524
- Testing
- 'MyDiagnostick
- Where
- Netherlands
- Volunteers
- 3,269 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Atherosclerosis
Conjugated Linoleic Acid and Atherosclerosis
Rationale: Cis-9, trans-11 conjugated linoleic acid (CLA) can protect against the atherosclerosis development in several animal models.
- Trial name
- NCT00706745
- Testing
- oil rich in cis9, trans11 conjugated linoleic acid
- Where
- Netherlands
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Intrauterine Abnormalities in Infertility
SIGnificance of Routine Hysteroscopy Prior to a First 'in Vitro Fertilization'(IVF) Treatment Cycle
BACKGROUND: Despite the numerous advances in the field of in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI), there still exists a maximum implantation rate per embryo transferred of about 30%.
- Trial name
- inSIGHT (NCT01242852)
- Testing
- Office hysteroscopy (in combination with a 'Saline Infusion Sonography'(SIS))
- Where
- Netherlands
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Minor Intra-uterine Abnormalities
The Impact of Treating Minor Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy in Unselected In Vitro Fertilization (IVF) Cases
This is a comparative, controlled trial to evaluate the impact of treating undetected, asymptomatic, predefined minor uterine cavity abnormalities on the success of IVF treatment.
- Trial name
- NCT00830401
- Testing
- Treatment of predefined abnormality by hysteroscopic surgery, Ofloxacinum/Doxycycline
- Where
- Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Cardiovascular Health, Metabolic Health
Children Follow-up of PCOS Women
Polycystic ovary syndrome (PCOS) is a complex and frequent disorder with a heterogeneous clinical presentation varying throughout life, from birth up to post-menopause.
- Conditions
- Cardiovascular Health, Metabolic Health, Pulmonary Health
- Trial name
- CHOPS (NCT01767051)
- Where
- Netherlands
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Stage III Non-small Cell Lung Cancer
MRI Optimization Study in Stage III NSCLC
Radiation therapy uses radiation to treat lung tumors and metastases in the mediastinum. In order to irradiate as precise as possible, and in order to evaluate the effect of radiation treatment, it is important to depict the lung…
- Trial name
- NCT02076282
- Testing
- 1 MRI scan
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Infertility
Vitrification Versus Slow Cooling of Human Cleavage Stage Embryos
Human embryos can be preserved for later transfers by freezing. Traditionally the slow cooling method has been used. About 70% of the embryos remain fully intact after thawing.
- Trial name
- NCT00886431
- Testing
- embryo vitrification
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Upper Respiratory Tract Infections, URTI
Innate Immune Response to (An)Aerobic Exercise in Rowing Athletes
Exercise induces innate immune response activation in athletes. The response starts during exercise and lasts for approximately 24 hours.
- Trial name
- INCREASE (NCT01893762)
- Testing
- Aerobic exercise, Anaerobic exercise
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Type 1 Diabetes Mellitus
Ovarian Ageing in Type 1 Diabetes Mellitus
In healthy women, early menopause is an event that is associated with the exacerbation of several risk factors of cardiovascular and skeletal disease.
- Trial name
- OVADIA (NCT01665716)
- Where
- Netherlands
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Chronic Fatigue Syndrome
Efficacy of Web-based Cognitive Behavioural Treatment for Adolescents With Chronic Fatigue Syndrome
The aim of this study is to determine the efficacy of FITNET (web-based cognitive behavioural treatment) for adolescents with Chronic Fatigue Syndrome (CFS) in The Netherlands.
- Trial name
- FitNet (NCT00893438)
- Testing
- FitNet treatment, Usual care
- Where
- 2 sites in Netherlands
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Healthy
The Lifestyle moDIfCation Study
Rationale: Lifestyle modifications, such as increasing physical exercise and reducing dietary salt and saturated fat intake contribute to prevention of cardiovascular morbidity and mortality.
- Trial name
- LUDIC (NCT01574040)
- Testing
- Promotion of stair climbing, Promotion of a low-salt soup alternative for the 'soup of the day', Promotion of a low-fat alternative for the butter croissants
- Where
- Netherlands
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Streptococcus Pneumoniae Infection
Effect of Two Versus Three Pneumococcal Conjugate Vaccinations
Two( 2) or three (3) instead of four vaccinations before the age of 6 months with pneumococcal conjugate vaccine are presumed to protect children against invasive pneumococcal disease like meningitis, at least on the short term…
- Trial name
- MNOES (NCT00189020)
- Testing
- PCV7
- Volunteers
- 1,005 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Alveolar Hypoventilation Resulting in Hypoxemia
Capnography During Nurse Administered Propofol Sedation
Rationale: The current standard of respiratory monitoring for patients during deep sedation is continuous pulse oximetry with visual assessment of the patient.
- Trial name
- NCT01220765
- Testing
- Capnography
- Where
- Netherlands
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht