Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Sensitivity (Hyper); Gastrointestinal
The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Sensitivity in Healthy Volunteers
Introduction and aim Stress is well known to affect visceral sensitivity in Human. The investigators speculate that visceral hypersensitivity plays an important role in symptom perception in gastro-esophageal reflux disease…
- Trial name
- CRH (NCT02674256)
- Testing
- CRH
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
Effect of the Motilin Receptor Agonist, Erythromycin, on Hunger and Food Intake; Study of Role of Cholinergic Pathways
In this study, the investigators will evaluate if the food intake associated with the infusion of erythromycin is caused by the phase 3 contractions or by another yet unknown effect of erythromycin.
- Trial name
- NCT02633579
- Testing
- erythromycin lactobionate, Atropine, Erythromycin with atropine
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sedentary Lifestyle
Investigating the Effectiveness of Exercise Coaching on the Physical Activity Behavior of Physically Inactive Employees.
The primary aim of this study is to investigate if and how a physical activity counselor can offer an added value in exercise promotion in physically inactive employees.
- Trial name
- NCT01759927
- Testing
- physical activity coaching
- Where
- Belgium
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
House Dust Mite Allergy
Role of the Central Nervous System in Allergic Rhinitis
In order to evaluate the effects a nasal provocation on the activation of different brain regions, the investigators want to set up a clinical trial investigating the short-term effects of a nasal histamine provocation in healthy…
- Trial name
- NCT01777464
- Testing
- histamine
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Nasal Hyper Reactivity
Comparison of Cold Dry Air Exposure, Discs and Capsaicin
Nasal hyper reactivity is defined as an increased sensitivity of the nasal mucosa to stimuli such as temperature changes, changes in humidity, emotional stress, physical activity, smoke and/or other scents and gives often rise to…
- Trial name
- NCT02334605
- Testing
- cold dry air, hyperosmolar discs, capsaicin nasal spray
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pain
Disposition of Intravenous Paracetamol in Young Women
Compared to early postpartum (10-15 weeks) observations, paracetamol clearance was significantly higher (21.1 vs 11.7 l.h-1, + 80 %) at delivery.
- Trial name
- NCT02590900
- Testing
- intravenous paracetamol (acetaminophen)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Individuals, Patients With Arm Pump
Arm Pump in Motorcross Training
Arm Pump is a sport specific term drivers use to describe Acute or Chronic Compartment Syndrome of the forearm. Drivers experience pain in the forearms due to increased blood pressure in forearm muscle compartments.
- Trial name
- NCT02096796
- Where
- Belgium
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Huntington's Disease
Functional Imaging of Social Cognition in Premanifest Huntington's Disease
Huntington's disease (HD) is a genetic progressive fatal neurodegenerative disorder. In the western world it affects 5-10 persons per 100000. The main brain changes include the loss of brain cells in subcortical structures.
- Trial name
- FISCIP (NCT02551705)
- Testing
- functional Imaging
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cystinosis
The Functional Consequences of the CTNS-deletion for the TRPV1-receptor in Cystinosis Patients
Cystinosis is a rare autosomal recessive disorder, characterized by the abnormal accumulation of cystine in the lysosomes. Cystinosis is mostly caused by mutations in the cystinosin gene (CTNS).
- Trial name
- NCT02533076
- Testing
- Challenge agent: capsaicin, Mechanical stimulation with Von Frey filaments, Temperature sensitivity measurement with Advanced Thermal Stimulation
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Volunteers
Biomarker Development for Future PAC1 Antagonists With Maxadilan
This will be a single center, open-label study in healthy male subjects between 18 and 45 years old to determine the dose response profiles of dermal blood flow in response to intradermal injections of maxadilan.
- Trial name
- NCT02355756
- Testing
- Maxadilan
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Allergic Rhinitis
Evaluation of Nasal Mucosal Permeability in Controls and House Dust Mite Allergic Rhinitis Patients
Recently, a critical role in the development of allergic rhinitis (AR) has been attributed to the nasal epithelium. The airway epithelium forms a physical barrier, protecting the nasal mucosa and underlying organs from damage…
- Trial name
- NCT02461797
- Testing
- healthy controls, AR patients without medication, AR patients with use of nasal corticoid spray
- Where
- Belgium
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Open Angle Glaucoma, Normal Tension Glaucoma
Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins
Retinal ischemia is thought to play an important role in the pathogenesis of glaucoma. Recent findings have confirmed that there is a direct correlation between the levels of venous oxygen saturation and the degree of the…
- Trial name
- NCT01794442
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Happiness in the General Population
Improving Happiness in Flanders
This study aims to assess the effects of two different types of interventions aimed at increasing happiness in the Flemish general population as compared to individuals that receive no intervention.
- Trial name
- HAP-FLA (NCT02041741)
- Testing
- Weekly tips, Daily Tips
- Where
- Belgium
- Volunteers
- 10,863 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Open Angle Glaucoma, Normal Tension Glaucoma
Ocular Blood Flow in Glaucoma Patients - the Leuven Eye Study
Glaucoma is a leading cause of blindness worldwide, whose treatment - intraocular pressure lowering - is only partially effective in preventing disease progression.
- Trial name
- NCT01840202
- Where
- Belgium
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Denture Hygiene
Microbial Evaluation of Denture Cleaning and Overnight Storage
Clinical guidelines for denture care are available, but evidence for optimal nocturnal storage is missing. The investigators (Duyck J., Vandamme K., Teughels W.) therefore performed a study (submitted for publication) to evaluate…
- Trial name
- NCT02454413
- Testing
- denture brushing with water and soap, ultrasonic denture cleaning, cleansing tablet
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Rhinitis
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls
Capsaicin nasal spray is used in daily practice against IR without knowledge about the exact mechanisms involved in this treatment.
- Trial name
- NCT01862523
- Testing
- Capsaicin, diluent
- Where
- Belgium
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sedentary Lifestyle
A stAPP to a Healthier Lifestyle
The main objective of the project is to make participants aware of their sedentary behavior (prolonged sitting behavior) and then to encourage behavioral change through the use of an innovative and fun application on a smartphone.
- Trial name
- NCT01975870
- Testing
- Application on smartphone
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Elderly
Objective Assessment and Promotion of Physical Activity in Elderly
The purpose of the present study is to evaluate the short-term and long-term effects of a cycle ergometer program on physical activity and physical fitness in elderly (65+).
- Trial name
- NCT01748461
- Testing
- Structured intervention, Coach intervention
- Where
- Belgium
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Invasive Pulmonary Aspergillosis
Evaluation of Exhaled Breath Condensate in the Diagnosis of Invasive Pulmonary Aspergillosis
The purpose of this study is to evaluate the diagnostic potential of biomarkers for invasive pulmonary aspergillosis in exhaled breath condensate.
- Trial name
- NCT01247142
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Iatrogenic Disease
Rationalisation of Polypharmacy by the Geriatric Consultation Team
Polypharmacy is a common problem in elderly, leading among others to increased adverse drug events. The aim of this pilot study was to evaluate whether a systematic medication evaluation by a geriatric consultation team using the…
- Trial name
- RASP-GCT (NCT02165618)
- Testing
- Medication review, based on but not limited to the RASP list
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven