Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Healthy
Rationalisation of Polypharmacy in the Elderly by the RASP Instrument
The aim of this study is to determine whether a clinical pharmacist using the RASP list (RASP = Rationalisation of home medication by an adjusted STOPP-list in older patients; STOPP = Screening Tool of Older Persons' potentially…
- Trial name
- RASP (NCT01513265)
- Testing
- Pharmaceutical care plan, mostly based on the RASP
- Where
- Belgium
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Adults
Does Transcutaneous Vagal Nerve Stimulation Improves Fear Extinction in Humans
A recent study with rats showed that electrical stimulation of the vagus nerve (VNS) facilitates extinction of fear (Pena, Engineer, \& McIntyre, Biological Psychiatry, 2013).
- Trial name
- t-VNSext (NCT02113306)
- Testing
- t-VNS
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoporosis, Sarcopenia
The Effect of 6 Months of Local Vibration Training in Institutionalized Elderly
This randomized controlled intervention study in institutionalized elderly investigates the effect of 6 months of local vibration therapy applied on the thigh and hip on muscle strength, muscle mass, bone density, and…
- Trial name
- NCT01499186
- Testing
- Local Vibration
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Open Angle Glaucoma, Normal Tension Glaucoma
Study on Ocular Blood Flow and the Orbital Cerebrospinal Fluid Pressure in Glaucoma
Ocular blood flow has been consistently demonstrated to be altered in glaucoma patients when compared to otherwise healthy individuals.
- Trial name
- NCT01802463
- Where
- Belgium
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alzheimer's Disease
The Detection of Early Dementia With the Digital Game Memory
The investigators are going to test if it is possible to detect early dementia with the digital game "memory". The investigators are going to test 15 healthy people and 15 patients with early dementia.
- Trial name
- NCT02041728
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alzheimer Disease, Late Onset
New Proteins in Body Fluids as Potential Biomarker for Alzheimer's Disease: a Pilot Study
Alzheimer's disease (AD) is the most common neurodegenerative disorder afflicting the elderly. Currently, some biochemical tests performed on Cerebrospinal Fluid (CSF) samples have demonstrated to discriminate to some extend…
- Trial name
- NCT01773915
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Allergic Rhinitis
Evaluating Symptom Control in in Allergic Rhinitis at Three Years After Starting Immunotherapy
Allergic rhinitis (AR) is defined as inflammation of the nasal mucosa after exposition to an allergen in sensitized patients. AR causes not only nasal symptoms such as sneezing, itchy nose, rhinorrhea and nasal obstruction, but…
- Trial name
- NCT01777438
- Where
- 2 sites in Belgium
- Volunteers
- 434 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sedentary Lifestyle
A Structural Approach to Implement the Role of 'Physical Activity Counselors' in Sports and Exercise Promotion
The primary aim of this study is to investigate how a physical activity counselor can offer an added value in the sports and exercise promotion in Flanders.
- Trial name
- NCT01516099
- Testing
- General Practitioners, Social-cultural organizations
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Effects of Strength Training in Older Adults
The Effects of Low- and High-intensity Resistance Exercise on Force-velocity Characteristics in Older Adults
The purpose of this study is to compare the impact of high- and low-intensity resistance exercise on force-velocity characteristics, muscle mass and inflammatory processes in older adults.
- Trial name
- NCT01707017
- Testing
- Strength training
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Non-cystic Fibrosis Bronchiectasis, Healthy
The Sputum Colour Chart as a Predictor of Lung Inflammation and Proteolysis in Non-cystic Fibrosis Bronchiectasis
Non-cystic fibrosis bronchiectasis patients (and controls) were recruited for the study. The investigators' aim was to study the relevance of clinical parameters in terms of underlying disease severity, proteolysis and…
- Trial name
- NCT01792440
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Primary Open Angle Glaucoma, Normal Tension Glaucoma
Correlation of Orbital Cerebrospinal Fluid Pressure and Retinal Venous Outflow in Primary Open-angle Glaucoma
A spontaneous venous pulsation over the optic disc is an ophthalmological sign that can potentially be found in up to 98% of healthy individuals.
- Trial name
- NCT01795014
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Open-angle Glaucoma, Low Tension Glaucoma
Waveform Analysis of the Doppler Curve of Ophthalmic Arteries in Glaucoma Patients
Color Doppler Imaging (CDI) has been providing information about ocular blood flow over the past decades. This non-invasive procedure based on ultrasound technique has identified increased resistance and decreased systolic blood…
- Trial name
- NCT01487655
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Open Angle Glaucoma, Low Tension Glaucoma
Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation
Retinal ischemia is thought to play an important role in the pathogenesis of glaucoma. Up until today, very little is known about the metabolic alterations in the retina of glaucoma patients, since only techniques for surrogate…
- Trial name
- NCT01391247
- Where
- Belgium
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Halitosis
Effect of Mouth Rinses in Oral Malodor
Bad breath or halitosis is caused by specific gases originating from the mouth or the expired air. In most cases the pathology lies within the mouth and in this case receives the name pathologic halitosis of oral cause or oral…
- Trial name
- MR2012 (NCT01747226)
- Testing
- Fluoride rinse, Halita, Meridol Halitosis
- Where
- Belgium
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glaucoma
ICare Self-tonometry - A Head-to-head Comparison to the Gold Standard Goldmann Tonometer
The purpose of this study is to compare glaucoma patients' own I Care measurements by the standard Goldmann applanation tonometer intraocular pressure (IOP) measurements.
- Trial name
- NCT01733550
- Testing
- Home iCare (study nurse), goldmann applanation tonometry, home iCare (by patient)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ageing Process, Muscle Quality
The Influence of Ageing on Muscle Quality
The purpose of the present study is to evaluate the influence of the ageing process on muscle quality. Therefore, muscle mass, muscle density and force-velocity characteristics are measured after a 5-yr interval in older adults…
- Trial name
- NCT01216917
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Halitosis
New "in Vitro" Diagnostic Test for Oral Malodour
This study will assess the ability of a first prototype (strip) of a new chair side test to detect oral malodour. The strip is based on a new enzymatic reaction able to detect amines in saliva.
- Trial name
- Striptest (NCT01226251)
- Testing
- In vitro chair side test
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Training, Ageing
The Long-term Effects of Training on Muscle Strength and Functionality
The purpose of the present study is to evaluate the long-term effects of 1 year of high-intensity fitness training and low-intensity whole-body vibration training on muscle strength and functionality.
- Conditions
- Training, Ageing, Muscle Strength, Functionality
- Trial name
- NCT01682330
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Volunteers
In Vivo Inhibition Profile of CYP2C9 by Pineapple Juice
The goal of this study is to evaluate the actual potential for in vivo pineapple juice inhibition with CYP2C9 substrates in human volunteers with use of diclofenac as a marker of CYP2C9 activity.
- Trial name
- NCT01649492
- Testing
- pineapple juice (Carrefour n°1) 500 ml/day 5 days
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Functionality, Strength
Objective Assessment of Physical Activity in Older Adults
The purpose of the present study is to evaluate the validity of 2 objective measures of physical activity among older adults. In addition, the investigators will examine the influence of functionality, walking aids, walking speed…
- Conditions
- Functionality, Strength, Validity During Daily Activities, Physical Activity
- Trial name
- NCT01621035
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven