Clinical trials: sponsored by University College, London
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London
Adolescent Idiopathic Scoliosis (AIS)
Detection of Scoliosis
This study aims to evaluate whether plantar pressure data collected during standing and walking can be used with machine learning to support early detection of scoliosis in young people.
- Trial name
- NCT07581015
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College, London
Menopause
Group Compassionate Mind Training for Adults Experiencing the Menopause Transition
Menopause transition occurs naturally for women aged 45-55. In addition to the hormone changes, there are often changes in other areas of life including low mood, anxiety, 'brain fog' and embarrassment.
- Trial name
- NCT06462157
- Testing
- Compassionate Mind Training
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University College, London
Huntington's Disease
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable…
- Trial name
- HDClarity (NCT02855476)
- Where
- 40 sites in United States, Canada and 8 more
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University College, London
HIV Prevention, Contraceptive Usage
Peer-led Service Delivery Model for Pregnant and Lactating Adolescent Girls and Young Women in Zimbabwe
This is a pilot cluster-randomized control trial co-led by Dr. Valentina Cambiano, Associate Professor of Epidemiology at University College London, UK and Professor Euphemia Sibanda, Research Director at the Centre for Sexual…
- Conditions
- HIV Prevention, Contraceptive Usage, Adherence, Medication
- Trial name
- Ontanga (NCT07546344)
- Testing
- Peers who are stars
- Where
- 3 sites in Zimbabwe
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University College, London
Aphasia Following Cerebral Infarction
Intensive Comprehensive Aphasia Programme for People With Post-Stroke Aphasia
Research question Does participation in an Intensive Comprehensive Aphasia Programme produce a meaningful change in the communication of people with aphasia, their quality of life and that of their carers? Background Aphasia is a…
- Trial name
- RCT of an ICAP (NCT07386652)
- Testing
- ICAP, Standard Care (in control arm)
- Where
- United Kingdom
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University College, London
Menopause
A Cognitive Intervention to Manage 'Brain Fog' in Menopause Transition: Feasibility Study
Cognitive complaints at menopause transition (MT), often described as 'brain fog'; can include difficulty recalling words and numbers, misplacing items, trouble concentrating and forgetfulness.
- Trial name
- NCT06940466
- Testing
- Online cognitive intervention
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University College, London
Neonatal Jaundice
NeoSCB App for Screening Jaundice in Newborns
About 60% of babies born after 36 weeks of pregnancy have jaundice during the first two weeks of life. Due to the accumulation of bilirubin in the bloodstream, jaundiced babies appear yellow, which allows healthcare professionals…
- Trial name
- neoSCB (NCT06963450)
- Testing
- Taking photos of a baby's eye
- Where
- United Kingdom
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University College, London
Healthy
Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs
This randomised controlled feasibility trial evaluates the Digital Intervention for Psychedelic Preparation (DIPP), a novel 21-day self-guided program designed to prepare individuals for psychedelic experiences.
- Trial name
- (DIPP-RCFT) (NCT06815653)
- Testing
- Psilocybin 25mg
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University College, London
Depression
Mechanisms Underlying Antidepressant Effects of Physical Activity
It is well established that any level of physical activity can help prevent and treat depression, with more strenuous activity having a greater effect.
- Trial name
- LIFE (NCT06387732)
- Testing
- Aerobic exercise, Stretching and relaxation
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University College, London
Myotonic Dystrophy 1, Dysphagia, Oropharyngeal
Profile of Dysphagia in Myotonic Dystrophy Type 1 (DM1)
The goal of this observational study is to learn about swallowing difficulties (dysphagia) in patients living with myotonic dystrophy type 1 (DM1).
- Trial name
- SwallowDM1 (NCT05865483)
- Where
- United Kingdom
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- University College, London
Dementia
BELIDE: Better Living With Non-memory-led Dementia
Around 48 million people worldwide 1 live with dementia, of whom 3.9 million start with symptoms before the age of 65 (young-onset dementia).
- Trial name
- BELIDE (NCT06241287)
- Testing
- Better Living with Non-memory led Dementia programme, Waiting list
- Where
- United Kingdom
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- University College, London
Bronchial Asthma, Bronchiectasis
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
Research is being conducted into chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, and bronchiectasis.
- Conditions
- Bronchial Asthma, Bronchiectasis, ILD, COPD
- Trial name
- NCT07060079
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Unicompartmental Knee Replacement, Osteo Arthritis Knee
RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
The overall aim of this prospective, randomised, single-blinded, controlled trial is to compare clinical outcomes and accuracy of implant positioning in Mako robotic UKA versus jig-based Oxford UKA with navigation control.
- Conditions
- Unicompartmental Knee Replacement, Osteo Arthritis Knee, Surgery
- Trial name
- NCT04095637
- Testing
- Medial knee arthroplasty
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University College, London
Obesity, Cardiometabolic Syndrome
A Study Comparing the Health Effects of Two Diets Following UK Dietary Guidance in People Living With Overweight or Obesity
There are two parts to this study: 1. The investigators will study if the benefit from eating a healthy, balanced diet depends on the types of food processing in the diet.
- Conditions
- Obesity, Cardiometabolic Syndrome, Overweight
- Trial name
- UPDATE (NCT05627570)
- Testing
- Healthy, balanced Diet A, Healthy, balanced Diet B, Behavioural support intervention
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University College, London
Siderosis, Neurological Disorder
Audiovestibular Function in Infratentorial Superficial Siderosis
One in six people in the United Kingdom and over 400 million people worldwide have disabling hearing loss. This figure will double by 2050 as predicted by the World Health Organisation.
- Conditions
- Siderosis, Neurological Disorder, Rare Diseases, Age Related Hearing Loss
- Trial name
- AViSS (NCT04200664)
- Testing
- Hearing assessment, Vestibular/balance assessment, Quality of life assessment
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University College, London
Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis
STI Prophylaxis and Emergence of Antimicrobial Resistance
The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted…
- Conditions
- Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis, Antibiotic Resistance, Bacterial, Microbiome
- Trial name
- SPEAR (NCT06778083)
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University College, London
Small Bowel Disease, Gastrointestinal Diseases
Anonymous Data Sharing for Small Bowel
Crohn's disease is characterised by an abnormal immunological response within the bowel wall leading to abnormal wall thickening, stricturing (narrowing), fistulation (abnormal connections) to adjacent organs and strictures…
- Trial name
- NCT06868875
- Where
- United Kingdom
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University College, London
People with Terminal Illness
Mapping Financial Support for the Terminally Ill
People living with terminal illness (an illness that is not curable and likely to lead to death) are often unable to work and experience increased costs associated with their health, such as caring costs, needing to purchase aids…
- Trial name
- NCT06793631
- Testing
- Participants will be interviewed qualitatively about experience of providing/receiving financial support for living costs
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University College, London
Depression - Major Depressive Disorder, Depression Anxiety Disorder
Evaluating the Effectiveness and Acceptability of a GPT-4o and RAG-Based Voice Chatbot for Depression Screening Using PHQ-9
This study aims to assess the feasibility and acceptability of a voice-based chatbot, powered by GPT-4o and Retrieval-Augmented Generation (RAG), for conducting depression screening using the Patient Health Questionnaire-9…
- Trial name
- GPT4-RAG-PHQ (NCT06801925)
- Testing
- GPT-4o and RAG Voice Chatbot for PHQ-9 Screening
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College, London