Clinical trials: sponsored by University Health Network, Toronto
Obesity, Morbid, Eating Disorder Symptom
Mindfulness Based Eating Awareness Training for Bariatric Surgery Patients
The purpose of this study is to evaluate the effects of Mindfulness Based Eating Awareness Training (MB-EAT) for patients who have had bariatric surgery on their weight and mental and physical health compared to patients who do…
- Trial name
- MB-EAT (NCT03488966)
- Testing
- Mindfulness Based Eating and Awareness Training
- Where
- Canada
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cancer, Breast Cancer
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for future research studies at the…
- Conditions
- Cancer, Breast Cancer, Lung Cancer, Colon Cancer
- Trial name
- LIBERATE (NCT03702309)
- Where
- Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Gynecologic Cancer
Impact of Cultural and Linguistic Backgrounds on Patient Care and Experience of Women With Gynecologic Malignancies
Purpose of this study to delineate the attitudes and experiences of patients, interpreters and cancer care professionals involved in the care of oncology patients with gynecologic malignancies with cultural and linguistic…
- Trial name
- iCALD-2 (NCT05971303)
- Testing
- Questionnaire
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Parkinson's Disease (PD), Essential Tremor
LIFUS For Neurological Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation.
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
- Trial name
- NCT07417280
- Testing
- LIFUS
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Pain Management
Erector Spinae Plane (ESP) Block Volunteer Study
Although erector spinae plane (ESP) block reportedly provides postoperative pain relieve, controversy remains regarding the accuracy and consistency of analgesic success following ESP block.
- Trial name
- NCT04401007
- Testing
- Erector Spinae Plane Block with 1.5% lidocaine
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Point-of-care Ultrasound
AI for Gastric POCUS ( Point-of-care Ultrasound)
The goal of this observational study is to train and test an AI (Artificial Intelligence)-based program to assist anesthesiologists in the interpretation of stomach ultrasound images and differentiate a "full" from an "empty"…
- Trial name
- POCUS (NCT07580456)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Caregiver Distress
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Caregivers of Patients With Advanced Cancer
The PEARL-C1 trial is a phase II open-label trial. Participants will receive a single high-dose (25 mg) of psilocybin in the context of Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) therapy.
- Trial name
- PEARL-C1 (NCT07048743)
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Diaphragm
Defining the Normal Range for Maximal Sniff Diaphragm Thickening Fraction
This study is investigating the normal range of maximal diaphragm thickness during a sniff inspiratory manoeuvre using ultrasound in healthy subjects stratified by age and gender.
- Trial name
- SNIFF II (NCT03129386)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Dysphagia, Oropharyngeal
Reference Values for Videofluoroscopic Measures of Swallowing
Dysphagia (swallowing impairment) is a serious health condition seen in many age-related disease and injury processes. Although videofluoroscopy (VF) is an international "gold standard" dysphagia diagnostic exam, there is a…
- Trial name
- NIA_RV (NCT05497219)
- Testing
- Videofluoroscopic Swallowing Study (VF)
- Where
- 5 sites in United States, Canada
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Atypical Femur Fracture
Personalizing Osteoporosis Care: Clinical & Genetic Risk Factors for AFFs
The overall objective of this project is to identify clinical and genetic risk factors for Atypical Femur Fractures (AFFs) in Anti-resorptive therapy (ART) users by conducting a case control study of 330 cases of AFFs and 660…
- Trial name
- NCT04110795
- Testing
- No Intervention
- Where
- 3 sites in Canada
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Dysphagia, Stroke
Development and Validation of an Online Independent Training Program for TOR-BSST© Dysphagia Screeners
Stroke is a leading cause of death and disability globally. Dysphagia, swallowing difficulty, is common following stroke, affecting about 55% of all stroke patients.
- Trial name
- NCT05379699
- Testing
- TOR-BSST© eLearning Training, Standard TOR-BSST© Training
- Where
- Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Myocardial Injury, Myocarditis
Myocardial Injury and Outcomes Following COVID-19 Vaccination (MYOVAX Study)
The study will focus on cardiac blood and imaging biomarkers to facilitate early recognition of patients at risk for myocardial injury after COVID-19 vaccination.
- Conditions
- Myocardial Injury, Myocarditis, COVID-19 Vaccination, SARS-CoV-2
- Trial name
- MYOVAX (NCT04967807)
- Testing
- Cardiac PET/MRI, Blood Biomarkers
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Head and Neck Squamous Cell Carcinoma
HN-QUEST: A Study of Head and Neck Imaging Biomarkers
This is a multi arm, single center, investigator initiated study to investigate online adaptive radiotherapy and biomarker development in patients with newly diagnosed HNSCC (Head and Neck Squamous Cell Carcinoma) receiving…
- Trial name
- HN-Quest (NCT05919290)
- Testing
- MRI
- Where
- Canada
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cancer
Magnetic Resonance-Guided Adaptive Radiotherapy (MRgART) Using an Integrated Magnetic Resonance Linear Accelerator (MRL)
This study is being done to help further understand how MR-guided adaptive RT in conjunction with the Integrated Magnetic Resonance Linear Accelerator (MRL) can improve patient outcomes.
- Trial name
- MRL1 (NCT04135794)
- Where
- Canada
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Nasopharyngeal Carcinoma
Nasopharyngeal Carcinoma Post IMRT
Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer. The last three decades of research in head and neck radiation oncology have largely focused on improvements in survival, which have mostly come at the cost of long…
- Trial name
- NCT02597426
- Where
- Canada
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Stress
COVID-19 Burnout Study
The aims of this study are to assess whether the use of a MBI therapy delivered remotely is associated with a reduction of perceived stress among HCPs in the Radiation Medicine Program (RMP) and with a decrease risk of burnout…
- Trial name
- NCT04594278
- Testing
- Mindfulness Based Intervention
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Carcinoma of Prostate
PSMA PET Registry (18F-DCFPyL)
The purpose of the Princess Margaret Cancer Centre PSMA registry is to assess the contribution of 18F-DCFPyL (PSMA) PET imaging (PET/MR or PET/CT) to the management of patients with prostate cancer (PCa).
- Trial name
- PM-PPR (NCT03535831)
- Testing
- 18F-DCFPyL
- Where
- Canada
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Trauma and Stressor Related Disorders, Pediatric Cancer
Emotion and Symptom-Focused Engagement (EASE) for Caregivers
The goal of this Phase III randomized controlled trial is to evaluate the effectiveness of a novel psychotherapeutic intervention called Emotion and Symptom-focused Engagement (EASE) in parents caring for a child or adolescent…
- Conditions
- Trauma and Stressor Related Disorders, Pediatric Cancer, Caregiver Burden
- Trial name
- EASE (NCT06367556)
- Testing
- Emotion and Symptom-Focused Engagement (EASE)
- Where
- 2 sites in Canada
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Gynecologic Cancer
Evaluation of a Brachytherapy Discharge Education Program to Improve Patient Care
Although brachytherapy is an effective treatment modality for gynecological cancer, a significant proportion of patients develop late treatment-related vaginal toxicity, negatively impacting their quality of life and limiting…
- Trial name
- BrachDEP (NCT04707937)
- Testing
- Online education, Regular standard of care education
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
Early Palliative Care for Patients With Multiple Myeloma and Aggressive Lymphoma
Patients with multiple myeloma experience a wide range of physical and psychological symptoms from the time of their diagnosis. Meanwhile, patients with aggressive lymphomas undergo unpredictable illness courses, resulting in…
- Conditions
- Multiple Myeloma in Relapse, Multiple Myeloma, Refractory, Multiple Myeloma Stage III, Multiple Myeloma Progression
- Trial name
- EPC-MM+L (NCT06485076)
- Testing
- Early Palliative Care
- Where
- Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto