Clinical trials: sponsored by University Hospital Heidelberg
Hospital Emergency and Operations Planning, Pediatric Hospital
State of In-hospital Disaster Protection at Children's Hospitals in Germany
Catastrophic situations demand a heigh preparedness from hospitals. In Germany, all hospitals are required to maintain an emergency and response plan for such situations. However, these plans are often insufficient.
- Trial name
- NCT07766941
- Where
- Germany
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Periodontitis, Adult, Periodontitis (Stage 3)
Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy
Periodontitis is a prevalent chronic inflammatory disease driven by a dysbiotic oral biofilm and a dysregulated host immune response.
- Conditions
- Periodontitis, Adult, Periodontitis (Stage 3), Periodontitis Stage IV
- Trial name
- PROPARO (NCT07443410)
- Testing
- Non-surgical periodontal therapy (NSPT) and supportive periodontal therapy (SPT), Probiotic lozenge (Limosilactobacillus reuteri; GUM® PerioBalance®), Vitamin B12 drops (natural elements)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Cognitive Change, Well-Being, Psychological
Impact of GPT Use on Essay Writing Performance and Cognitive Abilities
The goal of this randomized controlled lab experiment is to examine if using generated artificial intelligence (AI) technology will affect people's academic performance and cognitive abilities in the context of analytical writing…
- Trial name
- NCT06511102
- Testing
- GPT Support
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Cancer, Exercise
Multi-professional Care Pathway and Network for the Promotion of Needs-oriented, Resident-oriented Exercise Therapy for Oncological Patients
MOVE-ONKO is developing and implementing a guideline-based, multi-professional care pathway for the promotion and therapy of exercise for cancer patients.
- Conditions
- Cancer, Exercise, Implementation
- Trial name
- MOVE-ONKO (NCT06185777)
- Testing
- Exercise oncology counseling and referal
- Where
- 7 sites in Germany
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Non-small Cell Lung Cancer
Tumor-specific T Cells in Lung Cancer
Non-small cell lung cancer is characterized by aggressive growth and treatment resistance. New approaches include immunotherapeutic strategies but spontaneous immune responses against tumor antigens remain unclear.
- Trial name
- NCT02515760
- Testing
- Bone marrow aspiration from the iliac crest, Illinois bone marrow aspiration neddle
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Diabetes Mellitus, Hypertension
Strengthening Primary Healthcare Delivery for Diabetes and Hypertension in Eswatini
The WHO-PEN@Scale project is a three-arm cluster-randomized trial that is investigating the population-level effects of a healthcare reform in Eswatini, which aims to strengthen primary care for diabetes and hypertension.
- Trial name
- NCT04183413
- Testing
- DSD, CDP
- Where
- Eswatini
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Tooth Loss
Removable Partial Dentures Made of PEEK
As part of the clinical study, 25 patients each were provided with removable partial dentures with clasps made of PEEK in two centres (University Hospital Heidelberg, Department of Prosthodontics and University Hospital for…
- Trial name
- KLAP (NCT06191107)
- Testing
- Removable Partial Denture
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Head and Neck Cancer
Multiparametric Photoacoustic Imaging in the Course of Radiation Therapy of Malignant Head and Neck Tumors
Multispectral photoacoustic imaging enables the measurement of the optical absorption of various tissue components or exogenous contrast agents in vivo.
- Trial name
- NCT04437030
- Testing
- MSOT Acuity Echo device
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Unsatisfactory or Defective Restoration of Tooth
Minimal Invasive Rehabilitation of Tooth Loss in the Posterior Segment (MIZE-S)
Tooth loss can be addressed by different rehabilitative strategies. Implant-supported crowns and conventional bridges (fixed dental prostheses [FDPs]) are well established treatment alternatives.
- Trial name
- MIZE-S (NCT01997710)
- Testing
- all-ceramic inlay-retained RBFDP, all-ceramic RBFDP
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Osteosarcoma
Therapy Trial to Determine the Safety and Efficacy of Heavy Ion Radiotherapy in Patients With Osteosarcoma
The primary objectives of this trial are the determination of feasibility and toxicity of Heavy Ion Radiotherapy (C12) in patients with non-resectable osteosarcoma.
- Trial name
- NCT01005043
- Testing
- heavy ion radiotherapy (C12)
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Doctor-Patient-Communication
RCT Regarding SDM Online Training and Face-to-face SDM Training
Cancer patients often report that they are not included in important treatment decisions. Numerous studies have shown that a training concerning Shared Decision Making (SDM) for physicians can improve this situation.
- Trial name
- NCT02674360
- Testing
- SDM Training
- Where
- 2 sites in Germany
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Donor Nephrectomy
Hand-assisted Laparoscopic Donor Nephrectomy Periumbilical Versus Pfannenstiel Incision
Despite efforts to optimize the transplantation of deceased donor kidneys, the number of available kidneys continues to fall short of the demand. Living donor kidneys have been used to overcome this shortage.
- Trial name
- HAPERPACT (NCT03317184)
- Testing
- Periumbilical incision, Pfannenstiel incision
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Alteration of Mitochondrial Membrane, Type2 Diabetes
Mitochondrial Effects of C18:0 Supplementation in Humans
The purpose of this crossover study is to determine whether nutritional supplementation of C18:0 in humans has mitochondrial effects as shown in Drosophila and human cell culture.
- Conditions
- Alteration of Mitochondrial Membrane, Type2 Diabetes, Fatty Acid Deficiency
- Trial name
- NCT02957838
- Testing
- C18:0, mock
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Healthy
Oxytocin and Resting State fMRI
The goal of the study is to investigate the effects of intranasal oxytocin (OT) or placebo to resting state brain activity in healthy males.
- Trial name
- NCT02689596
- Testing
- Oxytocin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Unsatisfactory or Defective Restoration of Tooth
Minimal Invasive Rehabilitation of Tooth Loss in the Anterior Segment
Tooth loss can be addressed by different rehabilitative strategies. Implant-supported crowns and conventional bridges (fixed dental prostheses [FDPs]) are well established treatment alternatives.
- Trial name
- MIZE-F (NCT01997827)
- Testing
- metal-ceramic RBFDP, all-ceramic RBFDP
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Coronary Artery Disease
HsTnT in Stable Coronary Artery Disease
Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality worldwide. Life threatening manifestations such as acute myocardial infarction (AMI) and sudden cardiac death are the most important causes of…
- Trial name
- NCT01954303
- Testing
- Progress of CHD
- Volunteers
- 965 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Chronic Ankle Instability
Neuromuscular Control of the Ankle With External Support
Untreated ankle sprains often remain symptomatic and may end in chronic instability. The aim of our study is to quantify the stabilizing effect of different devices.
- Trial name
- NCT01781351
- Testing
- Taping the ankle
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Pediatric Overweight
Overweight Children - Musculoskeletal Consequences
The purpose was to investigate the consequences of pediatric overweight on the musculoskeletal system, postural control and proprioception, and to analyze prospectively the influence of ball games and nutrition counseling.
- Trial name
- NCT01825174
- Testing
- Ball games program, Nutrition counseling
- Where
- Germany
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Chronic Ankle Instability
External Ankle Supports - 3D Motion Analysis
Untreated ankle sprains often remain symptomatic and may end in chronic instability. The aim of our study is to quantify the stabilizing effect of different devices.
- Trial name
- NCT01810471
- Testing
- Applying ankle support device (white non-elastic tape, kinesiotape (TM), soft brace (Malleotrain TM)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Hallux Rigidus
Motion Analysis in Patients With Hallux Rigidus
The aim was to investigate with a multi-segmental foot model the kinetic and kinematic in patients with a hallux rigidus, before and after different type of surgery.
- Trial name
- NCT01804491
- Testing
- Motion Analysis
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg