Clinical trials: sponsored by University of Chicago
Pediatric Surgery, Informed Consent
Risk Sharing vs Risk Dumping: Parental Attitudes About Risks
This study will evaluate how parents or legal guardians perceive responsibility for surgical risk after the informed consent discussion for their child's operation, focusing on whether the process feels like "risk sharing" with…
- Conditions
- Pediatric Surgery, Informed Consent, Shared Decision-making, Parental Decision Making for Seriously Ill Children
- Trial name
- NCT07875712
- Testing
- Research data collection only
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Alzheimer s Disease, Dementia
CommunityRx-Dementia + Peer Navigation (CRxDpeer)
The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a "peer mentor", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and…
- Conditions
- Alzheimer s Disease, Dementia, Caregiver, Loneliness
- Trial name
- CRxDpeer (NCT07346183)
- Testing
- CommunityRx-Dpeer
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Nephrolithiasis
Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain
Post-operative pain and lower urinary tract symptoms are common following ureteroscopy in the treatment of stone disease. The use of bupivacaine as a topical pain medication is used routinely for other urologic procedures…
- Trial name
- NCT06635889
- Testing
- Bupivacaine, Normal saline
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Chicago
HIV, Pre-exposure Prophylaxis
Case Management Dyad
The overall goal of this study is to test whether dyadic and focused case management coupled with contingency management will (1) improve financial wellbeing, (2) improve access to food, (3) increase linkage and retention rates…
- Conditions
- HIV, Pre-exposure Prophylaxis, Case Management, Contingency Management
- Trial name
- CM2 (NCT06162897)
- Testing
- Dyadic Case Management
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Weight Loss
A Novel Intervention for Weight Loss in Young Adults
Obesity and cardiometabolic risks are significant public health issues, with about two-thirds of U.S. adults overweight or obese.
- Trial name
- NCT06230744
- Testing
- Lifestyle, Lifestyle II
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Chicago
HIV
Work2Prevent Plus: Structural Intervention to Promote HIV Care in Black Sexual Minority Men
The goal of this observational study is to learn about the pilot test of the employment program among young men living with HIV or part of a community highly impacted by HIV.
- Trial name
- NCT06894199
- Testing
- The Work Shop
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Breast Cancer
A Multi-Modality Surveillance Program for Women at High Risk for Breast Cancer
This study is aimed to establish a registry of women undergoing intensive surveillance for the early detection of breast cancer in high-risk women.
- Trial name
- CAPS (NCT03729115)
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- 3 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Myeloproliferative Neoplasms
Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation
The purpose of this research is to gather information on the safety and effectiveness determining maximum tolerated dose (MTD) of ruxolitinib in combination with ivosidenib in IDH1-mutated advanced-phase Ph-negative MPNs while…
- Trial name
- MPN (NCT06291987)
- Testing
- Ivosidenib, Ruxolitinib
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Influenza, COVID-19
Dime La VerDAD: Verify, Debunk, and Disseminate
Dime la Verdad (Tell me the truth) will evaluate the use of storytelling by community health workers as a communication strategy to disseminate reliable health information on social media and encourage informed decision-making in…
- Conditions
- Influenza, COVID-19, Communication Research, Health Behavior
- Trial name
- NCT06417762
- Testing
- Science Communication Curriculum Cohort 1, Science communication curriculum Cohort 2, Science communication curriculum Cohort 3
- Where
- 4 sites in United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Cancer
Engaging and Activating Cancer Survivors in Genetic Services Study
To address the gap in access to genetic services, this study will evaluate the effectiveness of an adapted model of remote delivery of genetic services to increase the uptake of recommended genetic assessment and testing in…
- Trial name
- ENGAGE (NCT04455698)
- Testing
- Remote Telegenetic Counseling by Phone, Remote Telegenetic Counseling by Videoconferencing, Usual Care Arm
- Where
- 3 sites in United States
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- University of Chicago
COVID-19
Can Vitamin D Reduce the Burden of COVID-19?
The purpose of this study is to compare the risks of COVID-19 in individuals from the Chicagoland area and other communities in the United States randomized to low (400 IU/day) versus moderate (4,000 IU/day) dose vitamin D.
- Trial name
- NCT07128069
- Testing
- Vitamin D 400IU, Vitamin D 4000IU
- Where
- United States
- Volunteers
- 2,093 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Health Related Social Needs (HRSN)
CommunityRx-Dementia
Caregivers of home-dwelling people with Alzheimer's Disease and related dementias (ADRD) are one of the most rapidly growing populations in the United States.
- Trial name
- CRx-D (NCT04146545)
- Testing
- Community Rx-Dementia "CRxD" Caregiver Resources
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Food Insecurity
CommunityRx-Hunger
CommunityRx-Hunger (CRx-H) is a hospital-based intervention that addresses food insecurity and other health-related social needs such as transportation, housing, utilities, and safety.
- Trial name
- CRx-H (NCT04171999)
- Testing
- Community Rx-Hunger (CRx-H)
- Where
- United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Celiac Disease
Tissue Destruction and Healing in Celiac Disease
The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells…
- Trial name
- NCT05680012
- Testing
- Gluten containing snack bar
- Where
- 3 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Chicago
SARS-CoV-2 Infection
Low vs. Moderate to High Dose Vitamin D for Prevention of COVID-19
The purpose of this study is to compare the risks of COVID-19 in individuals from Chicagoland communities randomized to low (400 IU/day) vs. moderate (4,000 IU/day) or high (10,000 IU/day) dose vitamin D.
- Trial name
- NCT04868903
- Testing
- Vitamin D3
- Where
- 2 sites in United States
- Volunteers
- 1,475 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Invasive Mechanical Ventilation, Children With Medical Complexity
Parent-to-parent Coaching While Awaiting Hospital Discharge With a Child With a Ventilator
The objective of the study is to pilot a parent-to-parent coaching model with experienced family members of children with Invasive Mechanical Ventilation (IMV) as parent coaches.
- Conditions
- Invasive Mechanical Ventilation, Children With Medical Complexity, Home Nursing, Empowerment
- Trial name
- NCT05880953
- Testing
- Parent-to-parent coaching
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Pregnancy, Child Development
Improving Maternal and Child Health Through Prenatal Fatty Acid Supplementation
The purpose of the study is to test whether nutritional supplementation during pregnancy is associated with 1) improved maternal health during pregnancy; 2) improved infant birth and neurodevelopmental outcomes, and 3) whether…
- Trial name
- NAPS (NCT02647723)
- Testing
- DHA, Sugar pill
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Healthy Adult
Effect of Monosodium Glutamate on Microbiome-Derived Imidazole Propionate Production in Healthy Volunteers
The goal of this clinical trial is to learn whether dietary monosodium glutamate (MSG), a common food flavor enhancer, increases the blood level of a gut-microbiome-derived compound called imidazole propionate (ImP) in healthy…
- Trial name
- NCT07700368
- Testing
- L-histidine, Monosodium glutamate (MSG), Sodium chloride (NaCl)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Chicago
LSD, Major Depressive Disorder
Mood Effects of Serotonin Agonists: Depression
This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression.
- Conditions
- LSD, Major Depressive Disorder, Depression
- Trial name
- MESA-D (NCT07017478)
- Testing
- LSD
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Vascular Lesion
Oxygenation in Vascular Lesions of the Colon
The goal of this clinical trial is to evaluate oxygenation in the colon in people with acquired vascular abnormalities in the proximal colon.
- Trial name
- NCT06230731
- Testing
- Oxygen saturation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chicago