Clinical trials: sponsored by University of Copenhagen
Obesity, Normal Weight
Hypothalamic GLP-1 Response in Healthy Weight and Obesity
The goal of this clinical trial is to learn how the gut hormone glucagon-like peptide-1 (GLP-1) helps the brain sense sugar. It includes adults with healthy weight and adults with obesity.
- Conditions
- Obesity, Normal Weight, Glucose Intolerance
- Trial name
- NCT07854886
- Testing
- Gastric glucose, GLP-1(7-36)NH2, Exendin(9-39)NH2
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Graves' Orbitopathy, Thyroid Eye Disease, TED
Early Risk Stratification of Thyroid Eye Disease in Newly Diagnosed Graves' Disease
The aim of this observational study is to investigate why some people with newly diagnosed Graves' disease (GD) develop thyroid eye disease (TED), also known as Graves' orbitopathy, while others do not.
- Conditions
- Graves' Orbitopathy, Thyroid Eye Disease, TED, Graves' Disease
- Trial name
- SOGO (NCT07812194)
- Testing
- Study-related ophthalmological assessment and biospecimen collection, Blood biomarkers and standardized blood samples including thyroid function status
- Where
- Denmark
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Menopause, Exercise Adaptation
The Effects of Menopausal Status, Isoflavone Supplementation and Training on Cardiometabolic Function Women
The goal of this clinical trial is to investigate the role of estrogen and isoflavone supplementation in exercise-induced cellular signaling and cardiometabolic adaptations in premenopausal and postmenopausal women.
- Conditions
- Menopause, Exercise Adaptation, Mitochondrial Alteration, Vascular Function in Healthy Volunteers
- Trial name
- EXISO (NCT07878741)
- Testing
- Red Clover Isoflavone Supplementation, Supervised exercise training
- Where
- 2 sites in Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cardiometabolic Diseases
Sustainable Diets and Cardiometabolic Health
This study aims to investigate the effects of sustainable diets on traditional and novel cardiometabolic risk factors. The primary objective is: To test the effects of a sustainable diet on traditional cardiometabolic risk…
- Trial name
- PlanetDiet (NCT07189676)
- Testing
- Dietary advice (PHD), Dietary advice (Ovo-lacto-vegetarian diet), Dietary advice (control)
- Where
- Denmark
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy Young Adults, Physiology
Does Paracetamol Influence the Release of Gut Hormones, Glucose Absorption and Glycemia?
The study aim is to determine whether acute inhibition of endogenous prostaglandin synthesis by paracetamol affects the release of gut hormones, glucose absorption and glycemia in healthy young individuals
- Trial name
- NCT07821515
- Testing
- Paracetamol
- Where
- 2 sites in Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Vision Impairment and Blindness, Glaucoma
Developing and Testing a Model to Identify Preventive Vision Loss Among Older Patients in General Practice
In this cohort study, the investigators will test vision screenings in Danish general practice for patients over 70 years of age with minimum one chronic condition.
- Conditions
- Vision Impairment and Blindness, Glaucoma, Age-Related Macular Degeneration, Cataract
- Trial name
- DETECT (NCT07015034)
- Testing
- focus on vision impairment in older patients in general practice
- Where
- 2 sites in Denmark
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Omega-3 Fatty Acids, Absorption of Omega-3
Study of Metabolic Absorption Rates of DHA-Taurine as a Source of Omega-3 Fatty Acids
Omega-3 fatty acids such as docosahexaenoic acid (DHA) have well-established health benefits and are widely used to improve cardiometabolic health.
- Conditions
- Omega-3 Fatty Acids, Absorption of Omega-3, Pharmacokinetics
- Trial name
- SMART (NCT07771309)
- Testing
- DHA-taurine, DHA ethyl ester
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Metabolic Health, Insulin Sensitivity/Resistance
Defining the Human Insulin Resistance Molecular Network; SIGNATURE
The goal of this intervention study is to learn more about what causes insulin resistance in otherwise healthy adults, and how short-term changes in physical activity or diet may influence it.
- Trial name
- SIGNATURE (NCT07255807)
- Testing
- Physical Inactivity, Hypercaloric High-Fat Diet
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Medium-chain Acyl-CoA Dehydrogenase Deficiency
Metabolic Effects of Medium-Chain Fatty Acids in Patients With Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Healthy Individuals
The aim of this project is to investigate the physiological effects of intake of long-chain fatty acids (LCFA) and medium-chain fatty acids (MCFA) in patients with Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) and…
- Trial name
- MEMCADD (NCT06623032)
- Testing
- Medium-Chain Fatty Acid (MCFA), Long-Chain Fatty Acid (LCFA)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Third Molars Extraction
The Use of Advanced Platelet-rich Fibrin in Mandibular Third Molar Surgery
The purpose of the study is to quantify the levels of platelets and inflammatory markers in A-PRF from a standard venous whole blood sample, and to evaluate the effect of A-PRF on postoperative discomfort and complications…
- Trial name
- NCT07761338
- Testing
- Third molar
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Perinatal Death, Hypertension, Pregnancy-Induced
Pregnancy in the Context of Urbanicity and Climate Change. The Overall Aim of the Project is to Co-create, Implement, and Test New Clinical Guidelines in Order to Improve the Quality of Care in Antenatal Clinics in the Context of Urbanisation and Climate Change in Dar es Salaam, Tanzania.
Tanzania's population is growing quickly, and Dar es Salaam is one of the fastest-growing cities in the world. At the same time, the city is increasingly affected by very hot weather, flooding, and air pollution.
- Conditions
- Perinatal Death, Hypertension, Pregnancy-Induced, Abortion, Spontaneous, Stillbirth
- Trial name
- NCT07751432
- Testing
- CC-ANC intervention group.
- Where
- Tanzania
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy Adult Participants, Bone Physiology
Postprandial Regulation of Bone Perfusion in Healthy Individuals
The goal of this clinical trial is to learn whether certain natural hormones - Glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-2, (GLP-2), and amylin - affect blood flow to the bones.
- Conditions
- Healthy Adult Participants, Bone Physiology, Bone Blood Flow Regulation, Peptide Hormones
- Trial name
- GA-27 (NCT07679516)
- Testing
- isotonic saline infusion, Infusion of GIP(1-42), Infusion of GLP-2(1-33)
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Fasting, Obesity (BMI>30)
The Effect of Fasting on Peak Fat Oxidation, Mitochondrial Coupling and Extracellular Matrix
The interventional study will recruit four groups (n=10 per group): Young men and women with normal weight (BMI 18-25), and young men and women with obesity (BMI >30).
- Conditions
- Fasting, Obesity (BMI>30), Sex Difference
- Trial name
- GlycoFast84 (NCT07692646)
- Testing
- Diet
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Emesis
The Antiemetic Effects of Increased Splanchnic Perfusion, Induced by the Gut Hormone GIP, in Healthy Individuals
This study investigates whether the gut hormone glucose-dependent insulinotropic polypeptide (GIP) can reduce feelings of nausea.
- Trial name
- GIP EMESIS (NCT07687589)
- Testing
- Glucose-dependent Insulinotropic Polypeptide (GIP), GLP-1 (7-36) amide, Apomorphine Injectable Solution
- Where
- Denmark
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Diet, Healthy, Breath Analysis
Why Calories Are Not the Same - a Gut Explanation?
The aim of this study is to understand how the gut microbiome influences how much dietary energy humans excrete via feces. This study is based on the hypothesis that levels of methane in exhaled breath represent two different gut…
- Trial name
- GutEnergy (NCT06932666)
- Testing
- Diet A group, Diet B group
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy, Constipation
Dairy Products to Your Gut and Brain
The goal of this intervention study is to compare the effects of fermented dairy and non-fermented dairy on bowel habits and cognitive performance in healthy women with defecations every other day or less.
- Trial name
- YourGutBrain (NCT06311097)
- Testing
- Fermented dairy, Non-fermented dairy
- Where
- Denmark
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy, Emotion Regulation
Testing the Effects of the Caregiver Interaction Profile Training on the Interactive Skills of Daycare Providers
The goal of this clinical trial is to test the Caregiver Interaction Profile (CIP) training program (Helmerhorst et al., 2017) promoting the relational quality between professional caregivers and children in daycare.
- Conditions
- Healthy, Emotion Regulation, Language Development, Interactive Skills Daycare Providers
- Trial name
- CDP (NCT05654116)
- Testing
- Caregiver Interaction Profile (CIP) training
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Non-Alcoholic Fatty Liver Disease, Obesity
Direct Versus Indirect Effect of Amino Acids on Hepatokines
Liver hormones are key metabolic regulators and increased in metabolic diseases, including fatty liver disease. The underlying mechanisms driving the elevated levels are currently unknown and presents a major challenge in…
- Trial name
- Diaakine (NCT06240039)
- Testing
- Evaluating the acute effect of an amino acid infusion with and without a concomitant infusion of the somatostatin analogue octreotide to eliminate endogenous production of glucagon
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Nutritional Status, Micronutrient Status
Health and Nutritional Outcomes Among Young Females and Children in Southwest Bangladesh
This study aims to examine how societal and climate changes influence the nutritional status and fish consumption of young women over a 10 year period in southern Bangladesh, and how these factors affect their children's health.
- Conditions
- Nutritional Status, Micronutrient Status, Omega 3 Fat Status, Diet Diversity
- Trial name
- AQUAFOOD (NCT07541742)
- Testing
- The follow-up aims to evaluate natural changes occurring from adolescence to young adulthood with respect to the study objectives due to lifestyle and environmental factors, without any intervention.
- Where
- Bangladesh
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Blood Sample, Interference With Routine Analyical Tests
The Acute Interference of Biotin in Blood Analysis
Biotin, also known as vitamin B7, is a water-soluble vitamin. It is essential for several metabolic processes in the body, including glucose, lipid, and protein metabolism, as it acts as a coenzyme in several carboxylation…
- Conditions
- Blood Sample, Interference With Routine Analyical Tests, Biotin Ingestion
- Trial name
- ABBA (NCT07302880)
- Testing
- Overall: To evaluate the acute effect of biotin intake on streptavidin-based laboratory assays during the hours immediately following consumption
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen