Clinical trials: sponsored by University of Nebraska
Stress
Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia
More than 15 million family caregivers provide support for individuals with Alzheimer's disease (AD) or related dementias. This number is expected to grow with the increasing population of persons with dementia (PWD).
- Trial name
- NCT06364228
- Testing
- Oxytocin Intranasal Spray 12 International Unit (12IU), Oxytocin Intranasal Spray 24 International Unit (24IU), Functional MRI
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Stress and Performance, Pilot Stress
The Investigators Want to See if There is a Correlation Between Stress and the Microbiome for Pilots and Astronauts and if There is a Way to Optimize This Balance for Pilots so That They Can Maximize Aerodynamic Decision Making on the Flight Deck.
The investigators are going to test the bacteria growing in your intestine to see if it influences your ability to manage stress while flying an airplane.
- Trial name
- NCT07829159
- Testing
- Flight simulator
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Cerebral Palsy Children, Healthy Adults
Evaluating the Effects of an Electrical Stimulator on Improving the Walking Ability of Children With Cerebral Palsy
The goal of this study is to see if gentle electrical stimulation can help children with cerebral palsy (CP) walk more easily. This stimulation, called neuromuscular electrical stimulation (NMES), sends small pulses to muscles to…
- Trial name
- CP (NCT06811545)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Amniotic Band Syndrome, Upper Extremity Deformities, Congenital
The Influence of 3D Printed Prostheses on Neural Activation Patterns
The neural basis underlying motor performance in children using a prosthesis has been severely understudied resulting in minimal empirical evidence.
- Trial name
- NCT04110730
- Testing
- 3D Printed Upper-limb Prosthesis, Home Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Dyspnea, Chronic Obstructive Pulmonary Disease
The Increase of Lung Capacity Using the Lung Master (Pulmonary Exerciser)
Investigators are studying how a device called The Lung Master device can help people breathe better. The investigational device increases the amount of air our lungs can hold, which is important for overall lung health.
- Conditions
- Dyspnea, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT06524856
- Testing
- Lung Master (Pulmonary Exerciser)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Motor Function
Feasibility Study of the Flash-Sole: A Wearable Midsole With Soft Actuators for Walking Assistance
The goal of this clinical trial is to test a new shoe device called Flash-Sole. The Flash-Sole is designed to help support the ankle while walking. It was developed by researchers at the University of Nebraska at Omaha.
- Trial name
- FLASHSOLE (NCT07507006)
- Testing
- Flash-Sole midsole device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Inflammation of Mouth
Association of Periodontal Inflammation on Immune Response in Wound Healing
Subjects who are in need of extraction of a posterior tooth will be recruited for this study. Prior to extraction, periodontal clinical markers of inflammation, body-mass index and dental radiographs will be measured/taken.
- Trial name
- NCT04805320
- Testing
- Dental Extraction
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Chronic Stress
Does Psychotherapy Change the Gut Microbiome in Women of Child-bearing Age?
The goal of this clinical trial is to learn if group therapy for six weeks changes the gut microbiome in women. The main questions it aims to answer are: Is chronic stress associated with the gut microbiome? Will six weeks of…
- Trial name
- NCT07200531
- Testing
- Psychotherapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Colorectal Cancer, Prevention
A Cross-sectional Partnership to Improve Prevention and Health Equity Among African Americans
African Americans face racial disparities in colorectal cancer (CRC), with lower screening rates and higher incidence and mortality rates.
- Trial name
- NCT05903885
- Testing
- On-site Fecal Immunochemical Test (FIT) Kit Distribution, On-site With Social Media Advertising Fecal Immunochemical Test (FIT) Kit Distribution
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Dietary Intervention, Gut Microbiota
Phenolic Dependent And Independent Effects Of Whole Grain Sorghum On Immunometabolism
Sorghum is a nutrient-dense ancient grain that, when eaten as a whole grain, provides health-beneficial dietary fiber, protein, and phenolics.
- Conditions
- Dietary Intervention, Gut Microbiota, Insulin Sensitivity/Resistance, Obesity & Overweight
- Trial name
- NCT07832071
- Testing
- Whole grain sumac sorghum, Whole grain white sorghum, White rice
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Peripheral Artery Disease (PAD)
Detecting Peripheral Artery Disease With the Pulse
1) The purpose of this study is to assess segmental pulse arrival time (PAT) as an alternative biomarker to detect lower-extremity peripheral artery disease (PAD), and to investigate the impacts of local skin heating and foot…
- Trial name
- NCT07226193
- Testing
- Segmental pulse arrival time assessment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Healthy Children, CP (Cerebral Palsy)
Training Upper Limbs of Neurodiverse Children by Connecting Brain Activities to a Virtual Reality Based Game
This study is testing ways to help children with cerebral palsy (CP) improve how their hands work. Investigators want to see if brain activity using a virtual reality (VR) program can make their hands work better.
- Conditions
- Healthy Children, CP (Cerebral Palsy), CP, Cerebral Palsy
- Trial name
- NCT06818877
- Testing
- Brain-Computer Interface (BCI)-HABIT-VR, Hand and Bimanual Intensive Therapy Virtual Reality (HABIT-VR)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Brain Injuries
Metacognition in Neurological Injury
The purpose of this study is to investigate the trajectory of metacognitive functioning throughout phases of recovery from neurological insult, and to determine its relationship to rehabilitation compliance and functional…
- Trial name
- NCT03752697
- Testing
- metacognitive performance
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Childhood Obesity Pevention, Diet Quality
Healthy Children, Healthy Communities: Effectiveness of a Multilevel Rural Community Engagement Model for Improving Children's Dietary Intake in Family Child Care Homes
The purpose of this study is to find out whether a program called "Healthy Children, Healthy Communities" can help young children in rural areas eat healthier and improve their health.
- Conditions
- Childhood Obesity Pevention, Diet Quality, Feeding Behaviors, Health Behavior Change
- Trial name
- NCT07160530
- Testing
- EAT Family Style, Better Kid Care
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Well-Being, Psychological, Engagement
The Impact of the Family Room App on Caregivers
Engaging families in patient care during serious illness can enhance care quality, reduce social isolation, boost satisfaction, and lower healthcare costs.
- Conditions
- Well-Being, Psychological, Engagement, Satisfaction, Consumer
- Trial name
- NCT06463158
- Testing
- Family Room Application
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Healthy Young Adults
Development of a Real-time Controller to Estimate Walking Performance Using a Bilateral Ankle Exoskeleton
This study is developing and testing a new controller for a robotic ankle exoskeleton (Biomotum) that can adjust itself in real time to better support people while they walk.
- Trial name
- NCT07393971
- Testing
- Adaptive Torque Control System for Ankle Exoskeleton
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Peripheral Arterial Disease, Peripheral Vascular Disease
Leg Exercise Assistive Paddling (LEAP) Therapy for Peripheral Artery Disease
The purpose of this study is to test the effects of leg exercise assistive paddling (LEAP) therapy during prolonged sitting (PS) on vascular and functional performance in those with peripheral artery disease (PAD) and age-matched…
- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Disease, Peripheral Artery Occlusive Disease, Peripheral Artery Disease
- Trial name
- NCT06389149
- Testing
- LEAP therapy, no LEAP therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Parkinson's Disease
Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease
This is an open-label, non-randomized, proof-of-concept comparison of clinical vs. research stimulation patterns in patients with Parkinson's disease (PD) being treated with Deep Brain Stimulation (DBS) through the Medtronic…
- Trial name
- NCT04799470
- Testing
- Novel DBS stimulation patterns
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Peripheral Artery Disease, Peripheral Vascular Diseases
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
Peripheral artery disease (PAD) is associated with elevated oxidative stress, and oxidative stress has been implicated as the cause of reduced endothelial reactivity in individuals with PAD.
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Diseases, Peripheral Arterial Disease, Peripheral Arterial Occlusive Disease
- Trial name
- NCT06319339
- Testing
- Vumerity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska