Clinical trials: sponsored by University of Toronto
Metabolic Syndrome, Overweight and Obesity
The Soy Treatment Evaluation for Metabolic Health (STEM) Trial
Strategies to reduce sugar-sweetened beverages (SSB) have become one of the leading public health targets to address the epidemics of obesity and diabetes.
- Conditions
- Metabolic Syndrome, Overweight and Obesity, PreDiabetes, Diabetes
- Trial name
- NCT05191160
- Testing
- Soy Milk, Cow's Milk, Sugar Sweetened Beverages
- Where
- Canada
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Financial Stress, Social Functioning
Livelihoods Intervention With Urban Refugee Youth in Kampala, Uganda
Displaced and refugee youth in Uganda are more vulnerable to health risks due to financial insecurity. As such, the investigators aim to explore the utility of an intervention aimed at improving livelihoods, called Creating…
- Conditions
- Financial Stress, Social Functioning, Social Skills
- Trial name
- NCT06270160
- Testing
- HIVST, mHealth, Creating Futures Livelihoods program
- Where
- Uganda
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Exercise
Bodyweight Interval Exercise in the Fed Versus Fasted State
The purpose of this study is to investigate the effects of a single session of at-home bodyweight interval exercise, performed in the fasted or fed state, on postprandial glycemic management, post-exercise fat oxidation, and…
- Trial name
- BWE (NCT06240442)
- Testing
- Fasted exercise, Fed exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Resistance Exercise, Physical Inactivity
Modified Breath Test to Determine Anabolic Sensitivity Across Physical Activity States
Developing tools to detect when our bodies are more resistant towards protein synthesis is valuable for identification of when someone may be at risk of losing body or muscle mass such as with aging or certain diseases.
- Conditions
- Resistance Exercise, Physical Inactivity, Amino Acids, Dietary Protein
- Trial name
- BTLP (NCT06209424)
- Testing
- Habitual Activity, Step-Reduction, Resistance Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Exercise Training
Exercise Dose-response and Protein Requirements
Study will investigate the impact of training volume on protein metabolism to estimate the impact on daily protein requirements of endurance athletes.
- Trial name
- NCT06138951
- Testing
- Endurance exercise
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Stroke
Development and Evaluation of iWalk: A Guide to Facilitate Evidence-informed Assessment of Walking After Stroke
Stroke remains a major health concern and the second highest cause of disability worldwide. After experiencing a stroke, many people lose the ability to walk independently.
- Trial name
- NCT04184843
- Testing
- iWalk Toolkit
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Depression
Shortened Depression Assessment Study
Participants will be asked to fill out an online questionnaire about their demographics information and all 42 items from the Depression Anxiety Stress Scale (DASS-42).
- Trial name
- NCT05123794
- Where
- Canada
- Volunteers
- 39,000 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Covid19
#SafeHandsSafeHearts: An eHealth Intervention for COVID-19 Prevention and Support
This project seeks to test the efficacy of a brief eHealth intervention in an international randomized controlled trial (RCT) to increase COVID-19 knowledge and protective behaviors, and reduce psychological distress among LGBT…
- Trial name
- COVID-19 (NCT04870723)
- Testing
- eHealth for Covid-19 prevention and support
- Where
- 3 sites in Canada, India and 1 more
- Volunteers
- 853 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Stress, Physiological, Stress, Psychological
Autonomic Modulation Training for Police Exposed to Post-Traumatic Stress Injuries
Police officers are exposed to hazardous, disturbing events that impose stress and long-term trauma. Upwards of 15-26% of public safety personnel (PSP) report one or more mental health symptoms.
- Trial name
- AMT (NCT05521360)
- Testing
- Autonomic Modulation Training
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Interventional
The Effect of Exercise and Presleep Nutrition on Muscle Connective Tissue Remodelling
The primary objective of this study will be to determine the influence of a presleep vitamin C-enriched, collagen-modelled supplement (CVC) on the metabolic fate of dietary glycine using a [2H5]glycine tracer within the…
- Trial name
- NCT06054620
- Testing
- Collagen and Vitamin C
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dietary Proteins
Determining the Effect of Protein Quality on Post-exercise Anabolism in Active Youth
Leucine-enriched proteins (e.g., dairy) are more effective than plant-based sources for supporting post-exercise rates of muscle protein synthesis in adults.
- Trial name
- PQS (NCT05052827)
- Testing
- Milk Protein Concentrate, Rice Protein Isolate, Soy Protein Isolate
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Contraceptives, Oral, Sex Hormone
Oral Contraceptive vs Menstrual Cycle Ex Vivo Model
Despite comprising half the population, females are often left out of muscle research due to the impact of changing hormones during the menstrual cycle and when using oral contraceptives.
- Trial name
- OCEV (NCT06124274)
- Testing
- Protein tracer drink
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Sedentary Behavior, Aging
Oral 'Breath Test' to Measure Anabolic Sensitivity in Young and Older Adults at Different Activity Levels
Recent work in the investigators laboratory has examined the ability of a non-invasive 13CO2 breath-test to assess differences in amino acid oxidation rates and net balance in young healthy males following protein feeding and…
- Conditions
- Sedentary Behavior, Aging, Sarcopenia, Amino Acids
- Trial name
- ARBT (NCT05216809)
- Testing
- Habitual Physical Activity, Step-Reduction
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Interventional
In Vivo and in Vitro Anabolic Potential of Essential Amino Acids Following Resistance Exercise
This study seeks to investigate the anabolic potential of a dileucine-enriched essential amino acid (EAA) formulation compared with a branched chain amino acid (BCAA) alternative and a collagen beverage on muscle protein…
- Trial name
- DiEx (NCT05754125)
- Testing
- Di-Leucine Supplement, BCAA Supplement, Collagen Supplement
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Vaccination Reaction, Vaccination Pain
CARD for Community Pharmacy Vaccinations
To integrate CARD in community pharmacy-led vaccinations and document impact on vaccine clients and pharmacy staff.
- Conditions
- Vaccination Reaction, Vaccination Pain, Community Pharmacy
- Trial name
- NCT06098703
- Testing
- CARD (Comfort Ask Relax Distract)
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Older Adults With Decreased Outdoor Walking Ability
Getting Older Adults OUTdoors (GO-OUT)
Community walking is an issue that older adults with chronic conditions have described as important to participation in the community.
- Trial name
- NCT03292510
- Testing
- GO-OUT Group, Workshop Group
- Where
- Canada
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dental Plaque, Dental Caries
Development of a Novel Anti-caries Chewing Gum
This research study is designed to evaluate the chewing gum's ability to modulate the oral microbiome in human participants, in addition to its safety.
- Conditions
- Dental Plaque, Dental Caries, Periodontal Disease
- Trial name
- NCT05946473
- Testing
- Gum base containing xylitol and essencial oils, Gum base with no additives
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Inactivity, Physical, Aging
Impact of Postprandial 'Exercise Snacks' on Protein and Glucose Metabolism Following a Period of Step Reduction in Older Adults
The purpose of this study is to assess the impact of 3-days reduced physical activity (<1500 steps/day) with/without 'exercise snacks' (15 chair stands with calf raises every 30 min) on skeletal muscle metabolic health.
- Conditions
- Inactivity, Physical, Aging, Healthy Aging, Sarcopenia
- Trial name
- NCT05810272
- Testing
- Metabolic Trial, 15 sit-to-stands with calf raises
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Increased Metabolic Requirement, Healthy
Protein Requirements in Male and Female Endurance Athletes
Protein is an essential macronutrient for post-exercise recovery through its ability to provide the amino acid building blocks that support increased rates of muscle and whole body protein synthesis.
- Trial name
- NCT04855474
- Testing
- Amino Acid Intake
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dietary Protein, Female Protein Metabolism
A 'Non-Invasive' Breath Test to Determine Anabolic Sensitivity in Females
The maintenance of lean body mass, especially skeletal muscle, is vital for optimal health and performance across the lifespan. The protein component of lean body mass is in a constant state of turnover, involving the…
- Conditions
- Dietary Protein, Female Protein Metabolism, Anabolic Sensitivity, Resistance Exercise
- Trial name
- FBT (NCT05422300)
- Testing
- Fed, Ex-Fed
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Toronto