Clinical trials: sponsored by Indiana University
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.3
This grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07594795
- Testing
- Temporal Interference (TI) Electrical Stimulation - dACC 20 Hz TI Active, Temporal Interference (TI) Electrical Stimulation - dACC Comparison Frequency TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Limited Ankle Dorsiflexion Due to Calf Muscle Tightness
Mechanisms of Instrument-Assisted Soft Tissue Manipulation (IASTM) Force Dose-Response Effects in the Calf-Foot Region
The goal of this clinical trial is to learn how different levels of force applied during instrument-assisted soft tissue manipulation (IASTM), a common rehabilitation treatment, affect muscle and soft tissue function in healthy…
- Trial name
- NCT07921459
- Testing
- quantitative instrument-assisted soft tissue manipulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dental Caries
In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization
The goal of this clinical trial is to evaluate whether BlueCheck® can accurately detect and monitor early-stage dental caries (tooth decay) and their remineralization in adults.
- Trial name
- NCT07100626
- Testing
- BlueCheck
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Incisive Technologies Pty Ltd
Alcohol Use Disorder
Sex Differences in the Response to Abstinence From Alcohol.
In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that…
- Trial name
- SPAR (NCT03827460)
- Testing
- Abstinence from alcohol, Usual drinking, Intravenous Alcohol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07215299
- Testing
- Temporal Interference (TI) Electrical Stimulation - NAcc TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc No-TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Subjects, HPV
BD Onclarity HPV Assay on the BD COR Instrument: Self-collected Vaginal Swabs Validation
This study is being done to help IU Health validate a new method for HPV testing using self-collected vaginal swab samples. Volunteers will collect two vaginal swabs during a single study visit.
- Trial name
- NCT07909499
- Testing
- BD Cor OnClarity Self-Collection, BD Onclarity HPV Assay
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Malaria
L9LS in Women of Childbearing Potential in Mali
Safety and Efficacy of L9LS, a Human Monoclonal Antibody Against Plasmodium falciparum, in a Randomized, Double-Blind, Placebo-Controlled Trial of Women of Childbearing Potential (WOCBP) in Mali
- Trial name
- NCT07060508
- Testing
- Single dose of 1800 mg L9LS SC
- Where
- 3 sites in Mali
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Autism, Autism Spectrum Disorder
COMPASS Across Settings (CAST) for Improving Transition Outcomes for Students With ASD
Purpose: The purpose of this project is to develop and test the COMPASS [Collaborative Model for Competence and Success] Across Settings (CAST) intervention to enhance the goal setting and attainment skills of autistic youth.
- Conditions
- Autism, Autism Spectrum Disorder, Autistic Disorder
- Trial name
- CAST (NCT06309160)
- Testing
- COMPASS Across Settings (CAST)
- Where
- United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Ball State University
Pregnancy
Impact of Standardization on Outcomes Following Cervical Ripening
The primary purpose of this study is to determine if vaginal delivery rate is impacted by the use of standardized methods of cervical ripening. Additional outcomes will be evaluated including maternal and fetal outcomes of labor.
- Trial name
- NCT07576881
- Testing
- Cervical Ripening with a double balloon catheter only, Cervical ripening with a double balloon catheter plus misoprostol, Usual-care control group
- Where
- United States
- Volunteers
- 1,158 people, healthy volunteers welcome
- Sponsor
- Indiana University
Coronary Artery Disease
Needle Free Assessment of Myocardial Oxygenation in Healthy Subjects
This is a prospective pilot study to evaluate the safety, tolerability and efficacy of utilizing precise computer controlled gas challenge in healthy subjects for identification of coronary artery disease.
- Trial name
- NIMO-Healthy (NCT06000540)
- Testing
- RespirAct
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Indiana University
Motor Activity
Modulation of Motor Learning Via tDCS in a Dexterous Video Game Task
The purpose of this study is to determine whether "transcranial direct current stimulation" (tDCS) is effective in enhancing learning of complex motor tasks of precision and accuracy that require the simultaneous coordination of…
- Trial name
- NCT07202702
- Testing
- tDCS
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Long QT Syndrome, Abnormalities, Drug-Induced
Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening
This research will determine if: 1) Oral progesterone attenuates drug-induced QT interval, J-Tpeak and Tpeak-Tend lengthening in postmenopausal women 50 years of age or older, and 2) Transdermal testosterone attenuates…
- Trial name
- NCT04675788
- Testing
- Progesterone, Ibutilide, Testosterone
- Where
- 3 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Subjects
ABVN Phase 1 - Vagal Maneuvers
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope to be able to measure the activity of the vagus nerve when it is stimulated through simple physical techniques.
- Trial name
- ABVN1 (NCT07881276)
- Testing
- Vagal Maneuvers, Multi-Electrode Array (MEA) Recording
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Subjects
ABVN Phase 1 - Ear Stimulation
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve.
- Trial name
- ABVN1 (NCT04206540)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gastroparesis, Healthy Subjects
ABVN Phase 2 - Ear Stimulation
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve.
- Trial name
- ABVN2 (NCT06491758)
- Testing
- ML1101 Stimulus Isolator
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Indiana University
Delayed Onset Muscle Soreness
Effects of Kinesio Tape on Delayed Onset Muscle Soreness
The purpose of this study is to determine the effect of Kinesio tape on delayed onset muscle soreness of the biceps muscle of your arm following strenuous exercise of the bicep muscle.
- Trial name
- NCT04128670
- Testing
- Kinesiotape
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.2
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07339072
- Testing
- Temporal Interference (TI) Electrical Stimulation - NAcc 5 Hz TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc 10 Hz TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gait, Balance
Sensor Ankle Brace for Special Operations Rehabilitation
The primary purpose of this study overall is to validate a modified version of a commercially available ankle brace. Inertial measurement unit sensors will be incorporated into an existing ankle brace ("sXAB") by TayCo Brace…
- Conditions
- Gait, Balance, Biomechanical Data, Postural Control
- Trial name
- NCT07776223
- Testing
- Sensor-enabled Athletic X Ankle Brace (sXAB)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Nutrition, Health
Nutrition for Precision Health, Powered by the All of Us
The goal of this Nutrition for Precision Health (NPH) powered by All of Us research study is to develop Artificial Intelligence/Machine Learning (AI/ML) algorithms that predict individual responses to diet patterns using rich…
- Conditions
- Nutrition, Health, Dietary Habits
- Trial name
- NCT05701657
- Testing
- Diet A, Diet B, Diet C
- Where
- 14 sites in United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Goal-Setting
Feasibility of an Implementation Strategy for a Physical Activity Program in Rural Middle Schools
The investigators aim to build on the pilot study data looking at the feasibility of implementation of Goal Setting alongside Hoosier Sport at two schools (Eastern Greene Middle School and White River Valley Middle School).
- Trial name
- NCT07859033
- Testing
- Goal-Setting in Sport-Based Youth Development, No Goal-Setting Program
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Indiana University