Clinical trials: sponsored by University of Manchester
Social Care, Falls (Accidents) in Old Age
Implementing Action Falls for Domiciliary Care
Every year, a lot of older people fall. These falls often lead to serious injuries and are a common reason for moving into care homes, increasing the amount of paid support at home or needing to rely more on family, friends and…
- Trial name
- HERON (NCT07913373)
- Testing
- Action Falls for home care
- Where
- United Kingdom
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dementia, Abuse Client
Partnership in Safeguarding People With Dementia From Primary and Social Care Perspectives
"Adult safeguarding is everyone's responsibility". The Care Act 2014 makes safeguarding a legal duty. It provides local authorities and other agencies in England with a responsibility to protect adults with care and support needs…
- Conditions
- Dementia, Abuse Client, Neglect; Care, Malnutrition
- Trial name
- NCT05883527
- Testing
- Not applicable as not an intervention - PLwD and family/carers, Not applicable as not an intervention - HCP's
- Where
- 5 sites in United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Anxiety, Cervical Cancer Screening
Cervical Cancer Awareness Education to Aid Confidence and Screening upTake (ACT): A Pilot Randomised Control Trial
Cervical cancer remains a major threat to women's health and wellbeing, with the burden disproportionately concentrated in low- and middle-income countries such as Nigeria, where inadequate awareness, limited access to screening…
- Conditions
- Anxiety, Cervical Cancer Screening, Health Education, Wellbeing
- Trial name
- ACT (NCT07863596)
- Testing
- cervical cancer Awareness education to aid Confidence and screening upTake (ACT), Control group
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Teesside University
Pollen Allergy, Venom Allergy
Identification of B Regulatory Cells by Flow Cytometry
The goal of this laboratory and observational study is to develop a test to quantify B-regulatory cells in blood. This will be used to detect changes in B-regulatory cell populations in pollen and insect venom allergic patients…
- Trial name
- NCT06876506
- Testing
- Venepuncture, Allergen Specific Immunotherapy
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Schizophrenia / Schizoaffective Disorder, Schizophrenia and Disorders With Psychotic Feature
Building a Computational Model of Auditory Hallucinations
Some people hear voices or sounds that other people cannot hear; these are called auditory hallucinations. The study aims to understand what is happening in the brain when this occurs and will use brain scans to learn more.
- Conditions
- Schizophrenia / Schizoaffective Disorder, Schizophrenia and Disorders With Psychotic Feature, Psychosis, SCHIZOPHRENIA 1 (Disorder)
- Trial name
- CLARITY WP1 (NCT07820553)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- King's College London
Polycythemia Vera, Essential Thrombocythemia
Myeloproliferative Neoplasms: an In-depth Case-control Study
There is a paucity of data on the aetiology of myeloproliferative neoplasms (MPNs). The investigators conducted a systematic review of the literature which identified several cohort and case-control studies that have investigated…
- Conditions
- Polycythemia Vera, Essential Thrombocythemia, Primary Myelofibrosis
- Trial name
- MOSAICC (NCT01831635)
- Testing
- Methodological pens, Methodological compensation, Methodological trolley tokens
- Where
- 3 sites in United Kingdom
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Anxiety, Prostate Cancer
proState Cancer Health Education to pRomote Early sreENing Uptake (SCREEN): A Pilot Randomised Control Trial
Prostate cancer is an issue of significant public health concern. Yet in low- and middle-income countries like Nigeria, men are adversely affected due to factors including poor early prostate cancer screening uptake.
- Conditions
- Anxiety, Prostate Cancer, Health Education, Screening and Brief Interventions
- Trial name
- SCREEN (NCT07800390)
- Testing
- proState Cancer awareness education to pRomote Early screENing uptake, Control group
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Teesside University
Fall Patients
Keep Exercising & Stay Steady: Development and Feasibility of a Health Intervention to Encourage Exercise Maintenance After Fall Prevention Exercise Programmes End.
Falls and broken bones are a common health problem faced by older adults. Worldwide, one third of adults aged over 65 years old, and half of adults aged over 80 years, fall each year.
- Trial name
- KESS (NCT06447948)
- Testing
- Keep Exercising and Stay Steady
- Where
- 4 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Falls
Action Falls for Domiciliary Care
Action Falls is a programme that helps older adults avoid falls and injuries. It finds out why someone might fall and suggests ways to help, like checking their medication and encouraging them to stay active.
- Trial name
- NCT07516054
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Anxiety, Mental Health
CONSCIOUS: A Pilot Trial of a Media Orientation Intervention to Encourage Men's Help Seeking for Mental Health Difficulties
Mental health difficulties among males are an issue of public health concern. Men are also at higher risk of suicidal ideation and self-harm and are poor at help-seeking due to factors including stigma, cultural norms and…
- Conditions
- Anxiety, Mental Health, Suicide Awareness, Awareness Training
- Trial name
- CONSCIOUS (NCT07627451)
- Testing
- Psychosocial media campaign, Intervention as usual
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Teesside University
Citrin Deficiency
Multi-omics Study in Citrin Deficiency
Citrin deficiency (CD) is an underdiagnosed and understudied condition characterized by several distinct phenotypes: 1) neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), 2) the adaptation or silent period, 3)…
- Trial name
- NCT06895746
- Where
- 23 sites in United States, Japan and 3 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johannes Haeberle
Cancer
MR-BIO: A Study to Evaluate Changes in MR Imaging and Biological Parameters
The MR BIO study aims to understand the changes in the tumour and normal tissues during a course of radiotherapy. This is accomplished by studying the MR images taken during each treatment session on the MR Linear accelerator (MR…
- Trial name
- MR-BIO (NCT04903236)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Cervical Cancer
Biomarkers for Clinical Hypoxia Evaluation in Cervical Cancer
Patients with locally advanced cervical cancer (LACC) are primarily treated with radiotherapy +/- chemotherapy however 5-year survival rates are <60% with significant treatment toxicity.
- Trial name
- Bio-CHECC (NCT05029258)
- Testing
- Biopsy of tumour, MRI scans
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Physiologically Based Pharmacokinetic, Healthy Volunteers
A Study on Oral and Intranasal Forms of Oxycodone in Healthy Volunteers Using Pharmacokinetic Modeling
This is a single-dose, 2-period, 2-sequence, fasting, open label, crossover randomized design, comparing the pharmacokinetics (PK) and pharmacodynamics (PD) of intranasal and oral oxycodone solutions.
- Trial name
- NCT07223450
- Testing
- Oxycodone IN, oxycodone
- Where
- Spain
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Smoking Cessation
Implementing an Intervention Named Volitional Help Sheets to Reduce Smoking Behaviour Among Young Adults in Indonesia
Indonesia is one of the countries that does not sign The World Health Organization Framework Convention on Tobacco Control (WHO-FCTC), and the numbers of Indonesian smokers increase every year.
- Trial name
- NCT05629039
- Testing
- Volitional Help Sheets
- Where
- United Kingdom
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Maternal Cardiometabolic Health, Infertility
St Mary's Assisted Reproductive Technology and Cardiometabolic Health: Modifiable Targets for Multimorbidity Prevention (START-HEALThY)
The main causes of death in women are conditions affecting the heart and blood vessels (cardiovascular disease, CVD). Women who have difficulties getting pregnant (infertility) may be at increased risk, but the reasons for this…
- Conditions
- Maternal Cardiometabolic Health, Infertility, Assisted Reproductive Technology, Cardiovascular Health
- Trial name
- START-HEALThY (NCT07173569)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Balance, Falls Prevention
Keep-On-Keep-Up (KOKU)
Falls are the primary cause of fatal and non-fatal accidental injuries in older adults. Around a third of community-dwelling older adults fall per year with high associated personal and societal costs.
- Conditions
- Balance, Falls Prevention, Functional Decline
- Trial name
- NCT06687135
- Testing
- KOKU, FaME / OTAGO leaflet and AGE UK Stay Steady Leaflet
- Where
- 2 sites in United Kingdom
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Patient Safety Concerns
Using IF-THEN Plans to Support Healthcare Professionals in Raising Patient Safety Concerns
This study aims to test whether a brief behavioural intervention can help healthcare professionals raise and respond to patient safety concerns in their work.
- Trial name
- NCT07506096
- Testing
- Implementation intention planning
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Anxiety, Vaccination Hesitancy
Media Orientation to Improve Childhood Vaccine Uptake and Address Parent and Caregivers Vaccine-related Anxiety: A Pilot Study
Vaccine hesitancy-defined as delayed acceptance or refusal of vaccines despite availability-remains a significant barrier to childhood immunisation uptake in Nigeria, a country with high zero-dose unvaccinated children.
- Conditions
- Anxiety, Vaccination Hesitancy, Vaccination Promotion, Vaccine Decision Making
- Trial name
- NCT07510230
- Testing
- ASSURed awareness campaign to encourage childhood vaccine uptakE (ASSURE) intervention, Intervention as usual
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Teesside University
Stillbirth, Perinatal Death
A Feasibility Randomised Control Trial to Evaluate Early Perinatal Bereavement Counselling for Parents Who Have Experienced a Perinatal Death
The goal of this feasibility randomised control trial is to determine if a trial to evaluate perinatal bereavement counselling for parents who have experienced a perinatal death is feasible.
- Conditions
- Stillbirth, Perinatal Death, Psychological, Grief
- Trial name
- PEARL-C (NCT07494760)
- Testing
- Bereavement Counselling, Usual bereavement care
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Manchester