Clinical trials: 5-FU
Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma
Hypofractionated Stereotactic Body Radiation & Fluorouracil or Capecitabine for Locally Advanced Pancreatic Cancer
Pancreatic cancer, most commonly adenocarcinoma, is the fourth leading cause of cancer death in the United States. The mainstay of management centers on surgical resection (if resectable) and although low (15% to 20%)…
- Conditions
- Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma, Stage I Pancreatic Cancer AJCC v6 and v7, Stage IA Pancreatic Cancer AJCC v6 and v7
- Trial name
- NCT03073785
- Testing
- Capecitabine, Fluorouracil, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Nebraska
Colon Cancer
Platform Study of Circulating Tumor DNA Directed Adjuvant Chemotherapy in Colon Cancer (KCSG CO22-12)
This study is a prospective, open-label, randomized phase 3 clinical trial. It aims to investigate if the early introduction of intensified chemotherapy (3 months of modified FOLFIRINOX) improves the 3-year disease-free survival…
- Trial name
- CLAUDIA (NCT05534087)
- Testing
- mFOLFIRINOX-FOLFIRI intensified chemotherapy, FOLFOX or CAPOX adjuvant chemotherapy
- Where
- 13 sites in South Korea
- Volunteers
- 236 people
- Sponsor
- Seoul National University Hospital
Head and Neck Neoplasms
Cetuximab Compared to Mitomycin-C and 5-Fluorouracil for Locally Advanced Squamous Cell Carcinomas of the Head and Neck
Concomitant radio-chemotherapy has become a standard therapy for advanced squamous cell carcinomas of head and neck. Local side effects caused by chemotherapy, like mucositis, increase in combination with radiotherapy.
- Trial name
- NCT02015650
- Testing
- Cetuximab, Mitomycin-C/ 5-Fluorouracil
- Where
- Austria
- Volunteers
- 4 people
- Sponsor
- Medical University Innsbruck
Colorectal Cancer
Radiation Therapy With or Without Chemotherapy Before Surgery in Treating Patients With Stage II or Stage III Rectal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as fluorouracil and leucovorin, work in different ways to stop the growth of tumor cells, either by killing the cells or…
- Trial name
- NCT00296608
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Volunteers
- 762 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Anal Squamous Cell Carcinoma
Adaptive Radiation in Anal Cancer
This is a 20 patient pilot study to examine the feasibility of dose-adapted radiation therapy for the treatment of locally advanced anal squamous cell cancer.
- Trial name
- NCT05838391
- Testing
- Artificial Intelligence Guided Daily Radiotherapy Treatment Planning and Delivery, Mitomycin-C, 5-Fluorouracil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Locally Advanced Rectal Carcinoma
Neoadjuvant Cadonilimab Plus Chemotherapy Following Short-Course Radiotherapy in Locally Advanced Rectal Cancer
The goal of this clinical trial is to test the efficacy and safety in patients with locally advanced middle and lower rectal cancer.
- Trial name
- NeoCaCRT (NCT05792735)
- Testing
- Cadonilimab Injection, Short-course radiotherapy, Consolidation chemotherapy
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Shenzhen People's Hospital
Esophageal Carcinoma
Induction Chemotherapy for Locally Advanced Esophageal Cancer
Evaluate mFOLFOX6 (5-Fluorouracil, Leucovorin and Oxaliplatin) chemotherapy as induction treatment prior to standard neoadjuvant chemoradiation to decrease the rate of distant recurrence among patients with locally advanced…
- Trial name
- NCT03110926
- Testing
- mFOLFOX6, Chemoradiation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Pancreatic Cancer, Cachexia
Study of Onivyde and 5-FU in Combination With Xilonix for Pancreatic Cancer With Cachexia
This study is being conducted to examine the safety of the investigational drug, Xilonix(™), in addition to standard doses of Onivyde® (nanoliposomal irinotecan) and 5- fluorouracil (5FU)/folinic acid (leucovorin) for pancreatic…
- Conditions
- Pancreatic Cancer, Cachexia, Weight Loss
- Trial name
- OnFX (NCT03207724)
- Testing
- Xilonix plus Onivyde and 5FU
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Andrew Hendifar, MD
Resectable Prancreas Carcinoma
Randomized Multicenter Phase II/III Study With Adjuvant Gemcitabine Versus Neoadjuvant / Adjuvant FOLFIRINOX for Resectable Pancreas Carcinoma
In this multicenter study, patients with resectable pancreatic carcinoma will be treated with (a) surgery followed by 6 cycles gemcitabine or (b) 4-6 cycles FOLFIRINOX followed by surgery followed by 4-6 cycles FOLFIRINOX.
- Trial name
- NCT02172976
- Testing
- Gemcitabine, Oxaliplatin, 5-Fluorouracil
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Krankenhaus Nordwest
Colorectal Neoplasms
MicroOrganoSphere (MOS) Drug Screen Pilot Trial in Colorectal Cancer
The purpose of the study is to determine the feasibility of generating sufficient MicroOrganoSpheres (MOS) from a biopsy of a subject's adenocarcinoma of the colon and/or rectum that is metastatic to the liver and completing a…
- Trial name
- MODEL-CRC (NCT05189171)
- Testing
- MicroOrganoSphere (MOS) drug screen
- Where
- 7 sites in United States
- Volunteers
- 46 people
- Sponsor
- Xilis, Inc.
Locally Recurrent Rectal Cancer
Hypofractionated Radiotherapy Combined With NALIRIF, PD-1 Antibody in Locally Recurrent Rectal Cancer(NOVELTY-R)
This is an open-label, single arm, phase 2 study. The study is to evaluate the activity of combination therapy of hypofractionated radiotherapy, Irinotecan Hydrochloride Liposome plus 5-FU and leucovorin (NALIRIF), Anti-PD1 and…
- Trial name
- NCT07183865
- Testing
- radiotherapy, Irinotecan Hydrochloride Liposome, 5-FU
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Fudan University
Rectal Neoplasms
Five Fractions of Radiotherapy Followed by Full Dose FOLFOX Chemotherapy as Preoperative Treatment for Rectal Cancer
To determine if short course radiotherapy followed by chemotherapy can maintain morbidity at or below levels reported with concurrent 5FU, oxaliplatin, and radiotherapy, while maintaining response rates comparable to what would…
- Trial name
- NCT01060007
- Testing
- External beam radiation, Oxaliplatin, Leucovorin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
Nasopharyngeal Carcinoma
A Phase III Study of Radiotherapy With or Without Adjuvant C/T in Advanced Stage Nasopharyngeal Carcinoma Patients
To investigate the efficacy of adjuvant PFL chemotherapy after radiotherapy vs radiotherapy alone in AJC stage IV nasopharyngeal carcinoma patients.
- Trial name
- NCT00201344
- Testing
- Cisplatin,5-FU,Leucovorin
- Where
- Taiwan
- Volunteers
- 320 people
- Sponsor
- National Health Research Institutes, Taiwan
Colorectal Cancer
Chemotherapy With Raltitrexed and Fluorouracil in Treating Patients With Advanced Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002828
- Testing
- fluorouracil, raltitrexed
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreatic Cancer
A Study of TNFerade™ Biologic With 5-FU and Radiation Therapy for First-Line Treatment of Unresectable Locally Advanced Pancreatic Cancer
The primary purpose of this study is to assess the safety and effectiveness of TNFerade™ Biologic when administered concurrently with 5-FU and radiation therapy as first-line treatment of unresectable locally advanced pancreatic…
- Trial name
- NCT00051467
- Testing
- TNFerade
- Where
- 25 sites in United States
- Sponsor
- GenVec
Esophageal Cancer, Squamous Cell Carcinoma
Low-Dose Nedaplatin (CDGP:Cis-Diammine-Glycolatoplatinum)/5-FU Combined With Radiation for Esophageal Cancer
The purpose of this study is to clarify efficacy and toxicity of daily low-dose Nedaplatin (CDGP) and continuous infusion of 5-FU combined with radiation in patients with esophageal squamous cell carcinoma.
- Trial name
- NCT00197444
- Testing
- CDGP/5-FU combined with radiation, Radiotherapy
- Where
- Japan
- Volunteers
- 33 people
- Sponsor
- Hamamatsu University
Pancreatic Ductal Adenocarcinoma
Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer
Abbreviated Title: Neoadjuvant FOLFIRINOX combined with Pembrolizumab followed by surgery for patients with resectable pancreatic cancer Trial Phase: Phase II Clinical Indication: Pancreatic ductal adenocarcinoma; Adenocarcinoma…
- Trial name
- NCT05132504
- Testing
- Pembrolizumab, Folfirinox
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Rectal Cancer
Induction FOLFOX With or Without Aflibercept Followed by Chemoradiation in High Risk Locally Advanced Rectal Cancer
This trial compares induction treatment with FOLFOX with or without aflibercept in a high risk population selected by MRI, prior to receiving standard chemoradiation (capecitabine combined with 50.4 Gy in 28 days) and surgery, in…
- Trial name
- RIA (NCT02340949)
- Testing
- Aflibercept, 5-Fluoruracil, Oxaliplatin
- Volunteers
- 180 people
- Sponsor
- Grupo Espanol Multidisciplinario del Cancer Digestivo
Head and Neck Cancer, Lung Cancer
ATATcH Alternating Treatment Plans for Advanced Cancer
The purpose of the research is to evaluate a new schedule of alternating cycles of induction chemoimmunotherapy (chemotherapy plus pembrolizumab) and immunotherapy (pembrolizumab) alone for the initial treatment of patients with…
- Trial name
- NCT05358548
- Testing
- Paclitaxel, Pemetrexed, 5Fluorouracil
- Where
- 11 sites in United States
- Volunteers
- 150 people
- Sponsor
- Rutgers, The State University of New Jersey
Esophageal Cancer, Gastroesophageal Cancer
Oxaliplatin-Based Chemotherapy and Chemoradiotherapy or Chemoradiotherapy in Esophageal or Gastroesophageal Carcinoma
The goal of this clinical research study is to learn if a combination of the investigational drug oxaliplatin with 5-Fluorouracil (5-FU) (given at the same time as radiation therapy) is as effective as a combination of these two…
- Trial name
- NCT00525915
- Testing
- 5-Fluorouracil, Oxaliplatin, Radiation Therapy
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- M.D. Anderson Cancer Center
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