Clinical trials: 5-FU, completed
Penile Carcinoma
Pembrolizumab Combined With Cisplatin-based Chemotherapy as First-line Systemic Therapy in Advanced Penile Cancer
This is a phase II clinical trial evaluating activity, safety and patients reported outcomes of first-line pembrolizumab plus cisplatin (or carboplatin) plus 5-FU for patients with advanced penile squamous cell carcinoma.
- Trial name
- HERCULES (NCT04224740)
- Testing
- Pembrolizumab, Standard of care therapy
- Where
- 11 sites in Brazil
- Volunteers
- 37 people
- Sponsor
- Latin American Cooperative Oncology Group
Advanced Solid Tumors, Colorectal Cancer
A Phase 1/2 Study of CAN04 in Combination With Different Chemotherapy Regimens in Subjects With Advanced Solid Tumors
This is a Phase 1/2, open-label, multicentric, non-randomised, parallel-arm study that aims to establish the safety, tolerability, and initial efficacy of CAN04 in combination with 3 SoC chemotherapies (mFOLFOX, DTX, and G/C).
- Conditions
- Advanced Solid Tumors, Colorectal Cancer, Non Small Cell Lung Cancer, Biliary Tract Cancer
- Trial name
- NCT05116891
- Testing
- CAN04 (nadunolimab), mFOLFOX, DTX
- Where
- 6 sites in France, Spain
- Volunteers
- 40 people
- Sponsor
- Cantargia AB
Head and Neck
A Multicenter Study of Intensive Concomitant Chemoradiotherapy With Filgrastim (GCSF) for Patients With Locoregionally Advanced Head and Neck Cancer
The goal of the study is to test a particular combination of drugs and determine their ability to completely eliminate head and neck cancer.
- Trial name
- NCT01693718
- Testing
- Hydroxyurea, 5- Fluorouracil, Cisplatin
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Chicago
Rectal Cancer
Study of Therapeutic Targets Tailored Ch and IMRT as Neoadjuvant Treatment in Rectal Carcinoma Patients
The parameter that best correlates with 5 years disease-free survival (DFS ) in patients (pts) with localized rectal cancer (RC) is the pathological TNM staging (ypTNM) after chemo-radiotherapy (Ch-RT).
- Trial name
- TT (NCT01366118)
- Testing
- Therapeutic target tailored chemotherapy
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Grupo Hospital de Madrid
Esophagus Cancer
Advanced Oesophageal Cancer Study to Compare Quality of Life and Palliation of Dysphagia.
To compare the treatment of gullet cancer with radiotherapy alone and assess the advantage and toxicity of adding chemotherapy. The hypothesis to be tested is as follows: That the addition of chemotherapy to a short course of…
- Trial name
- NCT00193882
- Testing
- Cisplatin, Radiotherapy, 5-Fluorouracil
- Where
- 25 sites in Australia, Canada and 2 more
- Volunteers
- 220 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Colorectal Neoplasms, Neoplasm Metastasis
Treatment of Colorectal Liver Metastases With Immunotherapy and Bevacizumab
Liver is the most common site of metastases from colorectal cancer. Neoadjuvant chemotherapy with targeted agents is usually recommended for borderline-resectable liver metastases that are technically difficult to resect for…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Colonic Neoplasms, Rectal Neoplasms
- Trial name
- CLIMB (NCT03698461)
- Testing
- Atezolizumab, Bevacizumab, Oxaliplatin
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Rectal Adenocarcinoma
Neoadjuvant Chemoradiation With Bevacizumab for Chinese Rectal Cancer Patients
The purpose of the study is to evaluate the efficacy and safety of the combination of cytotoxic chemotherapy (Oxaliplatin and 5Fu) with bevacizumab concomitantly with radiotherapy as neoadjuvant treatment for patients with…
- Trial name
- New Beat (NCT01554059)
- Testing
- Bevacizumab, Oxaliplatin, 5-FU
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Metastatic Colorectal Cancer, Chemotherapy Effect
Rechallenge of Prior Regimen in Third or Later-line Chemotherapy in Metastatic Colorectal Cancer
This is a single-arm, open-label, single-center prospective phase II study to evaluate the efficacy and safety of rechallenge chemotherapy in the third or later-line treatment in patients with advanced colorectal cancer.
- Trial name
- NCT03485027
- Testing
- the rechallenge regimen
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Fudan University
Stage-Ⅱ Colorectal Cancer
Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer
Open- Label, Single Arm Study. To evaluate the safety profile of Orectalip® (oxaliplatin), fluorouracil and leucovorin as adjuvant therapy in the treatment of high-risk stage-Ⅱ colorectal cancer.
- Trial name
- Oxaliplatin (NCT02284529)
- Testing
- Orectalip
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Sinphar Pharmaceutical Co., Ltd
Keloidscars
Treatment of Keloidscars With Intralesional Triamcinolone and 5-fluorouracil Injections-prospective, Randomized, Controlled Trial - Pilot Study
The aim of study is examine the efficacy of intralesional 5-fluorouracil injections in keloid disease treatment.
- Trial name
- NCT02155439
- Testing
- 5-fluorouracil, Triamcinolone
- Where
- Finland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Cervical Cancer, CIN2
Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV
The purpose of this study is to explore whether an anti-cancer medication (5-fluorouracil cream) placed in the vagina after a surgical excision procedure is an acceptable and useful form of treatment for cervical precancer among…
- Conditions
- Cervical Cancer, CIN2, CIN3, Human Immunodeficiency Virus
- Trial name
- ACT 2 (NCT05413811)
- Testing
- 5 Fluorouracil (5 FU) Cream
- Where
- South Africa
- Volunteers
- 180 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Preoperative Epirubicin Paclitaxel Aranesp Study (PREPARE)
The present clinical trial will investigate the efficacy of a sequential interval-shortened and dose-intensified preoperative use of epirubicin, paclitaxel and CMF with preoperative sequential administration of epirubicin and…
- Trial name
- NCT00544232
- Testing
- Epirubicin, paclitaxel, cyclophosphamide, Methotrexate, 5 FU, darbepoetin alfa, Epirubicin, Cyclophosphamide, Paclitaxel, dabepoetin alfa
- Volunteers
- 720 people
- Sponsor
- GBG Forschungs GmbH
Biliary Tract Cancer
Phase Ib/II Trial of Nal-Irinotecan and Nivolumab as Second-Line Treatment in Patients With Advanced Biliary Tract Cancer
The purpose of this study is to test the effectiveness (how well the drug works), safety, and tolerability of the investigational drug combination of nivolumab plus nanoliposomal-irinotecan, 5-fluorouracil, and leucovorin for…
- Trial name
- NCT03785873
- Testing
- Nivolumab, Nanoliposomal-Irinotecan, 5-Fluorouracil
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan Rogel Cancer Center
Head and Neck Cancer
Optimized Intensity Modulated Irradiation for Head and Neck Cancer
The purpose of this study is to test whether the use of advanced radiation therapy delivery techniques can spare a patient's normal tissue, including salivary glands, from radiation.
- Trial name
- NCT00580983
- Testing
- IMRT, Paclitaxel, Carboplatin
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Michigan Rogel Cancer Center
Nasopharyngeal Carcinoma
Study to Evaluate Induction Chemotherapy Using Docetaxel, Cisplatin and Fluorouracil in Concurrence With Intensity-modulated Radiotherapy for Local Recurrent Nasopharyngeal Carcinoma (NPC)
Study Objective: Primary 1. To evaluate the complete response (CR) rate with induction chemotherapy using Docetaxel, Cisplatin and Fluorouracil(TPF) followed by Docetaxel plus Cetuximab (TC) in concurrence with…
- Trial name
- NCT01326559
- Testing
- Docetaxel, Cisplatin, 5-FU and Cetuximab
- Where
- 4 sites in China
- Volunteers
- 33 people
- Sponsor
- Hong Kong Nasopharyngeal Cancer Study Group Limited
Colorectal Cancer
Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003594
- Testing
- irinotecan, fluorouracil, leucovorin calcium
- Where
- 466 sites in United States, Canada and 2 more
- Volunteers
- 1,691 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Recurrent Colon Cancer, Recurrent Rectal Cancer
Radiolabeled Monoclonal Antibody Therapy, Combination Chemotherapy, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Radiolabeled monoclonal antibodies can find tumor cells and either kill them or carry tumor-killing substances to them without harming normal cells.
- Conditions
- Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV Colon Cancer, Stage IV Rectal Cancer
- Trial name
- NCT01205022
- Testing
- irinotecan hydrochloride, leucovorin calcium, fluorouracil
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- City of Hope Medical Center
Gastrointestinal Neoplasm
Debulking and Chemotherapy With or Without Intraperitoneal Chemotherapy to Treat Peritoneal Carcinomatosis
This study will determine which of the two following treatment regimens provides greater benefit to patients with peritoneal carcinomatosis (gastrointestinal cancer that has spread throughout the abdomen): Surgical removal of…
- Trial name
- NCT00052962
- Testing
- Cytoreductive surgery, Continuous hyperthermic peritoneal perfusion (HIPEC/CHPP)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Adenocarcinoma of the Rectum, Mucinous Adenocarcinoma of the Colon
Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer
Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Adenocarcinoma of the Rectum, Mucinous Adenocarcinoma of the Colon, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00100841
- Testing
- cetuximab, bevacizumab, oxaliplatin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- National Cancer Institute (NCI)
Esophageal Squamous Cell Carcinoma
Study on FOLFOX6 as First-line Therapy to Treat Recurrent or Metastatic Esophageal Cancer
The aim of this study is to explore whether FOLFOX6 as treatment could improve the time to progression (TTP) and overall survival (OS) of the patient with recurrent or metastatic esophagus.
- Trial name
- NCT01605305
- Testing
- FOLFOX6
- Volunteers
- 60 people
- Sponsor
- Fudan University
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