Clinical trials: Best Practice
Lung Carcinoma
Evaluating the Impact of a Virtually Supervised Exercise Intervention and Group Counseling on Inflammation and the Microbiome of Smokers at High Risk for Lung Cancer, BE FIT Trial
This phase II trial evaluates how a virtually supervised exercise intervention in combination with group counseling affects inflammation and the bacterial composition (microbiome) of the gut in smokers who are at high risk for…
- Trial name
- NCT06445192
- Testing
- Best Practice, Biospecimen Collection, Exercise Counseling
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Sarcopenia, Cirrhosis, Liver
Impact of Dietary Assessment and Intervention on Outcomes in Liver Cirrhosis Patients
Malnutrition and reduced muscle mass have been associated with poor outcomes in many disease conditions including severe inflammatory bowel disease, liver failure and cancers.
- Trial name
- NCT05259930
- Testing
- Amino MP9
- Where
- Ireland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Anxiety Disorders
Empowering Anxious Parents to Manage Child Avoidance Behaviors
Efforts to develop and disseminate evidence based practices (EBPs) for youth anxiety have made great strides. Still, up to 82.2% of youth who need mental health treatment for anxiety never access care or drop out prematurely…
- Trial name
- EMPOWER (NCT04453865)
- Testing
- Project EMPOWER, Online Resources and Referrals
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Delirium, Delirium in Old Age
Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation
The goal of this step-wedge trial is to test the implementation of daily nurse screening for delirium in routine care and its impact on outcomes and complications in hospitalized older adults admitted to 6 general…
- Conditions
- Delirium, Delirium in Old Age, Delirium With Dementia, Delirium Superimposed on Dementia
- Trial name
- READI-SET-GO (NCT05915377)
- Testing
- READI-SET GO UB-CAM delirium screening into EHR
- Where
- 2 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- Penn State University
Neonatal Respiratory Distress
Study of PREMEdication Before Laryngoscopy in Neonates in France
This study is a national prospective survey on practices of premedication before laryngoscopy in neonates. The survey will evaluate adequation to the French best practice guidelines to improve their dissemination and to identify…
- Trial name
- SUPREMEneo (NCT06356909)
- Testing
- Survey of sedo-analgesia practices before laryngoscopy
- Where
- France
- Volunteers
- 741 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Hip Osteoarthritis, Knee Osteoarthritis
Determining the Impact of a Physiotherapist-led Primary Care Model for Hip and Knee Pain - A Cluster Trial
This is a cluster randomized controlled trial to to evaluate the individual and health system impacts of implementing a new physiotherapist-led primary care model for hip and knee pain in Canada.
- Trial name
- NCT06358521
- Testing
- Physiotherapist-led primary care model for hip and knee pain, Usual physician-led primary care model for hip and knee pain
- Where
- Canada
- Volunteers
- 647 people, healthy volunteers welcome
- Sponsor
- Queen's University
Colorectal Carcinoma
Audio and Video Brochures for Increasing Colorectal Cancer Screening Among Adults Living in Appalachia
This clinical trial compares audio brochures and video brochures to usual care for increasing colorectal cancer (CRC) screening among adults living in Appalachia.
- Trial name
- NCT05810714
- Testing
- Best Practice, Fecal Immunochemical Test, Health Education
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Labor Stage, First, Prolonged Labor
Maternal Maneuvers During Prolonged Labor
This pilot, randomized control trial will test whether or not a specific circuit of position changes improves maternal outcomes in cases of prolonged labor.
- Trial name
- CIRCUIT (NCT06636149)
- Testing
- Circuit of maternal position changes during labor
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Washington University School of Medicine
External Causes of Morbidity and Mortality, Stillbirth
Linking Facility-based Mortality Audits With Community Engagement in Gilgit-Baltistan, Pakistan
Pakistan is one of the countries in South Asia where neonatal mortality rates remain stagnant. Babies born in Pakistan encounter the highest risk of dying; of every 1,000 babies born, 46 die before the end of their first month…
- Conditions
- External Causes of Morbidity and Mortality, Stillbirth, Neonatal Death
- Trial name
- NCT03904706
- Testing
- Audits only, Audits with community feedback
- Where
- Pakistan
- Volunteers
- 1,871 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Urinary Tract Infection, Acute Pyelonephritis
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults
This is an open-label, randomized, multi-center, interventional, active-controlled Phase 4 study to evaluate the efficacy and safety of CAZ-AVI versus BAT in the treatment of infected participants with selected infection types…
- Conditions
- Urinary Tract Infection, Acute Pyelonephritis, Hospital Acquired Pneumonia, Ventilator-associated Pneumonia
- Trial name
- NCT04882085
- Testing
- Zavicefta, Ceftazidime-Avibactam, Best Available Treatment
- Where
- 37 sites in China
- Volunteers
- 60 people
- Sponsor
- Pfizer
Breast Cancer
A Study of Cardiac Safety in Patients With HER2 Positive Early Breast Cancer Treated With Herceptin
This is a single cohort observational safety study. All patients will be treated and monitored according to the local clinical practice.
- Trial name
- NCT01152606
- Testing
- trastuzumab [Herceptin]
- Where
- 205 sites in Austria, Belgium and 7 more
- Volunteers
- 3,942 people
- Sponsor
- Hoffmann-La Roche
Wound, Re-Epithelialization
Phenytoin in the Healing of Clean Surgical Wounds
The purpose of this study is to investigate the potential healing properties of phenytoin. The investigators will use the donor site of a split skin thickness graft (SSTG) to model a basic wound in a randomized controlled trial…
- Trial name
- NCT02413658
- Testing
- Phenytoin, Sugar solution
- Where
- Cambodia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Surgical Center, Cambodia
Bladder Carcinoma, Genitourinary System Neoplasm
Light Therapy and Occupational Therapy Fatigue Management-Based Intervention for Patients With Genitourinary Cancers
This clinical trial evaluates light therapy and occupational therapy in improving cancer related fatigue (CRF) patients with genitourinary cancers.
- Conditions
- Bladder Carcinoma, Genitourinary System Neoplasm, Kidney Carcinoma, Prostate Carcinoma
- Trial name
- NCT05519878
- Testing
- Best Practice, Bright White Light Therapy, Occupational Therapy
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- City of Hope Medical Center
Pancreatic Neoplasms
Phase 2 Nab® -Paclitaxel (Abraxane®) Plus Gemcitabine in Subjects With Locally Advanced Pancreatic Cancer (LAPC)
This clinical study is in subjects who are 18 years old or older with locally advanced pancreatic cancer who have not received prior treatment for their pancreatic cancer.
- Trial name
- LAPACT (NCT02301143)
- Testing
- nab-Paclitaxel, Gemcitabine, Chemoradiation
- Where
- 42 sites in United States, Canada and 3 more
- Volunteers
- 107 people
- Sponsor
- Celgene
Stroke, Acute
Endovascular Acute Stroke Intervention Trial - the EASI Trial
Stroke constitutes the primary cause of acquired disability in adults and the second cause of dementia following Alzheimer disease.
- Trial name
- EASI (NCT02157532)
- Testing
- mechanical thrombectomy, Best standard treatment
- Where
- 2 sites in Canada
- Volunteers
- 480 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
HIV, Malnutrition
Shamba Maisha: Pilot Agricultural Intervention for Food Security and HIV Health Outcomes in Kenya
This pilot study aims to determine whether an agricultural intervention will improve food security, prevent treatment failure, reduce co-morbidities, and decrease secondary HIV transmission risk among people living with HIV/AIDS.
- Trial name
- Shamba (NCT01548599)
- Testing
- Multi-sectoral agricultural intervention
- Where
- 2 sites in Kenya
- Volunteers
- 140 people
- Sponsor
- University of California, San Francisco
Opioid Use
24-hour Oral Morphine Equivalent Based Opioid Prescribing After Surgery
The investigators will utilize the electronic health record to individualize pain therapy in surgical patients after hospital discharge using last 24-hour opioid intake as the decision variable for the amount of opioid pain pills…
- Trial name
- NCT04043143
- Testing
- Arm 1 Prescription As Usual, Arm 2 Prescription Tool Intervention
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Colorado, Denver
Healthy Subject
HPV Vaccine Intervention for Young Sexual Minority Men
This phase III trial studies how well the Outsmart HPV intervention works in increasing HPV vaccine initiation and completion among young individuals who report having a history of same-sex partners, being sexually attracted to…
- Trial name
- NCT04032106
- Testing
- Best Practice, Informational Intervention, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 1,227 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colorectal Carcinoma
CoGENES Randomized Controlled Trial (RCT)
This clinical trial evaluates the effectiveness of trained community engagement specialists for improving communication on colorectal cancer (CRC) prevention and genetic testing among Hispanic/Latino/a/x (H/L) communities.
- Trial name
- NCT07229443
- Testing
- Best Practice, Health Promotion and Education, Survey Administration
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Severe Obesity, Renal Failure
Obesity Surgery and Kidney Transplant for Patients With Obesity and Renal Failure
Gastric Bypass followed by renal transplantation is superior to medical management followed by renal transplant for patients with severe obesity and renal failure.
- Trial name
- NCT02128802
- Testing
- Gastric Bypass, Weight Loss Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center