Clinical trials: Botulinum toxin type A
Muscle Spasticity, Stroke
Long-Term Study of OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity
This is a long-term safety and efficacy study of onabotulinumtoxinA in poststroke patients with upper limb spasticity.
- Trial name
- NCT02145689
- Testing
- onabotulinumtoxinA
- Sponsor
- Allergan
Bruxism
Botulinum Toxin-A for Bruxism Using Digital Occlusal Analysis
Bruxism is a repetitive jaw-muscle activity that may lead to tooth wear, muscle pain, headaches, and functional limitations. Current diagnostic approaches mainly rely on self-reported symptoms and clinical examination findings…
- Trial name
- NCT07640035
- Testing
- Botulinum Toxin-A injection
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Overactive Bladder
Efficacy and Safety of Botulinum Toxin A for the Treatment of Refractory Overactive Bladder.
Overactive bladder induce urgency, urge incontinence, nocturia and pollakiuria. This condition is often resistant to anticholinergic drugs used as a first line treatment for this purpose.
- Trial name
- NCT00231491
- Testing
- Botulinum Toxin A (Botox )
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Spasticity as Sequela of Stroke
Radial Extracorporeal Shock Wave Therapy as an Adjunct to Botulinum Toxin Type A for Post-Stroke Lower Limb Spasticity (SOLUTION)
The goal of this pilot clinical trial is to determine whether radial extracorporeal shock wave therapy (rESWT), when used as an adjunct to ultrasound-guided botulinum toxin type A (BoNT-A) injections, can enhance the therapeutic…
- Conditions
- Stroke, Spasticity as Sequela of Stroke, Lower Limb Spasticity, Upper Motor Neuron Syndrome
- Trial name
- SOLUTION (NCT07875868)
- Testing
- Radial shock Wave therapy (3000 pulses, 5 Hz, 2.5 bar)., Ultrasound-guided abobotulinumtoxin A
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Parc de Salut Mar
Overactive Bladder Syndrome
Use of Repris Needle in Bladder Injection
Treatment of overactive bladder (OAB) has been treated successfully by the injection of Botox. The Repris injection needle has a deflection that may assist in injection difficult to reach with standard straight needles.
- Trial name
- NCT04982120
- Testing
- Repris Needle
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Uro-1 Medical
Upper Limb Spasticity
Randomised, Evaluation-blinded, Crossover, Controlled Study Assessing Dynamic Hand Splinting in Adults With Post-stroke Hemiplegia (Orthox)
Upper limb spasticity is currently mainly managed with local toxin treatments. Recent studies suggested combining botulinum toxin injections with splinting to optimise rehabilitation in spastic patients.
- Trial name
- ORTHOX (NCT02888548)
- Testing
- botulinum toxins (Dysport°) alone, orthosis (Saebo Strech°) + botulinum toxins (Dysport°) combined
- Where
- France
- Volunteers
- 1 people
- Sponsor
- CHU de Reims
Muscle Spasticity
CORETOX® in Treatment of Post Stroke Upper Limb Spasticity (Phase1)
The purpose of this study is to evaluate the safety and pharmacodynamic of CORETOX® in the treatment of post-stroke upper limb spasticity
- Trial name
- NCT05164003
- Testing
- CORETOX®, BOTOX®
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Medy-Tox
Cerebral Palsy
Music Therapy During Botulinum Injections
The primary objectives for this study are: 1. To demonstrate that music therapy can be an effective means of procedural support for children undergoing botox injections. 2.
- Trial name
- NCT00178217
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Rochester
Cervical Dystonia
Physiotherapy and Botox for Cervical Dystonia: Impact of Sensory Tricks and Brain Imaging Insights
The primary aim of this study is to investigate improvements of dystonia severity in patients with cervical dystonia (CD) with (DYT-trick) and without sensory trick (DYT-no-trick) following 6 weeks of physiotherapy combined with…
- Trial name
- NCT06881147
- Testing
- Multimodal physiotherapy program
- Where
- Italy
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Hand-burned Children
Comparative Study Between Botulinum Toxin-A Injection and Shock Waves on Hypertrophic Scars in Hand-burned Children
PURPOSE: The study aims to compare study between Botulinum toxin-A injection and shock waves therapy on hypertrophic scars in hand-burned children.
- Trial name
- NCT06174155
- Testing
- physical therapy treatment, Botulinum toxin-A injection in addition to physical therapy program, shock wave therapy in addition to physical therapy program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Overactive Bladder, Overactive Detrusor
Minimizing Pain During Office Intradetrussor Botox Injection
This will be a prospective double-blinded randomized controlled trial comparing two pre-treatment protocols for patients undergoing intradetrussor botox injections to determine if a buffered lidocaine solution offers superior…
- Conditions
- Overactive Bladder, Overactive Detrusor, Overactive Bladder Syndrome, Overactivity; Behavior
- Trial name
- NCT04270526
- Testing
- Bicarbonate protocol, Standard protocol
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Boston Urogynecology Associates
Stomach Neoplasms
Botulinum Toxin for Stomach Cancer Treatment
Preclinical studies at our institution, using a genetic mouse model of gastric cancer, strongly suggest that innervation of the stomach wall is required not only for the development, but also for the progression of gastric…
- Trial name
- NCT01822210
- Testing
- Botox
- Where
- Norway
- Volunteers
- 7 people
- Sponsor
- St. Olavs Hospital
Glabellar Frown Lines
Clinical Trial to Evaluate the Efficacy and Safety of MBA-P01 in Treatment of Glabellar Lines
This study will determine the effect of MBA-P01 in subjects with glabellar lines at a range of doses compared with placebo. This study includes two treatment period; 1) Dose-ranging period, Day0 to 16weeks and 2) Open-label…
- Trial name
- NCT04143815
- Testing
- MBA-P01 (Botulinum toxin A)
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Medy-Tox
Stroke, Hemiplegia, Spastic
The Effect of Extracorporeal Shock Wave Therapy After Botulinum Toxin Type A Injection for Post-stroke Spasticity
There are few studies on whether botulinum toxin treatment and extracorporeal shock wave therapy are more effective than botulinum toxin alone treatment for post-stroke spasticity.
- Conditions
- Stroke, Hemiplegia, Spastic, Muscle Spasticity
- Trial name
- NCT05889026
- Testing
- Extracorporeal shock wave therapy, Botulinum toxin treatment
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Korea University Guro Hospital
Lower Back Pain
Investigation of Efficacy of Botulinum Toxin A (Dysport) in Chronic Low Back Pain
The scientific aim of this study is to investigate the efficacy of abobotulinumtoxinA (Dysport - Ipsen Pharmaceuticals) in chronic low back pain.
- Trial name
- NCT02221648
- Testing
- AbobotulinumtoxinA Treatment
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Yale University
Depression
The Treatment of Depression With Botulinum Type A Toxin
A 24-week Randomized, Double-blind study treating people who suffer from depression who also have moderate to severe frown lines in forehead region with Botox injections.
- Trial name
- NCT01392963
- Testing
- botulinum toxin type A neurotoxin complex
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seton Healthcare Family
Myofascial Pain, Temporomandibular Disorder
Occlusal Splints or Botulinum Toxin?
73 patients with myofascial pain due to bruxism were included in this study. The patient were allocated into three groups. Group A was treated with occlusal splint, Group B was treated with botulinum toxin injection, Group C was…
- Trial name
- NCT03891121
- Testing
- Occlusal Splint, Botulinum toxin type A
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Ankara University
Cerebral Palsy and Botulinum Toxin
Spread And Effectiveness Of Botulinum Neurotoxin A In Spastic Equinus In Cerebral Palsy
Objectives. To study the short-term neurophysiological and clinical outcome of botulinum toxin type A(BoNT-A), injected at standard doses, and assess toxin spread to neighboring uninjected muscles in children with cerebral palsy.
- Trial name
- NCT01276015
- Testing
- Botulinum Toxin Type A
- Volunteers
- 18 people
- Sponsor
- Universita di Verona
Glabellar Frown Lines
Study to Demonstrate Safety and Duration of Effect of 40 Units of PrabotulinumtoxinA-xvfs to Treat Glabellar Lines
The purpose of this study is to demonstrate the safety and duration of effect of 40 Units of prabotulinumtoxinA-xvfs (Jeuveau®) in providing temporary improvement in the appearance of moderate to severe glabellar lines (frown…
- Trial name
- NCT05320393
- Testing
- PrabotulinumtoxinA-Xvfs, OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Evolus, Inc.
Overactive Bladder
Botox for the Treatment of Overactive Bladder Secondary to Benign Prostatic Obstruction
This is a prospective, randomized, double-blind study comparing intravesical injection of BOTOX to placebo. Study subjects will be randomized (1:1 ratio) to one of the following treatment groups:
- Trial name
- NCT01220726
- Testing
- Botox
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
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