Clinical trials: Botulinum toxin type A
Facial Rhytides, Glabellar Rhytides
A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides
This is a safety and efficacy study of onabotulinumtoxinA in subjects with upper facial rhytides (forehead lines, glabellar lines, lateral canthal lines [crow's feet lines]).
- Trial name
- NCT02261493
- Testing
- OnabotulinumtoxinA, Normal Saline
- Where
- 24 sites in United States, Belgium and 2 more
- Volunteers
- 787 people
- Sponsor
- Allergan
Spasticity
Effectiveness of an Interprofessional Approach to the Treatment of Spasticity With Botulinum Toxin & Non-pharmacological Therapies
Many people with neurological conditions will experience spasticity, a nonvolitional and uncontrollable tightening and/or spasm of muscles.
- Trial name
- NCT07160699
- Testing
- Botulinum Neurotoxin Type A, Non-pharmacological therapies
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Technical University of Bern
Stroke, Spasticity
Early Injection of Botulinum Toxin on Motor Function and Gait Pattern in Stroke Patients
Spasticity, muscle weakness, abnormal gait pattern are co-morbidities commonly seen in stroke patients. They cause disabled condition of patients in activities of daily life and functional performance, and also accidental falls…
- Trial name
- NCT01817816
- Testing
- Botox_A, Botox_B
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Changhua Christian Hospital
Overactive Bladder
Instillation of Botox in the Bladder in Women With Overactive Bladder (OAB)
Instillation treatment with onabotulinumtoxin A (BOTOX®) in the urinary bladder
- Trial name
- NCT02735499
- Testing
- onabotulinum toxin A
- Where
- Norway
- Volunteers
- 14 people
- Sponsor
- The Hospital of Vestfold
Dislocation of Temporomandibular Joint TMJ, Subluxation of Temporomandibular Joint
Assessment of Botulinum Toxin Injection for Treatment of Temporomandibular Joint Dislocation
Assessment of the effect of Botulinum toxin injection on the frequency of luxation and TMJ Pain in patients with TMJ dislocation either chronic recurrent dislocation or subluxation
- Trial name
- NCT05863286
- Testing
- Botulinum toxin type A
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postherpetic Neuralgia
A Study Evaluating Botulinum Toxin Type A in Subjects With Postherpetic Neuralgia
4-month study including a 30-day baseline phase
- Trial name
- NCT00168441
- Testing
- Botulinum Toxin Type A
- Volunteers
- 117 people
- Sponsor
- Allergan
Parkinson's Disease, Neurogenic Bladder
Safety and Efficacy of botulinumA Toxin (BotoxA) for Treatment of Neurogenic Bladder of Parkinson's Disease
The basic nerve deficit of Parkinson's disease (PD) leads to lower urinary tract symptoms of frequency, urgency and urge urinary incontinence. Lower urinary tract symptoms tend to occur at more advanced stages of PD.
- Conditions
- Parkinson's Disease, Neurogenic Bladder, Urinary Incontinence, Clostridium Botulinum Toxin Adverse Reaction
- Trial name
- NCT01421719
- Testing
- Cystoscopic injection of Botox into the urinary bladder
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Piriformis Muscle Syndrome
Efficacy of Botulinum Toxin Versus Placebo on Pain and Health Related Quality of Life of Patients With Piriformis Muscle Syndrome
Piriformis muscle syndrome (PMS) is characterized by symptoms caused by compression or irritation of the sciatic nerve by the piriformis muscle as it exits the sciatic notch.
- Trial name
- PiriTox (NCT07624045)
- Testing
- Botulinum Toxin - A injections
- Where
- 7 sites in France
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Excessive Gingival Display
Decision Regret Following Yonsei-Point Botulinum Toxin for Gummy Smile
This study evaluates patient-reported decision regret in adult patients who previously received standardized Botulinum Toxin Type A (BoNT-A) injection at the Yonsei Point for excessive gingival display (gummy smile).
- Trial name
- NCT07874022
- Testing
- Botulinum Toxin Type A injection at Yonsei Point
- Where
- 2 sites in Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Myofascial Pain Syndrome (MPS), Masticatory Muscle Pain
EMG-Based Evaluation of Occlusal Splint and Masseter Botox Effects on Head and Neck Muscles
This randomized controlled clinical trial aims to evaluate the individual and combined effects of occlusal splint therapy and botulinum toxin type A (BTX-A) injections into the masseter muscle on the activity of head and neck…
- Trial name
- NCT07082972
- Testing
- Botulinum toxin injection, Occlusal splint, Botulinum toxin + Occlusal splint combined
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Istanbul University
Myofascial Pelvic Pain
Botulinum Toxin Type A Versus Saline Trigger Point Injections for Myofascial Pelvic Pain
The purpose of this study is to determine whether there is a change in patient-reported pelvic pain following pelvic floor injections of 200 units of Botox compared with 20cc of normal saline.
- Trial name
- NCT01905137
- Testing
- Intervention-Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston Urogynecology Associates
Migraine Headaches
Prospective, Multi-Center Evaluation of the Efficacy of Peripheral Trigger Decompression Surgery for Migraine Headaches
According to the peripheral trigger theory of migraine headaches, nociceptive inputs from irritated or compressed cranial nerve branches can lead to neurovascular changes in the brain that cause migraine headaches.
- Trial name
- NCT02351544
- Testing
- Botulinum Toxin Type A, Surgery, Daily headache diary
- Where
- 6 sites in United States
- Volunteers
- 44 people
- Sponsor
- Ohio State University
Parkinson Disease
Botulinum Toxin Type A (Botox) in the Management of Levodopa-Induced Peak-Dose Dyskinesias in Parkinson's Disease
The primary objective of this study is to determine whether intramuscular injections of botulinum toxin type A (Botox®) in selected cervical muscles at antidystonic dosages can reduce levodopa-induced peak-dose dyskinesias (LID)…
- Trial name
- NCT00477802
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Cincinnati
Migraine
OnaBotulinumtoxin-A in Chronic Migraine Patients With Short or Long Disease History (the BACH Study)
The goal of this observational prospective multicentric study, 12 months duration is to investigate whether the history of Chronic Migraine and, more precisely, its duration for over or less than 10 years, can predict OBT-A…
- Trial name
- BACH (NCT06537700)
- Testing
- OnabotulinumtoxinA OBT-A
- Where
- 6 sites in Italy
- Volunteers
- 115 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Endometriosis, Chronic Pelvic Pain
Botulinum Toxin for Pelvic Pain in Women With Endometriosis
Background: Some women with endometriosis have chronic pelvic pain. This pain may be caused by spasms of the pelvic floor muscles. These spasms can be detected by an examination.
- Conditions
- Endometriosis, Chronic Pelvic Pain, Pelvic Muscle Spasm, Quality of Life
- Trial name
- NCT01553201
- Testing
- Botulinum toxin (BoNT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Orthognathic Relapse
Effect of Botox Injection in Anterior Belly of Digastric on Skeletal Relapse Following Mandibular Advancement Surgery
The purpose of this study is to test whether Botox injection in anterior belly of digastric muscle in BSSO for mandibular advancement surgery could reduce the tendency of postoperative relapse.
- Trial name
- NCT05573581
- Testing
- Botox
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Glabellar Lines, Forehead Lines
A Prospective, Non-Interventional, Single-Centre Study Assessing the Efficacy of a Holistic Upper Face Treatment With Botulinum Neurotoxin A
The goal of this observational study is to learn about the safety, tolerability, and effectiveness of Letibotulinumtoxin A for the holistic treatment of the upper face in adults under 75 years old with moderate to severe upper…
- Conditions
- Glabellar Lines, Forehead Lines, Crow's Feet, Canthal Lines
- Trial name
- NCT07374965
- Testing
- Letybo®
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yuvell
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Vulvodynia
Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareuni and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT04057755
- Testing
- botulinum toxin A, NaCl
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Equinovarus; Acquired
Assessment of Gait After Dysport Treatment
This pilot study will aim to understand the potential benefit of the assessment of walking using video slow motion for muscle selection and the development of an image catalogue guide of the potential results of injection of…
- Trial name
- NCT03501043
- Testing
- Dysport
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Albert Einstein Healthcare Network
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