Clinical trials: Bupivacaine
Breast Cancer Female
PEMF and PEC Blocks in Mastectomy Reconstruction Patients
This is a prospective randomized controlled double-blind interventional study comparing the effect of pulsed-electromagnetic field device (PEMF), pectoral interfascial block (PIB), and placebo on postoperative pain control.
- Trial name
- NCT03360214
- Testing
- Bupivacaine Hydrochloride, Pulsed Electromagnetic Field (PEMF) Device, Ropivacaine Hydrochloride
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
PAIN
Postoperatory Analgesia After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a worldwide realized procedure, with 600.000 surgeries performed per year in the United States, with a 673% increase estimated until 2030.
- Trial name
- PAINCONTROL (NCT01700517)
- Testing
- Spinal anesthesia, Femoral nerve block, sciatic nerves block
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital Madre Teresa
Internal Derangement of Knee
Infrapatellar Nerve Block for Post-operative Knee Arthroscopy Pain Control
The purpose of this study is to determine whether infrapatellar branch of the saphenous nerve blocks are effective in decreasing analgesic use, promoting earlier mobility, and improving long term outcome scores after knee…
- Trial name
- NCT01279447
- Testing
- 0.25% Bupivacaine, Normal Saline
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hemorrhoids
Study to Evaluate Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy
Effective postoperative pain control to promote improved healing, faster patient mobilization, shortened hospital stays, and reduced healthcare costs.
- Trial name
- NCT00744848
- Testing
- Bupivacaine HCl, SKY0402
- Where
- 20 sites in United States
- Volunteers
- 204 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Foot and Ankle Procedures
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
The purpose of this research study to evaluate the effects of dexamethasone as an addition to peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on length of pain relief (analgesia)…
- Trial name
- NCT01975285
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Migraine
Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine
Migraine imposes a substantial burden on patients in terms of diminished daily functioning, quality of life, and financial loss.
- Trial name
- Tx360 (NCT01709708)
- Testing
- Marcaine, Saline
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Tian Medical Inc.
Postoperative Pain
PK and Safety After C-Section
The main goal of the study was to measure the amount of the active ingredients and other components of HTX-011 in plasma and expressed breast milk over time following postpartum administration in women undergoing a planned…
- Trial name
- NCT03955211
- Testing
- HTX-011, ZYNRELEF kit components for administration, MMA regimen
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Heron Therapeutics
Osteoarthritis of Hip, Regional Anesthesia
Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement
The purpose of this research study is to evaluate the analgesic efficacy of adding a single shot parasacral (sciatic) nerve block to a continuous lumbar plexus block in patients undergoing total hip replacement.
- Conditions
- Osteoarthritis of Hip, Regional Anesthesia, Other Acute Postoperative Pain, Total Hip Arthroplasty
- Trial name
- NCT02161484
- Testing
- Continuous Lumbar Plexus Block, Parasacral Nerve Block, Ropivacine 0.2%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rita Merman
Full Thickness Rotator Cuff Tear, Rotator Cuff Tendinitis
Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial
The purpose of this study is to compare the functional outcomes of patients with shoulder pathology treated with either ketorolac or corticosteroid injections, in a randomized double-blinded study.
- Trial name
- NCT04115644
- Testing
- Ketorolac, Kenalog
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Michael Khazzam
Postoperative Pain
Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty
The primary objectives of Part 1 are to (1) evaluate three dose levels of liposome bupivacaine versus placebo with respect to the magnitude and duration of the analgesic effect achieved following single dose injection femoral…
- Trial name
- NCT01683071
- Testing
- EXPAREL 67 mg, EXPAREL 133 mg, EXPAREL 266 mg
- Where
- 30 sites in United States
- Volunteers
- 297 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Opioid Use, Pain, Postoperative
Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery
Enhanced recovery pathways (ERPs) emphasize evidence-based, multimodal anesthetic and analgesic choices to minimize opioid consumption while providing adequate pain control after surgery.
- Trial name
- ESPB-Spine (NCT04156581)
- Testing
- Bupivacaine, Dexamethasone, Saline
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Hospital for Special Surgery, New York
Anterior Cruciate Ligament Reconstruction, Regional Anesthesia, Saphenous Nerve Block
Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Reconstruction
For patients undergoing Anterior Cruciate Ligament reconstruction surgery, the postoperative period can be a painful experience without adequate pain management.
- Trial name
- NCT01586806
- Testing
- Bupivacaine Only, Bupivacaine with 1 mg of Dexamethasone, Bupivacaine with 4 mg of Dexamethasone
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Hospital for Special Surgery, New York
Postoperative Pain
Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia
This is a Phase 2b, randomized, double-blind, saline placebo- and active-controlled, multicenter study in subjects undergoing primary unilateral total knee arthroplasty (TKA) to evaluate the analgesic efficacy, safety, and…
- Trial name
- NCT03015532
- Testing
- HTX-011, Bupivicaine HCl, Ropivacaine
- Where
- 24 sites in United States
- Volunteers
- 285 people
- Sponsor
- Heron Therapeutics
Shoulder Impingement Syndrome
Physical Therapy Versus Steroid Injection for Shoulder Impingement Syndrome
The purpose of this study is to evaluate and compare the short and long-term effectiveness of two common interventions, manual physical therapy versus corticosteroid injection, for the treatment of shoulder impingement syndrome.
- Trial name
- NCT01190891
- Testing
- Manual Physical Therapy, Corticosteroid Injection
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Madigan Army Medical Center
Hip Disease
Evaluation of Anterior Quadratus Lumborum Block for Postoperative Analgesia in Hip Arthroscopy
Hip arthroscopy is performed frequently and the postoperative course often involves moderate to severe pain. There remains no definitive perioperative pain regimen that has been proven to be effective and safe for this ambulatory…
- Trial name
- NCT03432650
- Testing
- Bupivacaine + dexamethasone, Ultrasound
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Hospital for Special Surgery, New York
Femoral Fractures
Effects of Liposomal Bupivacaine for Acute Pain in Hip and Femur Fractures
This is an investigator-initiated, single-center, randomized, patient blinded, controlled trial. The purpose of this study is to compare the effect of a fascia iliaca compartment block (FICB) using 0.2% ropivacaine vs.
- Trial name
- NCT02679560
- Testing
- Liposomal Bupivacaine, Ropivacaine HCL
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Ian Elliott Brown
Erectile Dysfunction
Randomized Trial of Ropivacaine & Bupivacaine for Inflatable Penile Prosthesis
The purpose of this research is to determine the effects of penile ring block for local anesthesia with liposomal bupivacaine vs ropivacaine mixture in subjects undergoing surgery for Penile Prosthesis Placement.
- Trial name
- ROVEX-IPP (NCT04801368)
- Testing
- Randomization of two local anesthetics.
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Coronary Artery Disease, Sternal Pain
Pecto-Intercostal Fascial Block for Postoperative Analgesia After Cardiac Surgery
The purpose of this study is to determine whether administration of a pecto-intercostal fascial plane block (PIFB) with bupivacaine is a more effective therapy for postoperative analgesia after cardiac surgery as compared to…
- Trial name
- NCT03482973
- Testing
- Bupivacaine Group
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Beth Israel Deaconess Medical Center
General Anesthesia, Propofol Target-controlled Infusion
Effects of Epidural Local Anesthetics on Propofol Induction
The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.
- Conditions
- General Anesthesia, Propofol Target-controlled Infusion, Thoracic Epidural Anesthesia
- Trial name
- NCT02000973
- Testing
- Lidocaine, Bupivacaine, Ropivacaine
- Volunteers
- 80 people
- Sponsor
- First Hospital of China Medical University
Postoperative Pain
A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty
The primary objective is to demonstrate that SKY0402 is superior when compared to bupivacaine HCl in the management of postoperative pain for patients undergoing total knee arthroplasty.
- Trial name
- TKA (NCT00745290)
- Testing
- Bupivacaine HCl, SKY0402
- Where
- 19 sites in United States
- Volunteers
- 245 people
- Sponsor
- Pacira Pharmaceuticals, Inc