Clinical trials: Buprenorphine
Opioid-Related Disorders
Methadone/Buprenorphine Cross-Over Study - 4
The purpose of this study is to explore ways to cross patients over from methadone to buprenorphine.
- Trial name
- NCT00000208
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Postoperative Pain
Prolonged Popliteal Fossa Nerve Blockade (Prolonged Pop)
This study looks at addition of medications to the local anesthetic for the nerve blockade.
- Trial name
- NCT02198235
- Testing
- Dexamethasone, Buprenorphine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Hospital for Special Surgery, New York
Major Depressive Disorder
A Study of ALKS 5461 for Treatment Refractory Major Depressive Disorder (MDD)
This study will evaluate the efficacy, safety, and tolerability of adjunctive ALKS 5461 in adults who have treatment refractory MDD.
- Trial name
- NCT03188185
- Testing
- ALKS 5461
- Where
- 35 sites in United States, Australia and 1 more
- Volunteers
- 278 people
- Sponsor
- Alkermes, Inc.
Compliance, Chronic Pain
Evaluation of a Compliance Marker in Prescription Opioid Abusers With Chronic Pain
In a small, well-characterized sample of prescription opioid abusers (POAs) with chronic pain and on buprenorphine therapy, this study will investigate the utility and feasibility of two novel tracer compounds, and in combination…
- Trial name
- NCT02276989
- Testing
- acetazolamide, Quinine, Riboflavin
- Where
- United States
- Sponsor
- Georgetown University
Drug; Withdrawal Symptoms, Neonatal, Withdrawal
Sublingual Buprenorphine Treatment for Neonatal Abstinence Syndrome - Pilot Study
Summary: There have been two published RCTs showing efficacy of buprenorphine treatment for NAS. However these trials excluded an estimated 22-47% of infants requiring pharmacologic treatment; those infants born to mothers with…
- Conditions
- Drug; Withdrawal Symptoms, Neonatal, Withdrawal, Fetus and Newborn Affected by Other Maternal Medication
- Trial name
- NCT02249026
- Testing
- BZDs + opiate exposure treated with BPN, Opiates exposure treated with BPN
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Gauda, Estelle B., M.D.
Opioid-maintained Pregnant Women
Neonatal and Maternal Effects of Buprenorphine and Methadone
In this retrospective chart review, the investigators plan to analyze the effects of buprenorphine compared to methadone in opioid-maintained pregnant women.
- Trial name
- NCT03024736
- Testing
- buprenorphin
- Volunteers
- 40 people
- Sponsor
- St. Louis University
HIV Infections, Substance Use Disorders
Peer Supported Collaborative Care Mental Health and Substance Use Disorder Care
This is a research study to assess the effectiveness of a peer-led collaborative care model for integrating treatment for substance use and or mental health disorders into HIV care settings.
- Conditions
- HIV Infections, Substance Use Disorders, Mental Health Disorder, Addiction
- Trial name
- NCT04601064
- Testing
- Collaborative Care Model
- Where
- United States
- Volunteers
- 405 people
- Sponsor
- Johns Hopkins University
Shoulder Arthroplasty
Interscalene Block With Liposomal Bupivacaine vs. Interscalene Block With Bupivacaine and Adjuvants
The purpose of this study is to determine whether the use of plain bupivacaine with common adjuvants for interscalene block (ISB) provides non-inferior analgesic results compared to the use of liposomal bupivacaine for ISB, in…
- Trial name
- NCT03845894
- Testing
- Liposomal bupivacaine, Bupivacaine with adjuvants
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Opiod Use Disorder
Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System
This study, called the Chicago Data-driven Opioid use disorder Screening, Engagement, Treatment and Planning (C-DOSETaP) System, tests a new system of clinical care for patients with opioid use disorder (OUD) across a large…
- Trial name
- C-DOSETaP (NCT07498322)
- Testing
- OUD screening, MOUD, Continuity of care
- Where
- United States
- Volunteers
- 271,031 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Healthy
Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations (Protocol ID: 855509)
The purpose of this study is to determine whether two different analgesic transdermal patch formulations lead to same plasma levels of active ingredient after multiple dose application.
- Trial name
- NCT00469053
- Testing
- Buprenorphine
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Clinical Decision Support, Buprenorphine
Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD
Emergency Departments (EDs) frequently care for individuals with Opioid Use Disorder (OUD). Buprenorphine (BUP) is an effective treatment option for patients with OUD that can safely be initiated in the ED.
- Conditions
- Clinical Decision Support, Buprenorphine, Opioid-use Disorder
- Trial name
- EMBED (NCT03658642)
- Testing
- Clinical Decision Support (CDS)
- Where
- 22 sites in United States
- Volunteers
- 5,047 people
- Sponsor
- Yale University
Food Security
Food Insecurity and Eating Behavior Among Adults Receiving Buprenorphine or Methadone Maintenance Treatment: Pilot Study 2
The goal of this study is to evaluate the effects of a novel, mail-based meal delivery intervention among individuals receiving MOUD on household food security status.
- Trial name
- NCT07251283
- Testing
- NE + Meal Delivery (NE+MD) intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Vermont
Chronic Pain, Cancer Survivor
Better Options for Chronic Cancer Pain
This proposal is relevant to the 240,000 cancer survivors who continue to use opioids long after they have successfully completed treatment for cancer at the VHA, placing them at risk of opioid addiction and overdose, and other…
- Conditions
- Chronic Pain, Cancer Survivor, Opioid Dependence
- Trial name
- NCT06574009
- Testing
- Multimodal pain care, Medication optimization, Buprenorphine rotation
- Where
- 2 sites in United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Heroin Dependence, Opioid-Related Disorders
Treatment Study: Reducing Cocaine/Heroin Abuse With SR-Amphetamine and Buprenorphine (ARC)
This research study takes place at Wayne State University and will take about 11 weeks to complete. This is a treatment research study for individuals who currently have cocaine abuse or dependence, and who may also have heroin…
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Cocaine Abuse or Dependence
- Trial name
- ARC (NCT00698737)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wayne State University
Opioid-Related Disorders
Rapid Opiate Detoxification and Naltrexone Induction Using Buprenorphine - 2
The purpose of this study is to develop a clinical protocol to detoxify patients from opiates to naltrexone using buprenorphine and to develop pilot data for a grant application for a controlled study of the efficacy of the new…
- Trial name
- NCT00000299
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Los Angeles
Poly Drug Exposed Pregnancies
Fetal Neurobehavior in Poly-drug Dependent Women
This project examines fetal neurobehavior and maternal physiology in poly-drug dependent women. This study also evaluates infant neonatal abstinence syndrome, infant neurobehavior and vagal tone in the post-partum period.
- Trial name
- NCT00653692
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Johns Hopkins University
Cocaine-Related Disorders, Heroin Dependence
Treatment Efficacy for Drug Abuse and AIDS Prevention - 2
The purpose of this study is to assess the safety and effectiveness of buprenorphine for treatment of concurrent intravenous heroin and cocaine dependence.
- Trial name
- NCT00000211
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder
Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).
The purpose of the study is to assess drug-drug interaction (DDI) and safety of AZD4041 and itraconazole in healthy participants (Part 1), and to assess efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD404…
- Trial name
- NCT06406400
- Testing
- AZD4041, Itraconazole, Buprenorphine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- AstraZeneca
Opioid-Related Disorders
Abuse Potential of Buprenorphine and Naloxone in Non-Dependent Opioid Users
Buprenorphine is a medication used to treat opioid addiction, but individuals who use this drug are at risk of abusing it. A buprenorphine and naloxone combination may reduce the likelihood of buprenorphine addiction.
- Trial name
- NCT00158236
- Testing
- Buprenorphine, Buprenorphine and Naloxone, Hydromorphone
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder
A Study to Test Whether BI 1356225 Improves Impulsive Behavior in People With Opioid Use Disorder Who Are Taking Buprenorphine
This study is open to people between 18 and 65 years of age with opioid use disorder. Opioid use disorder is also called opioid addiction or opioid dependence.
- Trial name
- NCT06628622
- Testing
- BI 1356225
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Boehringer Ingelheim