Clinical trials: CPAP
Obese
Nasal Continuous Positive Airway Pressure and Airway Patency in Obese Patient
The mechanism of Upper airway obstruction (UAO) during anesthesia shares many similarities with the upper airway obstruction observed during obstructive sleep apnea (OSA).
- Trial name
- NCT03024723
- Testing
- nasal mask CPAP
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Respiratory Distress Syndrome, Newborn
High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure for Respiratory Support of Preterm Neonates
This work is designed to: 1. Evaluate the efficacy of HHHFNC in comparison with nCPAP in preterm neonates. 2. Investigate hemodynamic changes associated with HHHFNC in comparison to nCPAP in preterm neonates during periods of…
- Trial name
- NCT04238273
- Testing
- Functional Echocardiography
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Ain Shams University
Quality of Life
Consequences of Respiratory Devices on Caregivers (CAP2)
The promoter of the study will conduct a monocentric cohort study that aim to evaluate the consequences of home respiratory devices on patient caregivers' quality of life.
- Trial name
- CAP2 (NCT04632836)
- Testing
- quality of life questionnaires
- Where
- France
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Asten Sante
Obstructive Sleep Apnea, Type 2 Diabetes
Effects of Continuous Positive Airway Pressure (CPAP) Treatment on Glucose Control in Patients With Type 2 Diabetes
The overall goal of the proposed protocol is to rigorously test the hypothesis that CPAP treatment has beneficial effects on glycemic control in patients with both type 2 diabetes (T2DM) and obstructive sleep apnea (OSA).
- Trial name
- CPAP (NCT01136785)
- Testing
- active CPAP Therapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Chicago
Obstructive Sleep Apnea, Cardiovascular Disease
Metabolic Profiling in Patients With Obstructive Sleep Apnea: From Plasma to Hypoxic Cell Model of Peripheral Monocyte
This three-year project aims to 1. Profile the differentially expressed metabolites in healthy patients with severe Obstructive sleep apnea (OSA) before and after six-month continuous positive airway pressure (CPAP) treatment 2.
- Trial name
- NCT02130050
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Apnea, Hypoxia
Effects of Automated Adjustment of Inspired Oxygen With Combined Adaptive Mechanical Backup Ventilation as Compared to Automated Oxygen Adjustment Alone in Preterm Infants With Intermittent Hypoxemic Events During Non-invasive Ventilatory Support
In this 2-phase cross-over study the investigators test the hypothesis that automated adjustment of the inspired oxygen with the combined use of synchronized noninvasive SpO2-sensitive and apnea-sensitive backup-ventilation…
- Trial name
- NCT02774408
- Testing
- Saturation sensitive backup ventilation
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Obstructive Sleep Apnea
Adherence and Preference of Continuous Positive Airway Pressure Versus Mandibular Advancement Splints in Obstructive Sleep Apnea Patients: A Randomized Trial
Obstructive sleep apnea (OSA) is a major health problem affecting over 1,000,000 Canadians. It is the cause of significant healthcare costs with increased morbidity and mortality.
- Trial name
- CHOICE (NCT02242617)
- Testing
- Positive Airway Pressure (PAP), Mandibular Advancement Splints (MAS)
- Where
- 3 sites in Canada
- Volunteers
- 79 people
- Sponsor
- University of British Columbia
Sleep Apnea, Obstructive, Sleep Apnea, Central
Application of Forced Breath Technique While CPAP Therapy for Apnea Classification
This study analyzes the application of the Forced Breath Technique (FBT) to classify apneas during CPAP therapy with a prismaLAB (device name) therapy device.
- Trial name
- FBT-CPAP (NCT03432910)
- Testing
- CPAP Titration using a Bilevel S/T mode with minimal pressure support and background rate
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heinen und Löwenstein GmbH & Co. KG
Mitral Valve Disease
The Effectiveness of Respiratory Physiotherapy in Mitral Valve Surgery
This trial was conducted to evaluate the effectiveness of the chest physiotherapy techniques to prevent pulmonary collapse based in an score applied in the patients submitted of the mitral valve surgery, after their ICU…
- Trial name
- NCT02278835
- Testing
- breathing exercises, incentive spirometry, Intermittent positive pressure breathing
- Volunteers
- 110 people
- Sponsor
- University of Sao Paulo General Hospital
Respiratory Syncytial Virus Bronchiolitis
Comparison of High Flow Oxygenation Therapy and CPAP in Children With Bronchiolitis.
Bronchiolitis in infants and young children often requires respiraty support. In Denmark Continous Positive Airway Pressure ( CPAP) are routinely used in children with moderate-severe bronchiolitis.
- Trial name
- NCT02618213
- Testing
- Optiflow Junior, Continous Positive Airway Pressure
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Autonomic Nervous System Imbalance, Hypovolemia
Autonomic Challenges From Mild Hypovolemia and Mechanical Ventilation
Heart Rate Variability (HRV) analysis has been studied in the critically ill patients although it is affected by several uncontrolled variables in the clinical conditions.
- Conditions
- Autonomic Nervous System Imbalance, Hypovolemia, Positive-Pressure Respiration
- Trial name
- NCT03244891
- Testing
- Increase of central volume, Ventilation mode
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Obesity Hypoventilation Syndrome
The Obesity-hypoventilation Syndrome Study of Clinical Characteristics and Predictive Factors of Response to Treatment
Main objective: To describe clinical and functional characteristics of the obese hypoventilating patient; to study the relation between the obesity-hypoventilation syndrome (OHS) and the obstructive sleep apnea hypopnea syndrome…
- Trial name
- NCT00938977
- Testing
- CPAP, Bilevel Support Ventilation (Non-Invasive Ventilation)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Transient Tachypnea
Prophylactic Continuous Positive Airway Pressure (CPAP) in Delivery Room, in the Prevention of Transient Tachypnea of Newborn (TTN): A Randomized Controlled Trial
Transient Tachypnea of the Newborn (TTN) is a disorder of delayed clearance of lung liquid and a common cause of admission of full term infants and late pre term infants (34 to 36 weeks) to Neonatal Intensive Care Units (NICU).
- Trial name
- NCT01082900
- Testing
- Prophylactic CPAP Administration
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- New York Hospital Queens
Obstructive Sleep Apnea
Improving the Frequency and Quality of Sleep Apnea Care Management
OSA is a major chronic condition affecting the quality of life of millions of Americans. Per the Institute of Medicine new treatment adherence strategies are needed to help improve the quality of care, reduce social and economic…
- Trial name
- NCT01916655
- Testing
- Self-Management Care, Self-Management Mobile Care, Usual Care
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
Acute Respiratory Failure, Diaphragmatic Function
Efficacy of High Velocity Nasal Insufflation
The purpose of this study is to assess the effect of HFNC on esophageal pressure and diaphragmatic function in patients with acute respiratory failure
- Conditions
- Acute Respiratory Failure, Diaphragmatic Function, Esophageal Pressure
- Trial name
- NCT03929055
- Testing
- Physiological assesment
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Milan
Sleep Apnea Syndromes, Oxidative Stress
Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea
Sleep-disordered breathing (SDB) is a condition in which a person experiences frequent breathing pauses during sleep, also known as sleep apnea.
- Conditions
- Sleep Apnea Syndromes, Oxidative Stress, Cardiovascular Diseases
- Trial name
- SASS (NCT00607893)
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Bronchopulmonary Dysplasia, Patent Ductus Arteriosus
MISA to NRDS：a Multicenter Study in China
BACKGROUND Treatment of neonatal respiratory distress syndrome with exogenous surfactant and mechanical ventilation made millions of preterm infants survived in neonatal intensive care unit (NICU).
- Conditions
- Bronchopulmonary Dysplasia, Patent Ductus Arteriosus, Intraventricular Hemorrhage, Necrotizing Enterocolitis
- Trial name
- NCT04077333
- Testing
- Minimal Invasive surfactant administration
- Where
- China
- Volunteers
- 237 people
- Sponsor
- Peking University Third Hospital
Obstructive Sleep Apnea, Cardiovascular (CV) Risk
Prospective Evaluation of New Metrics to Assess Cardiovascular Remodeling in Obstructive Sleep Apnea
The goal of this prospective study is to gain insight into the endophenotypic variation in OSA, with a focus on the underlying pathophysiological traits and the cardiovascular alterations associated with the condition.
- Trial name
- CARDOSA (NCT07427589)
- Testing
- Continuous positive airway pressure, Mandibular advancement device, Hypoglossal nerve stimulation
- Where
- Belgium
- Volunteers
- 270 people
- Sponsor
- University Hospital, Antwerp
Liver Disease
The Effect of Probiotics on Non Alcoholic Fatty Liver Disease
Nonalcoholic Fatty Liver Disease (NAFLD) has been suggested to be the most common cause of chronic liver disease in the general population in the Western World.
- Trial name
- NCT00808990
- Testing
- BioFemale
- Where
- Israel
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Obstructive Sleep Apnea
The Effect of Continuous Positive Airway Therapy on the Blood Pressure in Sleepy vs Non-sleepy Patients With Obstructive Sleep Apnea
Obstructive sleep apnoea (OSA) is one of the most common noncommunicable types of disease, it affects about 1 billion people across the world.
- Trial name
- ANDANTE-REDS (NCT07497412)
- Testing
- Primary airway therapy (e.g., CPAP), Control arm
- Where
- United Kingdom
- Volunteers
- 10,000 people
- Sponsor
- King's College London
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