Clinical trials: CPAP, completed
Obstructive Sleep Apnea
Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP)
More than 10% of the US population have obstructive sleep apnea (OSA). Standard of care is therapy with CPAP (continuous positive airway pressure) which virtually eliminates OSA.
- Trial name
- TOP-CPAP (NCT05951023)
- Testing
- Eszopiclone 2 mg
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Non-invasive Ventilation Versus Sham Ventilation in Chronic Obstructive Pulmonary Disease (COPD)
The investigators hypothesize that continuation of non-invasive ventilation (NIV) at home after an episode of acute hypercapnic respiratory failure (AHRF) treated by NIV in COPD patients would reduce the likelihood of death and…
- Trial name
- NCT00429156
- Testing
- Home non-invasive ventilation
- Where
- Hong Kong
- Volunteers
- 46 people
- Sponsor
- United Christian Hospital
Bronchopulmonary Dysplasia, Death
Continuous Positive Airway Pressure Via Binasal Prong vs Nasal Mask: a Randomised Controlled Trial
The investigators aimed to compare the effectiveness of nasal mask and prongs used in CPAP (nasal continuous positive airway pressure)as the initial respiratory support when using minimal ly invasive surfactant therapy (MIST) in…
- Trial name
- MASK (NCT02287116)
- Testing
- Easy Flow system and INCA® nasal cannulae set
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Rheumatic Valvular Heart Disease, Obstructive Sleep Apnea
CPAP Treatment and Postoperative Outcomes in Patients With Rheumatic Valvular Heart Disease
The prevalence of OSA (Obstructive sleep apnea，OSA) is 2%-4% in general population and 16%-47% in surgical-heart failure patients.
- Trial name
- CPAP (NCT03398733)
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Nanjing Medical University
Sleep Apnea
Telemedicine for Sleep Apnea Patients
Objective: Set up an interoperable telemedicine system for the follow-up of patients with sleep apnea syndrome.
- Trial name
- Respir@dom (NCT01848509)
- Testing
- With teletransmission
- Where
- France
- Volunteers
- 201 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome, Newborn
RAM Cannula Versus Short Bi-nasal Cannula in Respiratory Distress Syndrome
Noninvasive ventilation defines methods of providing ventilation support with constant or variable pressure using nasal or nasopharyngeal interfaces without endotracheal intubation or tracheostomy.
- Trial name
- NCT03366714
- Testing
- nasal CPAP support with RAM cannula, nasal CPAP support with Hudson cannula
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Inonu University
Sleep Apnea, Obstructive
Evaluation of an Algorithm to Detect Sleep and Wake in Continuous Positive Airway Pressure (CPAP)
The purpose of this engineering trial is to develop and validate an algorithm that will deliver Paced Breathing as a ramp feature to obstructive sleep apnea (OSA) subjects using Continuous Positive Airway Pressure (CPAP) therapy.
- Trial name
- PBSW (NCT01031914)
- Testing
- Paced Breathing
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Philips Respironics
Sleep Apnea Syndrome
Effect of Early Education on the Observance of CPAP Treatment
Sleep apnea (SA) affects more than 4% from general population and is largely underdiagnosed. SA can increase the occurrence of cardiovascular, endocrine and metabolic events (particularly stroke, diabetes \& obesity).
- Trial name
- CoachSAS (NCT02657304)
- Testing
- Coaching group, Control group
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Obstructive Sleep Apnea, Respiratory Insufficiency
Study of the Usability and Efficacy of a New Pediatric CPAP Mask
This study will evaluate a newly developed pediatric mask (known as Pixi) on children aged 2-7 using continuous positive airway pressure (CPAP), or Non-invasive ventilation (NIV) treatment.
- Trial name
- NCT01312948
- Testing
- Prototype mask (known as Pixi)
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- ResMed
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
NCPAP + Heliox as a Treatment for Infant Respiratory Distress Syndrome (RDS)
Infants born between 28 and 32 weeks' gestation with radiological findings and clinical symptoms of moderate RDS, requiring respiratory support with Nasal Continuous Positive Airway Pressure (NCPAP) within the first hour of life…
- Trial name
- NCT01383850
- Testing
- NCPAP + standard air, NCPAP + Heliox
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Obstructive Sleep Apnea
A Randomized Study to Compare Polysomnography With Overnight Home Oximetry and Auto - CPAP for Sleep Apnea
This study will look at an alternative new pathway for diagnosis and treatment based on simple procedures in the patient's own home compared with the current conventional laboratory based pathway.
- Trial name
- NCT00254059
- Testing
- Ambulatory diagnosis and titration with nasal CPAP using over night oxymetry and auto CPAP and vs conventional diagnosis and titration using polysomnography
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Obstructive Sleep Apnea
Mechanisms of Upper Airway Obstruction
The current study is designed to examine underlying mechanisms of action of lingual muscles in the maintenance of airway patency during sleep.
- Trial name
- DISE-CAD (NCT04322097)
- Testing
- Hypoglossal Nerve Stimulation
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea, Obesity
Effect of Nasal Positive Airway Pressure Versus Standard Care on Oxygenation and Ventilation During Propofol-based Sedation for Colonoscopy in Patients With High Risk of Airway Obstruction
The purpose of this study is to to compare oxygenation and ventilation on spontaneously ventilating obese patients or those with diagnosed or undiagnosed Obstructive sleep apnea (OSA) undergoing day colonoscopy under Propofol…
- Trial name
- NCT05524220
- Testing
- Standard care with a facemask., SuperNO2VA™EtCO2 (Nasal Oxygenating Ventilating Apparatus)
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obstructive Sleep Apnea
Investigative Headgear With CPAP Mask
This investigation is designed to evaluate the at-home usability, performance, user acceptance and reliability of the Headgear with a CPAP Mask for a duration of 2-4 weeks.
- Trial name
- NCT02323035
- Testing
- Headgear
- Where
- New Zealand
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Respiratory Distress Syndrome, Newborn, Infant, Newborn
Feasibility of Uninterrupted Infant Respiratory Support Treatment
Feasibility study of a simplified respiratory support system for newborn infants
- Conditions
- Respiratory Distress Syndrome, Newborn, Infant, Newborn, Respiratory Insufficiency Syndrome of Newborn
- Trial name
- FUIRST (NCT04244890)
- Testing
- Uninterrupted CPAP for the first hours of life
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska Institutet
Obesity Hypoventilation Syndrome
Alternative of Treatment in Obesity Hypoventilation Syndrome
Primary objectives: evaluate the efficacy of noninvasive ventilation (NIV) treatment versus continuous positive airway pressure (CPAP) and life style modification treatment in Obesity Hypoventilation Syndrome (OHS), with PCO2…
- Trial name
- NCT01405976
- Testing
- life style modification, noninvasive ventilation, CPAP
- Where
- Spain
- Volunteers
- 440 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Other Preterm Infants
Use of Topical Lidocaine to Reduce Pain in Preterm Infants Receiving Nasal CPAP Continuous Positive Airway Pressure
The main purpose of this study is to evaluate the relative efficacy of topical lidocaine on reducing pain associated with the application of nasal CPAP in preterm infants
- Trial name
- NCT02268968
- Testing
- Lidocaine 2% Gel
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University Children Hospital
Sleep Apnea, Obstructive
Evaluation of a Health Dashboard Intervention to Improve Engagement With CPAP Therapy in PAP-Naïve Patients: Project Neo
This is a prospective, open-label study to evaluate the effectiveness of providing a dashboard with merged health metrics of CPAP (continuous positive airway pressure/ PAP) usage, self-reported sleepiness, blood pressure (BP) and…
- Trial name
- NCT04912635
- Testing
- Neo App
- Where
- Australia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- ResMed
Autonomic Nervous System Imbalance, Hypovolemia
Autonomic Challenges From Mild Hypovolemia and Mechanical Ventilation
Heart Rate Variability (HRV) analysis has been studied in the critically ill patients although it is affected by several uncontrolled variables in the clinical conditions.
- Conditions
- Autonomic Nervous System Imbalance, Hypovolemia, Positive-Pressure Respiration
- Trial name
- NCT03244891
- Testing
- Increase of central volume, Ventilation mode
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Endotracheal Extubation, Infant, Premature
Comparison of NIV-NAVA vs. N-CPAP After Extubation in Preterm Infants Study
This study is a randomized controlled study to compare if a a non-invasive neurally adjusted ventilatory assist (NIV-NAVA) is better than nasal continuous positive airway pressure (N-CPAP) after extubation in infants' < 30 weeks…
- Trial name
- NCT02590757
- Testing
- NIV-NAVA, N-CPAP
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Seoul National University Hospital