Clinical trials: Celecoxib, completed
Osteoarthritis
Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial I
The objective of this study is to evaluate the efficacy and safety of TDS-943 (topical diclofenac spray) compared to oral celecoxib and placebo in subjects with osteoarthritis of the knee.
- Trial name
- NCT00546507
- Testing
- TDS-943 (topical diclofenac sodium 4% spray), celecoxib
- Where
- 43 sites in United States
- Volunteers
- 650 people
- Sponsor
- Mika Pharma GmbH
Familial Adenomatous Polyposis
Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal Cancers
Primary Objective: To determine whether celecoxib downregulates GATA-6 expression to upregulate 15-LOX-1 expression and induce apoptosis in human rectal tumors, researchers will measure GATA-6 and 15-LOX-1 expression, 13-S-HODE…
- Trial name
- NCT00503035
- Testing
- Celecoxib, Colonoscopy Biopsy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- M.D. Anderson Cancer Center
Ankle Sprain
Open Label Comparative Study On Celecoxib Efficacy And Safety Vs Non-Selective NSAID In Acute Pain Due To Ankle Sprain
To assess the efficacy of celecoxib loading dose of 400mg followed by 200 mg twice a day (BID) versus oral non-selective NSAIDs in acute pain due to ankle sprain.
- Trial name
- NCT00446797
- Testing
- Non-selective NSAIDS, Celecoxib
- Where
- 16 sites in Brazil, Costa Rica and 6 more
- Volunteers
- 278 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Osteoarthritis, Osteoarthritis, Knee
Effect of Diacerein vs Celecoxib on Symptoms and Structural Changes in Symptomatic Knee Osteoarthritis
Osteoarthritis (OA) of the knee is the most frequent cause of knee pain after the age of 50 years. OA is a joint disease characterised by articular cartilage loss associated with structural changes in the cartilage and adjacent…
- Trial name
- DISSCO (NCT02688400)
- Testing
- Diacerein, Celecoxib
- Where
- 22 sites in Austria, Belgium and 3 more
- Volunteers
- 380 people
- Sponsor
- TRB Chemedica International SA
Locally Advanced Rectal Cancer
Trial of Celecoxib With Preoperative Chemo- Radiation for Locally Advanced Rectal Cancer
This is a single arm phase II trial with combined celecoxib, tegafur-uracil, folinate and preoperative radiotherapy for patients with locally advanced rectal cancer.
- Trial name
- NCT00931203
- Testing
- Celecoxib
- Where
- Taiwan
- Volunteers
- 55 people
- Sponsor
- National Health Research Institutes, Taiwan
Osteoarthritis of the Knee
Safety and Efficacy of Etoricoxib 30 mg Versus Celecoxib 200 mg in Korean Participants With Osteoarthritis
The main purpose of this study is to establish that etoricoxib 30 mg is safe and not inferior to celecoxib 200 mg in the treatment of the signs and symptoms of osteoarthritis in Korean patients.
- Trial name
- NCT01554163
- Testing
- Etoricoxib 30 mg, Celecoxib 200 mg
- Volunteers
- 239 people
- Sponsor
- Organon and Co
Migraine Headache
Efficacy, Tolerability, and Safety Study of DFN-15
Efficacy, Tolerability, and Safety of DFN-15 in episodic migraine with or without aura, being conducted at multiple centers in the United States.
- Trial name
- NCT03006276
- Testing
- DFN-15 Active
- Where
- 45 sites in United States
- Volunteers
- 622 people
- Sponsor
- BioDelivery Sciences International
Autonomic Failure, Orthostatic Hypotension
Treatment of Orthostatic Hypotension in Autonomic Failure
The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function.
- Trial name
- NCT00223691
- Testing
- Atomoxetine, Acarbose, Pyridostigmine Bromide
- Where
- United States
- Volunteers
- 389 people
- Sponsor
- Vanderbilt University
Lung Cancer
Celecoxib in Preventing Non-Small Cell Lung Cancer in Tobacco Smokers
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. Celecoxib may be effective in preventing lung cancer in tobacco smokers.
- Trial name
- NCT00020878
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Other Acute Postoperative Pain
Study of Diclofenac Capsules to Treat Pain Following Bunionectomy
The purpose of this study is to determine whether Diclofenac [Test] Capsules are safe and effective for the treatment of bunionectomy pain.
- Trial name
- NCT01462435
- Testing
- Diclofenac Test (lower dose), Diclofenac Test (upper dose), Celecoxib
- Where
- 4 sites in United States
- Volunteers
- 428 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Pancreatic Cancer
Gemcitabine, Cisplatin, and Celecoxib Treatment of Metastatic Pancreatic Cancer
This study will examine an investigational (experimental) treatment using gemcitabine, cisplatin, and celecoxib. Preliminary studies have shown that this experimental treatment may be effective in reducing the size of cancerous…
- Trial name
- NCT00176813
- Testing
- Gemcitabine, Cisplatin, Celecoxib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan Rogel Cancer Center
COVID-19 Disease
Back to the Traditional: Anti-COX Drugs Can Improve the Outcome of COVID-19 Patients Admitted to ICU
Retrospective multicenter study to evaluate the data of COVID-19 patients who were admitted to university hospitals in relation to their recent administration or maintenance on non-steroidal anti-inflammatory drugs (NSAID) prior…
- Trial name
- NCT04757792
- Testing
- File inquiry
- Where
- Egypt
- Volunteers
- 475 people
- Sponsor
- Benha University
Sarcoma
Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors
RATIONALE: Drugs used in chemotherapy, such as vinblastine, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00061893
- Testing
- celecoxib, cyclophosphamide, doxorubicin hydrochloride
- Where
- 101 sites in United States, Australia and 2 more
- Volunteers
- 38 people
- Sponsor
- Children's Oncology Group
Lumbar Spinal Stenosis
Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)
BACKGROUND: Lumbar spinal stenosis - known by patients as "arthritis of the spine" - is a condition that is very common; found in about 30% of older adults.
- Trial name
- NCT01943435
- Testing
- NSAIDs; adjunctive analgesics; adjunctive anti-depressants, Lumbar epidural injection, Joint Mobilizations (spine, sacroiliac, hip)
- Where
- United States
- Volunteers
- 259 people
- Sponsor
- Michael Schneider, DC, PhD
Non Small Cell Lung Carcinoma
Phase II Study of Celecoxib and Concurrent Radiotherapy in Stage II-III NSCLC
The purpose of this study is to investigate the effect of the adminstration of celecoxib, a cox2-inhibitor in patients with stage II-III non small cell lung cancer receiving radical radiotherapy.
- Trial name
- NCT00181532
- Testing
- Celecoxib
- Where
- Netherlands
- Volunteers
- 102 people
- Sponsor
- Maastricht Radiation Oncology
Post Operative Pain
A Study Of Opioid Avoidance In Surgery Through Integrating Suzetrigine
This prospective, single-arm feasibility study will evaluate postoperative pain control, opioid use, and early recovery outcomes in adult patients undergoing elective outpatient facial plastic surgery who receive suzetrigine as…
- Trial name
- NCT07257133
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
No Evidence of Disease
Celecoxib in Decreasing the Damaging Effects of Sunburn in Healthy Volunteers
This clinical trial studies celecoxib in decreasing the damaging effects of sunburn in healthy volunteers. Celecoxib may reduce skin damage by blocking enzymes associated with sunburn in healthy volunteers.
- Trial name
- NCT02090933
- Testing
- Celecoxib, Laboratory Biomarker Analysis, UV Light Therapy
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Ovulation (Follicular Rupture Yes/no), Menstrual Cycles (Total Length, Bleeding Days)
The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle
The investigators propose to test the hypothesis that the use of a prostaglandin inhibitor will result in premature luteolysis (ovulation failure) in women.
- Conditions
- Ovulation (Follicular Rupture Yes/no), Menstrual Cycles (Total Length, Bleeding Days), Gonadotropin and Ovarian Hormone Levels (FSH, LH, E2, P)
- Trial name
- NCT00614406
- Testing
- Celebrex
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Anesthesia
Multimodal Opioid-free Anesthesia Versus Opioid-based Anesthesia for Patients Undergoing Cardiac Valve Surgeries: RCT
Several studies demonstrated the effectiveness of OFA in patients undergoing non-cardiac surgery. Preoperative use of Cox inhibitors, GABA analogues and acetaminophen have been shown to decrease use of opioids postoperatively .
- Trial name
- NCT04648540
- Testing
- Dexmedetomidine 0.5 mic/kg/h, Fentanyl 1 mic/kg/hr
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Amyotrophic Lateral Sclerosis, ALS
A Phase IIb, Multi-Center, Multinational, Double-Blind, Placebo-Controlled Study, With an Open Label Extension, to Evaluate Safety, Tolerability and Efficacy of PrimeC in Subjects With ALS
69 subjects with ALS will be enrolled in the study and randomized at a 2:1 ratio to receive the study drug or placebo tablets. Randomization sequences will be in random block sizes and stratified for ENCALS risk category [high…
- Trial name
- PARADIGM (NCT05357950)
- Testing
- PrimeC
- Where
- 4 sites in Canada, Israel and 1 more
- Volunteers
- 69 people
- Sponsor
- NeuroSense Therapeutics Ltd.