Clinical trials: Cholecalciferol
Solid Tumors
Safety Study of EF-022 ( Modified Vitamin D Binding Protein Macrophage Activator) in Subjects With Advanced Solid Tumors
Activated macrophages, present in excess during natural inflammatory responses, bear the potential to kill and eradicate cancer cells.
- Trial name
- NCT02052492
- Testing
- EF-022 (Modified Vitamin D Binding Protein Macrophage Activator)
- Where
- 2 sites in Israel
- Volunteers
- 24 people
- Sponsor
- Efranat Ltd.
Femur Fracture
Nutritional Support in Femur Fracture Rehabilitation
This randomized, observer-blinded trial tested the hypothesis that nutritional supplementation with muscle-target nutritional supplementation would increase the efficacy of a physical rehabilitation program in old adults with…
- Trial name
- NCT04306536
- Testing
- Fortifit®
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Barichella Michela
Tuberculosis, Vitamin D
Vitamin D Supplementation and TB
The goal of this study is to understand the effects of vitamin D supplementation on immunological outcomes among patients with tuberculosis.
- Conditions
- Tuberculosis, Vitamin D, Immunity
- Trial name
- NCT01992263
- Testing
- Vitamin D (600 IU), Vitamin D (2000 IU), Vitamin D (4000 IU)
- Where
- 2 sites in United States, India
- Volunteers
- 200 people
- Sponsor
- Cornell University
Delusion of Reference
Study the Effects of Vitamin D and Calcium Supplementation at Tolerable Upper Limit Doses on Calcium Metabolism.
Recently two distinguished committees, Institute of Medicine (IOM) and The Endocrine Society have proposed different intake guidelines for Calcium and Vitamin D.
- Trial name
- NCT02019381
- Testing
- Endocrine Society UL Dosage Vitamin D, Institute of Medicine Dosage Vitamin D, Calcium
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Winthrop University Hospital
Colorectal Cancer
Vitamin D, Genes and Colorectal Cancer
The aim of this study is to investigate the interaction between intake of vitamin D and polymorphisms in GC and CYP2R1 in relation to risk of colorectal cancer in a Danish prospective cohort study.
- Trial name
- NCT03370432
- Testing
- Observational
- Volunteers
- 2,895 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Bone Strength, Growth
Vitamin D Intervention in Infants - 6 Years Follow-up (VIDI2)
Exposure to vitamin D intervention in early life may have permanent effects on physiology and metabolism. Bone growth and mineralization, development of immunity, body composition and brain structure and functioning may be…
- Conditions
- Bone Strength, Growth, Body Composition, Infection
- Trial name
- VIDI2 (NCT04302987)
- Where
- Finland
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Hypovitaminosis D
Cholecalciferol Supplementation for Sepsis in the ICU
Sepsis in a clinical entity that occurs in patients with serious infections. Though the severity of illness may vary, every year, approximately 1.6 million Americans are treated for sepsis.
- Trial name
- CSI (NCT01896544)
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Osteoporosis
Vitamin D Supplementation in Postmenopausal Women With Osteoporosis: Proposal of a Therapeutic Regimen in Practice
The vitamin D deficiency (25OHD) is very common and affects about 80% of the population of French osteoporotic women over 50 years [5]. It contributes significantly to bone fragility and consequently the risk of fracture.
- Trial name
- VITAD (NCT02518763)
- Testing
- Vitamin D3, 100 000 IU weekly, 4 times, 25 OH vitamin D serum concentration measurements
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
Pregnancy
Vitamin D Status and Metabolism in Human Pregnancy
The purpose of the present study is to understand the effect of pregnancy on vitamin D metabolism and requirements as well as the modulatory role of the placenta in vitamin D metabolism during pregnancy.
- Trial name
- NCT03051867
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Cornell University
Obesity, Vitamin D Deficiency
Impact of Maternal Body Weight on Vitamin D Status During Pregnancy
Research shows high levels of vitamin D deficiency in pregnant women in Northern Ireland. Body composition is a determinant of vitamin D status.
- Trial name
- MO-VITD (NCT02713009)
- Testing
- Pregnancy multi-vitamin (including 10μg vitamin D3), 10μg vitamin D3
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Obesity, Vitamin D3 Deficiency
Vitamins D and K Effects on Vascular Function in Obese Adults.
A prospective, randomized, placebo-controlled, double-blind study that aims to evaluate the effects of combined vitamin D3 and K2-MK7 supplementation on vascular function, sympathetic tone, metabolic biomarkers and inflammatory…
- Trial name
- NCT05689632
- Testing
- Vitamin D3 + K2-MK7, Vitamin D3
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Pedro Ernesto
Peri Implant Mucositis, Peri Implant Bone Loss
Local and Systemic Inflammatory Bone Alterations Related to Dental Implant Survival.
Introduction: Dental implants offer a durable, aesthetic, and functional option for tooth replacement. However, they are not immune to failure.
- Conditions
- Peri Implant Mucositis, Peri Implant Bone Loss, Peri Implantitis, Calcium Deficiency
- Trial name
- NCT07766707
- Where
- Spain
- Volunteers
- 192 people
- Sponsor
- University of Barcelona
Vitamin D Deficiency
The Efficacy and the Safety of Vitamin D3 30,000 IU for Loading Dose Schedules
Treatment: A: Slower Loading Group (SLD): 30.000 IU cholecalciferol once weekly for ten weeks, followed by 30.000 IU cholecalciferol every two weeks for four weeks.
- Trial name
- NCT04476511
- Testing
- Cholecalciferol
- Where
- 7 sites in Hungary
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Asthma
Trial of Vitamin D3 Supplementation in Paediatric Asthma
Epidemiological and observational studies have linked vitamin D deficiency with increased asthma/allergy incidence . Vitamin D insufficiency (<75nmol/L) has been associated with increased incidence of severe childhood asthma.
- Trial name
- NCHVitDAst (NCT02428322)
- Testing
- VItamin D3
- Volunteers
- 53 people
- Sponsor
- Conor Kerley
Vitamin D Deficiency, Obesity
D-tecting Disease - From Exposure to Vitamin D During Critical Periods of Life
Vitamin D deficiency is common among otherwise healthy pregnant women and may have consequences for them as well as the early development and long-term health of their children.
- Conditions
- Vitamin D Deficiency, Obesity, Diabetes Mellitus, Pre-Eclampsia
- Trial name
- D-tect (NCT03330301)
- Testing
- D-tect
- Where
- Denmark
- Volunteers
- 222,776 people
- Sponsor
- Bispebjerg Hospital
Diarrhea-predominant Irritable Bowel Syndrome
Effects of Vitamin D on Gut Microbiota, Intestinal Barrier in IBS-D Patients
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disease. Evidence suggests that the concentration of serum VD is decreased in IBS patients, particularly in IBS-D.
- Trial name
- NCT05593367
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Cystic Fibrosis, Vitamin D Deficiency
Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients
The main aim of the research question to test the primary hypothesis of this study, namely, Does 12 weeks of an additional 5000 IU daily of cholecalciferol increase serum 25OHD levels in adults with Cystic Fibrosis (CF) who have…
- Trial name
- NCT00685971
- Testing
- 5000 IU of cholecalciferol
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Vitamin D Deficiency, Vitamin D Insufficiency
Solius UV Light Source in Improving Serum Levels of 25-hydroxyvitamin D
This is a feasibility interventional study seeking to determine the safety and efficacy of the Solius Photobiologic System in increasing the serum levels of 25(OH)D in a vitamin D deficient/insufficient adult population.
- Trial name
- NCT04865432
- Testing
- UVB treatment
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Boston University
Osteoporosis
A Phase II Study Evaluating SB-751689 in Post-Menopausal Women With Osteoporosis.
This is a 12 month study designed to evaluate the safety and effectiveness of SB-751689 in the treatment of osteoporosis in post-menopausal women, in comparison with 2 active comparators and placebo.
- Trial name
- NCT00471237
- Testing
- Ronacaleret, Teriparatide, Alendronate
- Where
- 49 sites in United States, Argentina and 12 more
- Volunteers
- 564 people
- Sponsor
- GlaxoSmithKline
Vitamin D Deficiency, Insulin Resistance
Effect of Escalating Oral Vitamin D Replacement on HOMA-IR in Vitamin D Deficient Type 2 Diabetics
In addition to its effect on maintaining calcium homeostasis and mineralization of bone, vitamin D has been linked to play a pivotal role in different medical conditions including type 2 diabetes mellitus.
- Conditions
- Vitamin D Deficiency, Insulin Resistance, Diabetes Mellitus, Type 2
- Trial name
- NCT04183257
- Testing
- oral vitamin D
- Volunteers
- 106 people
- Sponsor
- King Edward Medical University
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