Clinical trials: Esomeprazole, completed
Peptic Ulcer Bleeding
The Efficacy of Double Doses of Oral Esomeprazole in Preventing Rebleeding for Patients With Bleeding Peptic Ulcers
Patients with comorbidities have an increased risk of ulcer re-bleeding, especially within the 14 days after first bleeding event.
- Trial name
- DDE (NCT01591083)
- Testing
- esomeprazole (Nexium®, AstraZeneca AB, Södertälje, Sweden)
- Where
- Taiwan
- Volunteers
- 474 people
- Sponsor
- National Cheng-Kung University Hospital
Juvenile Idiopathic Arthritis
Assessment of Pharmacokinetics of a Single Oral Dose of VIMOVO in Healthy Adult Volunteers
This is an assessment of Pharmacokinetics of a single oral dose of VIMOVO in healthy adult volunteers.
- Trial name
- NCT01358383
- Testing
- naproxen, esomeprazole
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Non Erosive Reflux Disease, Chronic Gastritis
Esomeprazole Treatment Co-diagnosed Non Erosive Reflux Disease (NERD) and Chronic Gastritis Patients
To compare the symptom control rate between 8 weeks esomeprazole treatment regimen group and 2 weeks esomeprazole treatment regimen group in co-diagnosed NERD and chronic gastritis patients, as evaluated by GerdQ after 24 weeks…
- Trial name
- NCT01119768
- Testing
- Esomeprazole
- Where
- 8 sites in China
- Volunteers
- 305 people
- Sponsor
- AstraZeneca
Cystic Fibrosis
Effect of Proton Pump Inhibitors on CF Pulmonary Exacerbations
Gastroesophageal reflux disease (GERD) is a common problem in cystic fibrosis (CF). It may lead to worsening lung function and more respiratory infections for a person with CF.
- Trial name
- NCT01983774
- Testing
- Esomeprazole
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Columbia University
Stomach Neoplasms
The Efficacy of Esomeprazole Premedication on Intraoperative Bleeding During Gastric ESD
This will be a single-centre, randomised, endoscopist-blind, parallel-group study in patients who are scheduled endoscopic submucosal dissection (ESD) for gastric mucosal lesion.
- Trial name
- NCT02730533
- Testing
- Esomeprazole, No PPI treatment
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Arthritis
Study Evaluating the Bioavailability of Naproxen 375 mg in Two Formulations
We will evaluate the bioavailability of naproxen 375 mg in two formulations
- Trial name
- NCT00692055
- Testing
- PN400, Naproxen
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- POZEN
Helicobacter Pylori Infection
Clarithromycin Triple Therapy Plus Bismuth for Helicobacter Pylori First-line Treatment
Standard triple therapy including a proton pump inhibitor (PPI) and clarithromycin with either amoxicillin or metronidazole are no longer recommended as empirical first-line therapy to treat Helicobacter pylori infection because…
- Trial name
- NCT02732249
- Testing
- Esomeprazole, Bismuth Potassium Citrate, Clarithromycin
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Asthma, GERD
Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux Asthma
The purpose of this study is to determine whether treatment with esomeprazole for 6 months will improve asthma in adult patients with moderate to severe asthma and symptoms of gastroesophageal reflux disease.
- Trial name
- RELAX (NCT00317044)
- Testing
- Esomeprazole
- Where
- 130 sites in United States, Argentina and 12 more
- Volunteers
- 961 people
- Sponsor
- AstraZeneca
Variceal Hemorrhage
Clinical Evaluation of Hemospray in Hemostasis of Active Variceal Bleeding
The objective of this study is to assess the effectiveness of Hemospray in achieving initial hemostasis and decreased rate of re-bleeding in patients of acute variceal bleeding.
- Trial name
- NCT01783899
- Testing
- Hemospray
- Where
- 2 sites in Belgium, Egypt
- Volunteers
- 30 people
- Sponsor
- Theodor Bilharz Research Institute
Chest Pain, Gastroesophageal Reflux
Chest Pain Pilot Study
The purpose of this study is to compare the efficacy of Nexium® with placebo in relief of acid related pain or discomfort in the chest.
- Trial name
- NCT00251901
- Testing
- Esomeprazole
- Where
- 80 sites in Canada, Denmark and 4 more
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Upper Gastrointestinal Bleeding, Proton Pump Inhibitors
The Effect of Using Preendoscopic Proton Pump Inhibitors in Upper Gastrointestinal System Bleeding on Patient Prognosis
In this study, we aimed to investigate the effectiveness of ppi use in upper gastrointestinal bleeding in patients over the age of 18 who underwent endoscopy on mortality, length of hospital stay, rebleeding, and cost.
- Trial name
- NCT05467358
- Where
- Turkey (Türkiye)
- Volunteers
- 1,100 people
- Sponsor
- Ankara City Hospital Bilkent
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy
Increasing drug resistance presents a significant challenge to the efficacies of common empiric eradication regimens for Helicobacter pylori treatment in the mainland of China.
- Trial name
- NCT03708848
- Testing
- Esomeprazole, Bismuth Potassium Citrate, Clarithromycin
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Osteo Arthritis Knee
The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty
It is well recognized that a multimodal analgesia program targeting multiple pain pathways, is more effective for controlling pain during the hospital stay and in the acute postoperative period than monotherapy-based regimens…
- Trial name
- NCT04003350
- Testing
- Oxycodone, Tramadol, Tylenol
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Rothman Institute Orthopaedics
Heartburn
Acid-Associated Heartburn Symptoms and Dose of Esomeprazole
This is a multi-center, double-blind, parallel-group, randomized, proof of concept trial to investigate the relationship between dose of esomeprazole magnesium and acid-associated heartburn symptoms during 4 weeks of treatment.
- Trial name
- NCT00206024
- Testing
- Esomeprazole magnesium (Nexium)
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 330 people
- Sponsor
- AstraZeneca
Helicobacter Pylori Infection, Eradication
Furazolidone Quadruple Regimen Eradicate H. Pylori Infection
Research protocol: Experimental group: First line solution (furazolidone regimen): esomeprazole magnesium 20 mg +colloidal bismuth pectin 200mg+ amoxicillin 1000 mg + furazolidone 100 mg, twice daily, for 14 days.
- Trial name
- NCT06823791
- Testing
- Furazolidone, Clarithromycin
- Where
- China
- Volunteers
- 493 people, healthy volunteers welcome
- Sponsor
- Liaocheng People's Hospital
Healthy
A Multiple Dose Study of LY3502970 in Healthy Participants
The main purpose of this study is to assess how fast LY3502970 gets into the blood stream and how long it takes the body to remove it when administered in multiple oral doses as new formulation compared to that of reference…
- Trial name
- NCT05051566
- Testing
- LY3502970, Esomeprazole
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy
A Study in Healthy Men to Test How Esomeprazole Influences the Amount of BI 1819479 in the Blood
The main objective of this trial is to investigate the effect of the proton pump inhibitor esomeprazole on the pharmacokinetics of BI 1819479 in plasma.
- Trial name
- NCT05467475
- Testing
- BI 1819479, Esomeprazole
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Tooth Erosion
In Vivo Quantification of Dental Demineralisation Using OCT With and Without Esomeprazole
Dental erosions in 30 male and female patients with proven abnormal gastrooesophageal reflux will be assessed clinically and using a novel optical coherence tomography (OCT) laser technique before and after double-blind…
- Trial name
- NCT00564330
- Testing
- Esomeprazole
- Volunteers
- 30 people
- Sponsor
- Brain-Gut Research Group
Endoscopically-Proven GERD, Reflux
Pharmacokinetic Study of Esomeprazole Magnesium in Patients 1 to 11 Years-Old With Endoscopically-Proven Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to determine the area under the plasma concentration-time curve (AUC) of esomeprazole after single oral doses of 5 mg, 10 mg or 20 mg esomeprazole in pediatric patients 1 to 11 years-old inclusive…
- Trial name
- NCT00687245
- Testing
- esomeprazole magnesium
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Healthy Study Participants
A Study to Test Bioavailability of of 2 New Formulations of UCB0599 in Healthy Participants in Part A and to Test Safety, Tolerability, and Pharmacokinetic (PK) of UCB0599 in Healthy Japanese and Chinese Participants in Part B
The purpose of the study is to estimate the relative bioavailability of 2 new UCB0599 formulations under elevated and normal gastric pH conditions in healthy participants (Part A) and to asess the safety, tolerability and…
- Trial name
- NCT05845645
- Testing
- UCB0599, Esomeprazole
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- UCB Biopharma SRL