Clinical trials: Experimental
Physical Exertion
Acute Exercise and Microvascular Function
It is well recognized that chronic exercise protects against the development of cardiovascular diseases. However, the responses of vasculature to acute exercise (AE) are not well known and not consistent in literature.
- Trial name
- NCT02727439
- Testing
- Acute Exhausting Exercise (AE)
- Where
- Croatia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Blood Pressure
Computer Assisted Learning (CAL) Module Use for Re-training of Blood Pressure Measurements by Physical Therapy Students
The purpose of this study is to determine the effectiveness of a Computer Assisted Learning Module for supplemental blood pressure measurement retraining for doctor of physical therapy students.
- Trial name
- NCT05915039
- Testing
- Computer Assisted Learning (CAL) Module
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Youngstown State University
Maturity-onset Diabetes of the Young
Pathophysiological Implications of the Incretin Hormones in Maturity Onset of Diabetes of the Young (MODY)
The purpose of this study is to describe the incretin effect and postprandial incretin response in patients with MODY2 and MODY3 and a group of matched healthy subjects.
- Trial name
- NCT01342939
- Testing
- Oral Glucose Tolerance Test (OGTT), iso glycaemic intravenous (iv) glucose infusion (IIGI), Meal test
- Where
- Denmark
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Unexplained Subfertile Couples With a Good Prognosis.
FertiScreen: an Online Application to Improve the Quality of Fertility Care
Objectives The investigators present an online application to empower and inform patients and improve guideline adherence in unexplained subfertility.
- Trial name
- NCT01820039
- Testing
- FertiScreen
- Where
- Netherlands
- Volunteers
- 152 people
- Sponsor
- Radboud University Medical Center
Diffuse Large B-cell Lymphoma
R-DA-EDOCH Versus R-CEOP90, With/Without Upfront Auto-HSCT in Young Patients With High-risk DLBCL
Patients initially are randomized into 2 arms: Arm I: R-DA-EPOCH; Arm II: R-CEOP90; Patients who achieved complete remission (CR) or partial remission (PR) after 6 cycles of R-DA-EPOCH (Arm I) or R-CEOP90 (Arm II), continue to…
- Trial name
- NCT03213977
- Testing
- R-DA-EPOCH, R-CEOP90
- Where
- China
- Volunteers
- 475 people
- Sponsor
- Fujian Medical University
Obesity, Morbid
Clinical Efficacy of a Virtual Reality Tool for the Treatment of Obesity
The objective of the study, which is framed within European Union's H2020 project titled SOCRATES, is to assess the clinical efficacy of a Virtual Reality (VR) embodiment tool for treating obesity and to compare it to usual care…
- Trial name
- SOCRATES (NCT05094557)
- Testing
- Experimental Group 1: Body swapping VR intervention + psychoeducational video + Treatment As usual, Experimental Group 2: VR intervention without body swapping + psychoeducational video + Treatment As usual, Control Group: Psychoeducational video + Treatment As usual
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Endometrial Cancer
Calcium Channel Blocker Amlodipine for Endometrial Cancer Therapy
To explore the treatment efficacy of Progesterone Therapeutic Regimen Plus Amlodipine in patients with early endometrial carcinoma (EEC) for conservative treatment.
- Trial name
- NCT06942377
- Testing
- Amlodipine
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Peking University People's Hospital
Brain Metastases
Evaluating AGuIX® Nanoparticles in Combination With Stereotactic Radiation for Brain Metastases
This study evaluates the clinical impact of AGuIX® nanoparticles in combination with Fractionated Stereotactic Radiation in oligo brain metastases.
- Trial name
- NANOSTEREO (NCT04094077)
- Testing
- AGuIX
- Where
- 2 sites in France
- Volunteers
- 1 people
- Sponsor
- Centre Leon Berard
Psoriasis
BI 655066 Versus Placebo & Active Comparator (Ustekinumab) in Patients With Moderate to Severe Chronic Plaque Psoriasis
This is a randomized double blind, double dummy, placebo and active comparator controlled, parallel design study that is being performed to assess the safety and efficacy of risankizumab (BI 655066) to support registration for…
- Trial name
- NCT02684357
- Testing
- risankizumab, ustekinumab
- Volunteers
- 577 people
- Sponsor
- AbbVie
Food Allergy
Improving the Safety of Oral Immunotherapy for Cow's Milk Allergy
Allergy to cow's milk is the most common food allergy affecting children. There is currently no accepted routine clinical therapy to cure milk allergy.
- Trial name
- SOCMA (NCT02216175)
- Testing
- SLIT to cow's milk, Low dose OIT, Conventional OIT to cow's milk
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 68 people
- Sponsor
- Imperial College London
Focus: Anabolic Response to Food Intake in Young Individuals, Condition Relevance: Skeletal Muscle Health, Sarcopenia
Manipulation of Dietary Protein and the Anabolic Response
In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.
- Trial name
- PRO-ADAPT (NCT01820975)
- Testing
- High protein intake
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Asphyxia Neonatorum, Birth Asphyxia
Augmented Infant Resuscitator (AIR): Transitioning a Novel Behavior Change Innovation to Drive Newborn Ventilation Skills Enhancement
Augmented Infant Resuscitator (AIR) is an inexpensive add-on, compatible with nearly every existing bag-valve mask and many types of ventilation equipment.
- Conditions
- Asphyxia Neonatorum, Birth Asphyxia, Perinatal Asphyxia
- Trial name
- NCT05349175
- Testing
- Augmented Infant Resuscitator (AIR)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mitral Regurgitation, Mitral Valve Regurgitation
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional MR
The COAPT Continued Access Study (CAS) is an extension of the COAPT RCT under the same IDE (G120024). COAPT CAS was a single-arm, prospective, multicenter continued access registry that enrolled heart failure patients with…
- Trial name
- COAPT CAS (NCT07227675)
- Testing
- MitraClip® NT System
- Where
- 32 sites in United States
- Volunteers
- 162 people
- Sponsor
- Abbott Medical Devices
Infertility
Progesterone Microspheres Pharmacokinetic - Pharmacodynamic (PK-PD) Study
Phase: I pharmacokinetic - pharmacodynamic (PK-PD) study. Main objective: To establish the minimum effective dose of progesterone microspheres suspension, which administered by weekly intramuscular injection, will be able to…
- Trial name
- NCT01176175
- Testing
- Progesterone
- Where
- Mexico
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Productos Científicos S. A. de C. V.
Knee Osteoarthritis
Comparison of the Efficacy of Phenol Block and Corticosteroid-Local Anesthetic Block Applied to the Genicular Nerve
There are different neurolysis methods. Aim of this study is to compare two different methods, phenol block and corticosteroid local anesthetic block.
- Trial name
- NCT06265675
- Testing
- Phenol, Celestone, Lidocain
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Diabetic Peripheral Neuropathy (DPN), Paresthesia
Study of Acetyllevocarnitine Hydrochloride Tablets in Chinese Patients With Paresthesias Caused by DPN
The purpose of this study is to assess the efficacy of Acetyllevocarnitine Hydrochloride Tablets compared with placebo after 24 weeks, in chinese patients with paresthesia caused by Diabetic Peripheral Neuropathy (DPN).
- Trial name
- NCT05319275
- Testing
- Acetyllevocarnitine Hydrochloride Tablets
- Where
- 34 sites in China
- Volunteers
- 516 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Lung Transplant Rejection
Extracorporeal Photopheresis in Lung Transplant Rejection for Cystic Fibrosis (CF) Patients
Background/Rationale Acute rejection (AR) is common in the first year after lung transplantation. AR has usually been reversible with treatment, but it can trigger chronic rejection that is the leading causes of late morbidity…
- Trial name
- PHORLUCY (NCT03500575)
- Testing
- photopheresis
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Schizophrenia, Schizoaffective Disorder
Selective Estrogen Receptor Modulators for Women of Child-bearing Age With Schizophrenia
The aim of the project is to investigate the use of Raloxifene (a new form of estrogen) in the treatment of young women with schizophrenia and schizoaffective disorder.
- Trial name
- NCT02354001
- Testing
- Raloxifene hydrochloride
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- The Alfred
Heart Failure, Vitamin D Deficiency
Effects of Cholecalciferol Supplementation in Patients With Chronic Heart Failure and LOw vITamind D Levels
The purpose of this study is to determine whether cholecalciferol supplementation in patients with chronic heart failure and low vitamin D levels improves: 1. performance at six minutes walking test 2.
- Trial name
- ECSPLOIT -D (NCT01477801)
- Testing
- CHOLECALCIFEROL
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Azienda Unita' Sanitaria Locale Di Modena
Breast Cancer
MRI-guided Single Dose Preoperative Radiotherapy in Low-risk Breast Cancer
This study aims to evaluate the pathologic response at 12 months after single dose preoperative partial breast irradiation in early stage breast cancer patients. Furthermore, the aim is to collect data on response monitoring.
- Trial name
- ABLATIVE-2 (NCT03863301)
- Testing
- MR-guided single dose preoperative PBI
- Where
- Netherlands
- Sponsor
- UMC Utrecht
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