Clinical trials: Experimental, completed
Tinnitus
Hearing Aids With "Notched Amplification" for the Treatment of Chronic Tinnitus
Pilot study on safety, tolerability and clinical performance/randomized double-blind active-controlled pilot-study. Patients are being recruited from patients of the Tinnitus Center of Regensburg and groupwise randomized.
- Trial name
- NoA-Tin (NCT02408575)
- Testing
- Notched filtering (verum)
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University of Regensburg
Prostate Cancer
Radiation Therapy With or Without Goserelin in Treating Patients Who Have Undergone Surgery for Recurrent or Refractory Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as goserelin, may stop the adrenal glands from making androgens.
- Trial name
- NCT00423475
- Testing
- goserelin acetate, adjuvant therapy, radiation therapy
- Where
- 31 sites in France
- Volunteers
- 743 people
- Sponsor
- UNICANCER
Type 2 Diabetes Mellitus
Efficacy and Safety of Insulin Glargine/Lixisenatide Fixed Combination Versus Insulin Glargine Alone on Top of Metformin in Type 2 Diabetic Patients
Primary Objective: The purpose of this study was to compare insulin glargine/ lixisenatide fixed ratio combination (FRC) versus insulin glargine on glycemic control over 24 weeks, as evaluated by glycosylated hemoglobin (HbA1c)…
- Trial name
- NCT01476475
- Testing
- Insulin glargine /lixisenatide Fixed Ratio Combination, Insulin glargine, Metformin (Background drug)
- Where
- 70 sites in United States, Chile and 11 more
- Volunteers
- 323 people
- Sponsor
- Sanofi
Osteosarcoma
Sorafenib in Relapsed High Grade Osteosarcoma
Aim of this exploratory phase II study is to assess the clinical activity of sorafenib as single agent, in terms of percentage of patients with high grade advanced osteosarcoma free from progression following 4 months of therapy
- Trial name
- NCT00889057
- Testing
- sorafenib
- Where
- 4 sites in Italy
- Volunteers
- 35 people
- Sponsor
- Italian Sarcoma Group
Leukemia, Lymphocytic, Chronic, B-Cell
Bendamustine Combined With Alemtuzumab in Pretreated Chronic Lymphocytic Leukemia (CLL)
The primary objective of this study is to determine the percentage of patients achieving a response, defined as the percentage of patients achieving complete response, partial response and stable disease/ no change upon treatment…
- Trial name
- NCT00951457
- Testing
- Bendamustine, Alemtuzumab
- Where
- 7 sites in Austria
- Volunteers
- 20 people
- Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
Seroma, Aspiration
Seroma Reduction After Mastectomy
Rationale: Seroma formation and its sequelae form the mainstay of complications in breast cancer surgery. Seroma has an incidence of 3% to 85%.
- Conditions
- Seroma, Aspiration, Breast Cancer
- Trial name
- SAM (NCT03305757)
- Testing
- Artiss, vicryl sutures, Conventional
- Where
- Netherlands
- Volunteers
- 339 people
- Sponsor
- Zuyderland Medisch Centrum
IV Dislodgement
A Feasibility Study Evaluating the Use of SafeBreak Vascular in the Geriatric Trauma Population
SafeBreak Vascular is a medical device indicated for fluid flow control during the administration of IV fluids/medication to the patient's vascular system and to aid in the prevention of unintended disruption and dislodgment of…
- Trial name
- NCT03505957
- Testing
- SafeBreak Vascular
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lineus Medical
Acute Leukemia, Hematologic and Lymphocytic Disorder
Itacitinib, Tacrolimus, and Sirolimus for the Prevention of GVHD in Patients With Acute Leukemia, Myelodysplastic Syndrome, or Myelofibrosis Undergoing Reduced Intensity Conditioning Donor Stem Cell Transplantation
This phase IIa trial studies the side effects of itacitinib when given together with standard treatment (tacrolimus and sirolimus), and to see how well it works in preventing graft-versus-host-disease (GVHD) in patients with…
- Conditions
- Acute Leukemia, Hematologic and Lymphocytic Disorder, Myelodysplastic Syndrome, Primary Myelofibrosis
- Trial name
- NCT04339101
- Testing
- Fludarabine, Itacitinib Adipate, Melphalan
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- City of Hope Medical Center
Female Infertility, Polycystic Ovary Syndrome
Evaluation of Clinical Outcomes and Costs of a Lifestyle Intervention in Obese Infertile Women
BACKGROUND: Obesity increases the risk of polycystic ovary syndrome (PCOS), characterized by anovulatory cycles, but it is also associated with reduced fertility even in ovulatory women.
- Conditions
- Female Infertility, Polycystic Ovary Syndrome, Obesity
- Trial name
- OF (NCT01483612)
- Testing
- Interdisciplinary lifestyle intervention
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Université de Sherbrooke
Polycystic Ovary Syndrome
The Transtheoretical Model For Polycystic Ovary Syndrome
The main objective of this study was to investigate the impact of individual counseling programs which has been designed from the Transtheoretical Model (TM) suggesting a healthy diet and physical activity for the students…
- Trial name
- NCT04471012
- Testing
- Individual counselling program
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Afyonkarahisar Health Sciences University
Chronic Pain, Suicidal Ideation
Mindfulness for Pain and Suicide
The proposed study will assess the feasibility and acceptability of a mindfulness-based intervention to reduce functional impairment from chronic pain and risk of suicide.
- Conditions
- Chronic Pain, Suicidal Ideation, Suicide, Attempted, Opioid Use
- Trial name
- NCT05286112
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Health Education
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Canandaigua VA Medical Center
Sleep
A Single-Group Study to Examine the Efficacy of a Melatonin Lotion With Magnesium to Improve Sleep Quality and Quantity
This study will evaluate the efficacy of Asutra's 'Dream the night away' nighttime lotion with melatonin and magnesium on sleep health in terms of quantity, quality, ease of falling asleep or falling back asleep after waking in…
- Trial name
- NCT06146712
- Testing
- Asutra's 'Dream the night away' nighttime lotion
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Asutra
Morbid Obesity
Clinical and Health Economic Impact of Robot-assisted Surgery vs Conventional Laparoscopy : the Case of Gastric Bypass
The purpose of this study is to gather clinical and economic evidence on the use of robotics for bariatric surgery (gastric bypass).
- Trial name
- NCT01760512
- Testing
- Gastric bypass
- Where
- France
- Volunteers
- 118 people
- Sponsor
- IHU Strasbourg
Obesity, Periodontitis
Short-Term Changes in Salivary IL-6, TNF-α, and Periodontal Inflammation Following Sleeve Gastrectomy in Patients With Obesity: A Randomized Controlled Pilot Study
Obesity and periodontitis are chronic inflammatory conditions that may share biological pathways. This pilot randomized controlled study compared adults with obesity and stage I-III periodontitis assigned to laparoscopic sleeve…
- Trial name
- NCT07731412
- Testing
- Laparoscopic Sleeve Gastrectomy, Non-Surgical Obesity Management, Standardized Oral-Hygiene Instructions
- Where
- Romania
- Volunteers
- 32 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Influenza
Immunogenicity and Safety Study to Assess Influenza Vaccine Formulated With Haemagglutinin (HA) Antigen From Two Different Suppliers
The purpose of this study is to assess the humoral immune response and safety of the parenteral formulation of the 2010/2011-season virosomal subunit influenza vaccine Inflexal V using two different HA antigen suppliers (AdImmune…
- Trial name
- NCT01412281
- Testing
- Virosomal influenza vaccine (AdImmune HA Antigen), Virosomal influenza vaccine (CSL HA Antigen)
- Where
- Switzerland
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Healthy Volunteers
Measuring Daily Grain Intake Study
The primary objective of this study is to identify markers of daily whole grain oat and whole grain wheat intake in humans.
- Trial name
- NCT04104581
- Testing
- Control Refined Grain Diet, Low Whole Grain Oat Diet, High Whole Grain Oat Diet
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- USDA Beltsville Human Nutrition Research Center
Body Weight
Body Weight, Aspirin Dose and Pro-resolving Mediators
This study employs a placebo-controlled randomized cross-over design to investigate the impact of body weight and aspirin dose on levels of specialized pro-resolving lipid mediators in blood and neutrophils.
- Trial name
- NCT04697719
- Testing
- Aspirin 81mg, Aspirin 325mg
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Diabetes Mellitus, Type 2
First Research Study of the Possible New Medicine NNC0113-2023 in Healthy Men.
The aim of this study is to assess how safe the study drug is and how well a participant tolerates it after a single oral (taken by mouth) dose.
- Trial name
- NCT03617081
- Testing
- NNC0113-2023
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Evaporative Dry Eye
Comparison of Tear Evaporation Rate With Systane Complete in Dry Eye and Non-Dry Eye
The objective of the study is to compare the rate of tear evaporation, measured with a novel evaporimeter, before and for one hour after an eye drop containing nano-sized oil droplets has been instilled.
- Trial name
- BULLDOG (NCT04091581)
- Testing
- Systane Complete
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Parkinson Disease
Responders to Rhythmic Auditory Cueing in Parkinson Disease
Parkinson disease (PD) is the second most common neurodegenerative disease affecting approximately 10 million people worldwide. It is a complex movement disorder that results in reduced walking ability.
- Trial name
- NCT05733819
- Testing
- Subject-specific optimized RAS, Active Walking
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Boston University Charles River Campus
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