Clinical trials: Experimental Group
Visual Acuity
Clinical Evaluation of a Reusable Multifocal Optical Design in a Presbyopic Population Phase 2
This is a single-masked, randomized-controlled, dispensing clinical trial. A total of approximately 60 eligible hyperopic subjects will be targeted to complete this study.
- Trial name
- NCT03586648
- Testing
- senofilcon A Multifocal, senofilcon A Sphere, etafilcon A Multifocal
- Where
- 6 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Pain, Depression Anxiety Disorder
Hypnosis in Pain Management, Anxiety and Depression in Oncological Patients
The aim of this trial is to compare and evaluate the effects of hypnosis in cancer patients, to reduce the level of pain, anxiety and depression.
- Trial name
- HPMADOP (NCT02105740)
- Testing
- Hypnosis, Control
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Gil Montenegro
Local Anesthetic
Efficacy and Safety of Chloroprocaine 3% Gel and Oxybuprocaine 0.4% Eye Drops Anesthesia in Pediatric Population
The goal of this clinical trial is to assess the efficacy and safety of Chloroprocaine 3% eye gel compared to Oxybuprocaine 0,4% eye drops when used for inducing ocular surface anesthesia in pediatric patients.
- Trial name
- NCT05926258
- Testing
- Chloroprocaine 3% eye gel, Oxybuprocaine Hydrochloride 4 Mg/mL Eye Drops
- Where
- 3 sites in Italy
- Volunteers
- 74 people
- Sponsor
- Sintetica SA
Asthma
Trial of One Versus Two Doses of Dexamethasone for Pediatric Asthma Exacerbation
Comparing one versus two doses of oral dexamethasone for the treatment of asthma in the pediatric emergency department.
- Trial name
- R2D2 (NCT02725008)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Geoffrey W Jara-Almonte
Virus Diseases
A Study to Evaluate the Safety and Immunogenicity of a Candidate Ebola Vaccine in Children
The purpose of this study is to assess the safety and reactogenicity of a single IM dose of the GSK3390107A (ChAd3 EBO-Z) vaccine, overall and in children aged 1 to 5, 6 to 12, and 13 to 17 years, separately.
- Trial name
- NCT02548078
- Testing
- GlaxoSmithKline (GSK) Biologicals' investigational recombinant chimpanzee adenovirus Type 3-vectored Ebola Zaire vaccine (ChAd3-EBO-Z) (GSK3390107A), Nimenrix powder and solvent for solution for injection in pre-filled syringe; Meningococcal group A, C, W-135 and Y conjugate vaccine
- Where
- 2 sites in Mali, Senegal
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Community-acquired Pneumonia, Acute Otitis Media
Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions
The main goal of this study is to use automated electronic reports to assess and improve guideline-concordant antibiotic use for: 1) adult inpatients with community-acquired pneumonia; 2) pediatric inpatients with…
- Conditions
- Community-acquired Pneumonia, Acute Otitis Media, Pharyngitis
- Trial name
- EMPOWER (NCT06027593)
- Testing
- Quasi experimental intervention
- Where
- 2 sites in United States
- Volunteers
- 26,139 people
- Sponsor
- Children's Hospital of Philadelphia
Actinic Keratosis
Study Comparing Imiquimod Cream, 3.75% to Zyclara® (Imiquimod) Cream, 3.75% in the Treatment of Actinic Keratosis
To determine the comparability of the safety and efficacy of Imiquimod Cream, 3.75% and Zyclara (imiquimod) Cream, 3.75% (the reference listed drug) in subjects with actinic keratosis (AK) of the face or balding scalp.
- Trial name
- NCT01686152
- Testing
- Imiquimod Cream, 3.75%, Zyclara®, Vehicle of Test Product
- Where
- 23 sites in United States
- Volunteers
- 589 people
- Sponsor
- Teva Pharmaceuticals USA
Non-Small Cell Lung Cancer
Cancer Vaccine Study for Stage III, Unresectable, Non-small Cell Lung Cancer (NSCLC) in the Asian Population
The purpose of this study is to determine whether the cancer vaccine tecemotide (L-BLP25) in addition to best supportive care is effective in prolonging the lives of Asian subjects with unresectable stage III non-small cell lung…
- Trial name
- INSPIRE (NCT01015443)
- Testing
- Tecemotide, Single low dose cyclophosphamide, Saline
- Where
- 47 sites in China, Hong Kong and 3 more
- Volunteers
- 285 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Glioblastoma
Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas
This study was conducted to evaluate the efficacy and safety of depatuxizumab mafodotin (ABT-414) alone or with temozolomide versus temozolomide or lomustine alone in adult participants with recurrent glioblastoma.
- Trial name
- INTELLANCE-2 (NCT02343406)
- Testing
- Depatuxizumab mafodotin, Temozolomide, Lomustine
- Where
- 102 sites in United States, Australia and 19 more
- Volunteers
- 266 people
- Sponsor
- AbbVie
Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis
Phase 2a, Dose-ranging Study With PF-05221304 in Nonalcoholic Fatty Liver Disease (NAFLD)
Phase 2a, dose-ranging Study with PF-05221304 in Nonalcoholic Fatty Liver Disease (NAFLD)
- Trial name
- NCT03248882
- Testing
- PF-05221304
- Where
- 140 sites in United States, Australia and 4 more
- Volunteers
- 305 people
- Sponsor
- Pfizer
Schizophrenia, Schizoaffective Disorder
Targeting Physical Health in Schizophrenia: Physical Activity Can Enhance Life
Purpose: To develop and test the feasibility of an exercise intervention that combines group walking, activity tracking, and heart rate monitoring, and determine the effectiveness of this intervention on the physical and mental…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Brief Psychotic Disorder, Schizophreniform Disorder
- Trial name
- PACE-life (NCT03757988)
- Testing
- Exercise Intervention- PACE-Life
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
Heart Failure, Home-based Walking Excercise
The Impact of a Home-Based Walking Exercise Program on Heart Failure
Heart disease is the second leading cause of death in Taiwan, with approximately 700,000 individuals affected by heart failure. Despite the proven benefits of rehabilitative exercise, participation in cardiac rehabilitation…
- Conditions
- Heart Failure, Home-based Walking Excercise, Depression, Frailty
- Trial name
- NCT06791967
- Testing
- home-based walking program
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- National Taiwan University Hospital
Pseudofolliculitis Barbae
Pre-Shave Gel and Brush in Pseudofolliculitis Barbae
This will be a randomized investigator blinded study of 40 men age 20-60 (inclusive) with symptoms of mild-moderate PFB based on Investigator Global Assessment (IGA).
- Trial name
- NCT03043534
- Testing
- shave gel, Brush
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Wake Forest University Health Sciences
Relapsing Multiple Sclerosis
Long Term Safety and Efficacy Study of Tolebrutinib (SAR442168) in Participants With Relapsing Multiple Sclerosis
Primary Objective: To determine the long-term safety and tolerability of SAR442168 in RMS participants Secondary Objective: To evaluate efficacy of SAR442168 on disease activity, assessed by clinical and imaging methods
- Trial name
- NCT03996291
- Testing
- Tolebrutinib
- Where
- 37 sites in United States, Canada and 7 more
- Volunteers
- 125 people
- Sponsor
- Sanofi
Stroke
Robotic Training for Stroke Neurorehabilitation
The overall goal is to further develop a robotic exoskeleton for neurorehabilitation of arm function after stroke. The investigators previously developed a novel training protocol that combined the ARMin and HandSOME…
- Trial name
- NCT02639390
- Testing
- Robotic Therapy, Conventional Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- VA Office of Research and Development
Stroke
Adjunct Low Frequency Repetitive Transcranial Magnetic Stimulation With Physiotherapy Enhance Upper Extremity Function Restoration
Stroke is the leading cause of function disability or impairment. Non-promising functional return from upper limb rehabilitation has been reported.
- Trial name
- NCT02490371
- Testing
- Low frequency rTMS, structured physiotherapy upper limb training
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Academic Performance, Anxiety
Mindful Minds: Mindfulness-Based Neurofeedback for Underrepresented College Students
The study examines the efficacy of a mindfulness-based neurofeedback protocol designed to improve academic performance and reduce performance anxiety in racial and ethnic minority college students.
- Trial name
- NCT06784934
- Testing
- NeuroSky Mindfulness-Based Neurofeedback
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Florida International University
Child Abuse
Chatbot Facilitated Education on Child and Adolescent Abuse
The study aims to evaluate the effectiveness of chatbot-facilitated education (CFE) in assisting nursing personnel to prevent child and adolescent abuse and neglect (CAN). The main questions it aims to answer are: 1.
- Trial name
- NCT06167031
- Testing
- chatbot facilitated teaching, lecture-based teaching
- Where
- Taiwan
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Tzu Chi University
Adhesive Capsulitis, Adhesive Capsulitis of Unspecified Shoulder
Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis
We will recruit a total of 40 patients from the Vanderbilt Sports Medicine Clinics who have been diagnosed with adhesive capsulitis and have not undergone any previous treatment.
- Conditions
- Adhesive Capsulitis, Adhesive Capsulitis of Unspecified Shoulder, Frozen Shoulder
- Trial name
- DOXY (NCT03479502)
- Testing
- Methylprednisolone Injectable Product, Doxycycline Injection
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
HIV
Barbershop Talk: HIV Prevention for African American Heterosexual Men
This program utilizes a community-engaged research approach to implementing and evaluating a program that seeks to reduce sexual risk behavior among Black adult heterosexual men.
- Trial name
- NCT01980771
- Testing
- BTWB intervention, Cancer prevention and screening
- Where
- 2 sites in United States
- Volunteers
- 860 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
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