Clinical trials: Losartan
Ischemic Stroke
The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED)
To compare the effect of losartan vs amlodipine-based antihypertensive therapy on atherosclerotic inflammatory markers and cerebrovascular regulation in Ischemic stroke patients.
- Trial name
- NCT00754429
- Testing
- losartan, amlodipine
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Insulin Resistance, Type 2 Diabetes
Effect of Angiotensin Receptor Blockade on Insulin Resistance and Adipose Tissue Cytokines in Type 2 Diabetes
The study aims to investigate the effect of acute angiotensin receptor blockade on insulin action/insulin resistance and expressions of selected adipocytokines in subcutaneous adipose tissue in insulin-resistant subjects with…
- Trial name
- NCT01011062
- Testing
- Hyperinsulinaemia, Losartan, Saline
- Where
- Czechia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical and Experimental Medicine
Obesity, Insulin Resistance
Treating the Endothelium to Restore Insulin Sensitivity
A study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Pre-diabetes
- Trial name
- NCT00402194
- Testing
- Losartan
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hypertrophic Cardiomyopathy
Effect of Losartan in Patients With Nonobstructive Hypertrophic Cardiomyopathy
The purpose of this study is to determine whether taking losartan helps people with hypertrophic nonobstructive cardiomyopathy feel better by decreasing the amount of heart muscle thickening and/or the amount of heart muscle…
- Trial name
- NCT01150461
- Testing
- losartan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Hermansky-Pudlak Syndrome (HPS), Pulmonary Fibrosis
Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome
This study will examine whether five drugs (pravastatin, Losartan, Zileuton, N-acetylcysteine and erythromycin) used together can slow the course of pulmonary fibrosis (scarring of the lung tissue) in patients with…
- Conditions
- Hermansky-Pudlak Syndrome (HPS), Pulmonary Fibrosis, Oculocutaneous Albinism, Platelet Storage Pool Deficiency
- Trial name
- NCT00467831
- Testing
- Losartan, Zileuton, N-Acetylcysteine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Fasting
Bioequivalence Study of Amlodipine / Losartan/ Hydrochlorothiazide of PHARMALINE, Lebanon Under Fastion Conditions
To assess the bioequivalence of the investigational TEST product with the marketed REFERENCE products by measurement of Plasma concentrations of Amlodipine ,Losartan, Carboxylic acid losartan metabolite \& Hydrochlorothiazide in…
- Trial name
- NCT01713647
- Testing
- Amlodipin, losartan, HCTZ
- Where
- Jordan
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Pharmaceutical Research Unit, Jordan
Hypertension, Resistant to Conventional Therapy, Essential Hypertension
Monotherapy Versus Dual Therapy for Initial Treatment for Hypertension
To test whether the current custom of initiating treatment for hypertension with a single drug is less effective in the short-term than initial combination therapy, and results in the eventual need for comparatively more…
- Trial name
- Pathway 1 (NCT00994617)
- Testing
- Losartan and hydrochlorothiazide, Hydrochlorothiazide switched over with Losartan at 8 weeks
- Where
- 13 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- University of Cambridge
Kidney Disease
Pharmacokinetic Study in Patients With Chronic Kidney Disease and Healthy Volunteers
The purpose of this study is to find out how chemicals in the blood of patients with chronic kidney disease affect how medications are removed from the body.
- Trial name
- CKD (NCT01087749)
- Testing
- Propranolol, Losartan, Eprosartan
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy Normotensive Participants
Pharmacokinetic Interactions of Losartan and Hydrochlorothiazide
This study was conducted to investigate any potential reaction between losartan and hydrochlorothiazide.
- Trial name
- PKLH (NCT01858623)
- Testing
- Losartan/hydrochlorothiazide, Losartan, Hydrochlorothiazide
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Congestive Heart Failure, Low Cardiac Output
Losartan in Decompensated Heart Failure
The dual blockade of the renin-angiotensin-aldosterone system with an angiotensin-converting enzyme inhibitor and an angiotensin-receptor blocker used together in heart failure patients has been demonstrated to be beneficial.
- Trial name
- NCT01857999
- Testing
- Losartan
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- InCor Heart Institute
Hypertension, Stroke
Diurnal Variation in Hypertensive Stroke Patients
This study was conducted to evaluate and compare the effectiveness of Amodipin® (amlodipine camsylate) with that of Cozaar® (losartan potassium) in hypertensive patients with an acute ischemic stroke by measuring their 24-hour…
- Trial name
- NCT01830517
- Testing
- Amlodipine, Losartan
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Hypertension
The Efficacy and Safety Study of Anti-hypertension Combination Drug in Patients Uncontrolled With Monotherapy.
The purpose of this study is to evaluate the blood pressure lowering effects of an amlodipine/losartan combination treatment and losartan/Hydrochlorothiazide combination treatment in patients with essential hypertension…
- Trial name
- NCT01828359
- Testing
- Amosartan® tab, Cozaar® plus pro tab
- Volunteers
- 199 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Hypertension, Hyperlipidemia
A Study to Evaluate Pharmacokinetics and Potential Drug Interactions of a Fixed-dose Combination Tablet, HL-040XC, in Healthy Male Subjects
The objective of this study is: To evaluate the pharmacokinetics and safety of an experimental combination tablet containing 20 mg atorvastatin and 50 mg losartan potassium when administered orally as a single dose to healthy…
- Trial name
- NCT01806324
- Testing
- HL040XC, Losartan + Atorvastatin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- HanAll BioPharma Co., Ltd.
Drug Interaction Potentiation
A Drug-Drug Interaction Study of Losartan and PA21
The purpose of this study is to determine if Losartan potassium is affected by PA21.
- Trial name
- NCT01324752
- Testing
- PA21 and Losartan with Food, No PA21; Losartan with food, PA21 with food and Losartan 2 hours later
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Vifor Pharma
Type 2 Diabetes Mellitus, Diabetic Nephropathy
Effects of Spironolactone Combination Therapy on Proteinuria, Kidney Function, and Blood Pressure
The detrimental effects of aldostrone are not adequately arrested by the use of angiotensin converting enzyme (ACE), angiotensin II receptor blocker (ARB) or a combination of both.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Nephropathy, Essential Hypertension
- Trial name
- NCT01667614
- Testing
- spironolacone 25 mg tablets added to losartan
- Where
- Iran
- Volunteers
- 136 people
- Sponsor
- Tehran University of Medical Sciences
Hypertension, Stroke
Recurrent Stroke Prevention Clinical Outcome Study
1. Objectives and Hypothesis 1. Objectives: This study evaluates whether strict BP management is useful for the prevention of recurrent stroke.
- Conditions
- Hypertension, Stroke, Blood Pressure
- Trial name
- RESPECTS (NCT01198496)
- Testing
- Losartan, Losartan and HCTZ, Amlodipine , Spironolactone
- Where
- Japan
- Volunteers
- 5,000 people
- Sponsor
- Biomedis International Ltd.
Marfan Syndrome
Losartan Versus Atenolol for the Treatment of Marfan Syndrome
Marfan syndrome is a genetic disease of our connective tissue, which provides material and support for our skeleton, muscles, blood vessels and other parts of our bodies.
- Trial name
- NCT00593710
- Testing
- Losartan, Atenolol
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University of British Columbia
Hypertension
Effect of Losartan on Retinal Endothelial Function in Patients With Essential Hypertension
Essential hypertension is commonly associated with impaired endothelial function. The retinal vasculature is morphologically and functionally related to the cerebral vessels because of the common origin from the internal carotid…
- Trial name
- NCT00152633
- Testing
- Losartan, Metoprolol
- Where
- Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Memory, Long-Term, Memory, Short-Term
Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects
This project aims at identifying novel pharmacological targets for the treatment of memory disorders.
- Trial name
- LoDi-Basel (NCT01321021)
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Essential Hypertension, High Blood Pressure
Intensive Vasodilator Therapy in Patients With Essential Hypertension
The purpose of this study is to determine whether add-on of intensive vasodilator therapy can improve the coronary perfusion and reduce the total peripheral resistance in patients with ongoing treatment for essential hypertension.
- Trial name
- Vasomore (NCT01180413)
- Testing
- Amlodipine, Ramipril, Lercanidipine
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Aarhus University Hospital