Clinical trials: Morphine, completed
Postoperative Pain, Mitral Valve Disease
ESP vs ESP With PECS
Patients scheduled for minimally invasive mitral valve repair. Each patient will be treated with intravenous (i.v.) oxycodone - patient-controlled analgesia (PCA).
- Trial name
- NCT03592485
- Testing
- Erector Spinae Plane blockade, Pectoral Fascia block, Oxycodone
- Where
- Poland
- Volunteers
- 33 people
- Sponsor
- Medical University of Lublin
Percutaneous Nephrolithotomy
Erector Spinae Plane Block for Postoperative Pain in Percutaneous Nephrolithotomy Patients: a Retrospective Study
To evaluate the ability of Erector spina Plane block decrease postoperative pain and analgesia requirements in patients undergoing Percutaneous Nephrolithotomy.
- Trial name
- NCT03897933
- Testing
- Erector Spinae Plane block ( Group I), non- blocked Group (GROUP II)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Abdominal Pain
Continuous Local Anesthetic and Steroid Infusion in Abdominal Surgery
The aim of the study is the identification, comparing continuous infusion of local anesthetics and steroids intralesionally with the current gold standard therapy (PCA), of the effective dose of local anesthetics and steroids…
- Trial name
- GR-CWI (NCT02002663)
- Testing
- ropivacaine 0.2%, Methylprednisolone 1mg/kg, saline 0.9%
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Knee Injuries
Femoral/Sciatic Block for Knee Surgery
Knee arthroplasty has a high potential for postoperative pain. This study compares analgesia and postoperative bleeding from intrathecal morphine with the continuous femoral and a single-shot sciatic nerve blockades.
- Trial name
- NCT02882152
- Testing
- femoral nerve blockade, morphine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Inguinal Hernia
Effects of Morphine Added to Bupivacaine in Transversus Abdominis Plane Block for Inguinal Hernia Repair
This study is conducted to determine whether morphine added to bupivacaine in ultrasound guided (USG) transversus abdominis plane (TAP) block has beneficial effects than bupivacaine alone in providing postoperative analgesia for…
- Trial name
- NCT05379374
- Testing
- bupivacaine and morphine
- Where
- Nepal
- Volunteers
- 40 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Overactive Bladder, Urinary Urge Incontinence
Reduction of Bladder Injection Pain With Belladonna Opiate Suppository
The purpose of this study is to test whether using belladonna \& opiate suppositories (B\&Os) can improve patient discomfort during Onabotulinumtoxin A (BoNT) injection into the bladder for treatment of overactive bladder…
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Urinary Bladder, Neurogenic, Painful Bladder Syndrome
- Trial name
- ROBIN (NCT02600715)
- Testing
- Onabotulinumtoxin A (BoNT), belladonna, Morphine
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Edgar LeClaire, MD
Delirium, Anesthesia
Incidence of Postoperative Delirium in Cancer Patients After Laparoscopic Surgery in Trendelenburg Position
Postoperative delirium is an acute mental syndrome that is caused by diffuse cerebral dysfunction resulting from the action of predisposing and precipitating factors acting together.
- Trial name
- NCT03572517
- Testing
- Subarachnoid block, Spinal morphine
- Where
- Brazil
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- AC Camargo Cancer Center
Neonatal Abstinence Syndrome
Buprenorphine for Treatment of Neonatal Abstinence Syndrome in Infants With In Utero Exposure to Benzodiazepines
The opioid neonatal abstinence syndrome (NAS) is a condition of withdrawal symptoms after utero exposure to opioids. Sublingual buprenorphine shows promise as a new treatment in NAS.
- Trial name
- MOPPlus (NCT01671410)
- Testing
- oral morphine, sublingual buprenorphine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Thomas Jefferson University
Postoperative Pain Treatment for Total Knee Arthroplasty
Total Knee Arthroplasty Analgesia: Single-shot Femoral Nerve Block or Epidural?
Single-shot femoral nerve block is similar to continuous epidural technique for postoperative analgesia in total knee arthroplasty
- Trial name
- NCT02164825
- Testing
- Ropivacaine perineural injection, morphine and ropivacaine
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar do Tâmega e Sousa
Critical Illness
The Optimization of Procedural Pain Control in Intensive Care Unit (ICU) Patients
The purpose of this study is to determine the influence of morphine 2,5 mg or morphine 7,5 mg iv during a painful and unavoidable intervention in critically ill patients.
- Trial name
- OPCIC (NCT00558090)
- Testing
- morphine
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Colon Cancer, Inflammatory Bowel Diseases
Spinal Analgesia for Colonic Resection Using an Enhanced Recovery After Surgery (ERAS) Program
This is a blinded randomized controlled trial in patients undergoing laparoscopic colon surgery. The aim of this study is to assess whether spinal analgesia with a mixture of bupivacaine and morphine provides better pain relief…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT01477190
- Testing
- Spinal analgesia, Patient Control Analgesia (PCA) Morphine
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Critical Care, Palliative Care
An Algorithmic Approach to Ventilator Withdrawal at the End of Life
The proposed study is an important, under-investigated area of ICU care for terminally ill patients undergoing terminal ventilator withdrawal.
- Trial name
- NCT03121391
- Testing
- Ventilator withdrawal algorithm
- Where
- 5 sites in United States
- Volunteers
- 165 people
- Sponsor
- Wayne State University
Healthy
Fed Study of Chlorpheniramine Polistirex and Hydrocodone Polistirex Capsules and Tussionex® Pennkinetic® Extended Release Oral Suspension
The objective of this open-label, randomized, two-period, crossover study was to evaluate the oral bioavailability of the Mallinckrodt extended release test capsule formulation of chlorpheniramine polistirex/hydrocodone…
- Trial name
- NCT00853190
- Testing
- Chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate and hydrocodone polistirex equivalent to 10 mg of hydrocodone bitartrate capsule, 5 mL chlorpheniramine (8 mg/5 mL)/hydrocodone (10 mg/5 mL) extended release oral suspension
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Healthy, No Evidence of Disease
Effects of Garlic Supplements on Opioids in Healthy Volunteers
RATIONALE: Garlic supplements may alter the pharmacokinetics of oxycodone, thereby affecting its effectiveness as an opioid analgesic for the relief of moderate or severe pain.
- Trial name
- NCT00499460
- Testing
- garlic powder tablets, oxycodone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Acute Pain
Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine
Duloxetine is a serotonin-norepinephrine reuptake inhibitor primarily used for treatment of major depression and anxiety. Duloxetine also has been used in the treatment of chronic pain conditions, such as osteoarthritis and…
- Trial name
- NCT03560427
- Testing
- Duloxetine 60mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
PTSD
Connecting Women to Care: Home-based Psychotherapy for Women With MST Living in Rural Areas
Military sexual trauma (MST) is a common duty-related stressor which occurs among one in four female Veterans and is associated with substantial concerns about social isolation and high rates of PTSD.
- Trial name
- CWC (NCT03429166)
- Testing
- Skills Training in Affective and Interpersonal Regulation, Present Centered Therapy
- Where
- 2 sites in United States
- Volunteers
- 204 people
- Sponsor
- VA Office of Research and Development
Severe Traumatic Pain, Numeric Pain Rating Scale > 5 / 10
Intra Nasal Sufentanil Versus Intravenous Morphine for Acute Severe Traumatic Pain Analgesia in Emergency Setting
Intranasal (IN) administration of opiates is an appealing non-invasive way of treating acute traumatic pain in prehospital and Emergency departments (ED).
- Trial name
- ALGOFINE-2 (NCT02095366)
- Testing
- Morphine, Sufentanil
- Where
- 6 sites in France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Grenoble
Analgesia
Effects of SCALP Block on Postoperative Analgesia in Craniotomy Surgery
Patients undergoing craniotomy surgery often experience severe postoperative pain. This pain can affect the patient's hemodynamics, disrupt sleep patterns, and prolong hospital stays.
- Trial name
- NCT06588751
- Testing
- Scalp block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Konya City Hospital
Pruritus
Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section
Neuraxial anesthesia, which includes epidural anesthesia and intrathecal anesthesia, is a frequent anesthetic approach for caesarean delivery and other lower abdominal and lower limb anesthetic procedures.
- Trial name
- NCT03483870
- Testing
- Morphine Sulfate, Granisetron
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Constipation
Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery
In the present study, the primary aim was to evaluate if oxycodone-naloxone combination compared to oxycodone reduced opioid induced constipation in patients with or without chronic opioid treatment undergoing spine surgery.
- Trial name
- oksineukir (NCT02573922)
- Testing
- oxycodone-naloxone, Oxycodone
- Where
- Finland
- Volunteers
- 180 people
- Sponsor
- Kuopio University Hospital
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