Clinical trials: Morphine, completed
Pain
Epidural Morphine Following Vaginal Delivery
The investigators believe that pain management following a vaginal delivery can be improved. Many women receive epidural medication during labor and delivery, and the investigators felt that using the epidural following delivery…
- Trial name
- NCT00803114
- Testing
- Preservative-free epidural morphine
- Where
- Canada
- Volunteers
- 228 people
- Sponsor
- Mount Sinai Hospital, Canada
Congenital Heart Disease
Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery
The investigators hypothesize that intermittent bolus doses of morphine and midazolam can provide the same pain control after pediatric cardiothoracic surgery as bolus doses plus infusions while using smaller total doses of both…
- Trial name
- NCT02112448
- Testing
- continuous infusion, as needed dosing, Acetaminophen
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Wake Forest University Health Sciences
Post Operative Pain
Ultrasound Guided Erector Spinae Plane Block vs Intrathecal Morphine
Total abdominal hysterectomy (TAH) is a major surgical procedure after which significant post-operative pain and discomfort are anticipated.
- Trial name
- NCT05218733
- Testing
- Ultrasound Guided Erector Spinae Plane Block, Intra thecal morphine., General anesthesia using intravenous fentanyl (1µgm/kg)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Pain, Postoperative
Phase II Clinical Trial to Evaluate the Efficacy and Safety of LPM3480392 Injection for Moderate to Severe Pain After Abdominal Surgery
A randomized, double-blind, placebo/positive drug parallel controlled design was used to evaluate the preliminary efficacy and safety of intravenous infusion of LPM3480392 injection using different dosing regimens in subjects…
- Trial name
- NCT06204120
- Testing
- LPM3480392 Injection, morphine hydrochloride injection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Luye Pharma Group Ltd.
Pain Relief, Adverse Events
Lifeflight: Fentanyl Versus Morphine
The study is exempt from informed consent by the MetroHealth Medical Center institutional review board (IRB), because two standards of care are used and there is no increased clinical risk to the patient due to the study.
- Trial name
- NCT00580489
- Testing
- either fentanyl or morphine
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- MetroHealth Medical Center
Pain
An Efficacy and Safety Study of Oral Osmotic Therapeutic System (OROS) Hydromorphone Hydrochloride (HCl) in Participants With Cancer Related Pain
The purpose of this study is to compare the safety and efficacy of Oral Osmotic Therapeutic System (OROS) hydromorphone hydrochloride (HCl) with controlled-release oxycodone HCl in participants with cancer-related pain.
- Trial name
- NCT01205126
- Testing
- Hydromorphone HCl, Oxycodone HCl CR
- Where
- 12 sites in China
- Volunteers
- 260 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cancer, Mucositis
Effect of Topical Morphine (Mouthwash) on Oral Pain Due to Chemo- and/or Radiotherapy Induced Mucositis
Introduction: Oral pain due to mucosal lesion is quite frequent in oncology, geriatric as well as palliative care settings. The oncology patient is mainly suffering from radio- and/or chemotherapy induced oral mucositis.
- Trial name
- NCT00613743
- Testing
- mouth wash with morphine
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
STEMI, Morphine
Methylnaltrexone as a Method to Improve Ticagrelor Uptake in Morphine Treated STEMI Patients
This study will examine the impact of the peripheral opioid antagonist methylnaltrexone on the onset of effect of ticagrelor in morphine treated patients with ST elevation myocardial infarction (STEMI).
- Conditions
- STEMI, Morphine, Ticagrelor, Methylnaltrexone
- Trial name
- MOVEMENT (NCT02942550)
- Testing
- Methylnaltrexone bromide (Relistor®)., Sodium Chloride 9mg/mL
- Where
- 2 sites in Sweden
- Volunteers
- 82 people
- Sponsor
- Karolinska University Hospital
Knee Arthroscopy, Shoulder Arthroscopy
Non-Opioid Prescriptions After Arthroscopic Surgery in Canada (NO PAin)
This is a randomized controlled trial of 200 patients between the ages of 18 and 65 years undergoing outpatient knee or shoulder arthroscopy. Patients will be evaluated clinically at 2 and 6 weeks post-operatively.
- Trial name
- NO PAin (NCT04566250)
- Testing
- Non-Opioid Prescription and Infographic
- Where
- 3 sites in Canada
- Volunteers
- 200 people
- Sponsor
- McMaster University
Pain, Herpes Zoster
Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Management of Postherpetic Neuralgia
OBJECTIVES: I. Determine whether opioid (morphine) treatment results in better management of pain than treatment with tricyclic antidepressant (nortriptyline). II.
- Trial name
- NCT00004390
- Testing
- desipramine, methadone, morphine
- Volunteers
- 120 people
- Sponsor
- National Center for Research Resources (NCRR)
Pain
Study to Evaluate the Analgesic Efficacy and Safety of Hydrocodone Bitartrate/Acetaminophen Immediate-Release Tablets in Participants With Moderate to Severe Pain Following Bunionectomy
The primary objective of this study is to evaluate the analgesic efficacy of hydrocodone bitartrate/acetaminophen immediate-release tablets at doses of 5.0 milligrams (mg)/325 mg, 7.5 mg/325 mg, and 10 mg/325 mg every 4 to 6…
- Trial name
- NCT02487108
- Testing
- TV-46763
- Where
- 8 sites in United States
- Volunteers
- 569 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Colorectal Surgery
Effect of Anesthesia on Insulin Secretion in Patients With Preoperative Decreased Insulin Sensitivity
Epidural anesthesia has been found to manipulate the hyperglycemic response to surgery. It is unclear, however, whether the preoperative metabolic status of the surgical patient plays a role in the degree of this hyperglycemic…
- Trial name
- NCT01739413
- Testing
- Anesthesia
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Gabriele Baldini, MD, MSc, Assistant Professor
Obesity
Dexmedetomidine to Treat Bariatric Surgery-associated Pain
Obesity represents one of the most important public health issues according to the World Health Organization and it has reached epidemic proportions globally.
- Trial name
- NCT02880540
- Testing
- Fentanyl, Morphine, Dexmedetomidine
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Janelle Vaughns
Dermatitis, Radiation Induced
Retrospective Analysis of the Efficacy of Morphine Gel to Treat Pain Associated With Perineal RadioDermatitis
Retrospective study evaluating the efficacy of a pharmacy-prepared Morphine gel used in clinics for the treatment of pain associated with perineal radiodermatitis.
- Trial name
- ANTAGEL (NCT07207889)
- Testing
- morphine chlorhydrate in intrasite gel
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Institut Curie
Labor Pain
Oxycodone for Labor Pain - Pharmacokinetics (PK), Safety and Efficacy
Childbirth is one of the most painful events that a woman is likely to experience, and thus is a major concern for most parturient.
- Trial name
- Oksiobs (NCT01016821)
- Testing
- Oxycodone
- Where
- Finland
- Volunteers
- 15 people
- Sponsor
- Kuopio University Hospital
Postoperative Pain Management, Total Knee Arthroplasty
Pregabalin, Celecoxib, Total Knee Arthroplasty and Intrathecal Morphine
To evaluate whether pregabalin and/or celecoxib could improve analgesic efficacy of intrathecal morphine for patients after total knee arthroplasty.
- Trial name
- PCTKA (NCT01344213)
- Testing
- Pregabalin, Celecoxib, Pregabalin with celecoxib
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Tonsillectomy
Celecoxib After Tonsillectomy
Tonsillectomy is one of the most common pediatric surgical procedures in the United States. Postoperative pain is substantial, with typical regimens employing narcotic derivatives and acetaminophen for 1-2 weeks after surgery.
- Trial name
- NCT02934191
- Testing
- Celecoxib, Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Children's Hospital of Philadelphia
Relapsing Multiple Sclerosis, Clinically Isolated Syndrome
Effectiveness of Rebif® in Clinically Isolated Syndrome and Relapsing Multiple Sclerosis Using RebiSmart™
This is a Phase 4, interventional, multicenter study of subcutaneous Rebif® (interferon beta-1a) using RebiSmart™ device to assess effectiveness and adherence of treatment in subjects with clinically isolated syndrome (CIS) or…
- Trial name
- PROCEED (NCT02254304)
- Testing
- Rebif
- Where
- Germany
- Volunteers
- 106 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Post-Operative Pain
A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain
The study is intended to show that the Sufentanil NanoTab PCA System is as effective as morphine intravenous patient-controlled analgesia (IV PCA) for treating pain after surgery.
- Trial name
- NCT01539538
- Testing
- Sufentanil NanoTab PCA System/15 mcg, morphine IV PCA
- Where
- 16 sites in United States
- Volunteers
- 357 people
- Sponsor
- Talphera, Inc
Age Problem, Abdominal Cancer
Dosage of Epidural Morphine in Elderly Patients
This a clinical trial that evaluates the efficacy and safety of three different doses of morphine, namely 1.5 mg, 3 mg and 4.5 mg, via the epidural route regarding reducing pain in elderly patients after a cancer surgery in the…
- Trial name
- NCT04316871
- Testing
- 1.5 mg of Morphine Sulfate, Normal saline, 3 mg of Morphine Sulfate
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Assiut University
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