Clinical trials: Morphine, completed
Morphine, Histamine
Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine
The aim of this study is to the effect of opioid (morphine) intradermal application on histaminergic and non-histaminergic itch.
- Conditions
- Morphine, Histamine, Cowhage, Isotonic Saline
- Trial name
- NCT04672382
- Testing
- Morphine
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Gynecological Cancer Surgery, Regional Anesthesia Morbidity
The Effect of Analgesia Methods Applied in Gynecological Cancer Surgeries on Postoperative Analgesia
The aim of this study is to compare the effectiveness of intrathecal morphine and four-quadrant transversus abdominis plane block applied for postoperative analgesia in gynecological cancer surgeries.
- Trial name
- NCT06382376
- Testing
- Intrathecal morphine administered group, Four quadrant transversus abdominis plane block applied group
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Multiple Sclerosis
Cognition and HRQoL in Adults With Highly-active RMS in Year 3 and 4 After Initial Mavenclad® Dose (CLARIFY MS Extension)
The purpose of the study was the evaluation of the effect of a treatment for highly-active relapsing multiple sclerosis (RMS). This was the extension study to CLARIFY MS (NCT03369665), to assess cognitive impairment and health…
- Trial name
- NCT04776213
- Testing
- Mavenclad®
- Where
- 60 sites in Austria, Czechia and 8 more
- Volunteers
- 280 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Relapsed/Refractory Rhabdomyosarcoma, Non-rhabdomyosarcoma Soft Tissue Sarcoma
Study to Assess Safety and Preliminary Activity of Eribulin Mesylate in Pediatric Participants With Relapsed/Refractory Rhabdomyosarcoma (RMS), Non-rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) and Ewing Sarcoma (EWS)
This study will be conducted as an assessment of the safety and preliminary activity of eribulin mesylate in pediatric participants with relapsed/refractory rhabdomyosarcoma (RMS), non-rhabdomyosarcoma soft tissue sarcoma…
- Conditions
- Relapsed/Refractory Rhabdomyosarcoma, Non-rhabdomyosarcoma Soft Tissue Sarcoma, Ewing Sarcoma
- Trial name
- NCT03441360
- Testing
- Eribulin mesylate
- Where
- 41 sites in United States
- Volunteers
- 23 people
- Sponsor
- Eisai Inc.
Analgesia
Analgesic Requirements for Lumbar Fixation With General Anaesthesia Versus Continuous Caudal Epidural
In this clinical study, the investigators will justify the current practice of combined continuous caudal epidural with general anaesthesia in adult patients undergoing lumbar fixation versus general anaesthesia.
- Trial name
- NCT06929611
- Testing
- Combined continous caudal epidural with general anaesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Surgery
Outcomes of Intrathecal Analgesia in Colorectal Surgery
Multimodal analgesia, sometimes including intrathecal analgesia (IA), is essential in any enhanced recovery pathway (ERP). This study aimed to evaluate the safety, feasibility, and optimal IA regimen in colorectal surgical…
- Trial name
- NCT03411109
- Testing
- Hydromorphone Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 601 people
- Sponsor
- Mayo Clinic
Flutter, Atrial, Over 18 Years Old
Hypnosis in Interventional Electrophysiology
Hypnosis has already shown to decrease pain and anxiety in different surgical specialities. Nevertheless, its input has never been studied in cardiology.
- Trial name
- PAINLESS (NCT03250871)
- Testing
- Hypnosis
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Poitiers University Hospital
Non-obstetric Lower Abdominal Surgery
Preemptive Oral Gabapentin 600 mg in Reducing Morphine Requirement After Non Obstetric Lower Abdominal Surgery
This study aimed to get the information about the effectiveness of preemptive oral gabapentin 600 mg in reducing morphine requirement after non obstetric lower abdominal surgery
- Trial name
- NCT04434430
- Testing
- Gabapentin
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Universitas Indonesia
Healthy
Effects of Ethanol on Oxycodone Pharmacokinetics in Healthy Volunteers
To Estimate Bioavailability Of 40 Mg Doses Of Pf-00345439 Formulation K Under Fasting Conditions with 40% Ethanol Compared with Water in Healthy Volunteers
- Trial name
- NCT02165930
- Testing
- Oxycodone, Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pain Therapeutics
Narcotic Abuse
Aprepitant Effects on Oxycodone Response
Addressing the issue of opioid dependence and tolerance has public health implications for the treatment of opioid abuse (both heroin as well as pharmaceutical opioids) and for the treatment of pain.
- Trial name
- NCT00999544
- Testing
- Aprepitant 0mg, Aprepitant 40mg, Aprepitant 200mg
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Pain, Postoperative, Arthroplasty, Replacement, Knee
Intrathecal Morphine in Knee Arthroplasty
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement.We hypothesized that a dose greater than that used in…
- Trial name
- NCT00695045
- Testing
- intra thecal morphine
- Volunteers
- 60 people
- Sponsor
- University College Hospital Galway
Parkinson's Disease With Severe Pain
A Randomised Placebo Controlled Study of OXN PR for Severe Parkinson's Disease Associated Pain
To demonstrate superiority of OXN PR compared to placebo with respect to analgesic efficacy in subjects with chronic severe pain associated with Parkinson's disease (PD), as assessed by averaged 24 hour pain scores collected for…
- Trial name
- NCT01439100
- Testing
- Oxycodone/Naloxone Prolonged Release tablets
- Where
- 31 sites in Czechia, Germany and 5 more
- Volunteers
- 172 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Pain
Safety and Pharmacokinetic Study of Oral Morphine Sulfate in Pediatric Subjects
The purpose of this study is to evaluate the tolerability and safety of oral morphine sulfate in the treatment of postoperative pain in different pediatric age groups following multiple-dose administration.
- Trial name
- NCT01322360
- Testing
- Morphine Sulfate
- Where
- 11 sites in United States
- Volunteers
- 50 people
- Sponsor
- Roxane Laboratories
Chronic Pain
An Interventional Study to Compare the Efficacy and Tolerability With Targin® in Non-malignant Chronic Pain (GLORY)
Objectives: 1. Objective of main interest To assess the drop-out rate caused by adverse event* after 6 weeks treatment 2. Further objectives To assess the drop-out rate caused by adverse event* after 1 week treatment To assess…
- Trial name
- NCT01811186
- Testing
- Oxycodone/naloxone
- Where
- South Korea
- Volunteers
- 261 people
- Sponsor
- Mundipharma Korea Ltd
Postoperative Pain
Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia
The investigators designed a randomized double-blind placebo-controlled trial to evaluate the effect of preoperative single dose of oral melatonin and vitamin C administration on postoperative analgesia in patients undergoing…
- Trial name
- NCT02639741
- Testing
- Melatonin, Vitamin C
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Cukurova University
Pain, Opioids
The Immune and Endocrine Systems in Chronic Non-cancer Patients Treated With Opioids
The primary aim is to investigate the dose and time dependent effects of different opioids on the immune and endocrine systems. The secondary aim is to investigate whether associations between the function of the immune and…
- Conditions
- Pain, Opioids, Immune System, Endocrine System
- Trial name
- NCT02277080
- Volunteers
- 82 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain, Cancer
Phase 2 Study of Tapentadol Prolonged Release in Cancer Pain Participants
The purpose of this study is to evaluate the efficacy, safety and pharmacokinetics (how the drug is absorbed in the body, distributed within the body, and how it is removed from the body over time; explores what the body does to…
- Trial name
- NCT00805142
- Testing
- Tapentadol PR
- Where
- 21 sites in Japan
- Volunteers
- 78 people
- Sponsor
- Janssen Pharmaceutical K.K.
Opioid-Related Disorders
Study to Evaluate the Subjective Effects of PTI-801 in Non-Physically Dependent Subjects With a History of Drug Abuse
This is a single-center, randomized, 7-way crossover, double-blind, active and placebo-controlled study to evaluate the subjective effects of oxycodone combined with ultra-low dose naltrexone in comparison to oxycodone alone in…
- Trial name
- NCT00734461
- Testing
- oxycodone and naltrexone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Pain Therapeutics
Pain, Postoperative
Dose-response of Ketamine in Patient Controlled Analgesia in Orthopaedic Surgery Patients
To study the multimodal protocol combining adjunct ketamine with oxycodone in intravenous patient-controlled analgesia bolus dosing and effects in patients scheduled for posterolateral lumbar spine fusion with bilateral…
- Trial name
- DoseRespKeta (NCT02994173)
- Testing
- Oxycodone, S-Ketamine 0.25, S-Ketamine 0.5
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Advanced Cancers, Dyspnea
Breakthrough Dyspnea Fentanyl Study in Cancer Patients
The goal of this clinical research study is to learn if fentanyl given under the skin can reduce shortness of breath in cancer patients. Researchers also want to learn if it can help to improve your physical function.
- Trial name
- NCT01515566
- Testing
- Fentanyl, Walking Tests, Questionnaires
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
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