Clinical trials: Ondansetron
Chronic Myeloproliferative Disorders, Leukemia
Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients With Hematological Cancer
RATIONALE: Giving low doses of chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Myelodysplastic Syndromes
- Trial name
- NCT00816413
- Testing
- cyclosporine, mycophenolate mofetil, pentostatin
- Sponsor
- University of Nebraska
Laparoscopic Cholecystectomy
Comparative Efficacy of Dexamethasone - Ondansetron Versus Dexamethasone - Haloperidol in Reducing PONV
Nausea and vomiting following laparoscopic cholecystectomy remain common, with occurrence rates of 40-70% during the initial 24 hours post-operation.
- Trial name
- NCT06428084
- Testing
- Ondansetron, Haloperidol
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Padjadjaran
Vomiting in Infants and/or Children
Efficacy and Safety of the Administration of Ondansetron Versus Habitual Clinical Practice for the Treatment of Vomiting in Children With Mild and Moderate Dehydration: Randomized Clinical Trial
This clinical trial is intended to evaluate the efficacy and safety of the administration of ondansetron in children with mild-moderate dehydration.
- Trial name
- NCT04318847
- Testing
- Ondansetron 4 MG
- Volunteers
- 220 people
- Sponsor
- Lizar Aguirre Pascasio
Laparotomy
Feasibility and Efficacy of Enhanced Recovery After Surgery (ERAS) on Length of Stay Among Laparotomy Patients at Mbarara Regional Referral Hospital
The main goal of ERAS is to enhance the recovery of patients, and this has secondary effects, such reduced length of hospital stay, minimal postoperative complications and lessen readmission rates.
- Trial name
- ERAS-Lap (NCT03665376)
- Testing
- Carbohydrate drink load, Enhanced Recovery After Surgery (ERAS)
- Where
- Uganda
- Volunteers
- 33 people
- Sponsor
- Mbarara University of Science and Technology
Gastroparesis
G-POEM for Glycemic Control in Diabetic Gastroparesis
Gastroparesis, commonly caused by diabetes, affects 30-50% of diabetic individuals and complicates glycemic control due to its bidirectional relationship with blood glucose levels. Current treatments are often ineffective.
- Trial name
- DIAPOEM (NCT06965543)
- Testing
- Immediate G-POEM, Delayed G-POEM
- Volunteers
- 40 people
- Sponsor
- French Society of Digestive Endoscopy
Pancreatic Diseases
Evaluating the Safety and Efficacy of Ondansetron in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Endoscopic retrograde cholangiopancreatography (ERCP (, a key tool that is used in diagnosis and treatment of pancreato-biliary diseases.
- Trial name
- NCT06861010
- Testing
- Ondansetron
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Allergy
The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron
Perioperative anaphylaxis is a potentially life-threatening drug allergic reaction that can occur during anesthetic procedures. The purpose of this research is to determine the maximal nonirritating skin testing concentrations of…
- Trial name
- NCT07103720
- Testing
- Skin Testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nausea and Vomiting
Comparison of the Effect of Ondansetron and Combined Ondansetron and Betahistine on Postoperative Nausea and Vomiting After Gynecological Laparoscopy
Many patients undergoing gynecologic laparoscopic surgery experience postoperative nausea and vomiting (PONV) despite prophylaxis and treatment with HT3 receptor antagonists such as ondansetron.
- Trial name
- NCT02026778
- Testing
- ondansetron, ondansetron-betahistine
- Where
- South Korea
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Injection Site Irritation
Ondansetron as a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial
This study is a randomized, single-site clinical trial that will take place at Children's Healthcare of Atlanta at Egleston. The investigators want to see if in pediatric patients, giving Zofran prior to propofol, reduces the…
- Trial name
- NCT05378113
- Testing
- Ondansetron, Lidocaine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Emory University
Laparoscopic Surgery, Liposomal Bupivacaine
The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery
Laparoscopic surgery has become the preferred approach for abdominal surgical interventions due to its advantages of minimal invasiveness, rapid recovery, and reduced complication rates.
- Conditions
- Laparoscopic Surgery, Liposomal Bupivacaine, Transversus Abdominis Plane Block
- Trial name
- NCT07458282
- Testing
- Bupivacaine hydrochloride, Liposomal bupivacaine plus bupivacaine
- Where
- China
- Volunteers
- 318 people
- Sponsor
- Beijing Tiantan Hospital
Obsessive Compulsive Disorder
Ondansetron in Treatment Resistant Obsessive Compulsive Disorder (OCD)
Given that 5-HT3 receptors are indirect inhibitors of cortico-mesolimbic DA release, the 5-HT3 receptor antagonist ondansetron augmentation might potentially have efficacy in the treatment of resistant Obsessive Comulsive…
- Trial name
- NCT00796497
- Testing
- ondansetron
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Institute of Neuroscience, Florence, Italy
Acute Myocarditis
The Role of Levosimendan as Inotropic Agent in Acute Aluminum Phosphide-induced Cardiotoxicity
To evaluate the potential role of levosimendan as an inotropic agent in aluminum phosphide-induced cardiotoxicity
- Trial name
- NCT06478667
- Testing
- levosemindan
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Hypotension
The Effect of Ondansetron on Spinal Anesthesia in Caesarean Section
The purpose of this study is to compare the administration of two different doses of ondansetron to placebo to prevent hypotension and bradycardia following spinal anaesthesia.
- Trial name
- NCT03931863
- Testing
- Ondansetron 4mg, Ondansetron 8mg, 100ml normal saline 0.9 percent
- Where
- Greece
- Volunteers
- 180 people
- Sponsor
- Aretaieion University Hospital
Electroacupuncture, Olanzapine-contained Four-drug Antiemetic
Electroacupuncture for the Prevention of Chemotherapy-induced Nausea and Vomiting in Patients With Breast Cancer
This randomized controlled phase III trial aims to evaluate the use of electroacupuncture in combination with olanzapine-containing standard quadruple antiemetic drugs for the treatment of nausea and vomiting induced by highly…
- Conditions
- Electroacupuncture, Olanzapine-contained Four-drug Antiemetic, Nausea and Vomiting
- Trial name
- NCT06200168
- Testing
- Electroacupuncture, Standard antiemetic treatment
- Where
- China
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Jiuda Zhao
Anesthesia, Regional Anesthesia
M-Tapa Block vs External Oblique Intercostal Block for Laparoscopic Sleeve Gastrectomy Surgery
In obese patients, adequate pain relief in the postoperative period is an important parameter that affects patient comfort and hospital stay.
- Conditions
- Anesthesia, Regional Anesthesia, Postoperative Pain
- Trial name
- NCT05939635
- Testing
- Bilateral ultrasound guided external oblique intercostal block (EOIB), Bilateral ultrasound guided Modified thoracoabdominal nerves block through perichondrial approach(M-TAPA) block, IV morphine patient-controlled analgesia (PCA)
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ondokuz Mayıs University
Postoperative Pain Management, Laparoscopic Cholecystectomy
Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy
Brief Summary Background: Laparoscopic cholecystectomy is a common procedure where postoperative pain and nausea/vomiting (PONV) remain significant issues, impairing recovery.
- Conditions
- Postoperative Pain Management, Laparoscopic Cholecystectomy, Ondansetron, Postoperative Nausea and Vomiting
- Trial name
- PLUSO (NCT06632184)
- Testing
- Ondansetron Intraperitoneal Lavage, Saline Intraperitoneal Lavage
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Mexicano del Seguro Social
Oncology
Comparative Effectiveness of AKYNZEO® and Standard of Care (Including EMEND®) for the Prevention of Nausea and Vomiting (CINV) in Cancer Patients
This pragmatic trial addresses the clinical gap through the generation of evidence on the comparative effectiveness between AKYNZEO® and Standard of Care (SoC, including EMEND®) in the real-life setting
- Trial name
- NCT03831633
- Testing
- Akynzeo, Standard of Care
- Where
- France
- Volunteers
- 426 people
- Sponsor
- VIFORFRANCE
Postoperative Pain, Psychological Factors
Psychosocial Factors and Postoperative Pain in Aesthetic Breast Surgery
This study investigates the relationship between psychosocial factors, particularly self-esteem and personality traits, and postoperative pain in patients undergoing aesthetic breast surgery.
- Conditions
- Postoperative Pain, Psychological Factors, Breast Surgery, Aesthetic Surgery
- Trial name
- NCT06707818
- Testing
- Preoperative Interventions, Intraoperative Interventions, Postoperative Interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- V.K.V. American Hospital, Istanbul
Intra-operative Hypotension
Preoperative Point of Care Ultrasound Guided Fluid Optimization and Intravenous Ondansetron to Prevent General Anesthesia-Induced Hypotension
Hypotension is a common side-effect of general anesthesia induction and is related to adverse outcomes including significantly increasing risk of one-year mortality.
- Trial name
- NCT05784350
- Testing
- fluid boluses guided by IVC diameter via US/administration of pre-operative IV Odansetrone
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Meir Medical Center
Inguinal Hernia, Pain, Postoperative
Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair
One of the most common complications after hernia repair is postoperative and chronic pain. TAP (transverse abdominis plain) block is a recommended multimodal method of reducing postoperative pain in laparoscopic and open…
- Trial name
- NCT03023462
- Testing
- Oksykodonhydroklorid, Ondansetron and Droperidol, Ropivacaine
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Ostfold Hospital Trust