Clinical trials: Paracetamol
Fever
Acetaminophen Before Vaccines for Infants Study (AVIS)
The purpose of this study is to see whether giving acetaminophen (the medicine in Tylenol) for routine infant vaccinations is helpful in preventing fever or other symptoms.
- Trial name
- NCT00325819
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 374 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Lymphoma, Non-Hodgkin, Advanced Stage Diffuse Large B-Cell Non-Hodgkin's Lymphoma
Tailoring Treatment for B Cell Non-hodgkin's Lymphoma Based on PET Scan Results Mid Treatment
The purpose of this study is to assess whether patients who are likely to fail R-CHOP, as predicted by a mid-treatment PET scan, can have an improved outcome if switched to a standard salvage regimen R-ICE (rituximab, ifosfamide…
- Trial name
- LYTPET (NCT00324467)
- Testing
- Cyclophosphamide, Doxorubicin, Vincristine
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- British Columbia Cancer Agency
Thumb Basal Joint Osteoarthritis, Postoperative Pain
Journavx to Treat Pain After Thumb Basal Joint Arthroplasty
The purpose of this study is to find out how well suzetrigine, a newly FDA-approved non-opioid pain medication, works to relieve pain after thumb basal joint replacement surgery.
- Conditions
- Thumb Basal Joint Osteoarthritis, Postoperative Pain, Joint Replacement Surgery, Joint Replacement
- Trial name
- NCT07723352
- Testing
- suzetrigine 100mg, Acetaminophen
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Symptomatic Irreversible Pulpitis (SIP)
Comparison Of Acetaminophen, NSAIDs, And Trypsin-Chymotrypsin Plus Acetaminophen For Post-Endodontic Pain After Single-Visit Root Canal Treatment
This randomized control trial will be planned according to PRIRATE 2020 guideline for reporting randomized trials in Endodontics.
- Trial name
- NCT07759349
- Testing
- Acetaminophen, NSAID, trypsin-chymotrypsin
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Healthy Volunteers
Bioequivalence of a Fixed Dose Combination Tablet Containing 400 mg Ibuprofen and 60 mg Pseudoephedrine-HCl Compared to Two Film Coated Fixed Dose Combination Tablets RhinAdvil(R)(200 mg Ibuprofen and 30 mg Pseudoephedrine-HCl) Administered in Healthy Subjects
Primary objective To demonstrate the bioequivalence of a fixed dose combination tablet containing 400 mg Ibuprofen and 60 mg Pseudoephedrine-HCl vs.
- Trial name
- NCT02963701
- Testing
- Ibuprofen, Pseudoephedrine-HCl
- Where
- South Africa
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Pain, Long-bone Fractures
Analgesic Efficacy of Morphine Alone or Combined With Paracetamol and/or Ibuprofen for Long-bones Fractures in Children
The main objective of this study is to evaluate the efficacy of two drugs: paracetamol and ibuprofen in association with morphine, compared with morphine alone on analgesia in children seen in the emergency department for a…
- Trial name
- MORPHAPAIN (NCT02477007)
- Testing
- Paracetamol, Ibuprofen, paracetamol + ibuprofen
- Where
- France
- Volunteers
- 304 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Analgesia, Anesthesia, Local
Suprainguinal Fascia Iliaca Block in Knee Arthroplasty
Total knee arthroplasty is the most commonly performed orthopedic surgery, especially in patients with advanced gonarthrosis and limited joint movement. After total knee arthroplasty, patients experience unbearably severe pain.
- Trial name
- NCT06386575
- Testing
- control group; Patients who received physiological saline, suprainguinal fascia block; Patients receiving local anesthetic
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Cutaneous Tumors, Mohs Micrographic Surgery
Suzetrigine vs Norco-postoperative Mohs Pain
To compare suzetrigine versus hydrocodone/acetaminophen for postoperative pain control following dermatologic surgery.
- Trial name
- NCT07575230
- Testing
- Norco 5Mg-325Mg Tablet, Suzetrigine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Baylor Research Institute
Ankle (Ligaments); Instability (Old Injury), Ankle Sprain
A Study on Reducing Opioid Use After Ankle Arthroscopy
Study Title Effect of a Postoperative Multimodal Analgesic Protocol Predominantly Based on Non-Opioid Medications vs Opioid-Based Analgesia on Pain After Ankle Arthroscopy: A Noninferiority Randomized Clinical Trial Purpose This…
- Conditions
- Ankle (Ligaments); Instability (Old Injury), Ankle Sprain, Talus Osteochondral Defect, Opioid Analgesia
- Trial name
- NCT07154433
- Testing
- Opioid Analgesic Regimen, Non-opioid analgesic regimen
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Surgery, Upper Extremity
Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery
The purpose of this study is to learn about the effectiveness of different pain control options after hand and wrist surgery, specifically Ketorolac, Tylenol, and a regional nerve block.
- Trial name
- NCT07773155
- Testing
- Toradol, Oxycodone
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Chicago
Common Cold, Pharyngitis
Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold
The purpose of this study is to determine the efficacy and safety of 1000 mg Aspirin (study medication) by comparing 1000 mg Paracetamol (study medication) in treating the symptoms of sore throat associated with a common cold.
- Conditions
- Common Cold, Pharyngitis, Tonsillitis
- Trial name
- NCT01465009
- Testing
- Acetylsalicylic acid (Aspirin, BAYE4465), Paracetamol
- Where
- 8 sites in United Kingdom
- Volunteers
- 508 people
- Sponsor
- Bayer
Acetaminophen Toxicity
Adduct Dipstick for Diagnosis of Acetaminophen Toxicity
This study is a non-intervention, clinical study to test "research use only" APAP protein adducts dipsticks in human blood samples. The study will be conducted in two phases.
- Trial name
- NCT01575847
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Lung Neoplasm Malignant
Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)
The main goals are after treatment given before surgery, to measure the number of people who have no signs of cancer cells in tumors and lymph nodes removed during surgery; and to learn about whether the cancer gets smaller or…
- Trial name
- NCT06788912
- Testing
- Pembrolizumab (neoadjuvant), Cisplatin, Gemcitabine
- Where
- 39 sites in United States, Chile and 7 more
- Volunteers
- 60 people
- Sponsor
- Merck Sharp & Dohme LLC
Arthritis, Pain
Non-cancer Pain and Cognitive Impairment: A Disabling Relationship
To compare the efficacy of long-acting oxycodone to extended-release acetaminophen in older persons with no and mild to moderate cognitive impairment and persistent moderate or higher intensity non-cancer lower extremity…
- Conditions
- Arthritis, Pain, Cognitive Impairment
- Trial name
- NCT01264965
- Testing
- long acting oxycodone, extra strength acetaminophen
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Chicago
Pulsed Radiofrequency, Shoulder Individual Nerves Brachial Plexus
Pulsed Radiofrequency of Shoulder Individual Nerves Versus Brachial Plexus in Management of Chronic Post Mastectomy Shoulder Pain
this study aims to assess the role of pulsed radiofrequency of the brachial plexus or pulsed radiofrequency of shoulder individual nerves in the management of post-mastectomy shoulder pain.
- Conditions
- Pulsed Radiofrequency, Shoulder Individual Nerves Brachial Plexus, Chronic, Post Mastectomy
- Trial name
- NCT07002944
- Testing
- Brachial plexus pulsed radiofrequency, Sholder individual nerves pulsed radiofrequency, Control
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Surgical Procedures, Operative
The Excess Opioid Disposal Study
This study is designed to test the hypothesis that providing information to patients about excess opioid disposal, calling patients prior to their outpatient post-operative surgical appointment and providing a convenient drop box…
- Trial name
- NCT03694899
- Testing
- phone contact
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Postherpetic Neuralgia
Erector Spinae Plane Block in Post-herpetic Neuralgia
This randomized clinical study will be carried out on 72 patients admitted to the pain clinic in Tanta University Hospitals with post-herpetic neuralgia.
- Trial name
- NCT04546334
- Testing
- Medical treatment, Real Erector Spinae block, Real Erector Spinae block with magnesium sulphate
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Cesarean Delivery, Cesarean Section
Suzetrigine for Opioid-Free Recovery After Cesarean Delivery
The goal of this clinical trial is to determine whether suzetrigine increases the proportion of patients who remain completely opioid-free from completion of surgery through 72 hours after cesarean delivery.
- Conditions
- Cesarean Delivery, Cesarean Section, Pain, Postoperative, Opioid Consumption, Postoperative
- Trial name
- SPARE (NCT07534709)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Texas at Austin
Nephrotic Syndrome
Ofatumumab Versus Rituximab in Children With Steroid and Calcineurin Inhibitor Dependent Idiopathic Nephrotic Syndrome
Open-label, two-parallel-arm, controlled randomized clinical trial testing the superiority of Ofatumumab over Rituximab in maintaining steroid- and calcineurin-inhibitor-free disease remission in SD-INS.
- Trial name
- NCT02394119
- Testing
- Ofatumumab, Rituximab
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Istituto Giannina Gaslini
Acute Pain, Cancer Pain
Usefulness of Acetaminophen Associated With Strong Opioids for Acute Pain in Cancer Patients
Cancer pain is one of the most frequent and relevant symptoms in cancer patients and has a great impact on a patient's quality of life.
- Trial name
- NCT04779567
- Testing
- Acetaminophen
- Where
- Chile
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
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