Clinical trials: Physical activity
Weight, Physical Activity
A Virtual Support Pilot Program for Weight Loss Surgery Patients
Obesity affects over one-third of the US population, and is associated with serious medical problems like diabetes and heart disease.
- Trial name
- NCT01770366
- Testing
- Weight and Exercise Lifestyle Support (WELS), Usual Care
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Older Adults, Healthy Aging
danceSing Care Evaluation: Testing the Effectiveness
This pilot randomised controlled trial aims to compare the effectiveness of a 12-week music and movement intervention in older adults in care homes compared to a waitlist control group.
- Conditions
- Older Adults, Healthy Aging, Aging, Quality of Life
- Trial name
- NCT05601102
- Testing
- danceSing Care
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Stirling
Knee Osteoarthritis
Knee Arthroplasty Pain Coping Skills Training (KASTPain): A Randomized Trial
Patients undergoing knee replacement surgery and who have high levels of pain catastrophizing are at risk for poor outcome. The clinical trial is designed to determine if a pain coping skills training intervention delivered by…
- Trial name
- KASTPain (NCT01620983)
- Testing
- Pain Coping Skills Training, Arthritis Education, Usual Care
- Where
- 5 sites in United States
- Volunteers
- 402 people
- Sponsor
- Virginia Commonwealth University
Surrogate Decision-making, Healthcare Spokesperson
Choosing an Effective Healthcare Spokesperson: An Interactive Intervention
The investigators developed a "serious game" intervention called "Who Would You Choose: Serious Fun" (WWYC) to help people consider the key qualities healthcare spokespersons should have.
- Conditions
- Surrogate Decision-making, Healthcare Spokesperson, Advance Care Planning
- Trial name
- NCT04599166
- Testing
- Who Would You Choose: Serious Fun
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Obesity, Lifestyle-related Condition
Lifestyle Intervention in Preparation for Pregnancy (LIPP)
Studies evaluating lifestyle intervention in obese women during pregnancy have reported limited success in decreasing excessive gestational weight gain, and have failed to achieve the key outcome of breaking the obesity cycle and…
- Conditions
- Obesity, Lifestyle-related Condition, Macrosomia, Fetal
- Trial name
- NCT03146156
- Testing
- Lifestyle Intervention
- Where
- 4 sites in United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Functional Neurological Disorder
Body Signal Integration Training: A Case Series
The goal of this clinical trial is to learn about an intervention package in individuals with Functional Neurological Disorder (FND).
- Trial name
- NCT05941702
- Testing
- Body Signal Integration Training
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Manchester
Chronic Disease Prevention
Evaluate Health Coaching Support in Technology-based Interventions for Meeting Health Goals
This was a pilot evaluation conducted to test procedures for a possible future trial and provide preliminary insights regarding whether text messages sent to Veterans could help support nutrition and/or physical activity health…
- Trial name
- Coaching (NCT04021472)
- Testing
- Text message
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Carcinoma, Non-Small-Cell Lung
A Study of Lazertinib in Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Positive Advanced Non-Small Cell Lung Cancer (NSCLC)
The main purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of Lazertinib when given orally to participants with epidermal growth factor receptor single activating mutation positive (EGFRm+)…
- Trial name
- NCT04075396
- Testing
- Lazertinib
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 29 people
- Sponsor
- Janssen Research & Development, LLC
Heart Failure
Exercise and Cognitive Retraining to Improve Cognition in Heart Failure.
Cognitive impairment (CI) is a prevalent problem in persons with HF heart failure (HF) and is associated with adverse clinical outcomes, higher mortality and poorer quality of life.
- Trial name
- EXCITE (NCT02151266)
- Testing
- Exercise and Cognitive retraining, Exercise Only, Stretching and Flexibility
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Emory University
Primary Aldosteronism, Resistant Hypertension
Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension
Primary aldosteronism (PA) is common but rarely recognized cause of hypertension that carries excess cardiovascular and renal risk and has approved targeted treatments.
- Conditions
- Primary Aldosteronism, Resistant Hypertension, Secondary Hypertension, Hyperaldosteronism
- Trial name
- ALERT-PA (NCT05925569)
- Testing
- Best Practice Advisory Computerized Alert
- Where
- United States
- Volunteers
- 12,501 people
- Sponsor
- Brigham and Women's Hospital
Post-stroke Depression, Post-stroke Aphasia
Impact of Intensive Social Interaction on Post-Stroke Depression in Individuals With Aphasia
The present parallel-group, single-center, blinded-assessment controlled trial seeks to explore the feasibility - in terms of high completion rates - and potential efficacy of intensive communicative-pragmatic social interaction…
- Trial name
- CONNECT (NCT04318951)
- Testing
- Intensive communicative-pragmatic social interaction., Standard care.
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Medicine Greifswald
Cardiovascular Disease, Peripheral Artery Disease
Platelet Activity in Vascular Surgery and Cardiovascular Events
Pathological and clinical studies have consistently demonstrated that abnormalities in thrombosis and hemostasis play a major role in the pathogenesis of atherosclerosis and atherothrombosis.
- Conditions
- Cardiovascular Disease, Peripheral Artery Disease, Critical Limb Ischemia
- Trial name
- PACE (NCT02106429)
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- NYU Langone Health
Myelofibrosis
Study to Evaluate Activity of 2 Dose Levels of Imetelstat in Participants With Intermediate-2 or High-Risk Myelofibrosis (MF) Previously Treated With Janus Kinase (JAK) Inhibitor
The purpose of this study is to evaluate the efficacy and safety of 2 dose regimens of imetelstat in participants with intermediate-2 or high-risk myelofibrosis (MF) whose disease is relapsed after or is refractory to Janus…
- Trial name
- NCT02426086
- Testing
- Imetelstat 4.7 mg/kg, Imetelstat 9.4 mg/kg
- Where
- 72 sites in United States, Belgium and 9 more
- Volunteers
- 107 people
- Sponsor
- Geron Corporation
Heart Failure, Caregivers
Heart Failure Resilience Intervention for Caregivers
Heart failure (HF) patients with supportive caregivers have better physical health, emotional health, and quality of life. But caregivers have an increased risk of caregivers' own worsening health and often feel a sense of burden…
- Trial name
- HEROIC (NCT03963583)
- Testing
- HEROIC
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Treadmill Walking
Treadmill Oscillation Walking to Improve Weight Transfer During Gait Following Stroke
This study aims to determine the immediate and short-term effects of treadmill oscillation walking (TOW) exercise on hip and knee neuromechanics and gait characteristics in individuals post-stroke.
- Trial name
- TOW (NCT05541705)
- Testing
- Treadmill Oscillation Walking
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Texas at Austin
Heart Failure
Crome/Cobalt Respiration Study
The goal of this study is to compare measured respiration rates in various subject scenarios and use conditions between capnography and the Crome and Cobalt ICD and CRT-D MRI SureScan devices (derived using a Holter recorder).
- Trial name
- NCT06089694
- Testing
- Enabling Sensor Research Holter Mode feature
- Where
- 4 sites in United States
- Volunteers
- 61 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Stroke
Adaptive Physical Activity for Chronic Stroke
This study will compare the Adaptive Physical Activity program (APA) to a less vigorous group exercise program, (Sittercise) to see if APA leads to greater improvements in walking endurance, quality of life, and participation in…
- Trial name
- APA-Stroke (NCT00773370)
- Testing
- APA-Stroke, Sittercise
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- VA Office of Research and Development
Cancer
Improving Communication Between Cancer Patients & Oncologists
The overarching goal of this project is to improve communication between oncologists and their patients by ensuring that the patient's voice is heard in the medical encounter.
- Trial name
- NCT02969031
- Testing
- Enhanced SCOPE training, Standard Communication training
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Hepatitis C
A Study to Assess the Anti-viral Activity, Safety, Tolerability and Pharmacokinetics of TMC435350 in Participants Infected With Hepatitis C-Virus (HCV)
The purpose of this study is to assess anti-viral activity (inhibition of viral growth) of TMC435350 in genotype 2,3,4,5 and 6 hepatitis C virus infected participants who have never received treatment for their hepatitis C…
- Trial name
- NCT00812331
- Testing
- TMC435
- Where
- 10 sites in Belgium, Germany and 1 more
- Volunteers
- 37 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Pregnancy Complications, Obesity
Acute Exercise Effects in Obese Pregnancy
Obesity before and during pregnancy is associated with a higher risk for a number of obstetric and metabolic complications in women and their offspring.
- Conditions
- Pregnancy Complications, Obesity, Pre-Eclampsia, Gestational Diabetes
- Trial name
- NCT03750695
- Testing
- Resistance exercise, Aerobic Exercise, Rest
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
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