Clinical trials: Routine care
Bipolar Disorder
Improving Adherence in Adolescents and Young Adults With Bipolar Disorder
Although poor medication adherence occurs in more than 65% of adolescent and young adults (AYA) with bipolar disorder (BD) and is associated with poor recovery, high rates of relapse, and a 5.2 fold increased suicide risk, there…
- Trial name
- IGNITE (NCT04348604)
- Testing
- Customized Adherence Enhancement for Adolescents and Young Adults (CAE-AYA), Enhanced Treatment as Usual (ETAU)
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Case Western Reserve University
Anxiety
Reducing Anxiety and Stress in Primary Care Patients
Anxiety is common among primary care patients, but is undertreated. The purpose of this study is to evaluate whether a brief anxiety treatment designed for VA primary care is more effective at reducing anxiety symptoms in…
- Trial name
- NCT03794089
- Testing
- Brief anxiety intervention, Usual PC-MHI care
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- VA Office of Research and Development
Vancomycin-Resistant Enterococcus
Effect of Bed Bathing Methods on VRE Colonization in ICU Patients
This randomized controlled trial aims to compare the effects of two different bed bathing methods on vancomycin-resistant Enterococcus (VRE) colonization in adult intensive care unit patients.
- Trial name
- NCT07364435
- Testing
- Bed Bath, Disposable antibacterial bed bath wipes, Chlorhexidine gluconate 4%
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people
- Sponsor
- Özkan Kasap
Peripheral Artery Disease
FlowMet-R Blood Flow Measurement for the Diagnosis of Peripheral Artery Disease and Critical Limb Ischemia
Non-randomized, multi-center, longitudinal study of healthy subjects and subjects with PAD who are scheduled for ABI, TBI, and either Duplex Ultrasound or Angiographic assessments in a vascular clinic.
- Trial name
- NCT04120610
- Testing
- FlowMet-R, ABI, TBI
- Where
- 5 sites in United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Medtronic Endovascular
HIV Infections, Pregnancy Related
Happy Homes, Healthy Families: A Relationship Strengthening Intervention for Pregnant Couples Affected by HIV in Zambia
The objective of this study is to test the preliminary efficacy of a novel couples' counseling intervention to promote the health of pregnant women living with HIV in Lusaka, Zambia.
- Trial name
- NCT04729413
- Testing
- Couples Counseling, Enhanced Standard of Care
- Where
- Zambia
- Volunteers
- 478 people
- Sponsor
- University of Colorado, Denver
Pain
Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Burn pain is known to be one the most severe forms of acute pain often requiring large amounts of narcotics in addition to other adjuvants.
- Trial name
- LidocaineBurn (NCT02229578)
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Substance Use Disorders, HIV
Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care
Substance use disorders (SUDs), depression and anxiety in HIV-infected patients result in poor HIV outcomes, yet are often unrecognized and untreated.
- Conditions
- Substance Use Disorders, HIV, Depression, Anxiety
- Trial name
- PACE (NCT03217058)
- Testing
- Clinic-based screening and behavioral interventions
- Where
- United States
- Volunteers
- 10,821 people
- Sponsor
- University of California, San Francisco
Acute Heart Failure
Short Stay Unit vs Hospitalization in Acute Heart Failure
The majority of the over one million annual AHF hospitalizations originate from the emergency department. Admitting and re-admitting lower risk AHF patients who don't need prolonged hospitalization may increase their risk for…
- Trial name
- SSU-AHF (NCT03302910)
- Testing
- Short Stay Unit, Standard of Care
- Where
- 11 sites in United States
- Volunteers
- 194 people
- Sponsor
- Indiana University
Rheumatoid Arthritis
An Observational Study of RoActemra/Actemra (Tocilizumab) As Monotherapy in Rheumatoid Arthritis Patients in Routine Clinical Practice
This prospective, multi-center, observational study will evaluate factors influencing the use of tocilizumab (RoActemra/Actemra) as monotherapy in rheumatoid arthritis patients in real life setting.
- Trial name
- ACT SOLO (NCT01474291)
- Testing
- Tocilizumab
- Where
- 119 sites in France
- Volunteers
- 608 people
- Sponsor
- Hoffmann-La Roche
Intimate Partner Violence, Substance Abuse/Addiction
Intimate Partner Violence and Fatherhood Intervention in Residential Substance Abuse Treatment
The proposed stage 1 intervention development study is designed to address two significant co-occurring issues for fathers with substance abuse (SA) problems: Intimate partner violence (IPV) and child maltreatment (CM).
- Conditions
- Intimate Partner Violence, Substance Abuse/Addiction, Child Maltreatment
- Trial name
- NCT02979262
- Testing
- Fathers for Change, Parent Education
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of South Florida
Endometrial Cancer, Survivorship
Feasibility of a Patient Directed Tool to Assess Heart Health Among Endometrial Cancer Survivors
Investigators are conducting this study to find out more about what heart health means to participants and how healthcare providers can best help to manage heart health.
- Trial name
- NCT05796518
- Testing
- PREVENT Cardiovascular Health Assessment Tool, Survey, Interview Regarding Heart Health
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Wake Forest University Health Sciences
Insomnia, Alcohol Use Disorder
CBT-I on Alcohol Treatment Outcomes Among Veterans
Project SAVE aims to examine the feasibility, acceptability, and initial efficacy of a CBT-I supplement to alcohol treatment of Veterans.
- Trial name
- Project SAVE (NCT03806491)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene, Alcohol Use Disorder Treatment as Usual
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Lower Urinary Tract Symptoms, Overactive Bladder
Tetra-NIRS Clinical Study
The purpose of this evaluation is to validate the previous clinical study results using a Near-Infrared Spectroscopy (NIRS) device, as compared to the conventional urodynamics (UDS) testing.
- Trial name
- NCT00871975
- Testing
- Urodynamics + TETRA - NIRS
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 155 people
- Sponsor
- Laborie Medical Technologies Inc.
Trauma
Enhanced Consent for Symptom Provocation Research
The overall goal of the proposed study is to insure the protection and safety of human subjects who have been previously exposed to interpersonal traumatic events and who are participants in symptom provocation research.
- Trial name
- NCT01809899
- Testing
- Enhanced consent procedure, Consent as Usual
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Chronic Disease, Frail
Functional Exercise and Nutrition Education Program for Older Adults
There is strong evidence that specific types of exercise can improve health and physical function in older adults. While community exercise classes exist, many older adults with chronic conditions may need guidance from…
- Conditions
- Chronic Disease, Frail, Diabetes Mellitus, Cancer
- Trial name
- MoveStrong (NCT04037436)
- Testing
- Strength and Balance Training & Nutrition Education, Usual Care
- Where
- 5 sites in Canada
- Volunteers
- 44 people
- Sponsor
- University of Waterloo
Adductor Tendinitis
Adductor Longus Tenotomy & the BKFO Test
The bent knee fall out test (BKFO) is a common test for hip adductor flexibility. It is unknown whether the BKFO actually tests the the adductors or potentially hip range of motion instead.
- Trial name
- NCT04453592
- Testing
- No intervention assigned as part of this study.
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Aspetar
Patient-centered Medical Home Implementation
Implementation of Women's Health Patient Aligned Care Teams
VA has undertaken a major initiative to transform care through implementation of Patient Aligned Care Teams (PACTs). Based on the patient-centered medical home (PCMH) concept, PACT aims to improve access, continuity, coordination…
- Trial name
- WH-PACT (NCT02039856)
- Testing
- Multilevel stakeholder engagement, Quality improvement (QI) education/training, Technical support
- Where
- 13 sites in United States
- Volunteers
- 3,900 people
- Sponsor
- VA Office of Research and Development
Polytrauma
Inflammatory Markers in Trauma Patient Outcomes
It is unknown whether early modulation of inflammatory cytokines is associated with improved patient outcomes, reduced narcotic requirements in orthopaedic patient population, and improved patient subjective pain after hospital…
- Trial name
- NCT03671746
- Testing
- Ketorolac, Saline Solution
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Arun Aneja
Postoperative Complications, Hip Fracture
A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia
This pilot project will address the gaps in knowledge regarding the effect of anesthetic technique on the risk of delirium through an adequately-powered trial employing standardized regimens for treatment and outcome assessment…
- Conditions
- Postoperative Complications, Hip Fracture, Delirium
- Trial name
- NCT02190903
- Testing
- General endotracheal anesthesia, Regional (spinal) Anesthesia
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Bipolar Disorder
Project CARE: An Integrated Treatment Adherence Program for Bipolar Disorder at the Time of Prison Release - Pilot RCT
The aim of this program of research is to develop and pilot the CARE (Community treatment Adherence at Re-Entry) program, an adjunctive intervention for incarcerated individuals with bipolar disorder (BD) transitioning from…
- Trial name
- NCT04269772
- Testing
- CARE, Treatment As Usual
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Brown University