Clinical trials: Sildenafil
Anovulatory
The Effect of Sildenafil Citrate on the Success Rate of Ovulation Induction Using Clomiphene
The aim of the study is to evaluate the effect of sildenafil citrate on the pregnancy rate in women undergoing induction of ovulation using clomiphene citrate.
- Trial name
- NCT02663830
- Testing
- Sildenafil & clomiphene citrate, clomiphene only
- Volunteers
- 210 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 2, Endothelial Dysfunction
Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes
Type 2 Diabetes Mellitus (T2DM) represents a model of endothelial dysfunction, where chronic nitric oxide deprivation, hyperglycaemia and hyperinsulinemia and fibrogenic mediators lead to cardiovascular remodelling associated…
- Trial name
- CECSID (NCT00692237)
- Testing
- Sildenafil
- Where
- Italy
- Volunteers
- 59 people
- Sponsor
- University of Roma La Sapienza
High Risk Pregnancy
Sildenafil Citrate Added to Low Molecular Weight Heparin and Low Dose Aspirin in High-risk Pregnancy
Anticoagulant therapy is indicated during pregnancy for the prevention and treatment of venous thromboembolism, systemic embolism in patients with mechanical heart valves and, in combination with aspirin, for the prevention of…
- Trial name
- NCT04110444
- Testing
- Sildenafil
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Diabetes
Effect of Chronic PDE5-Inhibition on Endothelial Function in Diabetics
chronic PDE5-Inhibition improves endothelial function in diabetics
- Trial name
- NCT00420901
- Testing
- sildenafil
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Erectile Dysfunction
Combination Therapy of Tadalafil 2.5mg Plus Sildenafil 25mg Versus Tadalafil 5 mg Monotherapy for Treatment of Erectile Dysfunction: A Randomized, Placebo-Controlled Double-Blinded Cross-Over Study
Erectile dysfunction (ED) is characterized by the persistent inability to attain or sustain an erection adequate for satisfactory sexual intercourse.
- Trial name
- NCT07177326
- Testing
- Tadalafil 2.5 mg, Sildenafil 25 mg, Tadalafil 5 mg
- Volunteers
- 142 people
- Sponsor
- Assiut University
Erectile Dysfunction
A Study to Evaluate a Possible Superiority Expressed by the Faster Onset of Action and the Efficacy and Safety of Sildenafil Citrate 20mg Sublingual Tablet in the Treatment of Erectile Dysfunction of Different Etiologies
The purpose of this study is to evaluate the tolerability and safety of Sildenafil Citrate 20mg Sublingual tablet, as well as a possible superiority expressed by the faster onset of action compared to Viagra ® 50mg tablet Coated…
- Trial name
- NCT01321489
- Testing
- Sildenafil Citrate 20mg Tablet Sublingual, Viagra ® 50mg tablet Coated
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Laboratório Teuto Brasileiro S/A
Rectal Cancer
Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer
This study aims to evaluate the efficacy of erectile rehabilitation with Sildenafil, in men treated with neoadjuvant proctectomy and radiotherapy for rectal cancer, in preventing long-term erectile dysfunction at 12 months…
- Trial name
- RECTIL (NCT06123156)
- Testing
- Sildenafil
- Where
- 14 sites in France
- Volunteers
- 188 people
- Sponsor
- University Hospital, Rouen
Erectile Dysfunction
Pharmacokinetics Of Sildenafil Orally Disintegrating Tablet Formulation Versus To Viagra® Oral Tablet.
This study will evaluate if an orally disintegrating tablet of sildenafil will have similar pharmacokinetic properties as the conventional tablet of sildenafil.
- Trial name
- NCT01254383
- Testing
- Sildenafil Tablet, Sildenafil ODT
- Where
- Singapore
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
None Volunteer
Taste Test of a New Formulation of Sildenafil (Revatio)
taste of formulation
- Trial name
- NCT00768573
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Beta Thalassemia With Increased Tricuspid Regurgitant Jet Velocity
Clinical Study to Evaluate the Possible Efficacy and Safety of L- Carnitine and Sildenafil in Children Having Beta Thalassemia With Increased Tricuspid Regurgitant Jet Velocity
This study aims to investigate the possible efficacy and safety of L_Carnitine and Sildenafil on patient with Beta thalassemia complicated with increased Tricuspid Regurgitant Jet Velocity
- Trial name
- NCT05584956
- Testing
- L_carnitine, Sildenafil
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Erectile Dysfunction, Prostate Cancer
Erectile Recovery After Robotic-Assisted Laparoscopic Prostatectomy
The study is a prospective, randomized, double-blind, placebo-controlled drug study to evaluate the pattern of erectile function recovery after robotic assisted laparoscopic prostatectomy (RALP).
- Trial name
- NCT03406169
- Testing
- Sildenafil 25 MG Oral Tablet, Pentoxifylline
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Prostatitis
Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III
Viagra is a potent 5-PDE inhibitor that causes vasodilation in the penis and, therefore, erection in men with erectile dysfunction.
- Trial name
- NCT00194597
- Testing
- Viagra (sildenafil citrate)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Pulmonary Arterial Hypertension
Local Open-Label Access Study For Patients Who Completed A1481244 Study In Brazil
The purpose of this study is to provide sildenafil therapy to patients who completed the A1481244 study for the treatment of PAH, and reside in Brazilian States where Revatio™ is not supplied by Health Secretary, and are judged…
- Trial name
- NCT00866983
- Testing
- sildenafil (Revatio) 20 mg TID
- Where
- 2 sites in Brazil
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Heart Failure With Reactive Pulmonary Hypertension
Sildenafil in Heart Failure With Reactive Pulmonary Hypertension
The purpose of this study is to determine whether Sildenafil 20mg taken three times a day is effective in the treatment of Heart Failure with Reactive Pulmonary Hypertension. This is a double-blind, placebo controlled trial.
- Trial name
- Sildenafil-HF (NCT02304705)
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Maya Guglin
Pulmonary Arterial Hypertension
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - PDE5
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the…
- Trial name
- NCT05039086
- Testing
- PDE5 inhibitor, Endothelin Receptor Antagonists
- Where
- United States
- Volunteers
- 13,021 people
- Sponsor
- Brigham and Women's Hospital
Cystic Fibrosis
Effects of Sildenafil on CFTR-dependent Ion Transport Activity
Dehydrated airway surfaces resulting from sodium hyperabsorption and lack of chloride secretion are critical to the pathology that leads to the morbidity and mortality from Cystic Fibrosis (CF) lung disease.
- Trial name
- NCT01132482
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Jewish Health
Covid19, SARS-COV2 Infection
Sildenafil in COVID-19
This randomised trial aims to assess the role of sildenafil in improving oxygenation amongst hospitalised patients with COVID19.
- Trial name
- NCT04489446
- Testing
- Sildenafil
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Universidad Nacional Andres Bello
Persistent Pulmonary Hypertension of the Newborn
Efficacy of Milrinone With Sildenafil in Persistent Pulmonary Hypertension in Children
Neonates with persistent pulmonary hypertension (PPH) should be administered inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation (ECMO), but these are not available in most resource-constrained settings like ours.
- Trial name
- NCT06562036
- Testing
- Sildenafil, Milrinone
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Muhammad Aamir Latif
Cystic Fibrosis
Sildenafil Exercise: Role of PDE5 Inhibition
Exercise intolerance is an understudied phenomenon in people with CF. The investigators hypothesized that vascular dysfunction plays a significant role, and can be partially reversed by administration of the phosphodiesterase…
- Trial name
- NCT04039087
- Testing
- Sildenafil 40mg oral capsule
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- National Jewish Health
Pulmonary Embolism, Intermediate-high Risk
Sidlenafil in Combination With Oral Anticoagulants in Patients With Intermediate-high Risk of Pulmonary Embolism
Pilot randomized study of the sidlenafil efficacy in combination with oral anticoagulants in the treatment of patients with intermediate-high risk of pulmonary embolism
- Conditions
- Pulmonary Embolism, Intermediate-high Risk, Combination of Oral Anticoagulation Therapy and Sildenafil
- Trial name
- PSCAT (NCT02946944)
- Testing
- Sildenafil/apixaban, apixaban
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation