Clinical trials: Standard treatment
Acute Pain
Paravertebral Catheters for Pancreatic Surgery
Design: Level I randomized prospective outcomes study comparing two groups of patients. One group will receive bupivacaine and dilaudid thoracic epidural analgesia (PCA) post-operatively.
- Trial name
- NCT02363777
- Testing
- Epidural, Paravertebral catheters
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Osteoporosis, Osteopenia
Texture Analysis for Postmenopausal Osteoporosis
The purpose of this study is to determine if a new test for osteoporosis can be useful in monitoring treatment. We are studying a new method for examining the quality of bone by an experimental method of computerized analysis of…
- Trial name
- NCT00145977
- Testing
- Alendronate, Calcium Citrate, Vitamin D
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Chicago
HIV Infections, Preexposure Prophylaxis (PrEP)
Clinical Decision Support for PrEP
Scale-up of HIV preexposure prophylaxis (PrEP) is a key strategy of the federal initiative to end the HIV epidemic. However, healthcare providers lack tools to identify patients who are at increased risk for HIV infection and…
- Trial name
- PrEDICT (NCT05245201)
- Testing
- Standard of care, Clinical decision support for PrEP
- Where
- 3 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Harvard Pilgrim Health Care
Smoking Cessation, Tobacco Dependence
De-nicotinised Cigarettes Study
The aim of this study is to determine if using a behavioural replacement for smoking (de-nicotinised cigarettes; DNCs), in addition to standard treatment during the first two weeks after the target quit date, can reduce urges to…
- Trial name
- Denic (NCT01250301)
- Testing
- De-nicotinised cigarettes + standard treatment, Standard Treatment
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Major Depressive Disorder
Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation Therapy
This study will attempt to use magnetic resonance imaging (MRI) to take a picture of the brain to learn about changes that occur in the brain during Transcranial Magnetic Stimulation (TMS) in people receiving this treatment for…
- Trial name
- INSCAPE (NCT06043401)
- Testing
- Neuroimaging with Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Basal Cell Carcinoma
A Study to Assess the Effectiveness and Safety of Vismodegib (Erivedge®) in Participants With Advanced Basal Cell Carcinoma (BCC)
This prospective, observational, cohort study is designed to assess the effectiveness and safety outcomes of vismodegib and to assess actual day-to-day disease and participant management by the physician.
- Trial name
- ROSETT (NCT02371967)
- Testing
- Vismodegib
- Where
- 4 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis, Nurse's Role
The Effect of Nurse Practitioner (NP-led) Care Upon Mood in People With Multiple Sclerosis
MS is the leading cause of non-traumatic disability in young adults. Canada and Alberta, have the highest prevalence of people with multiple sclerosis (PwMS) in the world.
- Trial name
- NCT04388592
- Testing
- Nurse Practitioner (NP) Led Care Arm
- Where
- Canada
- Volunteers
- 248 people
- Sponsor
- University of Alberta
Tobacco Use Cessation
Enhancing Quitline Services for African American Smokers
This study proposes to test the value of a culturally specific program for African American smokers to quit smoking.
- Trial name
- NCT03064971
- Testing
- Standard Care, smoking cessation DVD, PTF DVD
- Where
- United States
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer, Oligometastasis
Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer
This is a prospective, open-label, multi-center seamless phase II to phase III randomized clinical trial designed to compare SST with or without PET-directed local therapy in improving the castration-resistant prostate…
- Conditions
- Prostate Cancer, Oligometastasis, Oligorecurrence, Recurrent Prostate Cancer
- Trial name
- VA STARPORT (NCT04787744)
- Testing
- PET-directed Local Therapy using Surgery, PET-directed Local Therapy using Radiation, Salvage Local Therapy for locally recurrent disease
- Where
- 20 sites in United States
- Volunteers
- 378 people
- Sponsor
- VA Office of Research and Development
Cerebral Palsy (CP), Activities of Daily Living
NAO Robot in Pediatric Occupational Therapy
Cerebral Palsy (CP) is a non-progressive neurological disorder that affects movement and posture, often impairing upper extremity function and daily activity performance.
- Trial name
- NAO Robot (NCT07283211)
- Testing
- Occupational Therapy Intervention, NAO Robot-Assisted Occupational Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Ankara Medipol University
HIV
Evaluation of Use of Clinical Decision Support System in HIV Care in Resource Constrained Settings
The purpose of this study is to determine whether the use of a Computerized Decision Support System (CDSS) in form of alerts to clinicians enhances early detection of immunological treatment failure in HIV patients.
- Trial name
- CDSS (NCT01634802)
- Testing
- EMR Only, EMR+CDSS
- Where
- Kenya
- Volunteers
- 1,460 people
- Sponsor
- Kenya Medical Research Institute
Adenocarcinoma, Neoplasms
Study Evaluating Biomarkers In Relapsed/Refractory Pediatric Solid Tumors
This is an open label, two-part study of temsirolimus given as a 60-minute intravenous (IV) infusion once weekly to pediatric subjects with advanced solid tumors.
- Trial name
- NCT00106353
- Testing
- Torisel
- Where
- 30 sites in United States, Canada and 5 more
- Volunteers
- 71 people
- Sponsor
- Pfizer
Liver Transplant Rejection, Immunosuppression
Immune Tolerance and Alloreactivity in Liver Transplant Recipients on Different Monotherapy Immunosuppressive Agents
This study is being done with the purpose of trying to understand if and why transplant recipients may develop tolerance to their transplanted organ.
- Trial name
- NCT01678937
- Testing
- Blood Draw - Rapamycin, Blood Draw from Control Subjects, Blood Draw - CyA
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Eclampsia
Eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES):
This is a double blinded, placebo-controlled trial to determine if IV dexamethasone more quickly than placebo assists resolution of Posterior Reversible Encephalopathy Syndrome (PRES) encountered in eclamptic patients.
- Trial name
- PRESIDEX (NCT02027272)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Mississippi Medical Center
BCLC Stage a Hepatocellular Carcinoma, BCLC Stage B Hepatocellular Carcinoma
BOLD MRI and FMISO PET for the Assessment of Hypoxic Tumor Microenvironment in Patients with Oligometastatic Liver Cancer Undergoing Yttirum-90 Selective Internal Radiation Therapy
This early phase I trial evaluates the use of hypoxia (lack of oxygen) as a measure in determining the outcome of Y90 selective internal radiation therapy in patients with liver cancer that has spread to a limited number of sites…
- Conditions
- BCLC Stage a Hepatocellular Carcinoma, BCLC Stage B Hepatocellular Carcinoma, BCLC Stage C Hepatocellular Carcinoma, Hepatocellular Carcinoma
- Trial name
- NCT05250895
- Testing
- 18F-Fluoromisonidazole, Biopsy, Dynamic Contrast-Enhanced Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Emory University
Depressive Symptoms, HIV Infections
Depression and ART Adherence in HIV+ Latinos
The current HIV treatment adherence project was designed to adapt culturally and then pilot test an empirically supported cognitive-behavioral therapy program for adherence and symptoms of depression (CBT-AD)with HIV+ Latinos…
- Trial name
- NCT01411839
- Testing
- Cognitive-Behavioral Therapy (CBT-AD)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Chest Pain, Anxiety
Mindfulness-Based Stress Reduction for Adults With Low-Risk Chest Pain Associated With Anxiety
This Emergency Department based study investigates the feasibility and effectiveness of a mindfulness based stress reduction (MBSR) training program referral for patients with chest pain at low risk for acute coronary syndrome…
- Conditions
- Chest Pain, Anxiety, Mindfulness
- Trial name
- MBSR (NCT03365375)
- Testing
- MBSR Referral, Usual Care Referral
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Indiana University
Diabetic Foot Ulcer
Derm-Maxx in Patients With Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone
This randomized controlled study evaluates the adjuvant use of Derm-Maxx in patients with diabetic foot ulcers
- Trial name
- NCT06455475
- Testing
- Derm-Maxx
- Where
- 11 sites in United States
- Volunteers
- 120 people
- Sponsor
- Capsicure, LLC
Breast Cancer, Pain
Pain After Tumescent Mastectomy or Standard Mastectomy in Women With Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: New surgery techniques may lessen pain after breast surgery. It is not yet known whether tumescent mastectomy or standard mastectomy results in less pain in women with breast cancer.
- Conditions
- Breast Cancer, Pain, Perioperative/Postoperative Complications
- Trial name
- NCT00859157
- Testing
- therapeutic conventional surgery
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of California, Davis
Periodontal Disease (PD), Cardio Vascular Disease
PMPR and Chlorhexidine on Periodontal Disease and Vascular Function
Gum inflammation is called gingivitis. Gum disease, known as periodontal disease, is a long-term inflammation of the gums and bone around teeth, leading to tooth loss.
- Conditions
- Periodontal Disease (PD), Cardio Vascular Disease, Oral-Systemic Link, Vascular Dysfunction
- Trial name
- CHX-PMPR-PERIV (NCT07311512)
- Testing
- Chlorhexidine (0.2%) mouthwash
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mahdi Mutahar
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