Clinical trials: Water, completed
Healthy
Bioequivalence Study of Empagliflozin & Metformin HCL From Empagliform 12.5/1000 mg F.C.T (Hikma Pharma, Egypt) and Synjardy 12.5/1000 mg F.C.T (Boehringer Ingelheim International GmbH, Germany)
Comparative randomized, single dose, two-way crossover open-label study to determine the bioequivalence of Empagliflozin \& Metformin HCL from Empagliform 12.5/1000 mg F.C.T (Hikma Pharma, Egypt) and Synjardy 12.5/1000 mg F.C.T…
- Trial name
- NCT05132023
- Testing
- Empagliflozin & Metformin (Test), Empagliflozin & Metformin (Reference)
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Genuine Research Center, Egypt
Healthy Volunteers
Malaria: Relative Bioavailability and Food Effect of DSM265
Phase 1 study designed to evaluate the relative bioavailability of a single dose of a test formulation, DSM265-TPGS 34% SDD powder in comparison with a reference DSM265 25% SDD powder formulation used in early clinical trials.
- Trial name
- NCT03637517
- Testing
- DSM265-TPGS 34% SDD, 400 mg fasted, DSM265-TPGS 34% SDD, 400 mg fed, DSM265 25% SDD, 400 mg fasted
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Burning Mouth Syndrome
The Role of Xerostomia in Burning Mouth Syndrome: Case - Control Study
Objectives: to evaluate xerostomia and salivary flow in patients with burning mouth syndrome (BMS) treated with amitriptyline before and after the use of antixerostomic topical medication.
- Trial name
- BMS (NCT01754740)
- Testing
- Uréia
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetes Mellitus, Type II
Bioequivalence Study for Acarbose / Metformin FDC
To establish the bioequivalence between Acarbose / Metformin FDC (50mg / 500mg) and loose combination of Acarbose (Glucobay) (50mg) and Metformin (Glucophage) (500mg).
- Trial name
- NCT01728740
- Testing
- Acarbose/Metformin FDC (BAY81-9783), Acarbose (Glucobay, BAYG5421), Metformin
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bayer
Taste Perception, Saliva Production
Effect of Flavored, Carbonated Drinks on Salivary Flow, Salivary Composition, and Taste Perceptions
To determine the effect of flavored, carbonated drinks on salivary flow rate, saliva composition, and taste perceptions compared with control drinks (water, carbonated water, non-carbonated)
- Trial name
- NCT06933290
- Testing
- Beverage
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Achilles Tendon, Tendinopathy
Eccentric Training and Cryotherapy Vs Eccentric Training and Whole Body Vibration in Achilles Tendinopathy
The purpose of this study is to determine the effectiveness of eccentric exercise combined with vibration or cryotherapy in Achilles tendon pathology.
- Trial name
- NCT03029910
- Testing
- Cryotherapy and eccentric exercise, Vibration and eccentric exercise
- Where
- Spain
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Chronic Obstructive Pulmonary Disease
Effects of Kinesio Taping Techniques in COPD Patients
Study will investigate effects of two different kinesio taping techniques on pulmonary parameters of patients with COPD.
- Trial name
- NCT04241510
- Testing
- Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Muğla Sıtkı Koçman University
Healthy
Safety, Tolerance, and Pharmacokinetics of Single Oral Doses of BI 201335 NA and Bioavailability in Healthy Male Subjects
The objective of this study was to investigate the safety, tolerability, and pharmacokinetics of BI 201335 NA following administration of single rising doses from 4 mg to 1200 mg.
- Trial name
- NCT02182323
- Testing
- BI 201335 NA
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Acute Lung Injury
Hemodynamics and Extravascular Lung Water in Acute Lung Injury
The purpose of this study is to test a treatment that tries to reduce the amount of fluid in the lungs of subjects with acute lung injury to see if this is helpful.
- Trial name
- HEAL (NCT00624650)
- Testing
- Diuresis (furosemide) part I, Fluid Bolus (crystalloid or albumin), Vasopressors (Norepinephrine, Vasopressin, Phenylephrine, Epinephrine)
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Oregon Health and Science University
Osteoporosis
Special Drug Use Surveillance on Long-term Use of Sodium Risedronate Tablets (Benet 75 mg Tablets) (12-month Treatment Survey)
The purpose of this study is to evaluate the safety and efficacy of sodium risedronate tablets (Benet 75 mg Tablets) in osteoporosis patients in daily medical practice, as well as to examine "the status of treatment compliance" …
- Trial name
- NCT02089997
- Testing
- Sodium Risedronate
- Where
- 2 sites in Japan
- Volunteers
- 3,304 people
- Sponsor
- Takeda
Coronavirus, Covid19
ACTIV-2: A Study for Outpatients With COVID-19
Drug studies often look at the effect one or two drugs have on a medical condition, and involve one company. There is currently an urgent need for one study to efficiently test multiple drugs from more than one company, in people…
- Trial name
- NCT04518410
- Testing
- bamlanivimab 7000mg, BRII-196+BRII-198, AZD7442 (IV)
- Where
- 252 sites in United States, Argentina and 7 more
- Volunteers
- 4,044 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
Bronchodilatation Effects of a Small Volume Spacer Used With a Metered-Dose Inhaler
The purpose of the present study is to determine whether use of a small volume spacer is associated with better bronchodilatation in an unselected population of patients with documented reversible airflow limitations.
- Trial name
- MDI (NCT00465413)
- Testing
- Small volume spacer and/or Rinsing the mouth with water
- Where
- 2 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- Mackay Memorial Hospital
Temperature Change, Body
Effect of Pressure on Skin Temperature When Using a Cryocompression Device
Cryotherapy after surgery is widely utilised and has numerous practical applications for post-operative rehabili-tation. Previous research has suggested that during cold therapy, the skin temperature of the knee should be reduced…
- Trial name
- NCT05454982
- Testing
- Cryocompression
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Winchester
HIV Prevention
Contraception and Menstrual Cycle Effect on Pharmacokinetics, Pharmacodynamics and Safety in Tenofovir Vaginal Gel Use
The purpose of the study is to examine the effects of two contraceptive methods and the menstrual cycle on the pharmacokinetics, pharmacodynamics of tenofovir 1% gel and the effect of the contraceptive methods on markers of…
- Trial name
- NCT01421368
- Testing
- Tenofovir 1% vaginal gel, Depo-medroxyprogesterone acetate (DMPA), Oral contraceptive: LNG 150 mcg and EE 30 mcg
- Where
- 3 sites in United States, Dominican Republic
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- CONRAD
Healthy
Neural Control of Kidney Blood Flow During Exercise in African American Adults
The goal of this clinical trials is to learn if healthy young African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults.
- Trial name
- NCT03981640
- Testing
- Acute exercise, Cold pressor test, Mental stress test
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Influenza
Assessment of CR8020, a Monoclonal Antibody Against Influenza A Viruses
The purpose of this study is to assess in healthy subjects the safety, tolerability, pharmacokinetics and immunogenicity of single escalating doses of CR8020, a monoclonal antibody against influenza A viruses.
- Trial name
- NCT01756950
- Testing
- 2 mg/kg CR8020, 5 mg/kg CR8020, 15 mg/kg CR8020
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Fat Metabolism, Sport Nutrition
The Effects of Acute Chicory Coffee Consumption on Exercise Performance and Metabolism
The goal of this clinical trial is to evaluate the acute effects of chicory coffee on metabolism and exercise performance in healthy, moderately active male participants aged 18-25.
- Conditions
- Fat Metabolism, Sport Nutrition, Exercise Metabolism, Inflammation
- Trial name
- NCT07094191
- Testing
- Chicory Coffee (Caffeine-free, polyphenol-rich beverage from roasted chicory root), arabica coffee, no beverage control
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fatma Özsel Özcan
Recurrent Pregnancy Loss Without Current Pregnancy, Anxiety Disorder
Altered Interhemispheric DLPFC Coordination and Cardiac Hyperreactivity During Multisensory Aversive Challenge in Recurrent Pregnancy Loss With Comorbid Anxiety
This exploratory clinical study, NEURO-CARD-2, will use simultaneous functional near-infrared spectroscopy (fNIRS) and electrocardiography (ECG) to investigate interhemispheric dysfunction in the dorsolateral prefrontal cortex…
- Trial name
- NCT07045818
- Testing
- Multisensory aversive emotional challenge task
- Where
- 4 sites in China
- Volunteers
- 70 people
- Sponsor
- Shenyang Medical College
Ultrasound Airway Imaging in Determining the Oral Cavity and Tongue Size
A Comparative Study of Ultrasound Versus CT Measurement of Tongue and Oral Cavity Size
Difficulty in managing the airway is the single most important cause of major anesthesia-related morbidity and mortality. The currently used clinical method of predicting airway difficulty used by anesthetists is limited and not…
- Trial name
- NCT02952560
- Testing
- Ultrasound scan
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Elderly Women
Effects of Two Water-based Aerobic Training Programs in Elderly Women
The aim of the study is to investigate the effects of two water based aerobic training programs on cardiorespiratory, neuromuscular and quality of life parameters in old women.
- Trial name
- NCT03289091
- Testing
- water-based continuous aerobic training, water-based interval aerobic training
- Where
- Brazil
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
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