Clinical trials: Water
Caries Active
Anxiety During Caries Removal Using Chemo-mechanical Versus Conventional Methods
This study aims to clinically assess this newly introduced Egyptian chemo-mechanical caries removal gel versus conventional drilling method .
- Trial name
- NCT07344415
- Testing
- Cariemove, Drilling using bur
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Overweight and Obesity, Time Restricted Feeding
Fasting ENHANCE Pilot Study
Grounded in the principles of geroscience, the proposed Fasting ENHANCE study will test whether a time restricted eating (TRE) regimen can improve cognitive function and other aspects of successful aging in a safe and sustainable…
- Conditions
- Overweight and Obesity, Time Restricted Feeding, Alzheimer Disease
- Trial name
- NCT05732935
- Testing
- Time Restricted Eating intervention, Successful Aging Comparison Group (LEARN)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Florida
Covid19
[COVID-19] Reduction of Sars-CoV-2 Oral Viral Load With Prophylactic Mouth Rinse
The purpose of this study is to test the effectiveness of prophylactic mouth rinses in reducing the amount of viruses, specifically SARS-CoV-2 in the oral cavity.
- Trial name
- NCT04719208
- Testing
- Water (E) Mouth rinse with the solution provided, Chlorhexidine gluconate (A) Mouth rinse with the solution provided, Hydrogen peroxide (B) Mouth rinse with the solution provided
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Prediabetic State, Metabolic Syndrome
Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects
The aim of this prospective interventional study is to investigate the metabolic effects of consuming artificial and natural sweeteners in persons with prediabetes.
- Conditions
- Prediabetic State, Metabolic Syndrome, Insulin Resistance, Thrombosis
- Trial name
- Sweetheart (NCT07377097)
- Testing
- Saccharin, Sucralose, Erythritol
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Hepatic Impairment, Healthy Volunteers
Evaluate the Pharmacokinetics of CC-220 in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared With Healthy Subjects
This is a multicenter, open-label study to assess the PK of a single 1-mg oral dose of CC-220 in subjects with mild, moderate, and severe hepatic impairment, and in matched healthy control subjects with normal hepatic function.
- Trial name
- NCT03824678
- Testing
- CC-220
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Celgene
Chronic Nausea and Vomiting Syndrome
Brain-Stomach Circuits in Chronic Nausea
The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea.
- Trial name
- NCT07276035
- Testing
- Transcranial Magnetic Stimulation, TMS
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- David Levinthal
Old Age
Effect of Preoperative Oral Carbohydrates on the Insulin Resistance of Elderly Patients
Postoperative cognitive dysfunction (POCD) is more common in older patients, and increased insulin resistance is an important factor for POCD.
- Trial name
- NCT04206189
- Testing
- carbohydrate group - carbohydrate (400ml)
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Parkinsonism
Efficacy and Safety of Astragalus for Non-motor Symptoms of α-Synucleinopathy
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom. However, there is still a lack of research on the treatment for non-motor symptoms of α-synucleinopathy, especially autonomic…
- Trial name
- NCT05506891
- Testing
- Physical therapy group, Astragalus
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University Union Hospital
Daytime Wetting, Enuresis
Voiding School as a Treatment of Children's Day-time Incontinence or Enuresis
The Voiding School is a simple educational intervention to treat children with daytime incontinence or enuresis.The purpose of this study is to implement the intervention in primary care, child welfare clinics.
- Conditions
- Daytime Wetting, Enuresis, Functional Incontinence
- Trial name
- NCT03478813
- Testing
- Voiding school
- Where
- Finland
- Sponsor
- Helsinki University Central Hospital
Maternal Health, Gut Health
Fermented Food - Achars (fermented Pickles) in Pakistan
The highest burden of malnutrition in the world is in South Asia and Africa. Over the last ten years, our work on Environmental Enteric Dysfunction in Matiari, a poor rural district in the Sind province of Pakistan, shows that…
- Trial name
- FF (NCT06748313)
- Testing
- Mango Pickle (Water-Based), Mango Pickle (Oil Based), Carrot Pickle (Water-Based)
- Where
- Pakistan
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Hemodynamic Instability, Autophagy
A Study of Exosome Proteomics and Hemodynamics in Sepsis
This research will be the first study for exosomes purified in blood and urine from septic patients who had multiple organ failures. Proteomics studies in exosomes from blood or urine specimens.
- Trial name
- NCT03267160
- Testing
- Hemodynamic parameters
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Benign Prostatic Hyperplasia, Nocturia Associated With Nocturnal Polyuria
A Clinical Observation Study of a Chinese Patent Medicine Combined With Tamsulosin in Improving Sleep and Nocturia Symptoms After Enucleation of the Prostate
This study will test whether a traditional Chinese medicine called Lingze tablets, when added to the standard drug tamsulosin, can better improve sleep and nighttime urination problems in men after prostate surgery.
- Trial name
- NCT07357324
- Testing
- Tamsulosin Hydrochloride Sustained-Release Capsules, Lingze Tablets
- Where
- China
- Volunteers
- 136 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Healthy
Lavender Essential Oil-based Product System for Sleep
The goal of this clinical trial is to learn whether lavender essential oil-based product system can affect gene expression, serum protein markers, and sleep quality in healthy volunteers.
- Trial name
- NCT06510335
- Testing
- Lavender essential oil-based product system
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- dōTERRA International
Skin Aging, Skin Hydration
A Clinical Trial to Evaluate the Effects of Naila's Collagen Marine Plus Food Supplement on Skin Hydration, Elasticity, Fine Lines and Wrinkles, and Hair and Nail Health
This is a single-group, open-label, virtual (decentralized) clinical trial evaluating the effects of Naila's Collagen Marine Plus Food Supplement on skin hydration, elasticity, firmness, fine lines and wrinkles, and hair and nail…
- Conditions
- Skin Aging, Skin Hydration, Skin Elasticity, Fine Lines and Wrinkles
- Trial name
- NCT07746076
- Testing
- Naila's Collagen Marine Plus Food Supplement
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gulf Bird
Insulinoma
Clinical Evaluation of 68Ga-NOTA-MAL-Cys39-exendin-4 Positron Emission Tomography in the Detection of Insulinoma
Glucagon-like peptide-1 receptor (GLP-1R) is a kind of G protein coupled receptor which regulate the insulin secretion and serves as potential target in the diagnosis of functional pancreas neuroendocrine tumor.
- Trial name
- NCT04185350
- Testing
- 68Ga-NOTA-MAL-Cys39-exendin-4
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Vascular Dementia
The Clinical Trial of Chinese Herbal Medicine (SaiLuoTong) Capsule
As a traditional Chinese medicine compound, SaiLuoTong capsule is proven to have beneficial effects on learning and memory ability in animal models of vascular dementia (VaD).
- Trial name
- NCT03789760
- Testing
- SaiLuoTong capsule
- Where
- 29 sites in China
- Volunteers
- 493 people
- Sponsor
- Shineway Pharmaceutical Co.,Ltd
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
Chronic Heart Failure
Evaluation of Vepoloxamer in Chronic Heart Failure
The purpose of this study is to evaluate whether vepoloxamer can provide a blood chemical marker and functional benefit to damaged heart muscle cells.
- Trial name
- NCT02596477
- Testing
- Vepoloxamer, 5% dextrose in water
- Where
- 4 sites in United States, Australia
- Volunteers
- 10 people
- Sponsor
- Mast Therapeutics, Inc.
Malaria
Determining a Tolerable Dose of Primaquine in G6PD-deficient Persons Without Malaria in Mali
The purpose of this study is to determine the highest tolerable dose of primaquine within 0.75 mg/kg. A tolerable dose is defined as one in which: Two or fewer participants (< 30%) experience hemolysis; No participant experiences…
- Trial name
- PQSAFETY (NCT02535767)
- Testing
- Primaquine
- Where
- Mali
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Multiple Cancers, Multiple Indications Cancer
HELP Study - Towards High Throughput and Efficient Long-axial PET With Oral [18F]FDG
Typically, PET scans involve an IV injection of 18F-FDG that helps identify cancer. Patients are scanned 60 minutes after injecting 18F-FDG.
- Conditions
- Multiple Cancers, Multiple Indications Cancer, Feasibility Studies
- Trial name
- HELP (NCT07295171)
- Testing
- Oral FDG scan
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- British Columbia Cancer Agency
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