Clinical trials: conventional surgery, completed
Surgical Wound Dehiscence
Trial of Versajet Compared With Conventional Treatment in Acute and Chronic Wounds
It is increasingly recognised that the debridement of devitalised, bacterially contaminated or senescent tissue is an essential component of the effective treatment of delayed healing wounds.
- Trial name
- NCT01050673
- Testing
- VERSAJET, Scalpel or blade
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Smith & Nephew, Inc.
Breast Cancer
Radiation Therapy After Lumpectomy in Treating Women With Ductal Carcinoma in Situ or Invasive Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Giving radiation during surgery followed by external-beam radiation to the entire breast may kill more tumor cells.
- Trial name
- NCT00054301
- Testing
- adjuvant therapy, conventional surgery, intraoperative radiation therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Case Comprehensive Cancer Center
Posterior Maxillary Atrophy, Maxillary Sinus Augmentation
Comparison of Three Surgical Approaches for Lateral Sinus Floor Elevation
This study compares three surgical approaches used during lateral sinus floor elevation, a procedure performed to increase bone height in the back part of the upper jaw before or together with dental implant placement.
- Trial name
- NCT07794293
- Testing
- Conventional Rotary Lateral Sinus Floor Elevation, Epinephrine-Soaked Cotton Roll, Piezoelectric Sinus Lift
- Where
- Turkey (Türkiye)
- Volunteers
- 504 people
- Sponsor
- Istanbul Aydın University
Colon Cancer
Laparoscopic Surgery Versus Robot Surgery for Right-side Colon Cancer: Short-term Outcome of a Randomised Clinical Trial
The recent introduction of robotic surgical system has revolutionized the field of minimally invasive surgery. The investigators hypothesized that adoption of a robotic surgical system for patients with right-side colon cancer…
- Trial name
- NCT01042743
- Testing
- robot-assisted surgery, laparoscopic right-hemicolectomy
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Kyungpook National University Hospital
Osteoarthritis
The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery
Application of "Evicel" hemostatic matrix during operation for unilateral total knee replacement surgery (TKA) will result in decreased bleeding and postoperative drain output, a reduction in transfusion requirements, and less…
- Trial name
- NCT01235715
- Testing
- Evicel fibrin sealant
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Hospital for Special Surgery, New York
Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
Pembrolizumab, Chemotherapy, and Radiation Therapy With or Without Surgery in Treating Patients With Anaplastic Thyroid Cancer
This phase II trial studies how well pembrolizumab, chemotherapy, and radiation therapy work with or without surgery in treating patients with anaplastic thyroid cancer.
- Trial name
- NCT03211117
- Testing
- Docetaxel, Doxorubicin Hydrochloride, Intensity-Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Lumbar Disc Herniation
Comparison of Ultrasound-Guided Classic And Lateral Approach Thoracolumbar Interfascial Plane Block
US-guided peripheral nerve blocks have been used increasingly due to the advantages of ultrasound in anesthesia practice. TLIP block is one of these nerve blocks performed under US guidance.
- Trial name
- NCT03854240
- Testing
- Classic block (Group C) and modified block (Group M) groups
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Bladder Exstrophy
Early Versus Delayed Closure of Bladder Exstrophy in Female Patients
This study compared two timings for primary single-stage surgery in female newborns with classic bladder exstrophy. Participants were randomly assigned to surgery within 72 hours of birth or at 6 to 12 weeks of age.
- Trial name
- NCT07794540
- Testing
- Early Primary Single-Stage Closure, Delayed Primary Single-Stage Closure
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- Khyber Teaching Hospital
Brain and Central Nervous System Tumors
Radiolabeled Monoclonal Antibody in Treating Patients With Glioblastoma Multiforme or Anaplastic Astrocytoma
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and deliver tumor-killing substances to them without harming normal cells. This may be an effective treatment for some types of brain tumors.
- Trial name
- NCT00004017
- Testing
- conventional surgery, iodine I 131 monoclonal antibody TNT-1/B
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Peregrine Pharmaceuticals
Inflammation, Systemic Inflammatory Response Syndrome
Inflammatory Response in Aortic Valve Replacement
The study investigates inflammatory and antiinflammatory response in patients with severe aortic valve stenosis needing either surgical treatment (surgical aortic valve replacement) or interventional cardiology treatment…
- Conditions
- Inflammation, Systemic Inflammatory Response Syndrome, Thoracic Surgery, Aortic Valve Stenosis
- Trial name
- NCT02324140
- Testing
- Whole blood analysis
- Where
- Switzerland
- Volunteers
- 101 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Opioid Free Anesthesia, Pectoral Nerve Block
Opioid Free Anesthesia Combined With Pectoral Nerve Block (PECS Block) in Breast Cancer Surgery
The aim of this study is to evaluate the efficacy of opioid free anesthesia combined with pectoral Nerve Block (PECS block) in patients undergoing breast cancer surgery.
- Conditions
- Opioid Free Anesthesia, Pectoral Nerve Block, Breast Cancer Surgery
- Trial name
- NCT07913789
- Testing
- Opioid Free Anesthesia, Opioid based anesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Edentulous Jaw, Missing Teeth
Treatment Outcomes With Full Arch Rehabilitations Retained by Immediate or Conventionally Loaded Implants
This study aims to assess the treatment outcomes (clinical, functional and subjective) of full arch rehabilitations supported by implants with or without an immediate loading protocol.
- Trial name
- ILOD (NCT04930835)
- Testing
- Implant supported dentures
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- University of Salamanca
To Compare the Efficacy and Safety of Hybrid ESD and ESD in the Treatment of Colorectal LST
Endoscopic Therapy for Laterally Spreading Tumors (LSTs)
This study will retrospectively include LST patients who were admitted to 6 medical centers (The Second Affiliated Hospital, College of Medicine, Zhejiang University; The Affiliated Jinhua Hospital, Zhejiang University School of…
- Trial name
- LST (NCT06464874)
- Testing
- Conventional ESD, Hybrid ESD
- Where
- China
- Volunteers
- 890 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Cholecystitis
A Prospective Cohort of Emergent Laparoscopic Cholecystectomy in PUMCH
A prospective cohort study comparing the surgical outcome of patients who underwent emergent laparoscopic cholecystectomy guided by indocyanine green cholangiography (ELC-ICGC) versus conventional laparoscopic operation.
- Trial name
- ELC-PUMCH (NCT06552949)
- Testing
- Emergent laparoscopic cholecystectomy guided by ICG cholangiography (ELC-ICGC)
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Peking Union Medical College Hospital
Ankle Fractures, Unstabel Ankle Fractures
Immediate Protected Weight Bearing Versus Conventional Non-Weight Bearing After Surgical Fixation of Unstable Ankle Fractures
This prospective randomized controlled trial evaluates the safety and effectiveness of immediate protected weight bearing following surgical fixation of unstable ankle fractures.
- Trial name
- NCT07814638
- Testing
- Immediate protected weight bearing, Rehabilitation
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Consorci Sanitari Integral
Macular Degeneration
Macular EpiRetinal Brachytherapy Versus Lucentis® Only Treatment (MERLOT)
Wet age-related macular degeneration is the most common cause of blind registration in the United Kingdom (UK). Standard treatment involves regular eye injections of a drug called ranibizumab (Lucentis).
- Trial name
- MERLOT (NCT01006538)
- Testing
- Epimacular Brachytherapy, Ranibizumab
- Where
- 24 sites in United Kingdom
- Volunteers
- 363 people
- Sponsor
- King's College Hospital NHS Trust
Head and Neck Cancer, Oral Complications
Paclitaxel and Radiation Therapy Plus Chemoprotection With Amifostine in Treating Patients With Stage III or Stage IV Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003193
- Testing
- amifostine trihydrate, paclitaxel, conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Endometriosis
Cardiovascular Disease Risk in Women With Endometriosis
To test the hypothesis that estrogen suppression impairs endothelial dysfunction in endometriosis.
- Trial name
- NCT03746535
- Testing
- Elagolix
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yale University
Maxillofacial Abnormalities
Ultrasonic Bone Scalpel in BSSO
The conventional saw compared with the piezo surgery in BSSO to evaluate cutting time, surgery duration, amount of bleeding. The purpose of this study was to answers following clinical questions: Is ultrasonic bonescalpel…
- Trial name
- NCT06273189
- Testing
- Conventional, Bone Scalpel
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Diabetes Mellitus, Type 2, Insulin Resistance
New Frontiers on Bariatric Surgical Procedures: Classical Bypass for Type-2 Diabetic Patients With Obesity Grade I
Bariatric surgery leads to remission of type 2 diabetes in morbid obese patients in 80% (Roux-en-Y gastric bypass)to 90% (biliopancreatic diversion and duodenal switch) of cases.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Obesity
- Trial name
- NCT00566189
- Testing
- Roux-en-Y Bypass Gastroplasty
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Campinas, Brazil