Clinical trials: conventional surgery, completed
Colorectal Cancer
Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00006366
- Testing
- fluorouracil, irinotecan hydrochloride, conventional surgery
- Where
- 235 sites in United States, Canada
- Sponsor
- Radiation Therapy Oncology Group
Neuroblastoma
Multiple Therapies in Treating Patients With Advanced Neuroblastoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00040872
- Testing
- filgrastim, monoclonal antibody 3F8, sargramostim
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
ERAS, Colorectal Surgery
Epidural Analgesia and Intraoperative Fluid Management in Colorectal Surgery
The Enhanced Recovery After Surgery (ERAS) protocols have demonstrated their efficacy in expediting recovery and minimizing postoperative complications, especially in patients undergoing abdominal surgery.
- Conditions
- ERAS, Colorectal Surgery, Goal-directed Fluid Therapy, Conventional Fluid Therapy
- Trial name
- NCT06810648
- Testing
- GDFT, GDFT/ED, CFT
- Where
- 2 sites in Greece
- Volunteers
- 121 people
- Sponsor
- University of Ioannina
Hypoxemia
Open Lung Protective Ventilation in Cardiac Surgery
Cardiac surgery with cardiopulmonary bypass (CPB) frequently induces post-operative respiratory dysfunction. The post-operative pulmonary complications (PPCs) significantly increase the peri-operative morbidity and require…
- Trial name
- PROVECS (NCT02866578)
- Testing
- Open lung protective ventilation strategy
- Where
- 6 sites in France
- Volunteers
- 494 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Ovarian Cyst
Single Versus Conventional Laparoscopy for Benign Adnexal Disease
Keyhole surgery for adnexal disease has traditionally been performed using three or four small incisions. The last years a new operating method has been introduced.
- Trial name
- NCT01288599
- Testing
- Laparoscopic surgery
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Renal Transplantation
Systematic Transplantectomy Versus Conventional Care After Kidney Graft Failure
Our hypothesis is early and systematic transplantectomy under a well-conducted immunosuppression is associated with a decreased risk of anti-HLA immunization against a conservative attitude including a gradual reduction of…
- Trial name
- DESYRE (NCT01817504)
- Testing
- Systematic transplantectomy, Progressive reduction of immunosuppression
- Where
- 9 sites in France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon
Type 1 Diabetes
Assessment of the Efficacy of the Artificial Pancreas Combined With a Qualitative Meal Size Estimation to Control Postprandial Glucose Levels
Postprandial glycemic excursions are major determinants of overall glycemic control in type 1 diabetes. Carbohydrate content of ingested meals is the main determinant of post-meal glucose excursion.
- Trial name
- NCT04031599
- Testing
- Single-hormone closed-loop system, Insulin pump, Continuous glucose monitoring system
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Pancreatic and Periampullary Tumors
Pancreatoduodenectomy in Pancreatic and Periampullary Tumors
Background: Recently it has been observed in pancreatic cancer that after apparently complete surgical resection, histological examination of the surgical specimen according to a standard protocol reveals tumor infiltration of…
- Trial name
- DUOPAN-EPAM (NCT02803814)
- Testing
- Superior mesenteric artery approach for pancreatoduodenectomy, Classic approach for pancreatoduodenectomy
- Where
- Spain
- Volunteers
- 154 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Anesthesia, Local, Hand Surgery
Postoperative Experience of 2 WALANT-type Modes of Anesthesia Used in Ambulatory Surgery of the Upper Limb.
Distal surgery of the upper limb under local anesthesia using the WALANT technique (Wide Awake Local Anesthesia No Tourniquet) has become the standard care in orthopedic surgery.
- Conditions
- Anesthesia, Local, Hand Surgery, Wrist Surgery, Elbow Surgery
- Trial name
- ROPIWA (NCT05343299)
- Testing
- Ambulatory surgery under Lidocaine alone, Ambulatory surgery under a combination of Lidocaine and Ropivacaine
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acoustic Schwannoma, Adult Anaplastic (Malignant) Meningioma
RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma
This phase I trial studies the side effects and best dose of gamma-secretase/Notch signalling pathway inhibitor RO4929097 (RO4929097) when given together with temozolomide and radiation therapy in treating patients with newly…
- Conditions
- Acoustic Schwannoma, Adult Anaplastic (Malignant) Meningioma, Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
- Trial name
- NCT01119599
- Testing
- 3-Dimensional Conformal Radiation Therapy, Gamma-Secretase Inhibitor RO4929097, Intensity-Modulated Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- National Cancer Institute (NCI)
Glioblastoma
MEDICO-ECONOMIC EVALUATION OF SURGERY GUIDED BY FLUORESCENCE FOR THE OPTIMIZATION OF RESECTION OF GLIOBLASTOMAS
Glioblastoma is the most frequent primary malignant brain tumor in adults (3,000 new cases per year) and is characterized by a poor prognosis (median survival 12 months).
- Trial name
- RESECT (NCT01811121)
- Testing
- 5-aminolévulinique acid (5-ALA)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Hospices Civils de Lyon
Protein-Energy Malnutrition
Reducing In-Hospital and 60-Day Mortality in ICU Patients After Surgery With Strict Nutritional Supplementation
Malnutrition in critically ill patients is a global concern due to its association with increased infectious complications, prolonged hospital stays, and higher morbidity rates.
- Trial name
- NCT06058247
- Testing
- Active nutritional supplementation, Conventional nutritional supplementation
- Where
- South Korea
- Volunteers
- 368 people
- Sponsor
- Seoul St. Mary's Hospital
Laminectomy, Post-laminectomy Syndrome
Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase
Traditionally, pain relief through spinal cord stimulation has been associated with the appearance of paresthesia in the affected area.
- Conditions
- Laminectomy, Post-laminectomy Syndrome, Spinal Cord Syndrome, Failed Back Surgery Syndrome
- Trial name
- NCT03702010
- Testing
- spinal cord stimulation conventional, spinal cord stimulation experimental
- Where
- 2 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement, Bone Grafting
Silicate-Added Beta-TCP in Fully Guided Immediate Implants in the Esthetic Zone
This study aims to evaluate bone and soft tissue changes clinically and digitally after using a customized healing Abutment with or without silicate-added beta-tricalcium phosphate (Si-β-TCP) putty.
- Conditions
- Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement, Bone Grafting, Customized Healing Abutment, Immediate Dental Implant Placement
- Trial name
- SA-TCP Implant (NCT07613320)
- Testing
- Silicate-added β-TCP putty for jumping gap grafting, Conventional healing/ No graft
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Uterine Disease, Postoperative Pain
Postoperative Pain After Total Laparoscopic Hysterectomy: a Comparison of Single-port and Three-port Laparoscopy
The objective of this study is to compare postoperative pain between single-port access total laparoscopic hysterectomy (SPA-TLH) using a transumbilical single-port system and conventional multi (three)-port access total…
- Trial name
- NCT02390804
- Testing
- single-port laparoscopic hysterectomy(single port trochar), multi-port laparoscopic hysterectomy(multi port trochar)
- Volunteers
- 60 people
- Sponsor
- The Catholic University of Korea
Pelvic Organ Prolapse
SORD-BILL Vs Conventional Options During Sacral Colpopexy for POP
This prospective randomized pilot study is aimed to verify if the operative time of a standard laparoscopic sacral colpopexy associated to subtotal hysterectomy for the treatment of POP could be further reduced using PKS BILL…
- Trial name
- NCT02479685
- Testing
- PKS BILL-PKS PlasmaSORD Versus Conventional surgical techniques
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Catholic University of the Sacred Heart
Lumbar Spinal Stenosis
Endoscopic Versus Conventional Lumbar Decompression for Lumbar Canal Stenosis
This is a randomized controlled trial comparing interlaminar uniportal endoscopic bilateral lumbar decompression with conventional open laminectomy in patients with degenerative lumbar canal stenosis.
- Trial name
- ENDOLSS (NCT07562035)
- Testing
- Interlaminar Uniportal Endoscopic Lumbar Decompression, Open Lumbar Laminectomy
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Ain Shams University
Ovarian Cancer
Combination Chemotherapy With or Without Surgery in Treating Patients With Stage III Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug or combining chemotherapy with surgery may kill more tumor cells.
- Trial name
- NCT00002568
- Testing
- cisplatin, paclitaxel, conventional surgery
- Where
- 55 sites in United States
- Volunteers
- 470 people
- Sponsor
- Gynecologic Oncology Group
Lymphoma
Surgery Alone or With CYC VBL and PRED or CVP Alone in Stage IA or IIA Nodular Lymphocyte-Predominant Hodgkin Lymphoma
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, vinblastine, and prednisolone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EuroNetLP1 (NCT01088750)
- Testing
- cyclophosphamide, prednisolone, vinblastine sulfate
- Where
- Germany
- Volunteers
- 225 people
- Sponsor
- Christine Mauz-Körholz
Head and Neck Cancer
Chemotherapy and Radiation Therapy in Treating Patients With Stage III or Stage IV Larynx or Oropharynx Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00014118
- Testing
- carboplatin, paclitaxel, conventional surgery
- Where
- 47 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
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