Clinical trials: conventional surgery, active
Lung Carcinoma, Lung Non-Small Cell Carcinoma
Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study
This phase II trial tests the effectiveness and safety of artificial intelligence (AI) to determine dose recommendation during stereotactic body radiation therapy (SBRT) planning in patients with primary lung cancer or tumors…
- Conditions
- Lung Carcinoma, Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Lung, Stage I Lung Cancer AJCC v8
- Trial name
- NCT05802186
- Testing
- Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University
Acute Kidney Injury
Intraabdominal Pressure Monitoring Urinary Catheter and Kidney Perfusion Pressure
The goal of this clinical trial is to determine whether monitoring intra-abdominal pressure (IAP) and adjusting blood pressure accordingly to maintain optimal renal perfusion pressure can reduce the risk of acute kidney injury…
- Trial name
- NCT06989762
- Testing
- Conventional Foley Catheter(Medline), Accuryn Foley Catheter
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Dang Tan Phat
Heart Failure
The "Seamless" Patient:From Preoperative Preparation to Postoperative Rehabilitation
The "seamless" patient: from preoperative preparation to postoperative rehabilitation. The effects of digital services for perioperative care of patients undergoing cardiac surgery will be investigated
- Trial name
- NCT06699446
- Testing
- pre rehabilitation
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Hannover Medical School
Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8
Testing Olaparib Either Alone or in Combination With Atezolizumab in BRCA Mutant Non-HER2-positive Breast Cancer
This randomized phase II trial studies how well olaparib with or without atezolizumab work in treating patients with non-HER2-positive breast cancer that has spread to nearby tissue or lymph nodes (locally advanced), that cannot…
- Conditions
- Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Locally Advanced Unresectable Breast Carcinoma, Metastatic Breast Carcinoma
- Trial name
- NCT02849496
- Testing
- Atezolizumab, Biopsy Procedure, Biospecimen Collection
- Where
- 58 sites in United States
- Volunteers
- 89 people
- Sponsor
- National Cancer Institute (NCI)
Anesthesiology, General Surgery
The Effect of Enhanced Recovery After Surgery (ERAS) in Gastric Cancer Surgery
The investigators aimed to clarify the clinical relevance of the ERAS protocol by evaluating the perioperative course in patients undergoing laparoscopic gastric cancer surgery.
- Trial name
- NCT06209983
- Testing
- ERAS, Conventional care
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- National Taiwan University Hospital
Breast Cancer
Comparison of the Safety and Aesthetic Outcomes of a Novel Endoscopic-Assisted Breast-Conserving Surgery (SRRSHzb-EABCS) With Those of Conventional Breast-Conserving Surgery
This multicenter, open-label, prospective, randomized controlled study compares a novel endoscopy-assisted breast-conserving surgery technique (SRRSHzb-EABCS) with conventional open breast-conserving surgery (CBCS) in women with…
- Trial name
- ZACA001 (NCT07920094)
- Testing
- Endoscopy-assisted breast-conserving surgery (SRRSHzb-EABCS), Conventional open breast-conserving surgery (CBCS)
- Where
- 22 sites in China
- Volunteers
- 422 people
- Sponsor
- Sir Run Run Shaw Hospital
Renal Calculi
Using Retrograde Intrarenal Surgery for Managing Staghorn Renal Stones.
This prospective, randomized study is comparing the safety and efficacy of using two types of ureteral access sheaths in managing staghorn renal stones by retrograde intrarenal surgery.
- Trial name
- NCT07342361
- Testing
- Retrograde intrarenal surgery
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Helwan University
Periodontitis
Comparative Evaluation of the Effect of Different Adjunctive Air Polishing Powders in Nonsurgical Periodontal Therapy in Patients with Stage II and III Periodontitis
The aim of this clinical trial is to evaluate and compare the effect of a newly designed air-polishing device (APD) using Erythritol, Glycine, and Trehalose air-polishing powders in nonsurgical periodontal therapy with control…
- Trial name
- GBT (NCT06726902)
- Testing
- GBT and SI with erythritol powder, GBT and SI with glycine powder, GBT and SI with trehalose powder
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Diana Ibrahim
Respiratory Mechanics, Hemodynamics
vNOTES vs Laparoscopy: Respiratory Mechanics and Hemodynamics
Pneumoperitoneum and Trendelenburg position are unavoidable in laparoscopic surgery and are known to have adverse effects on intraoperative respiratory mechanics and hemodynamics.
- Trial name
- NCT07667907
- Testing
- vNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery, Laparoscopic Gynecological Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Lung Nodules
Bronchoscopic Navigation Robot-guided Dye Marking-assisted Thoracoscopic Pulmonary Nodule Resection
With the widespread use of low-dose spiral CT screening for the lungs, an increasing number of small nodules are being detected, and surgical resection is the preferred method for clinical intervention of pulmonary nodules.
- Trial name
- NCT06821451
- Testing
- Bronchoscopic navigation robot, Conventional electromagnetic navigation bronchoscope
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Ruijin Hospital
Peri-implantitis
Electrolytic Surface Decontamination in the Surgical Treatment of Peri-implantitis: A Randomized Clinical Trial
The goal of this clinical trial is to learn whether adjunctive electrolytic surface decontamination can improve the outcomes of surgical treatment of peri-implantitis.
- Trial name
- NCT07644975
- Testing
- Electrolytic Surface Decontamination, Conventional Surgical Treatment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Recurrent Classic Hodgkin Lymphoma, Refractory Classic Hodgkin Lymphoma
Brentuximab Vedotin and Nivolumab for the Treatment of Relapsed/Refractory Classic Hodgkin Lymphoma Previously Treated With Brentuximab Vedotin or Checkpoint Inhibitors
This phase II trial studies the effect of brentuximab vedotin and nivolumab in treating patients with classic Hodgkin lymphoma that has come back (relapsed) or does not respond to treatment (refractory) that have been previously…
- Trial name
- NCT05039073
- Testing
- Brentuximab Vedotin, Hematopoietic Cell Transplantation, Nivolumab
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Emory University
Nasopharyngeal Cancinoma (NPC)
Multimodal Evaluation-Guided Surveillance-Intervention With Endoscopic Selective Neck Dissection for Post-Radiotherapy N3 Nasopharyngeal Carcinoma
This randomized trial evaluates a multimodal surveillance strategy in nasopharyngeal carcinoma patients with high-risk N3 cervical lymph node involvement after radiotherapy.
- Trial name
- NCT07692906
- Testing
- Multimodal Evaluation-Guided Surveillance Strategy
- Volunteers
- 80 people
- Sponsor
- Xuelei Ma MD
Oxidative Stress, Systemic Inflammatory Response Syndrome
Inflammatory Response and Oxidative Stress in Cardiac Surgery: Min. Invasive vs. Conventional Extracorporeal Circulation
The goal of our research project is to measure and compare oxidative stress markers, and systemic inflammatory response in patients undergoing open heart surgery with either conventional or minimally invasive extracorporeal…
- Conditions
- Oxidative Stress, Systemic Inflammatory Response Syndrome, Extracorporeal Circulation; Complications
- Trial name
- NCT06477757
- Testing
- Minimally Invasive Extracorporeal Circulation, Conventional Extracorporeal Circulation
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Maribor
Obesity, Bariatric Surgery
Flow-Controlled Versus Volume-Controlled Ventilation in Bariatric Surgery
This prospective trial aims to compare the effects of flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV) on intraoperative airway pressures and oxygenation in bariatric surgery under general anesthesia.
- Conditions
- Obesity, Bariatric Surgery, Mechanical Ventilation
- Trial name
- NCT07430111
- Testing
- FCV Group, VCV Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara Etlik City Hospital
Upper Gastrointestinal Wall Thickening
Multimodal Endoscopic Ultrasound in the Evaluation of Indeterminate Upper Gastrointestinal Wall Thickening
Multimodal endoscopic ultrasound can help to differentiate between benign (non-cancerous) and malignant (cancerous) causes of thickening of the upper digestive tract wall.
- Trial name
- MM-EUS-UGIWT (NCT07407296)
- Testing
- Endoscopic ultrasound
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Assiut University
Neck Pain, Zygapophyseal Joint Arthritis
End-on Versus Parallel Radiofrequency Lesioning for Neurotomy of the Cervical Medial Branch Nerves
Aim of the EndPaRL study is to compare the efficacy and effectiveness of the two techniques utilizing sharp straight conventional radiofrequency needle with a trident needle for radiofrequency neurotomy of Cervical Medial Branch…
- Trial name
- EndPaRL (NCT05818774)
- Testing
- Radiofrequency neurotomy (RFN) of Cervical Medial Branch Nerves (CMBNn) with parallel lesioning, Radiofrequency neurotomy (RFN) of Cervical Medial Branch Nerves (CMBNn) with end-on lesioning with multitined trident cannulae
- Where
- 3 sites in Canada, Spain
- Volunteers
- 72 people
- Sponsor
- University Health Network, Toronto
Wound Heal
Vacuum Sealing Drainage (VSD) in Promoting Wound Healing and Reducing Complications in Post-Infected Obstetric and Gynecological Surgical Sites
This study aims to evaluate the efficacy of VSD in promoting wound healing and reducing complications, such as re-infection, prolonged hospitalization, and need for further surgical interventions, in obstetric and gynecological…
- Trial name
- NCT07525674
- Testing
- Conventional Wound Care Group, Vacuum Sealing Drainage (VSD) Group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Coronary Revascularization, Coronary Artery Disease
The CORE Platform Trial
Background: The leading cause of death worldwide is cardiovascular disease, with an estimated 19.8 million deaths per year. Coronary artery disease is a type of cardiovascular disease that can be treated with revascularisation…
- Trial name
- CORE (NCT07892976)
- Testing
- MIDCAB procedure, CABG procedure
- Where
- 3 sites in Belgium, Denmark and 1 more
- Volunteers
- 15,000 people
- Sponsor
- Copenhagen Trial Unit, Center for Clinical Intervention Research
Liver Transplantation
Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation
Liver transplantation carries a substantial risk of bleeding, making precise haemostasis control essential, although assessing coagulation remains challenging.
- Trial name
- QUALIVERT (NCT06749405)
- Testing
- Transfusion algorithm based on Quantra®, Conventional transfusion algorithm
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Toulouse
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