Clinical trials: cyclosporine
Transplant, Kidney
Pilot Trial for Implementation of a MPA PK Monitoring Strategy
This study is a prospective interventional trial of de novo renal transplant recipients, aiming to validate a strategy which combines the use of early post transplant MPA AUC sampling, and subsequent MPA trough level monitoring…
- Trial name
- MPA (NCT00187915)
- Testing
- Mycophenolate mofetil + Tacrolimus, Mycophenolate mofetil + Cyclosporin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Kidney Transplant, Immunosuppression
Study to Evaluate the Safety and Efficacy of Switching Calcineurin Inhibitor to Everolimus After Kidney Transplantation in Adults
The purpose of this study is to demonstrate the efficacy and safety in the use of everolimus, with its onset after 3 months of treatment with calcineurin inhibitor.
- Trial name
- NCT01455649
- Testing
- Everolimus, calcineurin inhibitor
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Deise de Boni Monteiro de Carvalho
Familial Lipoprotein Lipase Deficiency
Safety and Efficacy in LPL-Deficient Subjects of AMT-011, an Adeno-Associated Viral Vector Expressing Human Lipoprotein Lipase [S447X]
LPLD is a rare autosomal recessive disorder, characterized by the presence of marked chylomicronemia and hence hypertriglyceridemia.
- Trial name
- NCT01109498
- Testing
- Alipogene Tiparvovec (AMT-011), Human LPL [S447X], Mycophenolate mofetil, cyclosporine
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Amsterdam Molecular Therapeutics
Familial Lipoprotein Lipase Deficiency
Efficacy and Safety of Human Lipoprotein Lipase (LPL)[S447X] Expressed by an Adeno-Associated Viral Vector in LPL-deficient Subjects
This trial is designed to expand the currently available data on the safety and efficacy of alipogene tiparvovec treatment in lipoprotein lipase deficiency (LPLD) and to further the understanding of possible mechanisms of action…
- Trial name
- NCT00891306
- Testing
- Alipogene Tiparvovec (AMT-011), Human LPL [S447X], mycophenolate mofetil, cyclosporine
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- Amsterdam Molecular Therapeutics
Liver Transplantation, Infection
Efficacy and Safety of Basiliximab, Cyclosporine/Cyclosporine Microemulsion, and Steroids in Pediatric de Novo Liver Transplant Recipients Avoiding Intraoperative Steroids
Systemic infection is still a major concern in young children with liver transplantation. The approach of this study is to reduce the risk of systemic infections by avoiding intraoperative steroids (another class of…
- Trial name
- NCT00149890
- Testing
- Basiliximab, Cyclosporine/cyclosporine microemulsion, Steroid
- Where
- Germany
- Volunteers
- 77 people
- Sponsor
- Novartis
Healthy, Drug Interaction
Single Dose Study Of The Effect Of Cyclosporine On The Pharmacokinetics Of PF-04991532 In Health Volunteers
The primary purpose of this study is to evaluate the pharmacokinetics, safety and tolerability of a single dose of PF-04991532 in healthy adult subjects with and without co-administration of cyclosporine.
- Trial name
- NCT01370343
- Testing
- PF-04991532 alone, PF-04991532 + cyclosporine
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Bronchiolitis Obliterans, Immunosuppression
Tacrolimus Versus Cyclosporine for Immunosuppression After Lung Transplantation
The purpose of the study is to compare efficacy and safety of two different immunosuppressive regimens for prevention of bronchiolitis obliterans syndrome (BOS) (chronic lung allograft rejection)after lung transplantation…
- Trial name
- EAILTX (NCT01429844)
- Testing
- Tacrolimus, Cyclosporine
- Where
- 14 sites in Australia, Austria and 4 more
- Volunteers
- 274 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ulcerative Colitis, Steroid Refractory
Study Comparing Cyclosporine With Infliximab in Steroid-refractory Severe Attacks of Ulcerative Colitis
PHASE: IV TYPE OF STUDY: With direct benefit. DESCRIPTIVE: Multicenter, randomized, open label study. INCLUSION CRITERIA: Steroid-refractory ulcerative colitis.
- Trial name
- CYSIF (NCT00542152)
- Testing
- CYCLOSPORINE VS INFLIXIMAB
- Where
- 41 sites in Belgium, Finland and 3 more
- Volunteers
- 115 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Chronic Plaque Psoriasis
Efficacy and Safety of Cyclosporine A Microemulsion in Maintenance Patients With Chronic Plaque Psoriasis
The study will evaluate the efficacy of cyclosporine at 2, 5 mg/kg/day bid (i.e. bis in a day), when administered twice a week compared to continuous administration, in patients with chronic plaque psoriasis.
- Trial name
- NCT00438360
- Testing
- Cyclosporine A microemulsion
- Where
- Italy
- Volunteers
- 243 people
- Sponsor
- Novartis Pharmaceuticals
Purpura, Schoenlein-Henoch
HSP-glomerulonephritis Trial: MP vs CyA
No curative treatment of severe HSP nephritis is known. Apart from corticosteroids, immunosuppressive drugs, such as azathioprine and cyclophosphamide, have been used to treat severe HSP nephritis.Limited patient series treated…
- Trial name
- NCT00425724
- Testing
- Methylprednisolone pulses plus prednisone versus Cyclosporine A
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Oulu University Hospital
Function of Renal Transplant
Polymorphism of the Cytochrome P450-system in Renal Transplants
In this study the researchers want to investigate genetic polymorphisms of cytochrome 450 enzymes and the multiple drug resistance (MDR) gene in renal transplant patients to look for differences in dosing of immunosuppressive…
- Trial name
- NCT00223054
- Testing
- tacrolimus, sirolimus, everolimus
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Schleswig-Holstein
Rosacea
Efficacy of Topical Cyclosporin for Ocular Rosacea
The purpose of this study is to determine whether Restasis (topical cyclosporin) is effective in the treatment of ocular rosacea
- Trial name
- NCT00348335
- Testing
- Cyclosporine 0.05%, Ocular lubricant
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Long Island
Acquired Haemophilia
Turkish Acquired Haemophilia Registry
Turkish Acquired Haemophilia Registry is a database in which information about clinical features and therapeutic management of acquired haemophilia is collected in Turkey.This is a multicentre, retrospective and prospective…
- Trial name
- EHEM (NCT01403740)
- Testing
- rFVIIIa, aPCC, FVIII, DDAVP, Azathioprine, Rituximab, Cyclosporin
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Turkish Society of Hematology
Dry Eye Syndromes
Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-005)
The purpose of this phase 3 study is to determine the safety and efficacy of cyclosporine in the treatment of dry eye syndrome.
- Trial name
- NCT00502073
- Testing
- cyclosporine
- Where
- United States
- Sponsor
- Sirion Therapeutics, Inc.
Dry Eye Syndromes
Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-007)
The purpose of this phase 3 study is to determine the safety and efficacy of cyclosporine in the treatment of dry eye syndrome.
- Trial name
- NCT00548301
- Testing
- cyclosporine
- Where
- United States
- Sponsor
- Sirion Therapeutics, Inc.
Graft Rejection, Kidney Failure
Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant Recipients
The primary purpose of this study is to determine whether converting from calcineurin inhibitor (CNI) therapy to sirolimus therapy will be more effective than continuing calcineurin inhibitor therapy with respect to renal…
- Trial name
- NCT00369382
- Testing
- cyclosporine or tacrolimus, sirolimus
- Where
- 23 sites in United States, Australia and 5 more
- Volunteers
- 121 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Transplantation Infection
Everolimus in Combination With Cyclosporine Microemulsion in de Novo Renal Transplant Recipients
The purpose of this study was to allow the continuation of everolimus treatment in patients who have completed the core study (NCT00170885) and to collect long-term safety, tolerability, and efficacy data in a group of patients…
- Trial name
- EVEREST (NCT01276457)
- Testing
- Everolimus 0.25 and 0.75 mg tablets, Cyclosporine very low dose (150-300 ng/mL) microemulsion, Cyclosporine low dose (350-500 ng/mL) microemulsion
- Volunteers
- 223 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Transplantation, Graft Rejection
Efficacy and Safety Study of Everolimus Plus Reduced Cyclosporine Versus Mycophenolic Acid Plus Cyclosporine in Kidney Transplant Recipients
The purpose of this study was to compare the safety and efficacy of three immunosuppressive treatment regimens following a kidney transplant.
- Trial name
- NCT00251004
- Testing
- Everolimus, Mycophenolic Acid (MPA), Cyclosporine A (CsA)
- Where
- United States
- Volunteers
- 833 people
- Sponsor
- Novartis
Kidney Transplantation, Living Donors
Randomized Trial of Cyclosporine and Tacrolimus Therapy With Steroid Withdrawal in Living-Donor Renal Transplantation
The use of steroids after kidney transplantation has been challenged because of variable adverse effects which may increase the patient morbidity and mortality.
- Trial name
- NCT00777933
- Testing
- tacrolimus, cyclosporine
- Where
- South Korea
- Volunteers
- 131 people
- Sponsor
- Samsung Medical Center
Liver Transplantation
RESCUE Study - Everolimus in Liver Transplantation Recipients With Renal Insufficiency
The purpose of the study is to assess the effect of everolimus initiation together with reduction or discontinuation of calcineurin inhibitor (CNI) on renal function in maintenance liver transplant recipients with CNI-related…
- Trial name
- NCT00267189
- Testing
- Everolimus, Calcineurin inhibitors (CNI), Mycophenolate acid (MPA)/ Azathioprine (AZA)
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 145 people
- Sponsor
- Novartis Pharmaceuticals